Researchers identified six protein kinases that predict the evolution of triple negative breast cancer, allowing for new pharmacological targets and potential treatment combinations. The study's findings indicate a high cure rate (95%) for patients with no activated proteins, but increased relapse risk if one or more are active.
Tropical Storm Norman is rapidly intensifying, with maximum sustained winds reaching near 60 mph, and a high chance of becoming a hurricane by Thursday. The storm's infrared satellite signature indicates significant strengthening over the next couple of days.
Researchers at Mount Sinai discovered that stromal cells in bladder cancer tumors prevent immune cells from attacking them, leading to low response rates with PD-1/PD-L1 inhibitors. The study identified genes linked to more aggressive cancers and found that tumors with these genes were less responsive to treatment.
Yuri Jang, PhD, receives GSA's 2018 Minority Mentorship Award for her exceptional mentorship of minority researchers in the field of aging. She has mentored over 30 scholars during her 15-year tenure, inspiring them to pursue research and careers promoting the well-being of minority older adults.
Researchers found that brain stimulation may be a viable treatment for RLS, which affects 10% of adults in the US. The study suggests that hyperarousal and excitability in the motor cortex are key factors contributing to the condition.
Researchers found liver cells do not need ORC1 to replicate DNA, a key component of cell division. This process, called an endocycle, allows cells to copy their DNA multiple times without dividing, resulting in larger cells with more DNA. Understanding this mechanism could help explain how cancer arises and how it spreads.
New archaeological evidence reveals extensive Mediterranean exchange networks for amber resources in Late Prehistory, with Sicilian amber arriving earlier than previously thought. The trade routes suggest Iberians engaged in significant exchange with the North and South, challenging previous hypotheses on amber origin.
A new genome-wide analysis of the rock gnome lichen reveals its genetic distinctiveness across different locations and informs conservation efforts. The research highlights the importance of preserving habitat and geography in maintaining biodiversity.
Dr. Potter-Baker received the award for her research on transcranial direct current stimulation for upper limb functional recovery after spinal cord injury. The study was published in 2017 and has shown promising results.
A newly discovered mammal fossil contains fossils of 38 babies, providing insight into the evolution of mammals' reproductive strategies. The discovery suggests that a key development in mammalian evolution was trading brood power for brain power.
Using deep learning algorithms, researchers have developed a system that forecasts aftershocks significantly better than random assignment. By analyzing earthquake data and physics-based models, they identified the second invariant of the deviatoric stress tensor as an important factor in predicting aftershock locations.
Researchers analyzed over 400 anthrax strains and found that human and animal samples tend to have more virulent plasmids than environmental sources. The study suggests a correlation between plasmid copy number and virulence, offering new insights into the severity of specific anthrax strains.
A new study uses satellite technology to measure the impact of droughts on photosynthesis and ecosystem respiration. Researchers found that during dry years, natural ecosystems removed about 30% less carbon from the atmosphere, leading to faster CO2 concentration increases.
Researchers found that genetic variation was the only factor associated with increased fracture risk, while vitamin D levels and calcium intake were not linked. Bone mineral density remained a key predictor of fracture risk.
Researchers used a boron nitride separation layer to grow InGaN solar cells, which were then lifted off their substrate and placed onto glass for improved light absorption. The new technique could boost solar cell efficiency up to 30 percent.
A study published in Royal Society Open Science found that Mongrel Mob members had low knowledge of viral hepatitis, leading to risky infection behaviors. The research also identified concerning liver health issues, including high rates of inflammation and damage.
A new study found that ketamine's antidepressant effect requires opioid system activation in humans, raising concerns about the risk of dependence. The study used naltrexone, an opioid blocker, to block ketamine's effects and found that it reduced antidepressant symptoms but not dissociative effects.
Akatosh, a new security analysis tool, provides deeper context to existing IT infrastructure, automating the process of sorting through intrusion detection system (IDS) alerts. This reduces the time and cost required to identify the source of a security incident and neutralize threats.
A comprehensive analysis found associations between exposure to toxic metals and increased risk of cardiovascular disease and coronary heart disease. The study's authors call for attention to metals as a significant source of cardiovascular risk, highlighting the need for population-wide strategies to minimize exposure.
A team of researchers demonstrated how attackers can modify medical test results remotely using unencrypted data transmission, highlighting the need for improved security measures. Countermeasures include password-protecting systems, network segmenting, and adopting the Fast Healthcare Interoperability Resource standard
A new Cornell University study reveals that the San Joaquin Valley in central California is sinking by up to a half-meter annually due to drought and ongoing groundwater extraction. Groundwater depletion has been estimated at 10 miles cubed between 2012 and 2016, posing significant engineering problems and threatening water quality.
