A team of researchers from Johannes Gutenberg University Mainz have successfully developed a new approach to improve the way data is processed and stored. By combining chirality in spin configurations and molecules, they aim to create faster, smaller, and more efficient data storage devices.
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
Dr. Christine E. Seidman, a renowned physician-scientist, has made groundbreaking discoveries in genetics and cardiomyopathy, leading to new pharmacological treatments. Her work has improved our understanding of disease risks and has led to unique targeted therapies.
The Midwest AIDS Training and Education Center at UIC will expand its services nationwide, using the $3 million grant to train medical professionals in patient care. The center aims to increase access to care and end the HIV epidemic by 2030.
Researchers used cryo-EM to obtain high-resolution images of actin filaments in three states, revealing the movement of hundreds of water molecules and their role in ATP hydrolysis. The study provides new insights into the assembly and aging of actin filaments, potentially leading to therapeutic applications.
A 6-month randomized clinical trial found that a low-carbohydrate diet intervention resulted in larger reductions in hemoglobin A1c (HbA1c) levels compared to usual diet among adults with elevated untreated HbA1c. The study suggests that this dietary approach may be useful for preventing and treating type 2 diabetes.
Researchers have discovered a newly found protein, CTENO189, that controls the unique locomotion of comb jellies. The protein is essential for the rippling movement of their comb plates, which propels them through the water.
Scientists from Harvard John A. Paulson School of Engineering and Applied Sciences have created a machine that uses surface tension of water to grab and manipulate microscopic objects, enabling nanoscopic manufacturing. The device can braid micrometer-scale fibers of synthetic material Kevlar, opening doors for high-frequency conductors.
Researchers explore the role of nutrition in cancer development, finding that precise nutritional strategies can be used to supplement treatment and treat cancer. Intermittent fasting is being studied as a promising approach to fight cancer, with studies showing it may increase toxicity on tumour cells and reduce side effects.
A study using contract tracing data in New York City found the city's program was efficient, producing data that informs neighborhood-level interventions like vaccination and reactive restriction. The researchers also identified large heterogeneity in reported close contacts and secondary infections across neighborhoods.
A phase I clinical trial found that Omomyc (OMO-103) has few side effects and can stabilize disease in some patients. The treatment showed stabilization of disease in 8 out of 17 evaluable patients, including one patient with pancreatic cancer who remained on the study for over six months.
Researchers at NUS discovered a new mechanism in water electrolysis that triggers a brand new electro-catalytic reaction when exposed to light. This breakthrough improves the efficiency of producing hydrogen, which can be used as a cleaner fuel source, and could revolutionize industrial processes.
A new ancient whale genus has been discovered in Morocco, dating back to around 40 million years ago. The species likely employed manatee-like swimming and feeding habits.
A study by Professor Dennis Murphy Odo found that automatic text simplification (ATS) software makes authentic materials more comprehensible for L2 learners with high reading proficiency. However, the tool's effectiveness is limited for learners with lower reading proficiencies. The researcher suggests that ATS tools need to be further...
The study of Bronze Age Politiko-Troullia in Cyprus reveals farming practices for sheep and cattle. Analysis of animal isotopes indicates communal feasting on wild game like deer and pigs during special occasions.
Dr. Eldrin F. Lewis, a clinician scientist at Stanford University School of Medicine, has been awarded the 2022 Clinical Research Prize by the American Heart Association. His work focuses on improving quality of life and care delivery models for patients with heart failure through point-of-care initiatives.
A study published in Science Advances reveals that physical exercise triggers a neuromuscular circuit that links the production of interleukin-6 to muscle fat breakdown. This circuit is crucial for weight loss and has significant implications for obesity treatment.
Researchers at UC San Diego identified a new signaling process involving GPCRs, suggesting untapped potential for therapies, including for multiple forms of cancer. The study challenges traditional views on GPCR-mediated signaling, revealing a new mechanism that originates at endosomes and propagates into the nucleus.
Researchers from Osaka University have developed a novel method for hydrogen purification using liquid organic hydrogen carriers, achieving high efficiency and purity. This breakthrough could increase the mid- and long-term prospects of hydrogen as a sustainable energy source.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
An automated texting program supported primary care patients after hospital discharge, resulting in significant reductions in acute care resource use. The patient-centered approach may serve as a model for improving post-discharge care.
