The new drug Ru-Pt combines cisplatin, phenylbutyrate, and a PDT drug into one compound, increasing the chances of killing all cancer cells. It shows significant efficiency in killing cancer cells and has a ten times higher efficiency for drug-resistant cell lines than single reagents.
Scientists at PSI analysed chemical compounds directly in aerosols and observed dissociation and release of gaseous formic acid. The findings will improve understanding of global processes involved in cloud formation and air pollution.
Researchers found that infants with insecure-resistant attachment to parents are more than nine times more likely to receive an ASD diagnosis by age 3. Early recognition of this attachment pattern could lead to interventions to help infants form more secure social relationships.
A new study found that testing blood pressure load, which detects elevated readings over 24 hours, is not necessary for diagnosing hypertension in children. Having high average blood pressure on a 24-hour test does strongly predict risk of cardiac and kidney disease.
The NCAM2 protein is essential for the formation of structures for cognitive learning and brain development. A deficit in NCAM2 causes incorrect neuron migration, altered morphology, and cytoskeleton changes, leading to neuronal polarization issues.
Researchers discovered a protein called gamma subunit that controls fatty acid synthase function in mycobacteria, allowing for the inhibition of pathogen proliferation without affecting human cells. This breakthrough could lead to new therapeutic approaches against tuberculosis and provide insights into cancer treatment.
A UK study emphasizes the significance of spirometry in identifying chronic obstructive pulmonary disease (COPD), particularly among patients with respiratory symptoms. The study found that over-reliance on radiological changes alone may lead to incorrect diagnoses, highlighting the need for comprehensive assessments.
Research reveals that prehistoric hyenas and humans migrated across continents at approximately the same time, with spotted hyenas showing extensive and complex migration patterns. The study also found signs of a detrimental impact on hyenas due to human activity.
Tropical Storm 22S formed near northeastern Madagascar after being observed by NASA's Terra satellite, which captured strong thunderstorms and rainfall in the western quadrant. The storm is expected to strengthen to 90 knots (104 mph) before becoming subtropical and potentially pass between Mauritius and Rodrigues.
Researchers demonstrate that fear memory involves strengthening neural pathways between the hippocampus and amygdala, which can be erased by weakening these connections. This discovery provides potential therapeutic strategies to suppress maladaptive fear memories in post-traumatic stress disorder patients.
Dr. Jeffrey D. Facteau, a renowned industrial-organizational psychologist, has been recognized as an SIOP Fellow for his significant impact on talent selection and assessment projects. He has published research in top-tier journals and made lasting contributions to the field of performance management.
Dr. Nathan A. Bowling has been recognized by the Society for Industrial and Organizational Psychology (SIOP) as a Fellow, demonstrating his impact on employee attitudes, counterproductive work behavior, and self-report questionnaires. With over 50 peer-reviewed journal articles and book chapters published in prestigious publications.
A new transcription factor (FaPRE1) has been identified as a key regulator of strawberry ripening, controlling the expression of genes related to color, aroma, and texture. The gene plays a twofold role in regulating expression, silencing development genes and beginning ripening genes.
Researchers discovered that Epo increases nerve cell production and connections in the brain, leading to improved cognitive performance. Cognitive challenges trigger oxygen deficits, stimulating Epo production, which drives neuroplasticity and neurogenesis.
Researchers found that smaller forest fragments result in fewer species and interactions between plants and seed-dispersing birds. This leads to a loss of ecological functions, including constant forest regeneration, with larger bird species playing a crucial role in dispersing large seeds.
Researchers discovered that resolvins, specialized lipids, can reduce inflammation and prevent memory loss in a preclinical model of Down syndrome. This finding has the potential to lead to new therapies for Alzheimer's disease, targeting inflammation as a key mechanism in healthy aging.
A new analysis of GM Bt cotton in India challenges its effectiveness, citing increased spending on fertilizers and insecticides as key factors behind productivity gains. Despite being credited with tripling cotton production, the seeds' impact is overstated due to factors beyond their agronomic benefits.
Researchers combined data from radio and optical telescopes to determine the origins and nature of quasar light. By measuring the polarization, they can tell which part of radiation came from the jet and determine its direction.
Dr. Joseph Allen has been named a Fellow of the Society for Industrial and Organizational Psychology (SIOP) in recognition of his outstanding contributions to the field of I-O psychology. His research focuses on workplace meetings, occupational safety and health, and community engagement, with significant funding from government agencies.
Researchers at Ben-Gurion University of the Negev found that treated wastewater contains minimal accumulation of organic micropollutants, posing no toxic effects on fish. The study suggests that tertiary wastewater treatment can be used for growing fish without compromising public health.
