An international study has introduced a genetics-based breast cancer precision prevention service using polygenic risk scores and telemedicine solutions. Preliminary results show that this approach can identify women at high risk of breast cancer and provide personalized screening recommendations.
A new study found that two-thirds of physicians and biomedical scientists reported harassment on social media, with women and minority groups facing higher rates. The survey highlighted the need for these individuals to be represented in combatting misinformation on social media, as their loss could exacerbate health inequities.
Peripheral artery disease (PAD) disproportionately affects Black adults, with higher rates of diagnosis and poor outcomes. Low-cost, routine testing can help reduce disparities and health care costs by identifying individuals at risk and providing preventive measures.
The Adaptive Spatio-Temporal Attention Neural Network (ASTANN) is proposed for cross-database micro-expression recognition. It extracts optical flow information and combines it with facial images to generate new representations, which are then processed by a deep neural network with spatiotemporal attention mechanisms.
Researchers in China have developed a new theoretical framework to understand and predict air pollution, highlighting the complexity of coal combustion and vehicle exhaust interactions. The Air Pollution Complex is a holistic approach that considers multiple emission sources and chemical processes.
Researchers have created an Aging Fly Cell Atlas, profiling <em>Drosophila</em> head and body tissues at different ages to understand the impact of aging on cell composition and gene expression. The study reveals dramatic changes in fat body nuclei and muscle nuclei with age.
Researchers found a link between short telomeres in ATII cells and lung fibrosis in post-COVID-19 patients. The study revealed loss of ATII cellularity and shorter telomeres concomitant with increased fibrotic lung parenchyma remodeling.
Researchers at UC San Diego have discovered that shattered DNA fragments are tethered together during cell division, allowing them to be reassembled in a different order. Destroying the tether may help prevent cancerous mutations and is now being explored as a therapeutic target.
Researchers discovered that ancient Alaskans between 13,000 and 11,500 years ago relied on freshwater fish like burbot, whitefish, and pike for sustenance. This finding provides insight into how early humans adapted to environmental changes, using techniques such as nets and weirs.
A new study predicts Arctic sea ice will vanish by the 2030s if greenhouse gas emissions continue unchecked. The research, published in Nature Communications, analyzes 41 years of data and confirms human activities as the primary cause of Arctic sea ice decline.
Researchers discovered microRNA-132 can impact different brain cells, including microglia, which are key players in neuroinflammation. The study suggests increasing microRNA-132 levels may be a therapeutic strategy for Alzheimer's disease.
Researchers identified three immune cell types within tumor niches that determine which patients respond positively to checkpoint blockade immunotherapy. The study may inform new approaches to cancer treatment.
Researchers discovered that astrocytes process serotonin to regulate olfactory sensation. The study found that serotonin triggers changes in gene expression patterns, turning astrocytes into hubs of olfactory processing.
Scientists develop a new technique for in-plane anisotropic excitation and propagation of hyperbolic polaritons, breaking mirror symmetry without low crystalline symmetry. This enables dynamic control over light guiding and propagation on the nanoscale.
Researchers warn of growing adverse impacts of light pollution on plants, animals, and entire ecosystems. Light pollution causes habitat loss, disrupts food webs, and declines insect populations.
Researchers at CRAG have discovered a key role for AtMC3, a metacaspase protein located exclusively in phloem tissue, in drought stress response. Increasing AtMC3 levels improves plant survival and photosynthetic capacity under water scarcity conditions, offering a potential tool to fine-tune early drought responses.
A new study by University of Delaware researchers assesses the effects of climate variability on crop production in the US. The study reveals that fluctuations in planted and harvested areas contribute significantly to crop production shocks, which can have severe impacts on food stability.
The study reveals that the midgut gland of Japanese scallops is a valuable source of fucosylated heparan sulfate, exhibiting anticoagulating and neurite outgrowth-promoting activities. Fuc-HS shows resistance to GAG-degrading enzymes, indicating its unique structure with a fucosyl group attached to GlcA.
Researchers found that 'concerning' CT imaging results were associated with lower clinical outcomes and shorter hospital stays in low-risk patients with acute pulmonary embolism. This suggests that emergency physicians may be managing these patients differently, leading to unnecessary hospitalizations.
Researchers at IUPUI will lead two grants totaling $11.7 million to discover a drug treatment for hydrocephalus, a condition commonly associated with traumatic brain injury. The studies aim to test the effectiveness of treatments for three types of hydrocephalus and may lead to a new treatment option.