Researchers at Rutgers University found that patients who participate in multiple outpatient visits early in treatment are more likely to continue care. Nearly half of these patients remained in treatment for six months or more, compared to just 2.9% of those with less frequent visits.
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
A study published in The BMJ found a small increased risk of thrombosis with thrombocytopenia syndrome (TTS) after vaccination against the Covid-19 virus, particularly with adenovirus vaccines. Researchers recommend considering these risks when planning future immunization campaigns and vaccine development.
In a patient trial, the AKT inhibitor ipatasertib showed signs of effectiveness in treating advanced cancers. 22% of patients experienced tumor shrinkage, while 56% had stable disease. Further research is needed to understand why some patients responded and others did not.
Dr. Bibbins-Domingo's research focuses on racial disparities in cardiovascular disease prevention, incidence, and outcomes. She explores long-term effects of early and poorly treated high blood pressure and develops strategies to prevent and manage CVD.
Researchers aim to use quantum computer-based AI to accelerate drug discovery, cutting costs and time by exponentially increasing processing power for complex problems. Quantum AI models have higher capability to approximate desired functionality compared to classical neural networks.
Physicists have observed novel quantum effects in a topological insulator at room temperature, opening up new possibilities for efficient quantum technologies. This breakthrough uses bismuth-based topological materials to bypass the need for ultra-low temperatures.
A new study by the University of Nottingham reveals that people who experience workplace bullying are more likely to engage in conspiracy theorizing. The research found that both bullying and conspiracy theories share similar psychological factors, such as feelings of paranoia. This can lead to a vicious cycle where victims of bullying...
Researchers at ICIQ have demonstrated that single molecules can retain properties even when the stimulus disappears, breaking previous expectations. This discovery has significant implications for molecular data storage and could lead to new possibilities for storing multifunctional information.
The INSPIRE project aims to close the gender gap in research careers and promote inclusivity. It will create a sustainable centre of excellence, set the worldwide standard for research on inclusive gender equality, and provide practical support for institutions implementing gender equality plans.
Researchers create a material with disordered molecular structure that conducts electricity well, defying conventional theories. The material's stability and versatility make it promising for new electronic devices.
Researchers from Northwestern University have synthesized open-channel superlattices with pores ranging from 10 to 1,000 nanometers in size. The new findings will enable the use of these colloidal crystals in molecular absorption and storage, separations, chemical sensing, catalysis, and optical applications.
Oregon State researchers have engineered inhalable lipid nanoparticles that effectively deliver messenger RNA to the lungs, prompting lung cells to manufacture a protein needed to thwarts the disease. The therapy shows promise in treating cystic fibrosis, a progressive genetic disorder affecting 30,000 people in the US.
A new concept, empathic disequilibrium, suggests a balance between cognitive and emotional empathy is needed for social functioning in individuals with autism. Research found those diagnosed with autism exhibited higher rates of empathic disequilibrium, which may hinder some social interactions.
The Beckman Institute has established a new national collaborative Biomedical Technology Research Resource to develop label-free optical imaging technologies. The center aims to create optical and computational imaging technologies that can serve as a resource for clinicians and researchers.
The American Heart Association honored Drs. Harriette Van Spall and Erica Gunderson with the 2022 Dr. Nanette K. Wenger Research Goes Red Award for their groundbreaking study on sex-specific clinical outcomes of heart failure patients. The research found that women experienced improved outcomes after receiving transitional care service...
Researchers will investigate immune system differences between men and women to better understand neurodegenerative diseases. The study aims to identify why certain neurological diseases primarily affect males or females, and how this difference impacts disease progression.
Dr. Mike Weisfeldt, a renowned cardiologist, will receive the American Heart Association's Eugene Braunwald Academic Mentorship Award for his efforts to increase diversity in cardiology and promote inclusivity. The award recognizes his leadership in recruiting underrepresented groups and fostering an equity-first approach in medicine.
A University of Maryland study found that stakeholders agree on the need for a decentralized approach to stormwater management but diverge on responsibility. Two groups believe stormwater poses a public threat, while the third sees it as an underutilized resource that can be managed with technology.
Researchers at the National Eye Institute have discovered a mechanism by which an area of the protein RPE65 converts vitamin A into a form usable by photoreceptor cells. This finding provides better understanding of RPE65's function and will inform potential treatments for vision disorders linked to gene mutations.
