An international team of scientists has discovered a link between Earth's ancient atmosphere and the chemistry of its deep mantle. The study found that sediment recycling provided atmospheric access to the mantle, leading to increased oxidation of calc-alkaline magma and altering the composition of the continental crust.
A team of researchers has developed an innovative approach to visualize individual molecule dynamics within nanofluidic structures using super-resolution microscopy and single-photon emitters. The study reveals new insights into the behavior of liquids on a nanometer scale, opening up exciting applications in optical imaging and sensing.
A study has shown that Buxu Tongyu granule effectively alleviates symptoms of acute myocardial ischemia in mice by activating the sGC–cGMP–PKG signaling pathway. The treatment demonstrates promise as a potential therapy for myocardial ischemia.
The study found that fruits pollinated by animals are 23% higher in quality, with benefits independent of geographical regions and pollinator species. This suggests that crop quality depends significantly on the presence of pollinating animals.
Researchers observed Ga-oxide islands embedded in the Cu surface and an ultrathin layer forming under CO2 hydrogenation reaction conditions. This finding exposes previously unconsidered catalytically active sites, providing insight into the reaction mechanism of methanol synthesis catalysts.
Researchers at Tokyo Institute of Technology have discovered a new strategy to stabilize the α-phase of α-FAPbI3, a promising solar cell material. By introducing pseudo-halide ions like thiocyanate into its structure, the team has successfully stabilized the α-phase, reducing its transition temperature and increasing its energy band gap.
Researchers from the University of Illinois warn that artificial roosts can be detrimental to bat health due to overheating and inadequate insulation. The experts emphasize the need for further study on the risks associated with these structures.
Researchers from Bar-Ilan University improved AI classification tasks by choosing the most influential path to the output, rather than learning with deeper networks. This approach can enhance existing architectures and pave the way for improved AI systems without additional layers.
Scientists have established the effectiveness of vaccines against leishmaniasis in animal studies, revealing specific molecular-level changes in host cells. The vaccines, created using mutated parasites, prompt distinct immune responses in hosts, offering new insights into their mechanisms and potential applications.
Researchers at CNRS develop new synthesis method for silicones, eliminating toxic cyclic oligosiloxanes and endocrine disruptors. The breakthrough could significantly impact the industrial sector with a more environmentally-friendly alternative.
A study of 11.7 million adults in Ontario, Canada, reveals that COVID-19 infection is associated with significantly higher mortality rates among cancer patients who do not receive prioritized critical care treatment.
Researchers have identified a cluster of neurons in the hypothalamus called GABRA5 that regulates energy expenditure. Astrocytes control this cluster, producing tonic GABA that inhibits it, leading to weight gain.
A team of astrophysicists at Northwestern University has successfully simulated the process of a black hole-neutron star merger, which is believed to have produced the unprecedented gamma-ray burst GRB211211A. The simulation reveals that the post-merger black hole launches jets of material from the swallowed neutron star.
Researchers used synchrotron techniques to study apatite inclusions in zircon crystals from old magmas, providing insights into the Great Oxidation Event. The findings suggest that sediments affected by an increasingly oxidised atmosphere modified the mantle and shifted the fugacity of magmas towards more oxidised conditions.
Researchers developed a new formulation of doxorubicin that targets cancer cells while reducing cardiotoxicity. The protein-shell encapsulation increases specificity for cancer cells and decreases harm to healthy heart cells.
Mayo Clinic researchers found that cells expressing PD-1 and PD-L1 within a certain distance of each other can predict the success of immunotherapy in patients with colorectal cancer. This spatial analysis may help select patients most likely to benefit from treatment, improving outcomes and minimizing unnecessary treatments.
Researchers developed a new strategy to target CD45, a surface marker found on nearly all blood cells, using CRISPR base-editing. This approach aims to overcome challenges in CAR T cell therapy, which currently targets specific cancer types, and could expand treatment options for virtually all blood cancers.
A study published in the Journal of Pediatrics found that feeding infants formula with a complex component of milk (MFGM) and lactoferrin for 12 months raised IQ by 5 points at 5 ½ years of age, improving speed of processing information and visual-spatial skills. The effects were seen long after the end of formula feeding.
A recent study using a novel method called FitCoal revealed a severe bottleneck in the human population that occurred approximately 117,000 years ago. This event led to a significant loss of genetic diversity, with an estimated 65.85% of current genetic diversity lost, but it also contributed to the formation of modern human chromosome 2.
Researchers at Brigham and Women's Hospital have developed a cohesive framework for evaluating biomarkers of aging, providing a robust classification system for the identification and validation of molecular markers. The framework highlights key criteria for evaluation, including age-sensitivity and generalizability across cell types, ...