Researchers propose that Mercury's surface chemistry lab, fueled by solar winds and hot temperatures, can produce ice over a period of 3 million years. This process could account for up to 10% of Mercury's total ice reserves.
Researchers found that machine-harvested edamame is more profitable at lower densities, with optimal rates ranging from 35,200 to 48,600 plants per acre. The new guidelines are specific to the unique aspects of the crop and aim to maximize profitability for US growers and processors.
Researchers developed a microRNA-based signature that predicts local-regional failure and overall survival in patients with pancreatic cancer. The four-miRNA risk score provides prognostic information for clinical outcomes after surgical resection.
Researchers found elevated concentrations of TPT in Chinese white dolphins and finless porpoises, with the highest concentration being five times higher than reported in false killer whales. Biomagnification of TPT compounds has significant implications for local dolphin populations and human health.
Scientists at Peking University have discovered Majorana zero modes (MZMs) at both ends of 1D atomic line defects in iron-based high-temperature superconductors. The MZMs exhibit robust properties and can be detected using scanning tunneling microscopy/spectroscopy, offering a promising platform for topological quantum computing.
Researchers at the Centre for Genomic Regulation discovered that a type of kinesin called KIF3A/B transports mRNAs, enabling neurons to build their cellular skeleton and form new connections. This process is crucial for memory formation and storage, with mRNAs playing a key role in reinforcing synapses.
The study reveals that jawless and jawed vertebrates share similar adaptive immune systems, despite independent evolution for over 500 million years. The researchers used CRISPR/Cas9 to disable a gene in lampreys, showing that they rely on a shared tool-kit to create antibodies.
University of Pittsburgh researchers develop microparticles that can trick the body into accepting transplanted tissue as its own, avoiding the need for lifelong immunosuppression. The treatment logistics are simpler and more efficient than current cell-based therapy methods.
The Oncotarget review explores the use of biomarkers, CA19-9, gemcitabine-abraxane, FOLFIRINOX, and other treatments to identify patients who benefit most from therapy in pancreatic cancer. Further studies are needed to better understand pancreatic cancer biology and improve prognosis.
A new study found that urbanization of coastal areas in New England leads to smaller size and poorer health in migratory alewife populations. The researchers examined nine coastal ponds and sampled alewife born in 2008, finding that those from more developed watersheds were nearly half as long and up to 10 times lighter.
Dr. Alexander Alonso has been named a Fellow of the Society for Industrial and Organizational Psychology (SIOP) for his outstanding contributions to I-O psychology. He is known for using I-O principles to advance human resource management and practice, with hundreds of publications and expertise in competency-based credentialing.
Researchers at KAIST developed a 3D hierarchically porous nanostructured catalyst that efficiently converts CO2 to CO, overcoming mass transport limitations. The new catalyst shows high selectivity and mass activity, promising large-scale applications for green energy.
Dr. Tara Behrend, a multidisciplinary scholar with expertise in workplace technologies and workforce readiness, has been recognized as an SIOP Fellow. She is known for her diverse research topics, including STEM education, automation, and decision-making, and has received significant grants and fellowships.
The Spiral Graph project uses a tracing method to accurately measure the winding of spiral galaxies' arms. This approach outperforms automated methods and can estimate parameters like black hole mass and dark matter content. By enlisting citizen scientists, researchers aim to better understand galaxy evolution.
A new study aims to identify molecular fingerprints of progressive kidney failure in patients with diabetes, while also exploring the development of targeted therapies. The Transformative Research in Diabetic Nephrology (TRIDENT) study is a $5 million collaboration between Penn Medicine and over 20 institutions nationwide.
Researchers discovered that blood stem cells can drive a rapid and efficient immune response if previously exposed to LPS, mimicking an infection. The cells store immune response circuits in their DNA using C/EBP? factor, enabling a more efficient response upon subsequent infections.
Dr. Dana Born, PhD has been recognized as a Fellow of the Society for Industrial and Organizational Psychology (SIOP) for her outstanding contributions to the profession. She is a pioneering leader who has made significant impacts in I-O psychology, including policy implementation for the Department of Defense.
Researchers at UMass Amherst developed a lower-sodium turkey breast that was preferred by consumers in a blind sensory test. The study found that using a blend of sodium salts with a larger molecular structure slowed down the overall sodium diffusion rate, providing enough saltiness without compromising juiciness and texture.
Researchers found that gallium maltolate (GaM) can treat subclinical foal pneumonia without increasing antibiotic-resistant bacteria. The study, published in Scientific Reports, suggests GaM as a viable alternative to overprescribed antibiotics.