Researchers at Tulane University have discovered that following a low-carbohydrate diet can lead to reduced hemoglobin A1c levels and improved fasting glucose levels among individuals with unmedicated diabetes and prediabetes. The study suggests that a low-carb diet may be a useful approach for preventing and treating Type 2 diabetes.
A 17th century child mummy was found to be malnourished and sick with pneumonia, despite being born into a powerful aristocratic family. The virtual autopsy revealed that the child's soft tissue showed signs of obesity, but his bones indicated severe rickets or scurvy due to lack of sunlight exposure.
Scientists have created a new method to stabilize precious metals as catalysts, enabling efficient use of expensive materials in various applications. The approach involves dispersing metal atoms within nanometer-sized islands of cerium oxide, which provides high surface area and stability.
Researchers found white matter differences in post-treatment Lyme patients using advanced imaging scans, correlating with cognitive difficulties and immune response. Axonal leakage in white matter was associated with better outcomes but also indicative of changed physiology.
Researchers found that blocking SARM1 prevents axon loss in neurodegenerative diseases, including Parkinson's and ALS. The study suggests new therapeutic approaches for diseases defined by axon loss, with potential treatments involving small molecule inhibitors or gene therapy.
Using transformation-induced plasticity (TRIP) and twinning-induced plasticity (TWIP), researchers design metastable alloys that can overcome the strength-ductility trade-off. The resulting materials are self-strengthening, making them suitable for applications such as earthquake construction, naval ships, and aerospace.
Dr. Louise D. McCullough is being recognized for her groundbreaking research on sex differences in stroke and their impact on immune response, which has led to a greater understanding of the biology behind these differences. Her work has also shed light on the importance of including females in pre-clinical research.
Dr. Paul Muntner receives the 2022 Joseph A. Vita Award for his work on identifying cardiovascular disease risk factors and improving hypertension prevention and treatment. He is recognized for his studies on environmental factors, blood pressure measurements, and African American adults.
A low-cost sensor disguised as a sea turtle egg can predict nest hatching time almost to the day. The TurtleSense system monitors nests remotely and detects synchronized developmental movement in real-time, enabling better decision-making for conservationists.
A recent study published in BME Frontiers developed an AI-based approach that rapidly transforms autofluorescence images into virtual histological images for accurate HER2 assessment. This computational staining process takes only a few minutes per sample and does not require expensive facilities or toxic chemicals.
A longitudinal imaging study found that early risk factors, such as inhibited behavior and blunted ventral striatum activity, are associated with later depression. Inhibited children who showed reduced brain activity in response to rewards were more likely to develop depression in young adulthood.
A recent study published in Science of The Total Environment found that many household wells in Nevada are contaminated with heavy metals such as arsenic, which can cause adverse health effects. The study suggests that frequent testing and improved treatment systems are necessary to ensure safe drinking water for rural communities.
McCullough's research advances the field of cardiovascular science, with a primary focus on sex differences in stroke. Her work has led to significant discoveries about cell death pathways during ischemic insults.
A multistate study found that mRNA COVID vaccines were less effective in immunocompromised adults, with protection rates ranging from 34% to 71% after multiple doses. The study emphasizes the importance of non-pharmaceutical interventions, such as masks and antibody treatment, for additional protection against severe COVID-19.
A new study found that psychological factors such as coping abilities play a significant role in individuals' risk or resilience to mental health disruptions during the COVID-19 pandemic. Brain connectivity within specific brain networks also predicted individual vulnerability to anxiety and depression symptoms.
A team of researchers from Japan sequenced the draft genome of Argonauta argo and discovered that the species' egg case protein-coding genes were not used to form shells in distantly related species. This suggests that the eggs case evolved independently, rather than being a modified shell.
Dr. George Alba has been named the inaugural American Thoracic Society/American Lung Association/American College of Chest Physicians- Harold Amos Medical Faculty Development Program Scholar. He will receive $420,000 over four years to support his research on pulmonary vascular thrombosis and acute respiratory distress syndrome.
Researchers found that sapanisertib can kill the malaria parasite at several stages during its life cycle, including in the liver and red blood cells. The study's findings offer new hope against a disease that kills over half a million people annually.
Scientists at EPFL have developed a method to enhance the packing of photosensitizer dye molecules, resulting in DSCs with power conversion efficiencies of up to 28.4% and long-term operational stability. This breakthrough offers promising prospects for applications as power supply and battery replacement for low-power electronic devices.