A team of researchers at the University of Tennessee Health Science Center has received a $3.07 million grant from the National Cancer Institute to develop new drugs targeting microtubules for breast cancer treatment. The goal is to improve overall survival and quality of life for patients with metastatic breast cancer.
Researchers at RIKEN have demonstrated a method to prevent severe weather events by inducing small perturbations in the Lorenz 96 model. This approach utilizes the inherent chaos in weather systems to limit extreme events, which become more common due to climate change.
New research found that social infrastructure in rural communities can provide essential support to older, non-white adults. This study highlights the importance of community spaces in promoting healthy aging among Black and Hispanic older adults, who are disproportionately affected by loneliness and mental health issues.
A team of scientists has created the first-ever brain atlas of the dwarf cuttlefish, a master of camouflage. The atlas maps the animal's 32-lobed brain structure and cellular organization, providing valuable insights into its remarkable ability to change skin color in response to visual stimuli.
A 12-month lifestyle intervention led by community health workers reduced systolic blood pressure in Nepal. However, a 5-year follow-up found that the benefit was not maintained, with blood pressure rising again after the intervention ended. This highlights the need for ongoing education and follow-up to prevent potential harm.
The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for anxiety disorders in older adults. Anxiety disorders are commonly occurring mental health conditions often unrecognized in primary care settings, leading to substantial delays in treatment initiation.
Researchers applied machine learning to brain responses and achieved near-perfect classification accuracy for songs that may become hits. The approach, called 'neuroforecasting,' uses data from a small group of people to predict population-level effects without needing to measure the brain activity of hundreds of people.
A novel study found that honokiol promotes healing of rotator cuff injury and may be an effective treatment for humans. The study suggests that SIRT3 activation plays a protective role in alleviating aging-induced fibrocartilage degeneration and promoting rotator cuff healing.
Researchers identified a molecule that allows HIV to hide in reservoirs within CD4+ T lymphocytes. The aryl hydrocarbon receptor protein plays a crucial role in viral latency and has shown potential as a good therapeutic target.
George Mason University CEHD researchers received $49,997 from the Appalachian Trail Conservancy to develop a conservation stakeholder engagement plan. The project aims to identify and engage diverse stakeholders in Appalachian conservation planning using a justice, equity, diversity approach.
Researchers at University of Nebraska-Lincoln are working on safeguarding US military base entry points against EV threats, focusing on high-speed ramming and zero-to-60 acceleration. The team will employ digital simulations and physical crash tests to refine barriers designed to withstand such impacts.
A team of SUTD researchers discovered a novel intrinsic nonlinear planar Hall effect, proposing a mechanism to characterize novel materials and their complex behaviors. This effect could lead to new designs in nonlinear rectifiers or terahertz detectors for long-range communications.
A computational psychological model predicts subtle behaviors in real traffic, such as hesitating before crossing and speeding up to deny pedestrians a crossing opportunity. The model accurately simulates 32 pairs of participants interacting as driver and pedestrian in a driver-pedestrian simulator.
A new NIH study suggests xylazine, a veterinary tranquilizer, can damage brain oxygen levels when combined with opioid drugs like fentanyl and heroin. This combination may lead to prolonged brain oxygen decreases, increasing overdose risk. Researchers hope to develop interventions to reverse overdoses and save lives.
Researchers at SRI International have identified genes that enable insects to produce terpenes, a key component of their chemical communication. This breakthrough provides a roadmap for understanding how these chemicals are used and could lead to new ways to protect crops and prevent insect-borne diseases.
Researchers have identified a new bacterial strain, Paenibacillus thiaminolyticus, as the underlying cause of postinfectious hydrocephalus in Ugandan babies. The bacteria was found to be resistant to antibiotics and carried a virulent toxin that causes high mortality rates.
Researchers developed Precious1GPT, a multimodal transformer-based approach for aging clock development and feature importance analysis. The model utilizes methylation and transcriptomic data to predict biological age and identify disease-related genes, providing a pathway for therapeutic drug discovery.
The study found that fiber straightness is a potential biomarker for diagnosing non-small cell lung cancer, while density is a poor prognostic indicator. The researchers also discovered abnormal stiffening of tissues in tumor samples, which may be related to immune system response and tumor progression.
