A study published in Nature Neuroscience reveals that romidepsin, an FDA-approved anti-cancer drug, restored gene expression and alleviated social deficits in mice deficient in the Shank 3 gene, a key risk factor for autism. The treatment had a profound and prolonged effect, lasting several years in humans.
A recent study using CRISPR-Cas9 technology identified new genes that may hasten neuron death in ALS and FTD patients. The researchers found that genes controlling cell movement and protein assembly were potential partners in DPR toxicity, suggesting novel therapies for ALS.
Researchers found that calcium deposits in large arteries increased the risk of heart attacks and mortality. The study suggests bone density tests can also screen for cardiovascular disease, making them a valuable tool in screening.
Researchers found Neotropical fruit species in Central and South America have larger geographic ranges when linked to human diets, suggesting human impact on species distribution. Human use of these fruits may have driven the expansion of their ranges.
Research found that African American mothers' parenting stress is associated with epigenetic differences in DNA methylation, particularly in genes related to stress signaling. This discovery has implications for understanding health disparities among African American women and their children.
A study estimates that historical lead exposure may be responsible for 256,000 premature deaths from cardiovascular disease each year in the USA. The study found that low-level lead exposure increases the risk of premature death, especially from cardiovascular disease.
Babies' movement in the womb is crucial for developing strong bones and joints. Research has identified that cells receive incorrect molecular signals when movement is absent, leading to brittle bones or abnormal joints. Understanding this mechanism can lead to improved treatments for joint injuries and diseases.
Urban heat islands are caused by cities trapping more heat than surrounding areas due to their structure, affecting energy consumption and air quality. Researchers studied 50 cities and found that well-organized cities with straight streets retain more heat at night, leading to increased energy bills in hot climates.
A recent study found that six-month dual antiplatelet therapy increases the risk of heart attacks in patients with acute coronary syndrome (ACS). The SMART-DATE trial showed that short-term treatment is not safe for ACS patients who have received drug-eluting stents, highlighting the need for prolonged DAPT in these cases.
A new iPad app that educates patients about different options for colon cancer screening and allows them to order their preferred test has been shown to significantly increase screening rates. In a randomized controlled trial, patients who used the app were twice as likely to undergo screening compared to those in the usual care group.
A researcher at George Washington University is studying the link between stress in the brain and obesity-induced hypertension, with a focus on understanding how cell stress may alter blood pressure regulation. The five-year study aims to identify potential new treatments for hypertension using existing drugs.
Researchers observed attosecond optical-field-enhanced carrier injection into the GaAs conduction band, a process previously thought to be impossible. Intra-band motion plays a significant role in this phenomenon, enhancing the number of electrons excited into the conduction band.
A global study of DNA samples from 520,000 individuals identified 22 new genetic risk factors for stroke, according to researchers. The findings are significant as they will increase potential targets for stroke drug development and provide valuable insights into dementia research.
The widespread adoption of Bt field corn led to significant reductions in European corn borer and corn earworm infestations. This resulted in lower recommended insecticide sprays, total insecticides applied, and crop damages on pepper, green bean, and sweet corn crops.
The research team found that, when learning a new task, the brain operates under a more stringent set of constraints than originally thought, resulting in good short-term learning but suboptimal performance. The brain tends to repurpose existing neural activity patterns rather than generating entirely new ones.
Researchers have identified 110 genes linked to an increased risk of breast cancer, including 32 genes related to survival rates. The study uses a genetic technique to analyze DNA regions and identify specific genes involved in raising a woman's risk.
The CARES trial found that long-term febuxostat use in patients with heart disease significantly increases the risk of death, despite not raising cardiovascular outcomes. Researchers were unable to identify a biological mechanism explaining this finding.
Scientists at HZDR aim to demonstrate that precession is sufficient to create a magnetic field using liquid sodium. The experiment could provide insights into the geodynamo and clarify the role of precession in generating the Earth's magnetic field.
Researchers develop therapeutic antibodies targeting the C-terminus of Sonic hedgehog, a protein involved in tissue homeostasis and repair. These antibodies show promise in inhibiting cancer cell growth and tumor formation in preclinical models.
Using near infrared chemical imaging can help maintain the safety of pharmaceutical tablets by monitoring active ingredient concentrations in real time. This technique provides a larger sample area compared to spectroscopy, reducing the risk of missed segregation areas.
SLU researchers determined the structure of calcium-independent phospholipase A2β, a key enzyme involved in the body's inflammatory response. This discovery opens up possibilities for developing new therapies for neurodegenerative disorders like Parkinson's disease.
