A clinical trial found that combination immunotherapy reduced melanoma brain metastases by 26% in 94 patients. The treatment, combining checkpoint inhibitors ipilimumab and nivolumab, also showed durable responses with 59.5% of patients remaining progression-free at nine months.
Scientists have unraveled how changes in nutrition determine the development of honeybees into queens or workers. Epigenetic patterns, including histones, play a crucial role in controlling gene expression and developmental outcomes.
Researchers at Loma Linda University Health found that kidney transplantation can be safely performed using organs testing positive for hepatitis C virus antibody but negative for active viral infection. The study expanded the number of kidneys available for those in need, addressing a shortage in organ donations.
Typhoon Soulik's highest concentrations of water vapor were found north of the eye, indicating strongest storms. The storm is moving northwest towards South Korea's southeastern coast.
Scientists develop peptide hydrogel that stimulates new blood vessel and dental pulp growth in teeth after root canals. The material aims to preserve more of the existing dental pulp and help grow new tissue, making the procedure less invasive.
Researchers developed an AI system to detect tiny lung cancer tumors in CT scans, achieving 95% accuracy compared to human eyes at 65%. The system uses a connection-based approach similar to facial recognition software to identify patterns.
A UCLA study reveals that magnetic stimulation of the lower spine can restore significant bladder control in people with spinal-cord injuries. The treatment improved patients' quality of life by an average of 60%, allowing them to urinate voluntarily for up to four weeks between treatments.
A new method allows for rapid generation of functional brain cells, known as astrocytes, from embryonic stem cells in just two weeks. This breakthrough enables researchers to study the role of astrocytes in various diseases, including neurodegenerative conditions such as dementia and ALS.
A new study by University of Illinois researchers found that the conical shape of murre eggs makes them more stable on cliffside ledges. Increasing the egg's conicality reduced its tendency to roll off the surface, providing experimental support for natural selection shaping the unique form of murre eggs.
Remnants of the extracellular matrix promote inflammation and airway remodeling in asthma. Accumulation of PGP may explain why LTA4H inhibitors have failed in clinical trials.
Researchers have developed a new drug that targets EBV-positive tumors and inhibits tumor development and metastases for EBV-related lymphomas. The findings suggest the drug may be useful in treating malignancies in EBV-positive patients.
Researchers from D'Or Institute and L'Oréal R&I successfully generated functional human sensory neurons that respond to painful stimuli. The breakthrough discovery has significant implications for the study of chronic pain, analgesic drugs, and the development of reconstructed human skin with enhanced neuro-inflammation predictivity.
Drs. Jonathan Rothberg, Roger Klein and Kevin Halling are being recognized for their groundbreaking work and longstanding commitment to advancing patient care and the field of molecular diagnostics. Drs. Rothberg is receiving AMP's highest honor for his pioneering work in genomics and inventions like massively parallel DNA sequencing.
Researchers at the University of Wisconsin-Madison created a robot named Minnie to serve as a reading buddy to middle school kids, resulting in increased excitement about books and attachment to the robot. The study showed that social learning through interaction with the robot improved comprehension and motivation for reading.
Research reveals a significant shift from clear to murky lakes in the continental United States over the past five years. Murky lakes have increased by 12% while clear lakes declined by 18%, posing concerns for water quality and aquatic life.
A team of researchers has discovered a molecular mechanism that causes leptin resistance in obese individuals, which blocks the brain's ability to recognize when it's full. By blocking this enzyme, MMP-2, scientists hope to develop treatments for obesity-related issues and explore its broader implications.
A study of 221 patients found that increased synovitis led to cartilage damage over time. Individuals with synovitis may be at greater risk for cartilage damage, and further research on treatment could help advance treatment paradigms.
A new study reveals that two-thirds of alcohol industry revenue in England comes from consumers drinking at risky levels. If all drinkers complied with the Chief Medical Officer's recommended guideline levels, alcohol sales would decline by £13 billion.
A study found strong associations between sleep apnoea severity and abnormal lipid levels, including higher cholesterol and lower HDL-cholesterol. Patients with sleep apnoea require careful management of cardiovascular risk factors.
Researchers have successfully controlled plasma instabilities in a way that could lead to the efficient operation of ITER, a key step towards harnessing fusion power. The experiments used high-pressure plasmas and resonant magnetic perturbations to suppress large ELMs and produce benign ones.