The University of Texas at Austin will build the nation's fastest academic supercomputer with a $60 million NSF grant, expected to enable major scientific discoveries in fields like astrophysics and zoology. The system, known as Frontera, will begin operations in 2019 and be twice as powerful as its predecessor.
Coastal wetlands in the southeastern United States are expanding and building soil to keep pace with sea level rise. Mangroves are showing increased surface elevation when warmed, indicating their potential as a natural barrier against severe weather events like hurricanes.
The National Heart Lung and Blood Institute will award $20 million to four academic centers over five years, with UC San Diego receiving $5 million. The program aims to correct the lack of attention given to glycans in biomedical research and train 18 early-career glycoscientists.
Researchers have successfully implanted a device in mice brains to detect, stop and prevent epileptic seizures. The device uses a neurotransmitter to signal to neurons to stop firing, effectively ending the seizure. Early results show promising potential for treating conditions like Parkinson's disease and brain tumors.
Astronomers create highest resolution molecular gas map of 'monster' galaxy, COSMOS-AzTEC-1, 12.4 billion light years away. The map shows a massive, ordered gas disk in regular rotation, defying previous theoretical predictions.
Research from King's College London has found that cannabidiol can help reduce psychotic symptoms by resetting abnormal brain activity. The study provides the first evidence of how cannabidiol acts in the brain to alleviate psychosis and suggests it could be a safer alternative to current treatments.
A 3D printed fluorescence imaging box called PFIbox allows researchers to analyze massive amounts of data from bacteria samples, helping them discover new antibiotics. The open-source tool costs $200 and can be improved upon by others.
A study found that athletes who feel more closely connected to their teammates are more likely to conform to their behaviors, including both positive and risky actions. The researchers suggest that teams should find ways to encourage bonding without pressuring members to engage in negative behavior.
Researchers identified six classes of genes that contribute to cancer resistance, including CDK4/6 inhibitors. Combining BET and CDK4/6 inhibitors completely stopped tumors from growing in preclinical experiments.
The European MACUSTAR consortium is conducting a multi-country clinical study on early AMD, focusing on intermediate-stage disease progression. Novel tests will be developed to assess earlier stages of the disease, improving diagnosis and treatment methods.
Dr. Manfred Diehl, a renowned gerontologist, has been awarded the GSA's Distinguished Mentorship in Gerontology Award for his outstanding mentoring skills and impact on the field. He has successfully mentored numerous students through various fellowships and training programs, inspiring them to innovate and strive for excellence.
A comprehensive analysis of the evidence found exposure to toxic metals like arsenic, lead, copper, and cadmium to be associated with an increased risk of cardiovascular disease. The study suggests that these metals may be an independent risk factor for cardiovascular disease, even at relatively low levels of exposure.
Fewer teens are experiencing physical abuse from their dating partners, with five percent of teens reporting dating violence in 2013. The researchers found 5.8 percent of boys and 4.2 percent of girls reported experiencing dating violence in the past year.
Heavy rainfall was observed in a band of thunderstorms wrapping into the low-level center of Tropical Storm Miriam, with rain rates reaching over 10 inches per hour. The storm is currently located about 1,165 miles east-southeast of Hilo, Hawaii, and is expected to begin weakening by Friday.
Researchers have developed a bifunctional compound that both relieves pain and suppresses opioid dependency in primates, providing 100-fold stronger pain relief than morphine. The compound lacks rewarding characteristics and motor impairment, indicating a safer alternative to traditional opioids.
Researchers developed a novel approach using glucose to assess how kidney cancer tumors use glucose. The study found that ccRCC tumors process glucose differently than most tissues, providing a potential target for new treatments.
A University of Houston engineer is leading a $800,000 project to improve the safety of storage containers for nuclear waste. The team will explore ways to reduce or avoid the degeneration of glass containers used to store radioactive waste.
Researchers develop biodegradable plastics that break down under diverse conditions, offering new options for disposal. The study examines the degradation of individual bioplastics and blends under managed and unmanaged environments, finding improved characteristics in certain blends.
A new study finds that NYC's tobacco-free pharmacy law substantially reduces tobacco retailer density overall, particularly in high-income neighborhoods. However, disadvantaged neighborhoods experienced little to no change in retailer density, highlighting unequal impact across neighborhoods.