Researchers uncover mechanism behind neuropathic pain and develop innovative treatment blocking FLT3 molecule. The treatment shows immediate and long-lasting therapeutic effects in animal subjects, reducing hyperalgesia and allodynia.
A new combination pill of three low-dose medications has been shown to significantly increase the number of patients reaching blood pressure targets compared to usual care. The 'Triple Pill' resulted in a 70% control rate at six months, with benefits seen straight away and maintained until six months.
Chronic stress leads to increased inflammation-promoting bacteria and weakened colonic mucus barrier in mice. This disruption can trigger an immune response and increase severity of induced colitis.
Engineers are conducting final testing at Northrop Grumman Aerospace Systems to ensure the observatory is ready for space. The science payload has already undergone rigorous testing, and the integrated spacecraft and sunshield will soon undergo their own launch environment tests.
A new study from the Intermountain Medical Center Heart Institute found that alpha blockers and alpha 2 agonist medications increase blood pressure variability, associated with a higher risk of death. Researchers recommend using alternative medications that show a decrease in mortality risk.
The Hubble Space Telescope has discovered a rare relic galaxy, NGC 1277, that remains unchanged for the past 10 billion years. This unique find provides valuable insights into the origin and evolution of galaxies billions of years ago.
Scientists discovered two new frog species with gastromyzophorous tadpoles, which use modified bellies to exploit fast-flowing streams. The frogs are endemic to Sumatra's rainforests and were classified into a new genus called Sumaterana.
In a groundbreaking study, African-American men with high blood pressure showed significant improvements when aided by pharmacists and local barbers. Nearly two-thirds of participants achieved healthy blood pressure levels after six months, with systolic blood pressure dropping from 153 mmHg to 126 mmHg.
Researchers discovered a gene called heat shock factor is co-opted by the sleeping chironomid to survive desiccation. The gene's activation leads to the synthesis of heat shock proteins protecting cells from misfolding, allowing the insect to regain life.
A majority of US adults (59.7%) would pay at least $1 for an Ebola vaccine, according to a national survey conducted during the 2014-2016 West African outbreak. Participants who had traveled internationally and were interested in getting vaccinated were more likely to be willing to pay.
A new study reveals young patients with type 2 diabetes experience worse blood sugar control and loss to follow-up when transitioning to adult care. Healthcare systems must address these unique needs to support the growing number of youth-onset type 2 diabetes cases globally.
A new iPad app, mPATH-CRC, was developed to improve colon cancer screening rates. The app simplified the process of ordering a screening test, increasing screenings from 15% to 30% among participants. While the app showed promise, it is not intended to replace doctors' care, but rather to augment it and encourage patient participation.
Scientists have generated a vast library of unique cyclic compounds that can bind to their targets with stability and effectiveness. The new compounds have the capacity to interrupt specific protein-protein interactions that play a role in disease, offering potential therapeutic agents for various conditions.
Researchers at TSRI have developed a new desulfonylative cross-coupling reaction that simplifies the synthesis of drug-like molecules, including alkyl-fluorinated compounds. This method paves the way for creating new types of compounds and facilitating the synthesis of pharmaceuticals.
New guidelines aim to improve care transitions for adults with DMD, emphasizing psychosocial issues, care coordination, and quality of life. Revised recommendations focus on preventing disease complications through prevention, earlier diagnosis, and better treatment.
A new study by University of Stirling researchers found disparities in wildlife management approaches across Europe, leading to worsening conflicts. The team assessed nine different schemes involving large grazing birds and discovered a lack of adaptation to changes in bird numbers and damage levels.
A recent study by the Academy of Finland found that daily and heavy smoking are independently linked to a higher risk of psychoses. Smoking begun at an early age was a particularly significant risk factor, with prevention of adolescent smoking likely to have positive effects on mental health in later life.
The TerraSentia crop phenotyping robot, developed by the University of Illinois, measures plant traits using various sensors and transmits data in real-time to operators' phones or laptops. This allows for more objective and efficient data collection, enabling better breeding pipeline outcomes.
A study found that excessive daytime sleepiness in older adults without dementia is associated with increased β-amyloid levels, a key biomarker for Alzheimer's disease. Disrupted sleep may contribute to β-amyloid accumulation and increase synaptic activity in the brain.
A team of researchers from the US Department of Energy's Argonne National Laboratory has developed a comprehensive model for nitrogen oxide formation in combustion. The study reveals that temperature and fuel mixture richness significantly impact NOx production, providing valuable insights for engine companies seeking to reduce emissions.
