Researchers found that activated neutrophils release proteins like galectin-9, triggering chronic inflammation and oxidative stress. Early screening for HIV is crucial, and finding ways to reduce negative effects of the infection could be key to improving outcomes.
Researchers found that tree-cover area, impervious surface area, and building density have a consistent impact on building energy use across cities. The study's results suggest that the relationship between urban form/density and energy use is city-specific and distance-specific.
Virginia Tech researchers have developed a miniature optical fiber treatment device that delivers cancer immunotherapeutic antibodies while monitoring tumor impedance to track treatment efficacy. The device elicits sustained anti-tumor immunity with complete tumor shrinkage in multiple tumor models.
The Department of Energy's Atmospheric Radiation Measurement mobile facility has relocated from Oliktok Point in Alaska to the southeastern United States. This move will allow for continued research on climate and weather models with a new fixed observatory at Utqiaġvik, formerly known as Barrow.
The University of Maryland School of Medicine has been awarded a $6.5M grant to develop a treatment for alcoholic liver disease-associated kidney dysfunction. The Institute of Human Virology and MitoPower will conduct clinical trials to test the safety and efficacy of MP-04, a lead compound in treating HRS.
Researchers have developed an autonomous robot that can open its own doors and find nearby outlets to recharge. The innovation addresses a significant challenge in robotics, enabling helper robots to work independently without human assistance.
Researchers at the University of Surrey have discovered a fundamental connection between atomic nucleus sizes and black hole thermodynamics. By applying geometrical thermodynamics, they were able to accurately calculate nuclear radii for helium isotopes without relying on conventional microscopic models.
Engaging stakeholders in case study development can enhance complex health care intervention implementation in primary care. Researchers provide a practical approach using participatory methods to assess the implementation of innovative interventions.
Four scientists will receive AFAR Scientific Awards of Distinction for their groundbreaking work on aging and disease. Malene Hansen, Morgan Levine, Andrea Gilmore-Bykovskyi, and Kali Thomas will present lectures on their research topics.
During the 2020 US presidential election, researchers collected data on over 1 million online political ads. The study found that these ads often used manipulative tactics to collect personal information, including fake polls and click-bait headlines. More than 56,000 of these ads were found on conservative-leaning websites.
Research by Beach et al found that clinicians who provided space for patients to elaborate on their emotions had longer visits. In contrast, explicitly addressing emotions resulted in shorter visits, with 56% of responses being non-explicit.
Scientists at NTU Singapore develop a new electrochromic window material that can block up to 70% of infrared radiation while allowing 90% of visible light to pass through. The material is designed to be energy-efficient and durable, with improved performance compared to existing technologies.
Researchers discovered that childhood cancer patients treated with abdominal or total body irradiation exhibit abnormalities in their adipose tissue, similar to those found in obese individuals with cardiometabolic disease. This suggests that strategies to reduce radiation dose to fat may be necessary to prevent long-term dysfunction i...
A NIH study found that sexual identity intersects with gender, age, and race/ethnicity to compound suicide risk for some lesbian, gay, and bisexual individuals. Rates of suicidal thoughts, plans, and attempts were higher among LGB adults compared to heterosexual adults across all demographic groups.
St. Jude researchers have identified a possible risk for late effects of treatment with the experimental cancer drug CX-5461, which targets topoisomerase II beta (TOP2β) instead of RNA polymerase 1. The study highlights the need for close monitoring of patients enrolled in ongoing clinical trials.
Researchers demonstrated Young's experiment for photons in reciprocal space, creating an interference pattern of light polarization with circular polarized stripes. The observation coincided with the 100th anniversary of spin discovery and showed a classic entanglement of two degrees of freedom - direction and polarization of light.
Researchers have developed a method to study proteins at their physiological temperatures by applying microscopic pulsed heating. They found that a critical protein complex regulating cell motility and morphology exhibits cooperative regulation of actin-myosin interaction by drebrin E, which is temperature-dependent.
Researchers developed a novel synthesis method using electric arcs to produce cobalt-based single-atom catalysts, outperforming traditional platinum catalysts in terms of oxygen reduction capabilities and durability. The method has the potential to commercialize next-generation alkaline fuel cells.
The University of Kansas team is creating new models to forecast water availability in Kansas, accounting for climate uncertainty. The project will improve tools for the Kansas Water Office to incorporate climate variability into future water supply planning.
A recent study found that Black patients in the US between 40-49 years old have lower incidence rates of colorectal cancer compared to their white counterparts. Rectal cancer rates were also significantly lower among Black individuals, highlighting a disparity in disease prevalence.