Researchers at Temple University Health System have identified four BAG3 gene variants linked to poor outcomes in African American patients with dilated cardiomyopathy. The variants facilitate programmed cell death and reduce autophagy, leading to worsening heart failure.
Research by neuroscientists at UMass Amherst found that naps and overnight sleep work together to benefit memory in young children. Naps contribute to emotion processing in preschoolers, which is consistent with parents' observations, but the benefits are delayed.
A Rutgers study finds that popular exotic pet reptiles and lizards are more likely to be released into the wild, causing ecological harm. The research highlights the need for education and resources to prevent these releases and mitigate invasive species.
A recent study published in PLOS ONE found that macaws use facial displays such as blushing and ruffling their head feathers to convey positive emotions during social interactions. The researchers observed that these behaviors were more common when the birds were interacting with humans, suggesting a form of visual communication.
A new study reveals that trace metals from aerosols affect biological productivity and change ocean ecosystems. Marine microorganisms like phytoplankton and bacteria take up metals, influencing the food chain.
Scientists compared two genetic sequencing methods to identify viruses behind illnesses in Tanzania. VirCapSeq-VERT proved more efficient than unbiased high-throughput sequencing, detecting Dengue virus and other pathogens with similar accuracy. The study's findings support the use of VirCapSeq-VERT as a cost-effective method for monit...
A recent study by researchers at Uppsala University reveals that catastrophic flood events can lead to decreased human proximity to rivers, particularly in areas with low structural flood protection. This shift may help reduce exposure to future flooding events.
Electrically charged volcanic ash from the 1815 Mount Tambora eruption may have contributed to Napoleon's defeat at Waterloo by 'short-circuiting' the ionosphere. Heavy rain brought about by this ash led to muddy and rainy conditions that hindered the Allied army.
The review identified gaps in using technologies, with a lack of information on extreme temperatures and flooding. Despite limitations, big data and ICT hold promise for potential solutions to harness diverse and chaotic data in disasters.
A study by the University of Liverpool identified 31 ecosystem services provided by marine biodiversity, including seafood, raw materials, and natural flood defences. The research highlights the importance of protecting biodiversity to maintain these essential services.
Researchers have developed a practical and inexpensive way to prevent lithium-ion battery fires by hardening the electrolyte on impact. The additive-based approach uses a shear-thickening behavior to block fluid flow, preventing electrode contact and fire.
Researchers at James Cook University found that shrimp clean parasites from injured fish without aggravating their injuries. The interaction between cleaner shrimp and client fish also reduces stress levels, potentially increasing the fish's ability to heal.
The University of Pittsburgh's Center for Energy will collaborate with Leidos and NETL on a ten-year, $365 million contract. The partnership aims to provide research support services and access to the university's talented faculty in various energy-related fields.
Research analyzed data from over 25,000 individuals in China to determine early life nutrition's role in metabolic disorders. The study found significant associations between low birth weight and increased risk of obesity, diabetes, and hypertension.
A recent study found that around 1.1% to 2.5% of ADHD patients treated with methylphenidate may experience psychotic symptoms, including hallucinations. The medication, commonly prescribed for attention deficit hyperactivity disorder and narcolepsy, can cause these adverse effects in some children and adolescents.
Researchers analyzed ancient and modern koala and kangaroo teeth to understand diet changes across millennia. The study found that tooth wear patterns are indicative of dietary habits, not environmental factors.
A team of Harvard researchers has created a system to represent and classify band structures in materials, allowing for the prediction of their properties. This breakthrough can aid in designing new materials with specific electronic properties, such as topological insulators, which have potential applications in quantum computing.
Researchers at MIT and Brigham and Women's Hospital discovered a novel mechanism for chronic rhinosinusitis, which involves distinct gene-expression patterns in epithelial cells. The study suggests that basal cells from patients with nasal polyps retain a memory of IL-4 and IL-13, immune response cytokines driving allergic inflammation.
Research found two brain areas associated with action control have varying volumes and connectivity in individuals with high versus low action control. Individuals with poor action control had a larger amygdala, while the dorsal anterior cingulate cortex (dorsal ACC) showed reduced functional connection to the amygdala.
Chris Carr, an Ohio undergraduate, discovered a new galaxy 37 million lightyears away using deep sky images from the Burrell Schmidt telescope. The detection is part of the Leo I galaxy group and is considered the lowest surface brightness object ever detected via integrated light.
A study led by Johns Hopkins Bloomberg School of Public Health researchers found that breast cancer survivors, particularly those with lymphedema, incur significant out-of-pocket costs. The average annual cost for those with lymphedema was $2,306 excluding productivity costs and $3,325 including productivity costs.