A new study has identified 22 new genetic risk factors for stroke, providing extensive insight into the biology and pathways leading to the disease. The results demonstrate shared genetic influences with multiple related vascular conditions, including blood pressure and coronary artery disease.
A new study by Mayo Clinic and international researchers found that genetic mutations associated with heart disease account for approximately 5% of SIDS deaths. The findings contradict previous estimates suggesting a higher prevalence of these genetic mutations in SIDS cases.
A recent study published in JAMA Pediatrics found that bariatric surgery significantly improved health outcomes for adolescents with severe obesity and type 2 diabetes. The research, led by Children's Hospital Colorado experts, compared the effectiveness of surgical intervention to medical therapies in treating these conditions.
A team of researchers from James Cook University and Cardiff University have created a fully synthetic flu vaccine that protects mice from swine flu and works on human cells in the laboratory. The vaccine is hyper-stable, meaning it can survive stomach acid and human blood, making it suitable for oral administration.
Tropical Cyclone 13P developed powerful storms with extremely cold cloud top temperatures, indicating strong storms capable of heavy rain. The Joint Typhoon Warning Center predicts the storm will continue strengthening before dissipating in four days.
A randomized controlled trial found that patients with myocardial injury after non-cardiac surgery experienced a 28% lower risk of major vascular complications when treated with dabigatran. The study showed significant benefits in reducing the risk of death, heart attack, and stroke.
The Alps boast an impressive array of lichens, comprising over 3,138 entries in the first ever comprehensive checklist. The publication sheds light on the ecology and taxonomy of these organisms, providing a valuable tool for research and further exploration.
A study published in CANCER found that living in low-income areas increases the risk of early death among patients with anal cancer. The researchers analyzed data from 9,550 patients and found that those in lower income areas had worse overall survival and cancer-specific survival compared to those in higher income areas.
Researchers at Lund University have developed a new drug that transforms aggressive breast cancer into hormone-sensitive luminal breast cancers, making them responsive to conventional hormone therapy.
Studies by Cornell University professors Stephen Ellner and Robin Snyder show that trait variation influences but is often overshadowed by luck in determining lifetime reproductive success. The research suggests that being above average can be more important than possessing exceptional traits to achieve reproductive success.
A study of 106 incarcerated male participants found that psychopaths and non-psychopaths could take others' perspectives, but psychopaths excelled only on tasks requiring deliberate consideration. This cognitive deficit may underlie facets of psychopathic behavior.
Researchers studying a rare skin disorder called DEB found that loss of collagen VII affected the cellular microenvironment, leading to abnormal mRNA and protein turnover. Meanwhile, another study used novel proteomics to characterize changes in O-GlcNAc modification sites on proteins involved in T cell activation.
Researchers have developed a new non-invasive method to measure the metabolic activity of brown adipose tissue, making it easier to verify its heat generation. The method uses multispectral optoacoustic tomography (MSOT) to visualize changes in oxygenated and deoxygenated hemoglobin, allowing scientists to study its effects on energy b...
Mice lacking the cold-sensing ion channel TRPM8 consumed more food during the day when they should be asleep, leading to obesity and high blood sugar in adulthood. This study reveals a previously unrecognized link between thermal sensing systems, thermoregulation and food intake.
A University of Guelph study found that human encroachment is the leading cause of death among Ontario's at-risk birds of prey, with trauma and starvation being the top causes. The study analyzed over 1,500 bird deaths from 1991 to 2014 and highlighted the need for public awareness and habitat preservation to protect raptor populations.
A new study found that genetics contribute to individual differences in empathy, with genetic variants associated with lower empathy linked to higher autism risk. Women are also more empathetic than men, but this difference is not due to DNA, suggesting non-genetic factors at play.
A study found that reducing co-payments for patients with heart attack medication improved both patient and physician adherence to recommended treatment. The study also found no significant differences in rates of death, heart attack, or stroke between groups.
A study found that women with breast cancer who took the beta blocker carvedilol during chemotherapy had lower levels of a protein indicative of heart injury, but no difference in heart function. The study's lead author notes that further research is needed to confirm these findings and explore potential benefits for higher-risk patients.
A study found that ACE-inhibitors and beta blockers can reduce the risk of heart damage in women receiving anthracycline-based chemotherapy alongside trastuzumab. However, these medications were not effective for those without a history of anthracycline exposure.