Researchers developed AfriBERTa, a neural network model that achieves state-of-the-art results for low-resource African languages. The model works with 11 languages spoken by over 400 million people and requires only one gigabyte of data, compared to thousands for existing models.
Researchers found that adding one of three Suicide Cognitions Scale items to the Patient Health Questionnaire-9 improved accuracy in identifying those at highest risk of suicidal behavior within a month. This augmentation can lead to reduced unnecessary treatment and misallocated resources, benefiting both patients and physicians.
The WVCTSI will deploy a mobile clinical trials unit in West Virginia, addressing health disparities and increasing participation in clinical research. The 39-foot Winnebago will provide on-site clinical trials and follow-up visits to rural residents.
Researchers analyzed similarities and differences of corpora amylacea in various tissues, revealing they contain waste products packed in a glycan skeleton. The term 'wasteosomes' is proposed for these structures, emphasizing their function.
The Person-Centered Primary Care Measure (PCPCM) demonstrated solid psychometric properties in 28 languages across 35 OECD countries. The results provide evidence for high comparability of data collection despite geographic, cultural, or linguistic variations.
Scientists discover that small RNAs recruit RNA Polymerase V to initiate DNA methylation, enabling crop breeders to avoid silencing from the start. This finding has substantial implications for reducing the cost and effort of producing transgenic crops.
The Assyrian army, led by King Sennacherib, built a massive siege ramp at Lachish using human chains and thousands of stone blocks. The ramp was constructed in about 25 days, allowing the army to breach the city walls and conquer the city.
A preliminary analysis of the condominium building collapse in Surfside, Florida, revealed low punching shear strengths and poor reinforcement detailing in typical slab-column joints. This can lead to a low safety margin, robustness, and resistance to progressive collapse.
Bans on menthol cigarettes in Canadian provinces resulted in substantial decreases in both menthol and total cigarette sales. The study's findings suggest a notable impact of these restrictions on the tobacco market.
High clinician and patient trust is associated with an emphasis on quality, communication, cohesiveness among clinicians, and values alignment between leaders. Addressing organizational culture may improve trust levels, crucial for patient adherence to public health recommendations.
Researchers from the University of Surrey and the University of São Paulo have developed a new analysis technique that enables scientists to investigate the complex inter-connected behaviour of supercapacitor electrodes made from layers of different materials. The technique, known as Distribution of Relaxation Times, allows researchers...
Researchers from Wellesley College discovered that honey bees (Apis cerana) produce unique sounds, including 'antipredator pipes', to warn fellow bees of giant hornet threats. These signals result in increased bee activity and defense actions against the attackers.
Researchers at the University of Texas at Austin have created a first-ever global river database tracking movement of the world's largest rivers over 40 years. The data reveals average migration rates for each river delta, helping identify stable areas and those experiencing major shifts.
A new monitoring protocol preserves coherence in quantum Otto engines, leading to improved power output and reliability. The 'repeated contacts scheme' avoids measurement-induced quantum effects, making the engine more capable and dependable.
Researchers identified bacteria and yeast on photovoltaic panels in Brazil, similar to those found in Spain, the US, Arctic, and Antarctic. The microorganisms have adapted to sunlight, temperature fluctuations, and water scarcity, making them suitable for biotech applications.
A new study reveals that by 2040, between 64 and 100 million households in India, Brazil, Mexico, and Indonesia will face cooling challenges, leading to potential discomfort. The study highlights the importance of considering household characteristics beyond income and climate in predicting air-conditioning adoption.
A study led by University of Gothenburg researchers found that both moderate and strenuous exercise significantly alleviate symptoms of anxiety in patients with the disorder. Exercise intensity was also found to impact improvement, with higher intensity exercising resulting in greater symptom reduction.
A life cycle assessment of carbon capture at Amager Bakke incineration plant reveals that the technology reduces CO2 emissions from incineration but decreases electricity production by 50%. The overall net energy efficiency is not affected, but heat output increases by 20%.
Researchers created a novel humanized mouse model to study hyperprogressive disease (HPD) and hyperprogression (HP) in mismatch repair-deficient colon cancer. The study found accelerated tumor growth after PD-1 blockade with pembrolizumab administration, and identified changes in human cytokine profiles.
A study by Karolinska Institutet found that low levels of microRNA-210 in red blood cells cause vascular damage in type 2 diabetes. The reduction in microRNA-210 levels impaired blood vessel endothelial cell function and led to increased risk of cardiovascular disease.
