Researchers have crystallized serotonin receptors bound to several compounds, revealing why some drugs cause severe side effects while others do not. The study provides valuable insight into the receptor's structure and binding mechanisms, enabling drug developers to create safer and more effective medications.
A recent study found that rates of viral suppression among HIV-infected adults improved from 32% in 1997 to 86% in 2015, but disparities persist across demographic groups. Closing treatment gaps and addressing social and economic barriers to care will be essential to ending the US HIV epidemic.
A recent study using sewage epidemiology found significantly higher levels of methamphetamine and amphetamine use, as well as increased opioid consumption, during festive events. The researchers also confirmed the intuitive assumption that drug use rises during celebrations.
A blood management program safely reduced transfusions in orthopedic patients undergoing hip and knee replacement surgeries. The program implemented strategies to minimize bleeding, resulting in lower hemoglobin thresholds and reduced complications.
The Lothagam North Pillar Site is the earliest and largest monumental cemetery in eastern Africa, built by an egalitarian society of mobile pastoralists around Lake Turkana. The site's construction contradicts traditional theories about the emergence of social hierarchy and its relationship to monument building.
A Rice University scientist has developed a new method to diagnose quantum computers, reducing the need for expensive measurements. This approach uses compressed sensing to minimize data while ensuring accurate results, making it possible to validate even large-scale systems.
A new EU-wide study found that more than half of severe listeriosis cases belong to clusters, which are often not detected quickly enough by current surveillance systems. The use of whole genome sequencing could lead to faster detection of multi-country outbreaks, saving up to 5 months of investigations.
A study published in the American Journal of Epidemiology found that a healthy diet high in fruits, vegetables, and whole grains can promote healthy cellular aging in women. The researchers used telomere length as a measure of cellular aging and found that higher diet quality indices were associated with longer telomeres.
A new study suggests that nitrous oxide, a powerful greenhouse gas, played a significant role in keeping early Earth warm. The research found that nitrous oxide could have reached ten times today's levels, providing an extra boost of global warming under the Faint Young Sun Paradox.
Young people who received radiation therapy for pediatric brain tumors struggle to create new memories, but retain those formed before treatment. Reduced neurogenesis in the hippocampus may contribute to this effect.
A team of researchers measured the force exerted by plant sperm cells as they navigate female flower tissues using microfluidic technology. The study found that the cellular pressure driving invasion corresponds to that of a car tire, and the pollen tubes adapt their growth pattern in response to physical resistance.
Researchers discovered a molecular mechanism behind variable penetrance, where identical gene mutations have varying effects on disease severity. They found an enrichment of combinations of regulatory and coding variants that act as protective against disease by decreasing the penetrance of coding variants.
Researchers at CNIO develop gene therapy with telomerase, proving effective in mice against diseases caused by excessive telomere shortening. The study finds that the gene therapy does not increase the risk of developing cancer, even in a cancer-prone setting.
The National Foundation for Cancer Research has received a $35,000 grant from Safeway Foundation to expand its Cancer Patient Navigation Hotline services. The hotline provides guidance and support to patients and their families at no cost, aiming to equip users with knowledge enabling better decisions about their cancer care.
A recent study by Yale researchers found that black patients are more likely to be tested for illicit drug use after starting opioids for chronic pain and have their prescriptions discontinued. The study highlights the need for a universal approach to monitoring patients prescribed opioids, particularly in addressing racial disparities.
A new position paper from the Association of Academic Surgeons and others advocates for supporting global surgeons in academic health centers. The authors argue that global surgeons can bring strategic value to AHCs with their research experience, education, and health equity work.
Research led by the University of Arizona found that workers in open bench seating had lower physiological stress during after-work hours and were more physically active at the office. This study provides objective measurements to inform policies and practices that affect the health and well-being of millions of office workers worldwide.
A Baylor University study finds that children with certain types of brain tumors who undergo radiation treatment are more likely to forget recent memories than pre-treatment ones. The study suggests that radiation impacts the development of new cells in the hippocampus, leading to deficits in forming new memories.
A study by the University of Kent demonstrates that ancient humans were able to produce advanced stone tools, such as spear points, only after evolving stronger grips. The research uses sensors attached to skilled flint knappers' hands to identify platform preparation behaviors, which required forceful precision grips.
A Kaiser Permanente study found that pregnant women with nausea and vomiting in pregnancy were significantly more likely to have used marijuana during pregnancy. Women with severe nausea and vomiting had nearly four times greater odds of prenatal marijuana use than those without symptoms.
