Researchers analyze neuroendocrine tumors at single cell resolution, unlocking key insights into tumor biology and potential evolution of tumor characteristics. The study reveals heterogeneity within tumor subtypes and identifies potential targets for immunotherapy treatment.
A phase 3 trial found that an internet-delivered cognitive behavioral therapy program significantly reduced depressive symptoms in patients with multiple sclerosis. The online program, modified for MS, led to a large drop in depressive symptoms compared to a control group.
Researchers have created MilliMobile, a tiny, self-driving robot powered only by surrounding light or radio waves. Equipped with sensors and tiny computing chips, it can move indefinitely on harvested power, enabling new abilities for swarms of robots in areas where other sensors struggle to generate nuanced data.
A single neuron in C. elegans worm uses multiple neurotransmitters to control egg-laying and locomotion, demonstrating the ability to 'borrow' serotonin from other neurons. The study reveals how a single neuron can influence complex behaviors over multiple timescales.
A new editorial paper highlights the importance of including older patients in lung cancer clinical trials, where they are often undertreated due to age-related factors. The paper emphasizes the need for increased collaboration among stakeholders to enhance enrollment and retention of older cancer patients.
A study of almost 1,000 vegan diet followers in Brazil found less than a tenth the average prevalence of dysfunctional eating behaviors. The researchers identified disordered eating attitudes among only 0.6% of participants, primarily associated with motivations for dieting rather than diet type.
A new study published in the New England Journal of Medicine found that semaglutide significantly improves symptoms and physical limitations associated with heart failure. Patients who received the medication lost an average of 11% of their body weight and showed improved walking distances, compared to those on a placebo.
A U of M Medical School professor has received a $3.5 million grant to develop a reproductive health curriculum for Tanzania that addresses the needs of people with disabilities. The project aims to improve healthcare services and build in-country capacity for comprehensive sexual and reproductive healthcare.
Weight gain in midlife women is linked to aging, menopause, and lifestyle changes, resulting in increased central adiposity and negative health ramifications. Comprehensive lifestyle interventions, including dietary changes and physical activity, are essential for weight management.
In Southeast Anatolia, 11,000 years ago, early Neolithic settlers hunted a large spectrum of bird species, including small passerine birds and cranes, for meat and possibly ritual purposes. The extent of their bird-hunting activities varied between settlements, with some prioritizing certain species over others.
A Cornell University-led study found that the brain's dopamine reward system dynamically retunes in response to changing priorities, prioritizing love over thirst. By using advanced techniques developed by researchers, they were able to track the brain's dopamine reward system and find for the first time that it flexibly tunes toward t...
A $600,000 grant from the National Science Foundation enables MSU researchers to create an AI-powered wearable tracker for children with developmental disabilities. The technology tracks parameters such as location, speech, and movement to infer peer interactions and provide feedback to educators.
A recent study published in Pediatric Obesity found that children from households with food insecurity experienced a significant increase in BMI, suggesting that food insecurity may hinder the effectiveness of pediatric obesity treatment. The researchers suggest that providers identify and address food insecurity in their patient popul...
A recent study by University of Illinois researchers highlights the struggles women face in establishing credibility for their medical problems and receiving proper treatment. These women engage in 'credibility work,' where they meticulously gather evidence, marshal witnesses, and carefully manage their appearance to convey validity. H...
Researchers have developed a novel borocarbonitride catalyst enriched with boron-oxygen species, showing improved performance in the oxidative dehydrogenation of propane. The catalytic activity depends on the pore structure and oxygen-containing boron species, enabling the regulation of reactivity.
Researchers confirmed that antimatter falls under the influence of gravity, ruling out gravitational repulsion as a cause for its absence in the universe. The study used an antihydrogen experiment to observe individual atoms taking a downward path, providing a definitive answer to long-standing questions about antimatter's behavior.
A new study reveals that Black women are less likely to receive hormone therapy than their White counterparts, despite experiencing more severe menopause symptoms. Women with psychiatric conditions also have a lower rate of hormone therapy prescriptions, highlighting the need for improved healthcare access and patient education.
A new solar-powered desalination system can produce drinking water at a lower cost and rate than traditional tap water. The system, developed by MIT engineers and their Chinese collaborators, uses natural sunlight to evaporate seawater, leaving salt behind, and has a higher production rate and rejection rate than previous designs.
Scientists at the University of St Andrews have developed an electrically driven organic semiconductor laser, overcoming a decades-long challenge. This breakthrough has significant implications for various industries, including communication, medicine, and manufacturing.
A large-scale survey study of 192,000 respondents reveals that diminished community mobility is associated with increased depressive symptoms. The findings highlight the need for strategies to understand the public health consequences of pandemic responses and mitigate their impact on mental health.