A study found that young adults, particularly college students, are high food wasters due to a lack of learned food management behaviors. The study's findings suggest that environmental factors, such as access to refrigerators and cooking facilities, also play a role in their behavior.
A study by University of Washington researchers found that policies in Puget Sound are shifting toward restoration projects that engage multiple social groups and offer various benefits. These projects, such as the Qwuloolt project, have been successful due to their inclusive planning processes and collaborative nature.
A new University College London study finds that lower indoor temperatures are associated with higher blood pressure, suggesting that keeping homes warmer could help manage hypertension. Researchers found that a decrease of 1°C in indoor temperature leads to rises in systolic and diastolic blood pressure.
The GPM core observatory satellite analyzed rainfall rates and cloud heights of Hurricane Lane on Aug. 22, revealing very heavy rain occurring within the storm's eye wall. The satellite showed moderate to heavy rainfall extending outward from the storm's center, posing a threat to the Hawaiian Islands with powerful storms.
New research suggests that depression in women may impact their children's stress and physical well-being, leading to higher cortisol and s-IgA levels. Children of depressed mothers tend to exhibit psychiatric disorders and social withdrawal. Early interventions targeting maternal stress and parenting behavior are advocated.
High performing students make strategic decisions about their time use to balance academic performance with enjoying college game days, leading to improved self-esteem, psychological well-being, and social identity.
Rice University scientists create iron-based TI contrast agent that outperforms gadolinium chelates, improving T1 MRI contrast performance by two-fold. The study demonstrates a method to load iron into nanoparticles, offering a safer and more effective alternative for radiologists.
The study reveals geographical patterns in epigenetic changes between 100 landraces of wheat, suggesting that these changes have arisen due to environmental conditions. This discovery provides breeders with a new tool to improve how plants respond to local conditions, enabling farmers to grow the best possible crop for their environment.
Researchers at Colorado State University have developed a cheap and easy-to-use detection device that can quickly identify counterfeit antibiotics. The device uses a simple paper-based test to detect the presence of antibiotics, with a strip turning red if a falsified sample is present.
Researchers at Osaka University demonstrate a link between IQ decline and work outcome in patients with schizophrenia. The study provides a method for estimating probabilities of work outcome, promoting reintegration into society and treatment motivation.
A study of 6,626 French adults aged 65+ found that those with optimal levels in six cardiovascular metrics (nonsmoking, weight, diet, physical activity, cholesterol, and blood pressure) had a lower risk for dementia. Each additional metric at the recommended level was associated with a lower risk for cognitive decline.
Typhoon Soulik's cloud top temperatures were observed by NASA's Aqua satellite, revealing a 50 nautical-mile wide eye with very strong thunderstorms surrounding it. The storm is tracking northwestward at 15 mph and is expected to slowly weaken before making landfall near Seoul, South Korea.
Researchers from Ben-Gurion University of the Negev present marine magnetic data that shows motion between East and West Antarctica continued for another 15 million years than previously thought. This discovery has significant implications for understanding tectono-volcanic activity in the Pacific Ocean.
A comprehensive analysis found high-risk HPV testing excellent for detecting pre-cancerous cells and cancer, with a higher detection rate compared to Pap smears. The research also showed that while high-risk HPV tests are effective, they can lead to more treatments with potential harms due to false positives.
This research article assesses two tools for cement crown retrieval, finding that the automatic tool improves reliability and efficiency. The study also reveals a significant difference in force patterns between the tools, with the compressed air-powered instrument producing sharper peak forces.
A new study reveals that carers for people with cancer are between 5 and 7 times more likely to experience clinically significant psychological morbidity compared to the general population. The study also found lower general health scores among carers, particularly at younger ages.
Researchers discovered long noncoding RNAs play a key role in regulating genetic circuits responsible for regeneration in highly regenerative animals. The discovery may lead to the development of drugs to trigger humans' dormant pathways for regeneration.
Scientists at Helmholtz Zentrum München discovered a metabolic network controlled by muscle cell circadian clocks, regulating fat storage and glucose metabolism. The study found that without this internal clock, mice became leaner and had more muscle mass.
Researchers have discovered a novel subtype of multiple sclerosis, called myelocortical MS (MCMS), which features neuronal loss but no demyelination in the brain's white matter. This new subtype is indistinguishable from traditional MS on MRI and has reduced neuronal density and cortical thickness.