Researchers used cryoelectron microscopy to visualize how ribosome-modifying enzymes squeeze RNA nucleotides and alter them, leading to drug resistance. The discovery may lead to the design of new antibiotic therapies targeting these enzymes.
Researchers have found a promising new mechanism to target aggressive forms of prostate cancer, where the LSD1 protein is involved. By inhibiting LSD1, the tumor suppressor gene p53 can be reactivated, leading to suppression of tumor growth.
A new UC Berkeley study explores how public psychiatric healthcare workers in metro Johannesburg coped during the COVID-19 pandemic, revealing seven major coping mechanisms that preserved well-being and improved patient outcomes.
A Swansea University study explores the rationale behind the UK's COVID-19 shielding policy for clinically vulnerable individuals, finding it was an untested strategy based on risk mitigation rather than evidence-based intervention. The research reveals challenges in implementing the policy and its impact on organizations and populations.
The Institute for Immigration Research (IIR) at George Mason University has received funding for a conference focused on refugee resettlement and STEM education. The event will bring together educational and employment stakeholders to discuss strategies for addressing humanitarian needs and expanding the nation's STEM workforce.
A three-year study investigates how showerhead features affect concentrations of DWPIs in shower water and aerosols. The research aims to provide insights for consumers to select healthier showerheads and minimize exposure risks.
A new study demonstrates the value of citizen science in monitoring a natural enemy that fights invasive Siam weed. Citizen scientists on iNaturalist.org shared observations of the moth Pareuchaetes pseudoinsulata, confirming its establishment in several countries, including Thailand, Vietnam, China, Cambodia, and West Malaysia.
A commentary suggests that governments should consider publicly funding minimally invasive procedures, such as hair removal and facial injectables, to support transgender and gender diverse individuals. These procedures are already recommended by the World Professional Association for Transgender Health Standards of Care Version 8.
Researchers found that bacteria with electrically conductive protein threads can corrode iron anaerobically, producing magnetite that facilitates further corrosion. The discovery has significant implications for corrosion protection and suggests taking material properties into consideration.
A new study suggests that applying crushed volcanic rocks to agricultural fields can draw down 217 gigatons of carbon dioxide, meeting the lower end of the IPCC's 2100 target. The method, called enhanced rock weathering, is more efficient in hot and wet tropical regions and works well in warmer temperatures.
New research found that plant water use efficiency has stalled since 2001 due to climate change, contradicting earlier hopes it would help improve water consumption. The study's findings suggest that rising temperatures and atmospheric CO2 may be undermining nature-based methods to achieve carbon neutrality.
Researchers developed a nanoscale material technique called inverse thermal degradation (ITD) to control high-temperature flames and tune material properties. By regulating oxygen access, ITD allows for smoldering rather than bursting into flames, producing carbon tubes with desired characteristics.
Researchers have identified key genes involved in producing large amounts of immunoglobulin G, a crucial antibody in the human body. The discovery could lead to advancements in manufacturing antibody-based therapies for diseases such as cancer and arthritis.
Researchers examine translational studies on peripheral surrogates of tumor burden, including circulating tumor DNA, miRNA, and HPV-specific antibodies, to inform chemotherapy and immunotherapy strategies. These biomarkers show promise as prognostic and predictive markers of response to treatment.
Researchers studied over 800 clinical assays on renal tumors with MiTF family genes TFE3 and TFEB. The findings show significant age differences between patients with TFEB amplification and those with TFE3 or TFEB translocation, with TFEB amplification being associated with poorer prognosis.
Researchers found significant increases in body mass index among US youth during the COVID-19 pandemic, with effects most pronounced in low-income youth. The study highlights how preexisting social inequalities were exacerbated by the pandemic, leading to greater weight gain among vulnerable populations.
Research found integrated behavioral health care improves children's mental health and school performance, supporting the potential benefits of pediatric integrated behavioral health care. The study, which included 51 children served by FQHCs in Massachusetts, showed significant improvements over 12 months.
Researchers developed a 'diversity factor' metric to capture paper's impact on health outcomes for all patients, particularly those in low- or middle-income countries. Most medical papers fail to meet this metric due to lack of diversity among authors and patient populations.
Scientists have discovered that SARS-CoV-2 can infect cells using multiple entry points beyond ACE2, explaining its ability to jump between species. This finding highlights the need for continued monitoring of coronaviruses and their potential to cause future pandemics.
