Updated phase 1 clinical trial results of crizotinib against MET-amplified non-small cell lung cancer show a 40 percent response rate and 6.7-month median progression-free survival. The study defines new criteria to define 'highly MET-amplified' cancer, suggesting that crizotinib may benefit more patients than previously thought.
The ALEX trial results show alectinib achieving a median progression-free survival of 34.8 months compared to 10.9 months for crizotinib in ALK-positive non-small cell lung cancer patients. Alectinib also demonstrated an improved overall response rate and fewer side effects than crizotinib.
A landmark study published in the New England Journal of Medicine found that most breast cancer patients with intermediate scores on a 21-gene test can safely avoid chemotherapy. The study's results have significant implications for doctors and patients, allowing for more personalized treatment options.
Research suggests that police officers on night shifts are more likely to receive public complaints due to elevated fatigue. Going to court during the day after a night shift further increases this risk, highlighting the need for duty schedules to consider court appearances.
Researchers at Kyoto University found that bonobos show a strong aversion to food contaminated with feces or soil, indicating an adaptive system of disgust. This instinctual response helps protect against parasites and pathogens in the environment.
A Phase II trial suggests that erdafitinib, an FGFR inhibitor, benefits patients with metastatic urothelial cancer harboring FGFR3 mutations. The therapy achieved a 40% overall response rate, including complete and partial responses, as well as stable disease in nearly half of patients.
A study published by the European Society of Anaesthesiology and Intensive Care found that taking aspirin before and after CABG surgery significantly reduced mortality risk. Patients who took aspirin had a 4-year mortality rate of 10.7%, compared to 16.2% in non-aspirin patients.
A new study found that hypnosedation is an effective alternative to general anesthesia for various surgeries, including breast cancer treatments, gynecological procedures, and superficial plastic surgeries. The technique reduces adverse effects, accelerates postoperative rehabilitation, and improves patient comfort.
A new journal paper highlights the limitations of economic models in assessing climate change impacts, particularly at moderate to high levels of warming. The authors argue that current models inadequately account for tipping points and uncertainties, leading to large discrepancies between scientific and economic estimates.
A study of 15,450 adult survivors of childhood cancer found that vigorous exercise reduces mortality risk. Regular physical activity is associated with a significant decrease in the risk of death among these patients., who have an elevated risk due to late cancer treatment effects.
Researchers at London School of Hygiene & Tropical Medicine identified six common categories of disgust related to infectious diseases, including infected wounds and poor hygiene. These findings could help target public health messaging and develop new methods to keep environments healthy.
A new Penn study finds that microRNAs in the blood can track responses to total sleep deprivation and predict individual differences in cognitive performance. The study identified 14 miRNAs reliably predicting behavioral attention performance, 7 for cognitive throughput, and 10 for memory performance.
The TAILORx trial found no benefit from chemotherapy for 70% of women with hormone receptor-positive, HER2-negative breast cancer. Treatment with hormone therapy alone after surgery was as effective as hormone therapy plus chemotherapy in reducing invasive disease-free survival and overall survival.
A new trial presented at ASCO18 shows that PET scans can improve treatment outcomes for esophageal cancer patients. Patients who responded to induction chemotherapy had a median overall survival of 46 months, while those who did not respond had a 27-month median survival, significantly better than previous studies.