A new technique, FBS-IDT, enables high-resolution imaging of intracellular tau aggregates in their native environments. It demonstrates potential correlations between tau fibrils and lipid accumulation, offering a cost-effective solution for neurodegeneration research.
A virtual reality project, Qikiqtaruk: Arctic at Risk, visualizes the impacts of climate change in the Canadian Arctic. The project, created by National Geographic Explorers and local communities, uses immersive technology to transport users to an island experiencing rapid thawing and environmental changes.
A survey study of 18,000 respondents across seven countries found that civil violence exposure was associated with an elevated risk of mental disorders for many years after initial exposure. The findings suggest that policymakers should consider these associations when projecting future mental disorder treatment needs.
A study found that social isolation is associated with a decrease in hippocampal volume, poorer cognitive performance, and an increased risk of developing conditions like Alzheimer's dementia. Conversely, maintaining a healthy social network can help preserve brain structure and function.
Researchers found that exercise-induced heart rate can cause plaque in moderately to severely blocked carotid arteries to migrate and halt blood flow to the brain. This can lead to ischemic stroke. The authors recommend checking arterial health regularly for people doing intense workouts.
Researchers mapped 39 interstellar clouds to understand high-mass star formation. They found over 800 stellar seeds that will evolve into stars, but only 1% have enough mass to become high-mass stars.
The Hunga Volcano eruption in Tonga created a plume that reached altitudes of up to 25 miles, producing the most intense lightning rates ever detected. The plume expanded outward as an umbrella cloud, creating fast-moving circular ripples and donut-shaped rings of lightning.
A new analysis found that expanding Medicaid eligibility to more people improved patient outcomes, prevention measures, and screening access. The study suggests that increasing health insurance coverage results in better health outcomes for those with heart disease.
A national study launched by UNCG's Prevention Strategies aims to prevent opioid misuse among high-risk occupations. The WorkWell mobile app, featuring evidence-based educational strategies, will be tested in the construction and nursing industries.
Alternative splicing expands the diversity of proteins and contributes to molecular pathology in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Dysregulation leads to aberrant protein production, affecting neuronal health and function.
Scientists have identified a natural gene variant in barley that enables plants to flower up to 18 days earlier, allowing for improved adaptation to climate change. This discovery could lead to the development of climate-resilient barley varieties with stable yields.
Researchers developed a new therapeutic molecule that activates WNT signaling to restore the blood-brain barrier's normal function. The treatment showed promise in treating conditions such as multiple sclerosis and ischemic stroke by reducing the severity of strokes and improving survival rates.
Scientists analyzed hoof prints and foot bones from modern horses to discover what happened to the lost digits. The team confirmed that the distant ancestors of modern horses had hooved toes instead of a single hoof, which vanished over time.
Researchers have developed a simulation of how people behave on roads based on cognitive theories, accurately reproducing pedestrian and driver behaviors in common scenarios. The model predicts complex underlying cognitive mechanisms that contribute to the difficulty in creating self-driving vehicles.
Scientists used CRISPR interference to study gene function in human and chimp stem cells, discovering genes essential for cell cycle regulation that are absent in humans. This approach sheds light on the evolution of human brain development and highlights the importance of studying gene interactions over DNA sequences.
Leading researchers discuss challenges associated with return to school for children and adolescents with TBI, highlighting the need for improved educator training and communication. Strategies for improving quality of life and outcomes are recommended by experts in this themed issue.
The January 15, 2022, eruption of Hunga Volcano in Tonga created a 'supercharged' thunderstorm that produced nearly 200,000 lightning flashes. Scientists analyzed high-resolution lightning data to gain insights into the eruption's timeline and behavior.
An AI model called SCORE-AI achieved human expert level performance in fully automated electroencephalogram interpretation. This technology has the potential to improve diagnosis and patient care in underserved areas and increase efficiency in specialized epilepsy centers.
Researchers found digital contact tracing apps were ineffective due to low adoption rates and privacy concerns, but may still be useful in targeted populations.
Researchers developed a new anode material that increases lithium-ion battery storage capacity by 1.5 times, allowing for fast charging in as little as six minutes. The innovation uses electron spin to enhance storage capacity and ferromagnetic properties.
Researchers have identified a gene in the placenta that produces a defense mechanism against viral infections, protecting fetuses during pregnancy. This discovery could lead to the development of new anti-viral treatments.