A long-term study found that drought helped ecological underdogs by stressing dominant species, while carnivores suffered when their prey became scarce. The Carrizo Plain National Monument revealed patterns relevant for climate change, with implications for conservation efforts.
ReMix uses wireless signals to pinpoint the location of ingestible implants inside the body with centimeter-level accuracy. This technology has the potential to improve proton therapy cancer treatment by allowing doctors to track tumors in real-time and deliver targeted radiation.
Researchers have identified 50 stool proteins that are consistently elevated in patients with inflammatory bowel disease. These biomarkers could help diagnose the condition earlier and more accurately, allowing for quicker treatment. The findings also suggest a potential self-care kit for monitoring the disease.
A Lehigh research team is developing a 'Google for research data' that can assist scientists in locating datasets across various disciplines. The team aims to create a domain-agnostic search engine that utilizes user-centric methods to develop dataset search tools and novel indexing techniques.
Researchers at Ruhr-University Bochum have developed semi-synthetic enzyme systems using DNA, which can replace protein cofactors. This innovation aims to create more stable biocatalysts that can be used in industry for climate protection and economic gain.
Researchers found that adult engagement and supervision during recess are the strongest predictors of children's engagement in activities. Longer recess periods also led to more physical activity, with boys being more active than girls. The study highlights the importance of a high-quality recess experience for children.
A new study examines the link between socioeconomic status and racial & ethnic disparities in childhood cancer survival. The research found that socioeconomic status significantly mediate the association between race/ethnicity and survival for certain types of childhood cancers, such as acute lymphoblastic leukemia, acute myeloid leuke...
Researchers find that glucitol-core-containing gallotannins from red maple leaves can block elastase activity, maintaining skin elasticity. The findings could lead to the development of plant-based skincare products and create new economic opportunities for farmers in eastern North America.
Researchers have discovered a way to make a thin material that enhances the flow of microwave energy by exploiting domain walls. This discovery could improve telecommunications by expanding the range of frequencies used as communications channels.
A study by Jonathan Mummolo found that militarized policing is ineffective in decreasing crime and protecting police officers, and may actually weaken the public's image of law enforcement. The study also reveals that SWAT teams are more often deployed in communities of color.
A new assay has been developed to detect genetic abnormalities in sarcomas, which outperform conventional techniques in analysis of multiple target genes simultaneously. The assay was validated on 81 samples and showed high sensitivity, allowing for accurate diagnosis even in small sample sizes.
Researchers from Kyoto University and ATR upgraded the interaction system for conversational android ERICA, giving her more dynamic speaking skills. The team focused on developing a system for 'attentive listening', allowing ERICA to engage in fluid dialogue with human subjects.
Researchers review options to reduce sugar in ice cream, yogurt, and flavored milk without sacrificing flavor, finding sweetener blends and sugar reduction techniques promising. Techniques like sorbitol and sucralose, erythritol, and lactitol show potential for reducing sugar content, improving taste and texture.
The GPM satellite provided highly accurate information about precipitation within Hurricane Lane, revealing intense feeder bands and eye wall storms. Rainfall rates reached over 89 mm/hour near the hurricane's eye, with some areas dropping rain at a rate of over 143 mm/hour.
Osaka University-led scientists created integrated gene logic-chips called 'gene nanochips' to control gene expression and program cells. These nanochips can switch genes on and off within a single chip, preventing unintended crosstalk.
A survey of southern California high school students found a correlation between concerns over increasing social discrimination and poorer behavioral health outcomes. The study suggests that public health attention and policy changes may be needed to address the impact of public expressions of discrimination on adolescent mental health.
A new study found that overweight mice with Type 2 diabetes who don't sleep well need more time to heal their wounds compared to healthy mice. The research suggests that sleep plays a crucial role in wound healing among obese mice with Type 2 diabetes.
Researchers at RCSI and Trinity College Dublin have discovered how the body clock regulates inflammatory response in macrophages, a key immune cell. This study may lead to targeted treatments at specific times of the day to alleviate excess inflammation in conditions like asthma, arthritis, and cardiovascular disease.
Researchers used light from distant quasars to determine measurements on pairs of entangled photons, finding correlations that exceeded Bell's original limit for a classically based mechanism. This strengthens the case for quantum entanglement and restricts options for the freedom-of-choice loophole.
A Colorado study found that more than half of sampled stores sold cigarettes to minors, despite a third being detected after multiple visits. The study suggests that testing each store more than once and verifying age from ID would improve enforcement.