Princeton researchers used data from NASA's Parker Solar Probe to determine that a catastrophic event, such as a high-speed collision or gaseous explosion, likely created the Geminids meteoroid stream. This is in contrast to most meteor showers, which originate from comets emitting tails of ice and dust.
The FRESCO-2 trial shows that fruquintinib significantly improved overall survival and progression-free survival in patients with refractory metastatic colorectal cancer. The median OS was 7.4 months with fruquintinib versus 4.8 months in the placebo arm.
Researchers at City of Hope have developed a universal donor stem cell therapy that can treat degenerative brain diseases such as Canavan disease and Alzheimer's. The therapy, which uses an 'off-the-shelf' approach, has shown promising results in preclinical studies, reducing toxic accumulation of metabolites and improving motor function.
A genuine bone industry was found at the Chez-Pinaud-Jonzac Neanderthal site, revealing that Neanderthals processed bone using their own techniques. Bone tools, including cutting tools and scrapers, were used for various activities and on multiple materials, contrary to previous assumptions about modern human influence.
A research team from HKUST identified CPEB4, an mRNA-binding protein, as a key player in maintaining mitochondrial metabolism and energy production. Restoring CPEB4 expression in aged muscle stem cells improved energy production and protected against cellular senescence.
A massive global study found five common shark species declined 60-73%, as overfishing removed sharks and prey, shifting reef communities towards ray dominance.
A new sensor patch detects digestive fluid leaks in the abdominal cavity through a sensitive reaction to changes in pH value and proteins. The patch can also visualize gas bubbles using ultrasound, reducing reliance on physical reactions or laboratory tests.
Researchers develop new approach to quantify respiration and its temperature sensitivity in terrestrial ecosystems. Their findings suggest lower temperature sensitivities than previously thought, but caution that natural components alone cannot mitigate climate change.
HaoSheng Sun, assistant professor at University of Alabama at Birmingham, has been selected as a Freeman Hrabowski scholar by the Howard Hughes Medical Institute. He will receive up to $8.6 million over 10 years to advance his research on neural development and plasticity.
Researchers have pushed back the age of the massive Ontong Java Plateau eruption by 10 million years using high-precision argon isotope dating. The revised dates suggest the event occurred after the onset of Ocean Anoxic Event 1a, challenging previous theories about its cause.
A large Danish study suggests that cannabis use disorder is associated with an increased risk of developing depression and bipolar disorder. The research analyzed data from over six million individuals and found a two-to-three-times higher risk of developing bipolar disorder in both men and women.
A recent study has found that impaired histone inheritance accelerates breast cancer growth and metastasis by disrupting the epigenetic state of cells. This disruption leads to the reactivation of genes associated with development, promoting tumor progression.
A new butterfly species, Caeruleuptychia harrisi, has been discovered and named in recognition of Brian P. Harris' decades-long work supporting researchers at the Smithsonian National Museum of Natural History. Harris provided critical support to visiting researchers, including the paper's lead author, Shinichi Nakahara.
A new study finds that clean energy microgrids can reduce power outages in wildfire-prone areas of California by up to 30%, cutting costs from 15-30 cents per kWh compared to conventional technologies.
A new study by University College London found that Latin Americans with greater Native American ancestry are at a higher risk of developing severe liver failure and associated high risk of short-term mortality. The study suggests that genetic ancestry and race may determine the outcome of advanced liver disease in patients.
A new study found a 67% increase in hospital encounters for benzodiazepine-related toxicity among young adults and a 44% rise in youth aged 18 or below in Ontario between 2013 and 2020. The increased risk is attributed to the growing presence of non-pharmaceutical benzodiazepines in the unregulated opioid supply.
Researchers developed a new tool, GASPACHO, to capture dynamic changes in gene expression along the innate immune response. They identified a gene variant affecting COVID-19 susceptibility, shedding light on molecular mechanisms underlying disease pathogenesis and identifying potential therapeutic targets.
A case of echovirus 11-induced hepatitis in Italian male twins has been reported, showing a close genetic relation to strains found in France among neonates. The study highlights the importance of rapid recognition and timely treatment to ensure survival, and suggests potential host genetic predisposition in male and twin categories.
New research from the University of Manchester reveals that areas rich in marine life are significantly impacting our ecosystems and climate. The study found that urea, a nitrogen-rich compound, is being transported over long distances through the atmosphere to benefit nutrient-deficient environments.
Researchers developed a new method for controlling lower limb exoskeletons using deep reinforcement learning, enabling more robust and natural walking control. The system has the potential to benefit users with spinal cord injuries, multiple sclerosis, stroke, and other neurological conditions.