A survey of over 9,000 teachers found that they perceived more conflict with Black boys and closer relationships with white girls. The study highlights systemic racism and white privilege in the US educational system, which can impact teacher-child relationships.
Researchers found that sequential vaccinations given in the same arm generated a stronger immune response than those administered in different arms. This is particularly true for cytotoxic CD8+ T cells and antibodies targeting the SARS-CoV-2 virus.
A new study reveals a 4,000-year-old system of ceramic water pipes in China demonstrates that neolithic people were capable of complex engineering feats without a centralised state authority. The discovery challenges earlier understanding in archaeological fields.
The University of Cambridge team warns that Africa's lack of hydromet infrastructure will lead to a surge in climate-related disasters and deaths. The continent has just 6% of the number of radar stations as Europe and North America, making it vulnerable to floods, droughts, and heatwaves.
A new scientific statement from the American Heart Association highlights the importance of shared decision-making in cardiovascular care. Key findings include improved patient understanding, acceptance, and satisfaction when healthcare teams involve patients in decision-making processes.
A new computer model quantifies the black market for drinking water in Jordan, revealing that 91% of traded water is extracted illegally. The study predicts a significant increase in household dependence on private water suppliers due to decreasing public water supply infrastructure.
A new study has discovered that metformin, a common diabetes medication, can significantly slow the progression of STAT3-positive prostate cancer. The research team identified the key factors regulating tumour cell growth and found that permanent activation of STAT3 prevents prostate cancer development and metastasis.
A study found that adolescents from low-income families gained more weight during the pandemic, with girls experiencing accelerated weight gain. The researchers tracked over 400 low-income Hispanic families and compared their weight gain to a cohort of wealthier families.
A study found that PSMA PET/CT can accurately diagnose advanced prostate cancer in elderly patients without the need for a biopsy. The procedure reduced the number of biopsies and associated complications, while providing clinical suspicion-based staging data.
Megumi Inoue received funding for Mason CARES Plus to assess the impact of Stress Busting Program (SBP) and Music and Memory program on reducing care partner stress. The study aims to identify effective strategies for improving care partner engagement with M&M program.
Chemists at the University of Basel have developed chromium compounds that can replace osmium and ruthenium in luminescent materials and catalysts. The new materials are nearly as effective as some osmium compounds and are about 20,000 times more abundant and cheaper than their noble metal counterparts.
A study of 92 straight men found that neo-traditional, egalitarian, and progressive masculinities have different benefits and challenges for mental well-being. Men who promote gender equity report improved mental health, while those who challenge these ideals may face isolation or criticism.
A nationally representative study found that higher residential levels of fine particulate matter were associated with greater rates of incident dementia. The findings suggest that intervening on key emission sources could have value in reducing dementia risk, although further research is needed.
Researchers at North Carolina State University found that connected vehicles improve travel time through intersections, but automated vehicles without connectivity actually increase wait times. The study suggests that incorporating vehicle-to-vehicle and vehicle-to-infrastructure communication is crucial for optimizing traffic flow.
A large US study found that social determinants of health are a major factor contributing to higher cardiovascular disease mortality rates in Black individuals compared to Whites. The study analyzed data from over 50,000 adults and found significant associations between social factors such as unemployment and food insecurity with CVD m...
A promising molecular diagnostic tool uses a single biomarker to detect primary bladder cancer in patients with hematuria, showing high sensitivity and accuracy. The noninvasive test offers advantages such as shorter turnaround time and efficient analysis of results.
An intensive lifestyle intervention was associated with increased employment rates and improved labor market outcomes. The study suggests that such interventions can positively impact individuals with type 2 diabetes, highlighting the importance of considering labor market productivity in disease management.
Scientists discovered that climate shifts during the last 400,000 years influenced the frequency of Neanderthal-Denisovan interbreeding. The researchers found that temperature changes triggered habitat overlaps, leading to increased contact between the two species.
A new imaging method developed by UC researchers can identify specific lung infections in real time, reducing diagnosis time from 2-3 days to hours. The method uses injectable probes that light up under a nuclear imaging machine, enabling faster treatment for critically ill patients.
The UK fashion and textile industry is set for a significant boost with a £6 million investment in sustainability research. The initiative aims to help the sector adopt more sustainable practices, reducing its environmental footprint and greenhouse gas emissions.
A new study shows that a rule-based natural language processing tool successfully identified patients with unstable access to transportation, food insecurity, social isolation, financial problems, and signs of abuse or exploitation. The tool performed better than deep learning algorithms in identifying these social determinants of health.
