Researchers at Duke University have identified chemical compounds that can latch onto the coronavirus's 3D RNA structures and block replication. The compounds, which target the virus's RNA specifically, offer a new mechanism of action against COVID-19.
Researchers at OIST Graduate University developed a new 3D scaffold design using 2-photon lithography that guides regenerating neurons in the right direction. The scaffolds promote directional growth of neurons, bridging gaps and repairing connections after spinal injuries.
Researchers from Kaunas University of Technology have developed an AI-based approach for contactless machine failure detection, using sound data from existing equipment. The solution is sustainable and relatively cheap, with no need for new sensors or equipment installation.
A unique research project aims to create a fairer system for crowd workers on platforms like Amazon Mechanical Turk. The project will use machine learning and visualization techniques to prompt job requesters to pay higher wages and match high-quality workers with tasks.
Researchers aim to create guidelines for effective institutions by addressing key issues like information asymmetry and moral hazard. They propose six robustness requirements to improve institutional performance.
Researchers have successfully demonstrated a strong exchange coupling of thin ferromagnetic layers to the antiferromagnetic compound Mn2Au, enabling large magnetoresistance effects. This breakthrough enables the use of well-established read-out methods in antiferromagnetic spintronics.
The loss of large-bodied grazers worldwide drastically altered fire regimes, increasing grassy ecosystem fire activity. This finding highlights the need to incorporate herbivore controls into fire models to better understand and predict global fire activity.
A study equipped seabirds with tracking technology to track their movements and feeding grounds. The research found that fishing vessels can help identify areas where seabirds go to feed, which is vital for protecting endangered species like the northern fulmar.
Scientists discover a promising approach to creating solid materials for photon upconversion, which can transform wasted long-wavelength light into more useful shorter wavelength light. The new van der Waals crystal solution exhibits outstanding performance and efficiency, enabling the development of novel photonic technologies.
A new study found that 60% of countries involved in SDG partnerships are high- or upper-middle-income, while lower-income countries have limited participation. The unequal distribution of partnerships may hinder sustainable development worldwide.
A new study found that Morpho butterflies adapted to understory habitats have powerful wing-flapping phases for fast flight, while canopy-dwelling species evolved efficient gliding abilities through unique aerodynamic mechanisms. The findings suggest multiple pathways of adaptive evolution for colonizing the forest's canopy.
A new study at the University of Chicago has found that individuals of European and African genetic ancestry respond differently to influenza infection, with a stronger type I interferon pathway activation in those of European ancestry. This variation in immune response may contribute to disparities in influenza outcomes between differ...
Researchers have discovered a specific type of gut bacteria in bees that can improve memory, with bumblebees showing enhanced memory when fed this bacteria. The study suggests a causal link between the gut microbiome and cognitive abilities, opening up possibilities for similar effects in humans.
Research reveals that urban tree leaves bud earlier in US cities compared to rural areas, influenced by warmer temperatures and artificial light, which can accelerate this effect. Artificial light's impact on trees is often overlooked when developing lighting strategies for city streets.
A new study reveals the oldest known punctate ivory pendant found in Eurasia, dating back 41,500 years. The pendant provides direct evidence of Homo sapiens' use of decorative motifs in Poland.
The Life-Saving Lullabies project, funded by UK Arts and Humanities Research Council, investigated the potential of song as a novel public health education intervention to reduce maternal and neonatal mortality. The project's successes demonstrate a model of best practice in community-led maternal and infant health interventions.
The human brain contains trillions of contact points, requiring massive computational resources. Researchers outline the need for exascale computing power to tackle brain complexity.
Researchers have identified a novel mechanism that coordinates the assembly of components inside cells that control gene expression, revealing a widespread role for disordered protein interactions. The findings suggest that disrupting these interactions can lead to impaired gene expression, providing potential new targets for treatment.
CNIO researchers have identified a new biomarker for early melanoma metastasis, proposing the use of NGFR to predict disease prognosis and define risk groups. Blocking NGFR drastically reduces metastasis in mice, paving the way for a potential first treatment to tackle metastasis in its earliest stages.
A systematic literature review found HIV seroprevalence in five key populations: men who have sex with men (MSM), people who inject drugs (PWID), prisoners, sex workers, and transgender people. The review identified significant gaps in data, particularly for transgender individuals.