Marimo algae balls sink at night and float during the day due to photosynthesis and biological circadian rhythms, according to a new study published in Current Biology. The research has implications for conserving these endangered species, which have experienced a global decline.
Researchers found that brain tumors can sequester immune cells in the bone marrow, preventing them from attacking the tumor. This trapping mechanism is mediated by a protein called S1P1, and releasing it may help unlock the immune cells' potential to target cancer.
Diabetologists are filling a crucial gap in patient care, but their growth is hindered by resistance from payers and colleagues. The new medical specialty aims to provide comprehensive diabetes management, but challenges persist due to reimbursement issues and varying opinions on scope of practice.
Ken M. Mitchell, a mechanical engineering graduate student at the University of Memphis, has won the 2018 AIAA Foundation Abe M. Zarem Award for his research paper on thermal conductivity and specific heat measurements. The award recognizes his outstanding scholarship in astronautics and aeronautics.
A recent study by Hokkaido University reveals that climate warming, ocean currents, and deforestation by invasive fish are driving the expansion of tropical corals into temperate zones in Japan. This shift is linked to increased grazing by herbivorous fish, leading to a decline in macroalgae populations.
Researchers found that e-cigarette users experience increased DNA damage related to acrolein exposure, which could increase their cancer risk. The study suggests that vaping may modify the genetic material in oral cells, highlighting the need for further research on the long-term health effects of e-cigarettes.
Researchers analyzed ape parasite genomes related to Plasmodium vivax, the main source of mosquito-borne malaria outside Africa. They found near-identical genomes between ape and human parasites, differing by only two percent within gene sequences that code for proteins.
Researchers at Gladstone Institutes discovered how to improve the survival of CD8 T cells, which can combat tumors and chronic infections. The study found that deleting two specific molecules enhances the survival of effector cells and yields more protective memory cells.
A study at Toronto General Hospital found that nearly half of patients who did not take opioids before surgery were able to wean off completely. The Transitional Pain Program uses non-opioid medications, psychological techniques, and exercise prescriptions to help patients manage pain. Patients who were on high doses of opioids before ...
Juelich researchers have designed a new cell type that can charge in under an hour, overcoming the low current hurdle. The battery uses a favourable combination of materials to enable high charging rates.
A new analysis by NYU psychologists reveals that beauty may be an intense pleasure rather than a special experience. The study, which spans thousands of years and multiple disciplines, finds that certain features like symmetry and roundness make things more beautiful on average.
Scientists developed a flexible, high-density artificial retina using 2D materials that mimics the human eye. The device has shown promising results in laboratory and animal studies, and could potentially restore sight to millions of people with retinal diseases.
Researchers have developed bioengineered tooth buds that exhibit features of natural teeth, paving the way for a promising tooth replacement therapy. The new method uses postnatal dental cells to create bioengineered tooth buds with innervation, eliminating the need for immunosuppressors.
A USC study found that kids stressed over public acts of discrimination show increased behavioral problems, including depression and substance use. The study tracked 2,572 11th-grade students in L.A. County and found a significant association between concern about discrimination and adverse behavioral outcomes.
The study found that warmer temperatures and earlier springs lead to an increase in epizootic shell disease, which can cause a 70% mortality rate in infected lobsters. Disease prevalence doubles during early-molting years and correlates strongly with summer heat.
A review of research on summer weather stalling highlights the impact of Arctic warming on air circulation patterns, leading to more frequent extreme weather events. The study suggests that prolonged sunny episodes can turn into heat waves and heavy rainfall, posing a major climate risk.
A study analyzing over 220,000 pregnancies found that women with mild or severe nausea and vomiting in pregnancy had a greater likelihood of using marijuana during the first trimester. The overall frequency of marijuana use among pregnant women was 5.3 percent.
A recent study found that consuming milk at breakfast with high-protein content reduces postprandial blood glucose concentration and increases feelings of satiety. This effect is more pronounced when whey protein is present, which can aid in slower digestion of carbohydrates and maintain lower blood sugar levels.
Biologists at Rice University have discovered a new trophic interaction between love vines and gall-forming wasps. The study found that the vines attack tumor-like growths called galls made by the wasps, leaving behind mummified adult wasps.
A simple laboratory score has been developed to diagnose patients with heart attack symptoms, reducing the number of blood tests and time spent in emergency departments. The score can identify patients at risk of subsequent heart issues after discharge.