The Citrus Growers` Association of Southern Africa (CGA) has played a crucial role in the industry's success, driving growth through a resilient coalition of growers and independent resources mandated by the government. The CGA invests in research and development to stay ahead of changing market demands and fosters competitive rivalry ...
Researchers at Boston University School of Medicine have improved methods for identifying glycopeptides, which are proteins with attached carbohydrates. Conventional mass spectrometry methods are sufficient for peptides with one glycan, but an additional step is necessary for those with two or more glycans.
The UCLA-led team has developed a solution to improve cryo-electron microscopy's imaging capabilities for smaller protein molecules, enabling higher-resolution images. This advance is expected to help researchers identify specific locations on proteins that can be targeted for therapeutic purposes.
This study elucidates the molecular mechanism of METTL8-mediated mitochondrial tRNA m3C modification, highlighting a broad spectrum of heterogeneous tRNA substrates. The N-terminal extension acts as a key RNA-binding element in the catalytic process, differing from cytoplasmic m3C modification enzymes.
Researchers at SLU discovered high concentrations of microplastics in Cliff Cave's water and sediment, with highest levels near the entrance and in sediment. Flooding increases microplastic transport through the cave system, depositing debris in higher abundances near the mouth.
MSU is working to make drinking water safer by better understanding pathogens like Legionella and disinfection byproducts in distribution systems. The research aims to create a systematic way to monitor water systems and assess health risks associated with these contaminants.
A longitudinal study led by Professor Markus Paulus found that babies' ability to imitate is influenced by their caregivers' sensitivity and imitation. As a result, children learn various skills through imitation, including language acquisition and cultural gestures.
A recent study published in Radiology: Artificial Intelligence found significant racial and sex-related biases in an AI chest X-ray foundation model, affecting its performance across patient subgroups. The researchers highlighted the need for comprehensive bias analysis to ensure diversity and representativeness in dataset collection.
A new study suggests that higher hair cortisol levels are associated with worse attention and working memory performance, while higher salivary cortisol levels are linked to worse depressive symptom severity. The findings provide initial evidence on the correlation between HPA activation and cognitive decline during perimenopause.
A new experiment at CERN has shown that gravity pulls antimatter downward, eliminating the possibility of antigravity. The gravitational acceleration of antimatter is close to that for normal matter on Earth, with a value within about 25% of normal gravity.
A new study published in Neurology suggests that a longer reproductive lifespan may be associated with a lower risk of cerebral small vessel disease. Researchers analyzed data from 9,000 postmenopausal female participants and found that those with higher lifetime hormone exposure had smaller white matter hyperintensity volumes.
Researchers found that humpback whales worldwide were observed rolling with and playing in clumps of kelp and seaweed at the water's surface. The behavior may serve benefits in ectoparasite removal, skin treatment, and socializing.
A small molecule drug improved the fitness of hematopoietic stem cells used in cell transplants, potentially enhancing the success of procedures like ex vivo gene therapy. The study found that targeting extracellular vesicles relieved stress on cells outside the body, improving their performance when transplanted back in.
A research team led by Yongjie Huang is exploring the complex interactions between convective clouds and their surrounding environments. They aim to understand how convection initiates and how convective cells interact with their environment, ultimately improving computer models for forecasting.
A new cell model has been created to simulate the evolution of a common form of childhood leukemia, B-cell acute lymphoblastic leukaemia. The model replicates the disease in children's cells, providing a crucial tool for researchers to develop new therapeutic strategies.
Researchers used paleoaltimetry technique to reveal early mountain range uplift in Southern Tibetan Plateau. The study found that the region had achieved an elevation of approximately 3.5 kilometers by 63 to 61 million years ago, challenging established notions of Tibetan Plateau formation.
Researchers fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material stronger than steel but incredibly lightweight. This novel technology has inspired innovative applications in drug delivery, electronics, and more.
A new study reveals that sperm tail movement follows the same mathematical template as zebra stripes and other natural patterns. This discovery, published in Nature Communications, suggests that flagellar undulations can arise spontaneously without external influence, using a reaction-diffusion system first proposed by Alan Turing.
A meta-analysis published in Neurology found that short-term exposure to air pollution is linked to an increased risk of stroke and death from stroke. The study involved 110 studies with over 18 million cases of stroke.
A new study suggests that obese women experience an increase in menopause symptom prevalence and lower efficacy of hormone therapy. Women with obesity are more likely to self-identify as Black, report hot flashes, genitourinary symptoms, mood disturbances, and decreased libido.