A study using GDPR-compliant mobile phone data found significant decreases in household mixing during the first two lockdowns, but increases during the third, coinciding with the vaccine rollout.
The study found that 43% of adults aged 50 or older experienced moderate or high levels of depressive symptoms at the beginning of the pandemic, which increased over time. Loneliness was the most significant predictor of worsening depressive symptoms.
Researchers from UC Riverside developed a revolutionary imaging technology that compresses light into a nanometer-sized spot, allowing for unprecedented 6-nanometer color imaging of nanomaterials. This advance improves the study of unique properties and potential applications in electronics and other fields.
A recent study estimates that COVID-19 vaccination prevented almost 470,000 deaths among people aged 60 years and older across Europe. The authors found that early implementation of vaccination was associated with the largest reduction in expected deaths.
Researchers used TRAPPIST-1's harmonious orbits to determine the impact history of its seven Earth-sized planets. The study found that these planets could have withstood only limited late bombardment, implying a relatively small amount of water arrived on time for potential life.
By 2050, renewable electricity is expected to become the cheapest form of energy globally, accounting for up to three-quarters of all demand. This shift can be achieved through accelerated electrification of industries, such as steel production and transportation, which can reduce energy consumption and lower carbon intensity.
A team of scientists has proposed a three-step framework to implement global biodiversity goals at the national level. The first step involves translating global targets into national action plans, engaging various sectors in co-design. The second step requires implementing actions across sectors using behavioral intervention tools and...
A team of researchers solved the case of zirconium-80's missing mass by combining experimental and theoretical approaches. They used NSCL's Penning trap mass spectrometer to measure the nucleus's mass with unprecedented precision, revealing new insights into its structure and properties.
A new study found that genetic ancestry shapes the immune response to the influenza virus, with increased European ancestry associated with a stronger type I IFN response. This finding has potential clinical implications for understanding COVID-19 susceptibility and disease progression.
A new study found that the loss of ancient grassland grazers led to an increase in fire activity globally. Fire extent increased after megagrazer extinctions, with continents that lost more grazers experiencing larger increases.
A new field study in six developing countries finds that community policing did not improve trust between citizens and the police, nor did it reduce crime. The findings suggest that law enforcement agencies need to implement structural changes before incremental reforms can succeed.
A team at the University of Cambridge created a jelly-like material that can withstand compression forces equivalent to an elephant, while maintaining its original shape. The material's properties are seemingly contradictory, but can be controlled through changing the chemical structure of guest molecules.
Researchers at University of Technology Sydney identified microRNA-21 as a potential therapeutic target for chronic obstructive pulmonary disease (COPD). Inhibition of microRNA-21 using antagomir-21 reduced inflammation and improved lung capacity in experimental models.
Researchers analyze new seismic data from the Mars InSight mission to plan for future planetary seismographs. The findings provide insights into Martian seismic activity, signal processing, and instrument operation, paving the way for upcoming missions to the Moon, Mars, and Jupiter's moon Titan.
The Phase II trial demonstrated a significant clinical response to belzutifan, with 49% of patients experiencing objective responses and 96% reaching progression-free survival after 24 months. This breakthrough treatment offers new hope for patients with VHL disease-associated kidney cancer.
Researchers at Universitat Pompeu Fabra have identified the role of the mechanosensitive Piezo1 ion channel in controlling cell division. The study found that this channel generates a calcium signal that promotes the recruitment of proteins to facilitate cytokinesis, the separation of cells into daughter cells.
A team of Chinese scholars used deep seismic reflection profiling to uncover the fine details of continental collision, solving a decades-long mystery. The study found four key points: northward subduction, a crustal-scale vertical collision, and southward subduction under the Qilian Mountains.
Researchers found Himalayan bats have reduced functional diversity at high elevations but maintain phylogenetic diversity. This study provides insights into the diversity of bats in the Himalayas and its response to environmental changes.
Researchers have developed a new pressure sensor that can be stretched up to 50% while maintaining its sensing performance, enabling advanced robotics and prosthetic applications. The sensor is sensitive enough to detect the pressure of small objects and responds rapidly to changes in pressure.
Researchers found that COVID-19 infection in mothers leads to distinct immune changes in babies, including altered cytokine profiles and T cell responses. The study also identified potential correlations with clinical complications such as preeclampsia and fetal growth restriction.