A newly discovered fungus has been found to transform the toxic compound patulin into less harmful byproducts, offering potential solutions for controlling its presence in food products. The fungus, identified as Acremonium sp., was shown to degrade patulin into desoxypatulinic acid and other compounds, which are significantly less toxic.
A machine-learning model has achieved human-level proficiency at describing odors, according to a study published in Science. The model matched the prose descriptions of a molecule's odor with its molecular structure, creating a novel data-driven map of human olfaction.
Researchers at McMaster University found that peer-led group cognitive-behavioral therapy delivered online significantly improved symptoms of postpartum depression and anxiety in new mothers. The model has the potential to substantially improve access to effective treatment for mothers with postpartum depression.
Astronomers have found a Neptune-sized planet denser than steel, suggesting extreme planetary collisions that stripped away lighter atmosphere and water. The discovery provides new insights into the formation and evolution of planetary systems.
A recent study published in Science suggests that an early ancestral bottleneck may have pushed modern humans to the brink of extinction. The research, conducted by scientists at the Chinese Academy of Sciences Headquarters, analyzed ancient DNA samples and found evidence of a significant population decline around 200,000 years ago.
A study by McGill University found that higher-income individuals and those with university education had increased rates of melanoma, while those earning less than $50,000 were more likely to work outdoors and experience occupational sun exposure. Men also had higher rates of melanoma and other skin cancers due to increased UV exposure.
Researchers at Weill Cornell Medicine have discovered a unique site on BK channels that allows small molecules to selectively access the channel, potentially leading to the development of targeted drugs. This finding could help treat a range of diseases, including epilepsy and hypertension.
Researchers found that Dectin-1 stimulation induced a unique immune signature in HIV-positive older adults, characterized by increased levels of IL-12, TNF-α, and IFN-α. This signature may contribute to the pro-inflammatory environment associated with HIV and aging.
A new study finds that children's books in the US continue to lack diversity, with only 2% of characters pictured as Black and 4% as Latinx. Mainstream books are also cheaper than those highlighting diverse identities, suggesting a possible reason for the disparity.
Researchers at McGill University have developed a potato super pangenome, capturing the genetic diversity of nearly 300 varieties and their wild relatives. This extensive collection aims to identify key genetic traits for breeding more resilient, nutritious and disease-free potatoes.
Research finds that infants born during the pandemic have fewer types of bacteria in their gut compared to those born earlier. The study suggests that social changes caused by the pandemic may have influenced this change, with potential implications for infant health.
Researchers from University of New Mexico and Massachusetts Institute of Technology have detected two long-period giant planets orbiting an early K dwarf star. The exoplanets, TOI-4600 b and c, have orbital periods of 82.69 days and 482.82 days, respectively, making them the longest-period planets found by TESS to date.
Scientists have quantified a direct link between greenhouse gas emissions and polar bear survival, overcoming a loophole in the Endangered Species Act. The study provides a template for estimating the demographic impact of proposed GHG-emitting actions on polar bears.
Researchers have identified specific genetic elements in a highly virulent Lyme disease strain, suggesting key factors contributing to its infectiousness and human dissemination. The study's findings provide new insights into the spread of this debilitating disease.
A new study has found that higher levels of inflammation in patients with obesity undergoing bariatric surgery predict poorer weight loss. The research suggests that personalised interventions targeting inflammation could improve physical and mental health outcomes after surgery.
Metal organic framework nanosheets were found to optimize the morphology and texture of zinc anodes, reducing dendrite formation and side reactions. This enables efficient ion flux decoupling and improves cycling performance at both low and high rates.
The Regenstrief Institute has introduced an innovative mentorship model called Agile Mentorship, which fosters personalized relationships between mentors and mentees. This approach aims to create a psychosocial safety net for mentee success and promote career growth across generations.
Researchers demonstrate high levels of Raman amplification at 2.2 μm using a highly nonlinear silicon core fiber platform, extending the reach to 4 mm and beyond via cascaded processes. The work provides a crucial step towards compact and tunable mid-infrared systems.
A new study published in Management Science found that vertical integration in hospitals results in higher costs and decreased patient care quality. The study, which analyzed data from Medicare patients treated by gastroenterologists, suggests that financial incentives are a major factor driving these changes.
A team of researchers has improved photoclick chemistry by engineering the phenanthraquinone triplet state, increasing photoreaction quantum yield and reaction rates. The study's findings pave the way for efficient photoclick transformations with unprecedented efficiency.
