Researchers developed a novel computational tool called ADmiRE to annotate human microRNA variants and determine their potential contribution to diseases. The tool successfully identified microRNA mutations in miR-142 and miR-21 linked to hematologic cancers and esophageal cancer, respectively.
A team of scientists designed a bioreactor device that induces partial hindlimb regeneration in adult frogs by stimulating tissue repair at the amputation site. The device triggers complex downstream outcomes, resulting in bigger, more structured appendages.
Researchers develop nano-immunotherapy that prevents immune cells from activating and attacking transplanted organs, allowing for long-term acceptance. This approach could transform patient care and help overcome barriers to successful transplant outcomes.
Researchers at Kyoto University successfully created intense terahertz pulses to fine-tune the switching behavior of a phase-change memory material. This breakthrough could lead to faster and more stable memory technologies with increased density.
The University of Arizona has received a $1.075 million NSF grant to support underrepresented minority students in engineering graduate programs. The Bridge to the Doctorate program combines financial assistance with opportunities for professional development, aiming to bridge the gap between minorities and STEM doctorates.
Researchers found that adolescent marijuana use reduces perineuronal net formation around inhibitory cells, affecting decision-making and self-control. This alteration may have long-term consequences for brain function and behavior.
A synthetic compound based on a brain hormone has shown surprising benefits in treating lung and other cancers in mice, but its effect on human cells was the opposite. The compound, MR409, is one of several GHRH analogs that spur healthy tissue growth and may alleviate concerns about stimulating cancer cell growth.
The American College of Cardiology, American Heart Association, and Heart Rhythm Society have published a guideline for evaluating and treating patients with bradycardia. The guidelines recommend diagnostic testing tools, lifestyle interventions, pharmacotherapy, and pacing devices to manage the condition.
Researchers at Trinity College Dublin have discovered the specific non-coding section of the 'speed gene' that limits myostatin protein production, affecting skeletal muscle development and race distance aptitude. The findings provide valuable insights for thoroughbred breeders and trainers, a multi-billion dollar industry.
A new study published in Radiology uses deep learning to predict Alzheimer's disease from brain imaging, achieving 100% sensitivity in detecting the disease an average of more than six years prior to final diagnosis. The algorithm has the potential to complement existing tests and provide opportunities for early intervention.
A recent study from the University of Colorado Boulder found that academic ideas tend to spread faster from highly-ranked universities, even when the quality of the idea is mediocre. This suggests a power imbalance in academia, where elite institutions have an advantage in spreading their research to others.
Invasive Asian jumping earthworms alter US soil composition by creating nutrient-rich aggregates that lock up essential nutrients. Research by Jenelle Wempner reveals the physical effects of worm droppings on soils, with implications for controlling worm populations and understanding land use implications.
Research by the University of Kent found that women who have a boy are at a higher risk, with complications during delivery increasing the likelihood by 174%. The study identifies male infants and birth complications as new postpartum risk factors.
Using computer modeling, a team discovered that plasmas activate metal catalysts in packed bed reactors, causing faster and more efficient chemical reactions. This process could lead to more efficient processes for removing air pollution, converting CO2 into fuels, and producing fertilizer.
Researchers found that AI models performed significantly worse on X-rays from outside their own network compared to those from within. The study highlights the importance of carefully testing AI performance in real-world clinical settings.
The Italian team aims to extract ice cores from glaciers threatened by global warming, providing centuries of historical climate data. The project involves an international governance to conserve and utilize the samples for future scientific analyses.
A recent study published in the British Journal of Cancer found a positive association between type 2 diabetes and an increased risk of colorectal cancer (CRC) in men, with a moderately higher risk observed. In contrast, the association was weaker and not statistically significant for women. The study followed up over 87,000 women and ...
Researchers found spotted seatrout continued spawning in late August 2017 during Hurricane Harvey, with the storm only briefly disrupting their pattern. This finding suggests these fish are well-suited to handle changing conditions and may be key indicators of climate resilience.
A new study finds that long noncoding RNA lincRNA-Cox2 regulates the activity of genes involved in inflammation and immune system responses. It boosts production of the Cox2 enzyme and influences expression of other genes, shedding light on previously dismissed 'junk DNA' functions.
Researchers identified a novel anti-inflammatory bacterial protein, Aeromonas immune modulator (AimA), that reduces gut inflammation and delays death by septic shock in zebrafish. The study suggests that AimA acts as a mutualism factor, promoting both bacterial colonization and host survival.
A new study finds significant variation in opioid prescription rates and child removal rates among states, with some states experiencing a positive association between the two.