A novel framework guides informed and effective soil management as carbon sinks, considering context-dependent environmental conditions. Management targeting 'labile' carbon is more effective in increasing carbon sequestration than focusing on 'stabilized' carbon.
A new study published in Educational Researcher found that the top 5% of teachers who refer students to principals' offices for disciplinary action effectively double the racial gaps in such referrals. The study analyzed data from over 2,900 teachers and 79,000 students across 101 schools in a large urban district in California.
A study by Florida Atlantic University's Harbor Branch Oceanographic Institute found domoic acid toxin in 87% of samples from the southern Indian River Lagoon, which can harm shellfish, finfish, birds, and humans. The toxin is more prevalent in cool temperatures and high salinity waters, suggesting it may be a resident population.
Interventions with wearable activity trackers increased physical activity levels, reduced sedentary behavior, and improved physical functioning in hospitalized adults. This systematic review and meta-analysis of 15 studies and 1,900 participants supports the use of wearable technology to enhance patient outcomes.
Researchers found that vaginal microbiota seeding improved C-section babies' early development by colonizing their guts with maternal bacteria. This approach may reduce the risk of neurodevelopmental disorders like ADHD and intellectual disabilities.
Research presented at ENDO 2023 found women with PCOS died 47% earlier than those without the condition. They were also at higher risk for deaths due to cardiovascular disease, tumors, diabetes, and lung infections.
A new study found that Kenyan smallholder papaya farmers are willing to adopt biological control methods to combat the papaya mealybug. Farmers demonstrated high levels of awareness of the negative impacts of chemical pesticides, but lacked knowledge and support for biological control.
Researchers have made a significant finding in detecting brain tumors by exploiting folate receptors. Folate receptor expression is significantly higher in glioma tissue compared to adjacent healthy brain tissue, presenting a promising target for future treatments.
Research at Columbia University Mailman School of Public Health found a rise in binge drinking among people aged 31 and over in US states with recreational cannabis laws. Binge drinking declined among younger age groups, including those aged 12-20 and 21-30.
A new study from the University of Illinois shows that carbon mitigation payments can increase net returns and reduce income risk for farmers growing bioenergy crops. The researchers found that higher biomass prices and targeted carbon credits can make these crops more appealing to farmers, regardless of their risk preference.
Researchers identify a unique centromere structure in Chionographis japonica with 7-11 evenly spaced units, similar to monocentric species but larger than others. This arrangement enables more stable and robust chromosomes during cell division.
A study by Swansea University found that teaching mental health literacy in schools significantly improves pupils' knowledge, behaviours, and intentions to seek help. The Guide Cymru programme, developed with Action for Children, demonstrates a positive impact on young people's wellbeing.
Craig Ferguson has been appointed manager of the DOE Thomas Jefferson Site Office, leading in oversight and contract management of Jefferson Lab. Donté Davis, previously in the role, will support the office's wide range of oversight programs.
High-energy electrons pose significant radiation damage to satellites; a new study sets benchmark levels for extreme space weather events. Satellite operators must prepare against these risks as the global space economy relies on over 5,465 operational satellites.
Researchers have developed a new DNA sequencing method that allows for precise mapping of 5-methylcytosine, a key regulator of gene expression. This technique, called Direct Methylation Sequencing (DM-Seq), enables scientists to profile DNA using small samples and without damaging the sample, making it suitable for liquid biopsies and ...
A new analysis of the CLEAR Outcomes Trial found that bempedoic acid lowered LDL cholesterol levels by 21% and reduced cardiovascular events by 13%. This suggests that different classes of cholesterol drugs have similar benefits for cardiovascular health.
Researchers at Washington University School of Medicine developed a catalog to classify protein variants associated with limb girdle muscular dystrophy. The approach enables doctors to determine the pathogenicity of variants, leading to more precise diagnoses and potential therapies.
Research reveals that women with PCOS experience significant body image concerns, including greater self-classification as overweight and lower body satisfaction scores. This correlation may increase the risk of developing eating disorders like anorexia or bulimia.
Bioactive glasses with ionic silver show improved antimicrobial activity and can retain effectiveness against antibiotic-resistant bacteria. The study demonstrates the potential for this combination to deliver more effective wound protection than conventional alternatives.
A new study led by Cornell University's Wendy Erb found that orangutan vocal changes can be used to assess their health, as they alter their frequency and quality of sounds in response to wildfire smoke. This innovative method could help monitor the endangered species' well-being without putting them at risk.