A population-based cohort study found that boys with undescended testes had a 2.4 times increased risk of adult testicular cancer compared to unaffected boys, as well as a 20% lower chance of paternity and higher use of assisted reproductive technologies for infertility.
A new study published in Addiction journal found that single-step nasal spray naloxone is the most successful and rapid method of administration among community members. Community members were able to administer the nasal spray with a higher rate of success than intramuscular naloxone, and also more quickly.
A study published in Neurology suggests that spinal muscular atrophy drug nusinersen may be effective for muscle control even when treatment is started in children seven months and older. The research found significant muscle control improvements in participants, including an 8-year-old child, with some able to sit up without support.
A study by the University of Nottingham discovered that a lack of protein in a father's diet can negatively impact his offspring's long-term health. The research found that low-protein diets affect sperm quality, leading to increased obesity, type 2 diabetes, and reduced metabolic gene expression in offspring.
Researchers found a 3% better survival rate for patients who received laryngeal tube (LT) devices on scene compared to traditional intubation breathing tube methods. The study showed that LT devices could potentially save over 10,000 lives annually.
Researchers created a new algorithm to safely herd flocks of birds away from airports, reducing bird strikes and potential damages. The drone-based system successfully diverted entire flocks without fragmenting their formation.
A clinical trial of over 250 participants with progressive multiple sclerosis found that ibudilast slowed down brain shrinkage compared to a placebo. The study showed a difference of approximately 2.5 milliliters of brain tissue between the two groups, but it is unclear if this translates to improved symptoms or function.
Osaka University-led researchers developed non-toxic nanoparticles that emit vivid, clean colors with high energy efficiency. The new particles use a chaotic material shell to achieve pure colors without rigid structures.
The ACCION program has increased screening rates in West Texas to around 50 percent, compared to a national average of about 70 percent. The program's success is attributed to its use of promotoras and partnerships with community organizations to make screenings more accessible.
Margaret Gatz, a renowned expert in clinical geropsychology, has been awarded the GSA's 2018 Distinguished Career Contribution to Gerontology Award. Her pioneering work includes the world's largest twin study of dementia and extensive research on age-related changes in depressive symptoms.
A new study has found that warmer water from hundreds of miles away is penetrating deep into the Arctic's interior, leading to a two-fold increase in heat content over the past 30 years. If this 'archived' heat reaches the surface, it could melt the entire sea-ice pack covering most of the region for most of the year.
A new study has developed highly sensitive and specific assays to detect infectious agents in pigs, a crucial step towards ensuring the safety of xenotransplantation. The assays were validated on over 300 pig specimens and showed promising results, suggesting they can identify potential pathogens in donor pigs.
Researchers at TUM demonstrated that food increases thermogenesis in brown fat, contrary to the long-held assumption that it only responds to cold. This discovery could lead to new ways to prevent obesity and diabetes.
Researchers at Wake Forest School of Medicine discover a safe and non-addictive pain medication called AT-121, which suppressed addictive effects of opioids and produced morphine-like analgesic effects. The compound also blocks abuse potential of prescription opioids like buprenorphine, offering hope to treat pain and opioid abuse.
Kenneth Ferraro and Frank Infurna received the award for their innovative publications on aging and life course development. The research highlights the complexity of resilience in the face of spousal bereavement, challenging previous assumptions.
A team of scientists from the University of Kent has developed a new technique to manipulate bacterial cellular structures, enabling them to convert sugar into fuel. The breakthrough could lead to the production of biofuels and vaccines using synthetic biology.
Researchers at UH University have won a $3.5M grant to develop technology suggesting the best combinations of antibiotics to kill certain resistant bacteria. The project aims to combat antibiotic resistance, a major public health threat.
A new treatment approach aims to address substance use problems in young people with mental illness, targeting early intervention and integrated services. This funding will support developing prevention-oriented drug and alcohol and mental health services for young people aged 12-25.
Researchers at Hong Kong Baptist University have developed a metal compound that inhibits the enzyme lysine-specific demethylase 5A (KDM5A) in TNBC tumours with less toxicity in mice. This discovery holds great promise for the development of targeted drugs for TNBC therapy, offering a new approach to treating this difficult form of bre...
A $3.8 million NIMH grant will support the development of a predictive model that uses machine learning techniques to identify neural signatures of suicidal ideation and behavior. This technology has the potential to improve clinicians' ability to detect and treat suicidal patients, reducing suicide risk among young adults in the US.