Researchers at Case Western Reserve University School of Medicine used high-tech microscopes to view serotonin activating its receptor for the first time. The study highlights distinct conformations of the receptor that could lead to more precise drugs targeting specific regions or functions of serotonin receptors.
Researchers identified specific CD8 T cell states associated with patient response to checkpoint immunotherapy for melanoma. The study found that tumors responding to therapy had a higher proportion of stem-cell-like memory CD8 T cells, while non-responding tumors had more dysfunctional/exhausted T cells.
Researchers have long believed cell membranes act like a viscous liquid, but a new study suggests they are closer to a semi-solid like Jell-O. The discovery was made by Harvard University scientists who used fluorescent protein and mechanical actuators to measure membrane tension.
Researchers have generated a new anti-flu antibody that offers long-lasting protection from various influenza viruses. The approach shows promise as a preventative measure for vulnerable populations like the elderly or immunocompromised.
QuesTek and Pitt engineering researchers will utilize new computer modeling and optimization techniques to enable faster adoption of additive manufacturing in various NASA missions. They aim to improve the quality and structural integrity of components with reduced costs.
The study aims to determine the accuracy of irregular-pulse detection by the watch and compare it with simultaneous ECG patch recordings. Researchers hope this study will help better understand how wearable technologies can inform precision health.
Uveitis, a serious eye disease, affects 200,000 people in the US and can lead to irreversible blindness. MDM2 inhibitors have been found to inhibit ocular inflammation, suggesting a new treatment option with reduced systemic side effects.
Researchers have found that wild monkeys in the Americas are transmitting the Zika virus to humans via mosquitoes, changing our understanding of the ecology and transmission of Zika virus in the region. This natural transmission cycle involving local mosquitoes and wild primates makes complete eradication of the virus highly unlikely.
A new study suggests that policymakers should consider the socioeconomic circumstances of an area when establishing early intervention initiatives. The research found a link between economic growth and cancer incidence, with poorer people having a greater likelihood of developing certain types of cancer.
The study found that coordinated CAVs can stabilize traffic flow, reduce fuel use by more than 40 percent, and improve travel time. The team's results also explored the potential of CAVs to indirectly influence human-driven cars' performance. Additionally, researchers at ORNL studied neutron-rich nuclei, improving understanding of nucl...
A new study found that individuals with serious psychological distress (SPD) are half as likely to quit smoking as those without the condition. The researchers suggest that disparities in smoking rates between those with and without mental health problems may be contributing to these low quit rates.
Researchers have successfully detected and described four whale species using detailed satellite imagery, providing a cost-effective method for monitoring population changes and behavior. The study identifies key inaccessible whale populations that can benefit from satellite-based tracking.
Researchers found that ezogabine, an FDA-approved anti-seizure medication, significantly reduced depressive symptoms in patients with Major Depressive Disorder. The study showed a 45% reduction in depression and improved resilience after treatment.
Researchers at the University of Eastern Finland have developed novel antibacterial compounds targeting LsrK kinase, a key player in bacterial quorum sensing. The identified LsrK inhibitors have shown micromolar activity and will be further optimized to improve understanding of inhibition of LsrK in the AI-2 pathway.
A new study by the University of Texas at Austin found that where produced water is stored underground increases earthquake risk. The research identified factors that can help reduce seismicity, including managing injection rates and regional volumes.
A University of Houston graduate student has received a NASA fellowship to incorporate predictions of biogenic volatile organic compounds from vegetation into a climate model. The project aims to better understand the impact of extreme drought on emissions and atmospheric composition.
A new modeling study suggests that older women who test negative for human papillomavirus (HPV) with a DNA test may be at low risk of cervical cancer and could safely stop screening. However, regular cytology screening up to age 75 can still prevent cancers and is recommended for countries using HPV testing.
The special issue explores composite materials' potential for sustainable applications, including biodegradable composites for packaging and recycling of plastic waste.
New research published by the Journal of the Royal Society of Medicine highlights the high burden of sport-related injuries among children and adolescents. The study found that almost half of sport injury-related emergency department attendances involved children under the age of 19, with fractures being the most common type of injury.
Researchers at Yale University found that majority-group members hold negative views of minority-group individuals with dual identities due to perceived disloyalty. However, this bias can be mitigated when minority-group members demonstrate loyalty to the majority group.
A University of Arizona researcher is working on a potential treatment strategy targeting cardiac fibroblasts responsible for excessive collagen production in the heart. The goal is to prevent progression to heart failure by slowing down the overproduction of scar tissue.