A survey by The BMJ found that patients in deprived areas have limited access to vital diagnostic tests for respiratory conditions. Despite NHS promises, GPs report 'troubling' lack of services, while Asthma + Lung UK warns of acute and long-term deterioration without timely diagnosis.
The University of Texas at El Paso has received a $7 million grant from the National Science Foundation to establish the first full portrait of the effectiveness of all grants funded by the NSF HSI program. The grant will develop evaluation and research approaches to assess how past, current, and future programs are serving Hispanic an...
Long-term combined oral contraceptive users experience adverse mental health symptoms similar to those during menses, questioning the pill pause from a mental health perspective. The study's findings challenge the use of pill pauses and highlight the importance of considering hormonal effects on mental well-being.
A University at Buffalo-led research team has created a new, sturdier membrane that can withstand harsh environments associated with industrial separation processes. The membrane, made from an inorganic material called carbon-doped metal oxide, is a potential alternative to energy-intensive processes like distillation and crystallization.
A recent study identified 17 genetic changes contributing to MASLD, revealing seven disease subgroups that can be targeted with new treatments. The research also found high-risk individuals who may benefit from early screening and targeted care.
A new study reveals that weather conditions are a significant driver of global insect decline. Researchers found that unfavourable weather anomalies can lead to reduced insect survival probabilities, particularly in combination with other extreme weather events.
A new laser-based process chain has been developed to fabricate fused silica optics with high laser-induced damage thresholds, overcoming conventional manufacturing limitations. The process uses CO2 lasers for uniform layer-by-layer surface removal, precisely eliminating subsurface mechanical damage and surface/subsurface contamination.
A study proposes a therapy to reverse memory deficits in mice exposed to alcohol during pregnancy and lactation, identifying the neurobiological mechanism responsible. The treatment involves pioglitazone, which stimulates PPAR receptors, alleviating cognitive memory deficits in individuals with fetal alcohol spectrum disorders.
Researchers at DESY and European XFEL developed a new generation of atomic clocks using scandium, enabling unprecedented precision. The team detected an extremely narrow resonance line in the element's nucleus, which enables accuracy of one second in 300 billion years.
Researchers detected nine types of polymers and one type of rubber in cloud water, confirming microplastics play a key role in rapid cloud formation. The presence of hydrophilic polymers in the atmosphere could lead to significant changes in ecological balance and severe loss of biodiversity.
Researchers have discovered that brain tumors manipulate immune cells called neutrophils to promote tumor growth and suppress anti-cancer responses. The study identifies key mechanisms by which the tumor microenvironment converts neutrophils into immunosuppressive agents, providing new avenues for treating gliomas and brain metastases.
Researchers have developed a standardized synthetic molasses with a fully known composition that can be used as a culture medium for yeast fermentation. This breakthrough enables scientists to study the influence of specific components and develop bioprocesses worldwide, facilitating comparative research and industrial applications.
A study of 619 high-risk young adults in Ontario, Canada found that frequent cannabis users showed a decrease in use and consequences over time. Small increases in use were observed among those who never used cannabis before legalization, but without corresponding changes in negative outcomes.
Scientists have identified a previously unknown class of bacterial proteins that suppress the growth of methane clathrates as effectively as commercial chemicals, but are non-toxic and scalable. This discovery has significant implications for reducing greenhouse gas emissions and increasing the safety of transporting natural gas.
Researchers create novel approach for manufacturing quinoxalines directly from biomass-derived carbohydrates, reducing energy consumption and environmental impact. The process achieves high overall yield with minimal byproducts, offering a promising alternative to traditional fossil-based methods.
A study showed that yoga therapy can improve heart failure patients' endurance, strength, balance, symptom stability, and overall quality of life. Additionally, echocardiographic parameters revealed improved left ventricular systolic function in the yoga group compared to the non-interventional group.
A study by University at Buffalo researchers found exposure to unclean cooking fuels and passive smoke during pregnancy and early childhood are associated with developmental delays in children. Infants and young children spend more time indoors and are particularly vulnerable to indoor pollutants.
Engineering associations between plants and nitrogen-fixing microbes using genetic engineering could lessen dependence on synthetic fertilizer. This approach involves bi-directional signaling to release fixed nitrogen, promoting efficient communication between engineered plants and microbes.
A new study from Aarhus University found that acute kidney injury causes significant cell death in kidneys, which then spreads to healthy tissue over several days. This finding may increase the risk of patients developing chronic kidney damage and highlights the need for timely intervention measures.
Researchers found that blueberries infected with Colletotrichum fioriniae emit odors repelling spotted-wing drosophila. By recreating this aroma, farmers can trick flies into perceiving healthy fruit as infected, reducing the need for insecticides.