Researchers at RiKarbon create a bio-based oil from plant scraps and natural oils to replace petroleum-based products in cosmetics, lubricants, and renewable energy. This eco-friendly oil reduces carbon footprint and minimizes pressure on petroleum resources, offering a sustainable solution for industries.
Rat models reveal factors contributing to relapse, withdrawal, and addiction vulnerability, highlighting the need for new preventions and treatments. Sensation-seeking behavior is linked to severe opioid withdrawal and addiction risk.
New research presents significant breakthroughs in brain-computer interfaces, enabling improved prosthetics and therapies for people with conditions such as paralysis, stroke, and blindness. Advanced technologies are being developed to restore task-related sensations to amputees and improve vision for the blind.
Researchers used French Sign Language and American Sign Language to analyze the logical structure of spoken language. Sign languages reveal a hidden logical structure that must be inferred indirectly in spoken language, like the sentence 'Sarkozy told Obama that he would be elected'. This study highlights both strengths and limitations...
A study using algae deaths reveals the amount of uplift during the 2016 magnitude 7.6 Chiloé earthquake was approximately 25.8 centimeters, confirming a 3-meter maximum fault slip. This finding helps assess seismic hazards in the Chilean Subduction Zone and informs efforts to predict future major earthquakes.
A study found that warmer ocean temperatures reduce maternal care and immune response in fur seal pups, leading to increased hookworm infections and deaths. In colder years, pups receive more care and have a stronger immune system.
Researchers at Brown University have developed an electroencephalography-based test to measure pain levels, providing a more objective approach than the traditional visual analogue scale. The test uses brain activity oscillations to determine pain levels and has shown promise in evaluating medication efficacy in animal models.
A new study reveals that tropical mountain species are highly adapted but also more susceptible to climate change due to their narrow niches and limited movement. This paradox creates a risk for these species as they cannot withstand large temperature shifts.
Researchers discovered that toddlers with autism spectrum disorder display enhanced anger and frustration but decreased fear in response to naturalistic situations. The capacity to experience joy appears intact in the early stages of the disorder, which may help harness emotional competence for therapeutic purposes.
A study by Washington State University researchers suggests that inhibiting CDK2 activity can alleviate chemotherapy-induced heart damage in rodents. The finding could be used to develop treatment strategies and drugs to reduce heart disease risk in cancer survivors, particularly those treated with doxorubicin.
Research finds distinct temporal and geographical patterns in knife crime among young people, with children most at risk of stab injuries on the way home from school. The study reveals that stabbings peak between 1600-1800 hours, accounting for over one-fifth of all injuries, and nearly half of injuries occur within 1-5 km of home.
A new model simulates and understands flow transitions in hypersonic vehicles, revealing points of transition from smooth to turbulent flows. This research has the potential to inform safer vehicle design and improve overall performance.
Two Virginia Tech professors, Amy Pruden and Marc Edwards, are leading studies on antibiotic resistance in recycled water and plumbing. Their research aims to identify effective disinfectants and designs for preventing the spread of resistant bacteria in water systems, a growing concern that affects public health.
The prevalence of female genital mutilation/cutting among girls up to 14 years old has decreased in most African regions over the past three decades. However, the practice remains pervasive in Western Asia-Iraq and Yemen.
A research team led by M. Kit Delgado will investigate strategies to reduce cell phone use while driving, including smartphone-based 'nudges' and usage-based insurance programs. The goal is to develop insights on how safe driving discounts could be redesigned to reward safer drivers with lower insurance premiums.
A new study by Duke University Medical Center reveals that people under 40 with high blood pressure are at increased risk of heart failure, strokes, and blood vessel blockages as they age. The study used the 2017 guidelines to assess risks for younger individuals.
A new prosthetic hand system has been developed by Arizona State University researchers, allowing users to feel sensations in their phantom limbs. The Neural-Enabled Prosthetic Hand (NEPH) system has restored sensation and confidence in daily tasks for the first time, with potential applications to lower limb amputations.
A study published in Atmospheric Chemistry and Physics reveals clear seasonality of CO2 over Asia, varying with latitude, longitude, and altitude. The data shows a distinct depletion of CO2 concentration over South Asia to Southeast Asia in August to September, linked to the Asian summer monsoon anticyclone.
The CanSUR summer program at Case Western Reserve University School of Medicine will support 32 undergraduates annually in cancer-focused research. The five-year NIH grant will provide a solid foundation in cancer science and laboratory experience.