A new study highlights the potential of living cell banks to contribute to global conservation priorities. Cryo-banked samples provide crucial genetic diversity and reintroduction opportunities to increase adaptability and resilience in threatened species.
Ferroelectric materials like hafnia show promise for non-volatile random-access memory (RAM) due to their stability at high temperatures. Hafnia's unique properties, including the movement of oxygen vacancies, make it an attractive candidate for memristors that mimic brain-like computer architectures.
A University of Essex-led study found that fast-oscillating brain waves linked to brief pain and touch differ widely in scans, with individual patterns stable across time. The research challenges previous findings on the relationship between pain and gamma oscillations.
The Hotchkiss Brain Institute will recruit and train emerging neuroscience research leaders to improve brain and mental health globally. Dr. Deepika Dogra's innovative method screens anti-seizure drugs for children using cerebral organoids.
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
Researchers have developed flexible photodetectors that can detect visible to long-wave infrared radiation, covering the full spectrum of greenhouse gases without complex optical components. The new detectors are simple and cost-effective to make, with production at room temperature.
A study by Macquarie University researchers explores how players respond to morality meters in games, showing that most ignore clear moral choices but use them when ambiguous. The research provides insights into the impact of morality meters on player behavior and has implications for moral education and awareness.
Researchers at the University of California - Riverside have developed a low-cost technology using biochar to remove harmful compounds from reclaimed water, making it safe for agricultural reuse. The biochar-based polishing systems have shown promising results in removing antibiotics and resistant bacteria, potentially reducing the spr...
Researchers at the Complexity Science Hub found that periodic outbreaks of warfare can account for boom-bust patterns in population dynamics of early farming societies. The study suggests that social conflict played a crucial role in shaping the population dynamics of these societies, contrary to previous assumptions that climate chang...
A new machine learning algorithm analyzed high-resolution digital images of herbarium specimens, revealing that factors other than climate have a strong effect on leaf size within a plant species. The study also demonstrates how AI can be used to transform static specimen collections and quickly document climate change effects.
A University of Kent-led study found that well-functioning ecosystems are essential for human health and wellbeing, with species traits contributing to physical, emotional, social, spiritual, and global wellbeing. The study highlights the importance of maintaining biodiversity in natural environments to support human health.
A review article proposes zero-waste methodologies to convert 100% of marine macroalgae (seaweed) into cosmetics ingredients using industrially available green technology. This enables the cosmetics industry to meet environmental sustainability and ESG requirements, while leveraging the potential of Brazilian seaweed.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
Researchers have reconstructed the face of a 16-year-old woman buried near Cambridge with an incredibly rare gold and garnet cross, revealing she moved to England from Central Europe as a young girl. Analysis shows that her diet changed significantly after arrival, indicating a short and challenging life.
Researchers found that probiotics help preterm babies achieve a balanced gut microbiome and eradicate harmful bacteria. The study also shows that probiotic-supplemented preterm newborns have lower risk of carrying antimicrobial resistant bugs despite frequent antibiotic treatment.
A new gene variant, RBL1, has been identified in a type of rice that can be modified to improve performance without yield penalties. This breakthrough could lead to more disease-resistant rice crops with high yields, addressing a major threat to the industry and meeting growing global demand.
A comprehensive dataset of neurotransmitter receptors has been made publicly available, revealing potential role in distinguishing internal thoughts and emotions from external influences. The study's findings have exciting implications for understanding brain function and developing new treatments.
Researchers have identified and fabricated a new electrocatalyst using theoretical predictions, significantly improving the oxygen evolution reaction. The discovery uses cerium-doped cobalt oxide to achieve an overpotential of only 261 mV at 10 mA cm−2, outperforming individual cobalt oxide.
A supersized database of over 45,000 traits tracks the behavior, distribution, and life patterns of fruit eaters and birds in Central and South America. The Frugivoria database provides crucial insights into their role in maintaining forest composition and health.
A recent study found a positive association between short-term exposure to fine particulate matter (PM2.5) and increased hospital admissions, length of stays, and associated costs in all major diseases. The study's findings suggest that improved air quality since 2013 saved CNY2.28 billion in medical expenses in 2017.
Researchers link Kawasaki disease to ultrafine aerosols rich in metals from intensive farming and urban pollution. Exposure to high levels of metals is associated with increased incidence of the disease.