Researchers found that patients prescribed opioids after tooth extraction reported worse pain, and half of prescribed opioids remained unused. The study suggests that alternatives such as nonsteroidal anti-inflammatory drugs or acetaminophen control pain better and improve patient satisfaction.
Researchers found the average serial interval for COVID-19 in China to be approximately four days, indicating a short window for public health responders to identify and isolate cases. This study provides evidence of asymptomatic transmission, which may require more aggressive control measures to curb the spread of the disease.
Researchers at SUTD develop bioplastic production process using urban waste and bio-inspired engineering, enabling global adoption of sustainable manufacturing. The process reduces energy requirements and transportation costs, using abundant biological polymers like chitin and cellulose.
Researchers found that gastric bypass surgery alters both fecal and mucosal microbiomes, leading to improved metabolic outcomes. The study suggests manipulating the gut microbiome could be a potential alternative to surgery for sustained weight loss.
A new study reveals that maternal obesity triggers cellular stress in the endoplasmic reticulum, disrupting hypothalamic development and leading to offspring obesity. Bile acid treatment mitigates these changes, reversing obesity-related metabolic issues in mice offspring.
Researchers sequenced three hornwort genomes, revealing genes that could boost crop efficiency and reduce nitrogen fertilizer use. The findings shed light on the evolution of early land plants and provide insights into the unique biology of hornworts.
Researchers at the National Eye Institute have discovered a tooth-enamel protein, amelotin, that is also present in eyes with dry age-related macular degeneration. The protein may play a role in the formation of calcium deposits in the eye and could be a therapeutic target for treating the blinding disease.
A new composite catalyst has been developed to enhance the performance of metal-air batteries (MABs), which are considered a strong candidate for next-generation electric vehicles. The catalyst, combining two types of materials, improves charge and discharge efficiency by synergistically enhancing the reaction rates.
Dr. Christopher M. Barnes has been recognized by the Society for Industrial and Organizational Psychology (SIOP) as a Fellow, acknowledged for his pioneering research on sleep deprivation and work. His notable contributions have been cited over 3,000 times, solidifying his impact on the field.
Dr. Nathan Ainspan has been recognized as a leading figure in industrial-organizational psychology, focusing on veterans' and disability issues through his research and advocacy efforts. His work has impacted millions of people across the US and internationally.
UC San Diego researchers found that the enzyme SPRK1 plays a crucial role in untangling a sperm's genome by kicking out special packing proteins. This process allows for major reorganization of the paternal DNA and enables the fusion of the mother's and father's half-genomes.
A University of Montana professor collaborated with Malaysian authorities to create protected areas for endangered species, ensuring their survival. This initiative demonstrates the impact of interdisciplinary partnerships in conservation efforts.
A recent study published in Oncotarget found that microRNA (miR) dysregulation is associated with immune cell activation, gastric inflammation, and carcinogenesis. Specifically, miR-155 upregulation is considered a key marker of chronic gastric inflammation and predisposes patients to gastric carcinogenesis.
A brief entrance test can predict students' success within their first year of study in Economics, outperforming intelligence tests and school grades. The WiWiSET project found that the test assesses domain-specific knowledge and skills, allowing for a reliable prognosis of study progress.
A review of COVID-19 infections in children reveals milder symptoms and lower risk of severe disease compared to adults. Children account for only two percent of hospitalizations and most recover within one to two weeks after symptom onset.
Research found statistically associated CpG sites were analyzed in blood samples from atherothrombotic stroke cohorts, revealing differences in DNA methylation status of MMP24 between stable and unstable carotid plaques. The study suggests a correlation between DNA methylation patterns and plaque instability.
Researchers discovered that keratohyalin granules, which form through phase separation, carry molecular messages that prompt skin cells to flatten and die. This process is crucial for maintaining the skin barrier against pathogens.
Researchers used super-resolution imaging and a computational algorithm to study how bacteria multiply and grow into dense biofilms. They found that growth patterns are analogous to urbanization, with individual bacteria forming 'cities' that merge and expand over time.
Researchers discovered a temperature-sensing nerve cell that transmits signals activating or inhibiting receiving nerve cells, explaining how worms respond to good or bad temperatures. Genetic studies identified three conserved genes involved in this response, suggesting a similar mechanism may exist in higher organisms.
Dr. Sharon Glazer has been recognized as a Fellow of the Society for Industrial and Organizational Psychology (SIOP) for her meaningful impact on cross-cultural practice and theory in I-O psychology. She is known for her research on occupational stress, culture, and global virtual teams.
Researchers discovered that bones change shape in response to forces, curving to prevent fractures. The study used computational methods to monitor shape changes over an extended period, finding that the curving process needs to be highly targeted and can lead to a built-in warning mechanism.