The University of Cincinnati is studying landslides to improve public safety and understanding of these natural disasters. The research aims to add specific details on landslides to Nevada's map of known hazards, including areas prone to wildfires, flash-flood zones, and earthquake fault lines.
A study calls for a shift in focus from coral reefs to seagrass meadows as they face increasing threats from climate change and human activities. Seagrass conservation is crucial for global fisheries production, carbon cycle, and coastal ecosystem health.
Researchers at MIT have developed an innovative acoustic imaging system that enables the instant visualization of massive cod shoals, shedding light on the health of this depleted species. The team's findings suggest that average cod shoal sizes serve as a critical indicator for tracking population recovery.
A study by MIT researchers found that about one-third of Requests for Comments on Wikipedia go unresolved, citing factors such as poor initial arguments and excessive discussion. The researchers developed a machine-learning model to predict when RfCs may go stale, and recommended digital tools to improve deliberation and resolution.
New population studies support that low calorie sweeteners can meet public health recommendations on sugar intake reduction and are linked to a higher-quality diet. Human clinical trials consistently show that low calorie sweeteners aid in weight loss and glucose control when used as a replacement for sugar.
Olsen's research aims to understand the role of lipid production in longevity and long-term health, with implications for age-related diseases like Alzheimer's. She hopes to develop new medications or lipid replacement treatments to alleviate disease and promote healthy aging.
Researchers found high levels of psychological distress and feelings of guilt in parents whose child had a burn injury. Adopting self-compassion appeared to help cope with the trauma. The study emphasizes the importance of screening for psychological distress in all families, regardless of burn size or severity.
Researchers identified a novel missense mutation in tyrosyl-tRNA synthetase (YARS) causing severe recessive disorder. The study found that affected individuals exhibited poor growth, developmental delay, and various organ dysfunctions, including liver disease, pancreatic insufficiency, and hearing loss.
Researchers discovered that melanomas produce BRAF proteins that become active complexes with MEK, making them resistant to RAF-inhibiting drugs. Blocking this complex can restore the potency of the therapy.
Researchers at Georgia Tech developed an open source decision support tool using machine learning to analyze RNA expression tied to patient outcomes with specific drugs. The system predicted the chemotherapy drug that had provided the best outcome 80 percent of the time, and its accuracy could improve with additional patient records.
Researchers at the University of Vienna and McGill University have created a new approach to synthesizing RNA, making it up to a million times more efficient than previous methods. The breakthrough uses photolithographic fabrication technology and a new protecting group to produce RNA chips with high yields.
Researchers found that moth fur provides acoustic stealth by reducing echoes of body parts from bat calls. The thorax fur acts as a lightweight porous sound absorber, offering a significant survival advantage against bats.
Two new studies link high blood pressure to premature cardiovascular disease in adults younger than 40, emphasizing the need for better understanding of its causes and prevention strategies. Experts suggest that lifestyle measures such as regular physical exercise and weight management can help maintain optimal blood pressure levels.
Researchers identified the function of a protein controlling allergic diseases, which can lead to medication development for autoimmune disorders and certain cancers. Increasing this protein blocks CD4+ T lymphocytes responsible for producing cytokines triggering allergic reactions.
A study of 28 middle school and high school students found that they take on significant responsibilities in managing medications, often without formal education. The investigation also highlights the importance of recognizing and supporting youth caregivers to promote their well-being and contribute to patient care.
A new study conducted by Finnish and American researchers found that mothers are more likely to invest in their daughters than men in their sons. The Trivers-Willard hypothesis predicts that parents in good conditions will bias investment towards sons, but the study failed to support this theory.
Researchers trained neural nets to detect pneumonia in chest X-rays and found reduced accuracy when tested on external data. A random forest model can predict future diagnosis of high myopia among Chinese school-aged children up to 8 years in advance with clinically acceptable performance.
A study of over 8,000 older women found that frequent back pain was associated with a 24% increased risk of death. Disability measured after back pain helped explain this association, suggesting that better management of back pain could prevent disability and improve life expectancy.
Researchers have found an extremely hot magnetosphere around a white dwarf, a remnant of a star like our Sun. This discovery sheds light on the origin of highly ionised metals in some white dwarfs, which were previously a puzzle. The study reveals that the magnetic field traps material flowing from the surface, heating it up dramatically.
Most cystic fibrosis patients do not achieve high enough antibiotic concentrations in their blood to effectively fight bacteria responsible for pulmonary exacerbations. Real-time monitoring of serum antibiotic concentrations could help improve clinical outcomes and reduce worsening pulmonary function.