Scientists propose a new method to study the origin of life by merging laboratory experiments and evolutionary biology. Electron transport chains, crucial for energy metabolism in all living organisms, are identified as a key area of study.
A new study from Tulane University found that Black adults are 54% more likely to die of cardiovascular disease than White Americans, largely due to social factors. The study's lead author suggests that addressing unemployment, low income, and lack of a partner can help reduce this disparity.
A new study by Paula Mayer proposes a practical tool for identifying areas of high human-bear conflict in the Abruzzo region. The model considers factors such as habitat suitability, migration corridors, and human-made food resources to inform local measures promoting coexistence.
Researchers successfully created stem-cell derived organoids from human stem cells that secrete three essential enamel proteins. These proteins form a matrix that undergoes mineralization to create a hardened enamel structure. The breakthrough offers hope for developing novel treatments to repair and regenerate teeth.
Researchers at Max Planck Institute for Human Cognitive and Brain Sciences have identified distinct cortical networks associated with subregions of the human medial temporal lobe. The study used precision neuroimaging to explore the distributed anatomy of the MTL, overcoming previous challenges in studying this region.
Researchers at the University of Leeds have created plant protein microgels that transform dry plant proteins into hydrated ones, mimicking the sensation of fat. The breakthrough could lead to the development of healthier, palatable, and sustainable plant-based foods.
Scientists at Oak Ridge National Laboratory are developing new cancer treatments that target the metabolic pathway hijacked by cancer cells. Using neutrons and x-rays, researchers mapped the enzyme structure to design roadblocks along the pathway.
Researchers at City of Hope have identified new molecular targets on a cell receptor that play a major role in cardiovascular regulation. The findings could lead to improved drugs for heart disease, an unfortunate side effect of some cancer therapies.
Researchers have successfully transformed black soldier fly carcasses into degradable plastics through a process of extraction and purification. The resulting bioplastics can absorb water and potentially address drought situations, making them a promising solution for sustainable agriculture.
Researchers have identified patterns of brain injury that underlie hidden consciousness, a phenomenon where brain-injured patients appear unconscious despite having some level of awareness. The study found that all patients with hidden consciousness had intact brain structures related to arousal and command comprehension.
In Ghana, WhatsApp is used to connect national-level executives with local candidates, extending to rural areas. In Nigeria, individual actors drive campaigns with loose party control, lacking formal online structures.
A new technique enables fast and efficient reconstruction of the full quantum state of entangled particles. By analyzing coincidence images, researchers can reconstruct the unknown wave function, enabling faster and more accurate characterization of quantum systems.
A new open-access journal, eGastroenterology, has been launched to accelerate research in gastroenterology and hepatology. The journal focuses on applying real-world data to guide clinical practice and improve patient outcomes.
A large study of 175,000 participants found that shift work significantly increases the risk of depression and anxiety. Lifestyle factors, such as diet, exercise, and social connections, partially mediate this association, highlighting the need for public health interventions to promote healthy lifestyles among shift workers.
Scientists at CUNY ASRC have shown that photons can collide and interact, allowing for new technologies to be developed. This breakthrough enables the manipulation of wave propagation, benefiting wireless communications, imaging, computing, and energy harvesting technologies.
A first-in-human trial of deep brain stimulation (DBS) for post-stroke rehabilitation patients has shown that DBS to target the dentate nucleus improves motor impairment and function, with gains nearly tripling initial scores. The study also found significant improvements in quality of life.
HBP researchers used glucose uptake to locate alpha waves' generation, finding subcortical areas drive cortical activity associated with consciousness. The study reveals an inverted u-shape relation between alpha power and brain function in patients with disorders of consciousness.
Researchers at Oregon Health & Science University have found that implanting a specific molecule in the brain can effectively reduce alcohol use among chronic heavy drinkers. The study showed a 90% reduction in drinking behavior in nonhuman primates, with the implanted virus permanently increasing dopamine levels and reducing cravings.
Researchers developed a unique approach to predict metal ductility using quantum mechanics, filling the need for an inexpensive and efficient method. The new approach was tested on refractory multi-principal-element alloys and showed robust results, confirming its effectiveness in distinguishing between ductile and brittle materials.
A proof-of-concept study reveals that 'forever chemicals' in soil from firefighting foam can be degraded through a simple and cost-effective method called ball milling. This innovative technique has the potential to revolutionize the cleanup of contaminated sites worldwide, addressing a significant environmental concern.