Research conducted by Brigham and Women's Hospital found that cervical cancer rates are significantly higher in low SES neighborhoods of New York City. The study analyzed data from two databases and calculated a 73 percent greater risk of cervical cancer in these neighborhoods compared to high-SES areas.
Researchers at Aarhus University have developed a groundbreaking technology to accurately map and characterize groundwater systems. The new method uses surface-based NMR measurements, enabling detailed hydrogeological and geological analysis in previously inaccessible areas.
Researchers at MIT discovered how molecular clusters in the nucleus interact with chromosomes, forming small, stable droplets that give the genome a gel-like structure. This interaction helps control gene expression and maintain stable interactions between distant regions of the genome.
A team of University of Pennsylvania biologists used citizen science data to create a comprehensive abundance map of the black-legged tick, responsible for transmitting Lyme disease. By correcting biases in the data, they were able to increase its value and provide insights into tick distribution across the Northeast US.
Researchers created a new ultra-thin material with quantum properties emulating rare earth compounds. The material exhibits the Kondo effect, leading to macroscopically entangled state of matter producing heavy-fermion systems.
Experts warn that proposed UK law changes could lead to increased financial abuse of older people, particularly those with dementia. Healthcare professionals are called upon to play a vital role in safeguarding vulnerable individuals through training and support.
Researchers at Stockholm University developed a resource-efficient method to produce lignin-based materials that can be thermally reprocessed and used as substitutes for thermosetting resins and adhesives. The new material exhibits tunable mechanical properties and can be tailored from hard and brittle to soft and tough.
The North American Monsoon originates from the interaction of mountain ranges with extratropical atmospheric circulation, deflecting the jet stream and generating a stationary wave. This unique case has implications for models forecasting heavy rainfall events brought by the monsoon.
Researchers highlight the need for disease transmission assessments and mitigation measures to prevent pathogen spread from humans to wild animal populations. The study's recommendations include disease risk analysis to identify gaps in data and minimize the risk of disease transmission.
A study found that covid infection risk gradually increases after a second vaccine dose, with protection waning over time. The research suggests that a third (booster) dose might be warranted to prevent breakthrough infections.
A new study found that cognitive behavioral therapy (CBT-I) prevented major depression in older adults with insomnia, decreasing the likelihood of depression by over 50%. CBT-I was more effective than sleep education therapy in preventing depression and promoting sustained remission of insomnia.
Researchers found that using shopping trolleys with standard horizontal handles reduces spending, while parallel handle designs encourage more purchases. Shoppers who used the standard trolley spent £22, while those with parallel handles spent £29.
A team of scientists from GIST developed an AI-based approach to analyze and extract user behavior data, estimating the optimal demand response management for each household. The study showcases how AI can improve electricity consumption, leading to lower prices and a smaller carbon footprint.
Researchers found that antihistamines improve responses to immune checkpoint inhibitors in cancer patients, particularly those with pre-existing allergies or high plasma histamine levels. The study suggests targeting the histamine receptor HRH1 may be a useful treatment approach.
Researchers from South Korea have demonstrated that applying an electric field during air stripping can significantly improve ammonia removal efficiency from wastewater. The study found that electric fields with alternating current of 50 MHz and power of 15 V/cm increase efficiency from 51% to 94%, even under sub-optimal conditions.
A new confocal platform using artificial intelligence and multiple lenses improves volumetric resolution by over 10-fold while reducing phototoxicity. The platform uses Deep Learning algorithms to distinguish between high-quality images with low signal-to-noise ratio and better images.
Researchers at Durham University have developed a sugar-containing polymer coating that can repair damaged artificial joint implants by mimicking the way cartilage works to lubricate human joints. The coating uses water to create a slippery surface, protecting the surfaces from wear and tear.
Researchers developed an algorithm predicting COVID-19 patient outcomes based on individual data, achieving high accuracy (over 90%) for up to ten days. This innovation enables hospitals to allocate staff and resources efficiently, potentially saving lives during future pandemic waves.
New research from RCSI shows that an irregular body clock can drive inflammation in the body's immune cells, leading to chronic diseases like heart disease and diabetes. Macrophages without a body clock take up more glucose and produce inflammatory products.
Researchers at the University of Toronto have identified FAM72A as a crucial gene in antibody development, enabling high-quality antibodies by facilitating AID's effect. The findings also suggest that increased levels of FAM72A could spur cancer development and progression.