A new study from Aarhus University reveals that indoor air pollution from candle smoke and cooking fumes can cause irritation and inflammation in young individuals with mild asthma. The research found indications of DNA damage and signs of inflammation in the blood, highlighting the need for proper ventilation when cooking or burning c...
Researchers from the Max Planck Institute have recreated an ancient Egyptian woman's scent used in her mummification, revealing complex ingredients and trade connections. The 'scent of eternity' blend includes beeswax, plant oil, and exotic resins, highlighting sophisticated mummification practices and long-distance trade.
Researchers at Prolacta and MD Anderson Cancer Center found a human milk-based synbiotic to safely control the gut microbiome in adults, opening the door to precision microbiome engineering. The study demonstrates significant precision in modulating adult gut microbiomes.
A team of scientists used a new method to estimate mutation rates in wild whale populations, revealing higher rates similar to smaller mammals. This led to a significant revision of previous estimates, suggesting that only 20,000 humpback whales remained in the North Atlantic before commercial whaling.
Researchers from Helmholtz Munich and TU Dresden develop AI-powered biomarker detection that outperforms previous approaches. The algorithm achieves high sensitivity on resection tissue samples and shows promise as a pre-screening tool for biopsy tissue.
Researchers developed a novel approach called 'countercation engineering' to impart thermoresponsiveness to graphene-oxide nanosheets. The method involves synthesizing GO nanosheets with specific countercations, resulting in inherent thermoresponsive behavior without the need for thermoresponsive polymers.
Scientists discovered oxygen production from vacuum ultraviolet photodissociation of sulfur dioxide, a possible trigger for the Earth's Great Oxidation Event. The study found that this process contributed to transient oxygen accumulation in the primitive atmosphere.
A team of researchers at the University of Waterloo and Dalhousie University have developed a method for forecasting short-term disease progression using limited data. The Sparsity and Delay Embedding-based Forecasting model, or SPADE4, uses machine learning to predict epidemic progressions with high accuracy.
A recent study by McGill University found that young adults who experience more frequent psychotic thoughts also spend more time on digital media. However, the study suggests that digital media use does not cause or exacerbate these experiences. Instead, it may be a factor in accessing mental health information and services.
Scientists have developed a new finger sweat test to detect antipsychotic drugs in patients, providing a quicker and more comfortable alternative to blood draws. The test was tested on 60 patients receiving clozapine, quetiapine, or olanzapine, with promising results.
Research highlights associations between adverse childhood experiences (ACEs) and workers' insomnia among Japanese adults. ACEs, including bullying and family dysfunction, are known to have detrimental health consequences.
A soft ball designed to support mental health has been invented, giving users a tangible representation of their breath to regulate emotions. The device, called PAWS, shows significant improvement in reducing anxiety and increasing protection against worry-induced thoughts, with an average 75% reduction in anxiety.
A new study reveals that positively-framed genomics conversations can lead to cynicism and mistrust among underrepresented communities. Researchers suggest acknowledging and validating concerns before introducing scientific details for more effective engagement.
A new study from the University of Michigan Department of Neurosurgery and Rogel Cancer Center shows promising early results that a therapy combining cell-killing and immune-stimulating drugs are safe and effective in extending survival for patients with gliomas, a highly aggressive form of brain cancer. The treatment improved survival...
Research reveals that heart transplant recipients from economically disadvantaged areas are at a greater risk of graft failure and mortality, with a 10% increased relative risk compared to those from non-distressed communities. The disparity in outcomes has widened since the implementation of the 2018 UNOS Heart Allocation policy.
Researchers at Case Western Reserve University have identified a new function of the key protein LSD1 that leads to cancer and other diseases. They found that degrading LSD1 rather than just short-circuiting its catalytic activity could be more effective in slowing or stopping cancer growth.
Research confirms the EIH hypothesis on a global scale using extensive data, showing that plants from vast, species-rich regions are most successful at naturalizing. Additionally, economic plants from these regions also show similar patterns of invasion and cultivation, suggesting interactions between biological and cultural systems.
A team at Tohoku University has used cryo-electron microscopy to study a crucial protein involved in zinc ion transport. The study reveals new insights into the mechanisms governing zinc transport, which play a vital role in enzyme catalysis, DNA binding, and gene regulation.
Researchers developed an automated viral plaque assay method combining time-lapse holographic imaging and deep learning to greatly reduce detection time. This technique can aid in developing new vaccines and antiviral drugs by expediting the testing process, allowing for faster response times to virus-induced health emergencies.
Researchers developed a methodology to link gene activity with cellular behavior in human pancreas cells, revealing the dynamic behaviors of pancreatic cells and their role in diabetes. The study shows that certain genes, such as NEUROG3, are active for short periods during development and have implications for therapeutic applications.