Researchers found that nearly 75% of pregnant women with stretch marks reported moderate to prominent embarrassment, which impacted their social activities, self-esteem, and clothing choices. The study highlights the need for open discussions about stretch marks to normalize them and identify potential mental health issues.
While medical specialty boards have complied with a mandate for parental, caregiver, and medical leave, policies vary and need greater clarity to support trainees. The availability of family, caregiver, and medical leave is essential for the next generation of physicians.
A retrospective study published in Mayo Clinic Proceedings found that dasatinib lowers serum glucose levels in patients with pre-existing type 2 diabetes to a greater degree than imatinib and comparable to first-line diabetic medications. Researchers suggest further study is needed to determine the primary mechanism behind dasatinib's ...
Researchers discovered melatonin's antitumor effects in gallbladder cancer cells, promoting ROS-mediated apoptosis and suppressing the PI3K/Akt/mTOR signaling pathway. The study suggests melatonin as a potential novel candidate for gallbladder cancer treatment.
Researchers trained a GAN to generate novel refractory high-entropy alloys with specific properties, surpassing human intuition and guesswork in material design. The model produces alloy compositions in milliseconds, offering a promising tool for determining suitable materials.
A study published in eLife found that 70% of researchers report sex differences without statistically comparing male and female responses. In contrast, authors who tested for sex-specific effects reported them only 63% of the time.
A new multiplex network developed by Jörg Menche's research group maps all genes and their interactions, improving the identification of genetic defects and assessing their consequences. The network increases the probability of finding the crucial gene aberration threefold compared to separate networks.
The article highlights the critical need for routine vaccinations to recover from the COVID-19 pandemic. A decline in vaccine rates, particularly among children, poses a significant risk to future population health and overtaxes the healthcare system.
Researchers have developed a 'time machine' framework that uses artificial intelligence to learn from past environmental changes and predict future biodiversity loss. This framework can help decision-makers prioritize conservation approaches and mitigation interventions, leading to more effective management of ecosystem services.
Researchers at the University of Toronto have demonstrated that listening to personally meaningful music induces beneficial brain plasticity in patients with mild cognitive impairment or early Alzheimer's disease. The study showed changes in neural pathways correlated with increased memory performance on neuropsychological tests, suppo...
The use of dexamethasone has been confirmed as an effective treatment for COVID-19, reducing ICU admissions and deaths by 56%. However, the treatment can increase blood sugar levels in patients with diabetes, highlighting the need for monitoring and potential co-treatments.
Researchers at Politecnico di Torino developed a new method for creating nanoresonators using 3D printing, achieving mechanical performances similar to silicon-based devices. The technique enables the creation of complex and miniature sensors with improved sensitivity and strength.
Researchers developed a wrist-worn monitoring device that identified patterns in patients with drug-resistant epilepsy, providing about 30 minutes of warning before a seizure occurred. The device worked well most of the time for five of six patients studied, offering a potential solution to forecast seizures and minimize their effects.
Researchers create biosensors that can be integrated into clothing, allowing for more precise measurement of muscle activity and improving therapeutic outcomes. The technology uses a combination of silver and gold nanocomposites to enhance conductivity and biocompatibility.
Researchers found that very preterm born adults scored lower on friendship relationships but perceived their family, partner, work, and educational experiences as comparable to term-born peers. Parents, schools, and workplaces may help improve social relationships by providing opportunities for friendship development.
Researchers have identified specific bacterial interactions in disease-resistant children that protect against chronic middle ear infections. This discovery could lead to new treatments and preventative measures for Indigenous communities, which are disproportionately affected by the condition.
A new imaging technique called single-shot photoluminescence lifetime imaging thermometry (SPLIT) measures temperature in 2D, without contact, and in real-time. This technology could improve photothermal therapy and help detect skin cancers.
Primary care practices showed significant improvements in cardiovascular quality measures after receiving QI training. The study suggests that light facilitation can support important changes in small practices, leading to better patient outcomes.
Researchers have developed an ultra-stable amorphous Ta2O5/C nanocomposite with a hollow multishelled structure that can improve the efficiency of water purification. The composite decreases the energy required for water evaporation and enables a super-fast evaporation speed of 4.02 kg m-2 h-1.
A new study reveals that compound hot extremes, where days and nights are simultaneously extreme, pose significant health risks, especially for female and older residents. Urban compound hot extremes have increased by 1.76 days per decade in eastern China, driven by anthropogenic emissions and urbanization.