A study of 10,000 individuals with insomnia found significant racial disparities in prescription medication, with Black patients less likely to receive FDA-approved treatments. The research suggests that providers may be undertreating insomnia, particularly in non-White populations.
The study found that food allergies were highest among Asian, Hispanic, and non-Hispanic Black individuals compared to non-Hispanic white individuals. Socioeconomic factors and environmental exposures may contribute to the disparity in food allergy prevalence.
Researchers have designed new light-responsive membrane carriers for the translocation of peptide cargos inside living cells, offering a promising strategy for remotely controlled delivery of large biomolecules. The light-triggered system utilizes azobenzene units to control the transport of cationic peptides across lipid membranes.
New research on homelessness in Ireland reveals a significant increase in emergency accommodation usage since 2015. The study highlights the need for improved mental health support, effective harm reduction programs, and better strategies for frequent ED attenders.
Researchers developed methods to emphasize higher-frequency components of bone-conducted speech signals, improving intelligibility in noisy environments. The study's findings have potential real-life applications in BC-type hearing aids and auditory augmentation.
A study by University of Zurich researchers found that global warming is accelerating the decomposition of soil humus and affecting plant storage of carbon. The findings have significant implications for relying on soils as a natural carbon sink to tackle global warming.
Researchers found a distinct gut microbiome in people with pre-symptomatic Alzheimer's, differing from healthy individuals. This discovery opens the possibility of analyzing gut bacteria to identify risk factors and designing preventive treatments.
A yearlong science program with family members led to increased interest in STEM subjects and a lifelong engagement. Children who participated showed more enthusiasm for science and were more likely to envision themselves as scientists, while their families reported renewed interest in science at home.
The use of psychedelics in mental health treatment is gaining traction, but concerns about patient safety and regulation need to be addressed. Psychedelic-assisted therapy shows promise in treating conditions like depression and PTSD, but more research is needed on dosages, settings, and guidelines.
Research identified three genetic risk factors for Dupuytren's contracture, a condition affecting fingers, that originated from Neanderthal DNA. The study, based on 7,871 affected individuals and 645,880 healthy controls, provides evidence of the intermingling between Neanderthals and modern humans influencing disease prevalence.
Scientists discover that warmer temperatures cause sea sponges to lose essential microbes, leading to tissue poisoning and necrosis. This study highlights the impact of climate change on marine ecosystems and the potential loss of medicinal molecules.
Researchers at Purdue University have developed a new steel alloy with extraordinary strength and plasticity, achieving a yield strength of about 700 megapascals. The treatment produced ultra-fine metal grains that exhibit super-plasticity, allowing the material to stretch and bend without rupturing.
A community-wide program in Washington, D.C., supports adolescent mothers, caregivers, and community members, addressing barriers to childcare and education. The 'collective impact' model has improved access to essential programs, including housing and food security, for over 550 young parents.
Researchers have developed a sonodynamic cancer immunotherapy based on semiconducting polymer nanoparticles that can be activated by ultrasound, effectively treating orthotopic pancreatic cancer in mouse models. The treatment induces immunogenic cell death and kills cancer cells without causing excessive immune responses.
A recent study published in Diabetologia has uncovered a crucial gene called RELA that plays a vital role in maintaining normal blood-sugar levels. The researchers found that when the RELA gene is removed, it leads to impaired insulin secretion and pre-diabetic conditions.
A German federal funding program will support a five-year research collaboration to develop specialty lipids and auxiliaries for mRNA vaccines. The project aims to enhance production capacities and improve the resilience of supply chains for future mRNA therapeutics.
A systematic review of evidence found that Covid-19 led to an initial rise in depression and anxiety disorders across Europe, but rates did not return to pre-pandemic levels for many services. The pandemic exacerbated existing treatment gaps, with potential long-term repercussions.
Scientists at RIKEN Center for Brain Science find that somatic mutations in six genes lead to intracranial aneurysms, which can be blocked with a drug. The study establishes the first non-surgical animal model of intracranial aneurysm and provides a potential new treatment option.
A study by Chinese researchers found that financial reports produced during fiscal years mismatched with annual business activity may be less reliable due to rigid accounting regulations. This can result in higher abnormal accruals, lower analyst forecast accuracy, and longer audit reporting delays for affected companies.
Scientists have discovered that stagnant lid tectonics, not plate tectonics, existed on early Earth, releasing heat and forming continents. This finding contradicts previous assumptions about the role of mobile plate tectonics in life's emergence, suggesting an alternative mechanism was present.
A new meta-study confirms the 'integration paradox', where well-educated and socially integrated immigrants report more experiences of discrimination. Factors such as language skills, public life engagement, and self-confidence play a significant role in this phenomenon.
Scientists have developed a new AI tool called Bambu that uses long-read RNA sequencing to identify and quantify novel transcripts, providing a better understanding of gene expression and function. This innovative tool can be used in both clinical and research settings to discover new genes and their roles in human diseases.
A six-month study found daily multivitamin/multimineral supplementation had a positive effect on key nutrition biomarkers in healthy older men. The researchers also found that the changes in nutrition status could have direct connections to cellular function.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
A research team developed a radiative transfer model for plant leaves in the thermal infrared spectrum and found that as the cuticle layer decreases, leaf reflectance increases with decreasing water content. This study provides essential theoretical foundations for understanding TIR spectral behavior of leaves.
Researchers have developed a biodegradable ultrasound device that can open the blood-brain barrier, allowing chemotherapy to penetrate and kill brain cancer cells. The device is as powerful as traditional ceramic-based devices and has shown promising results in animal trials.
Researchers found that psychedelic drugs such as LSD, psilocybin, and MDMA reopen critical periods in mice, enabling them to learn from their social environment. The length of time the critical period stayed open varied among drugs, with some lasting up to four weeks.
A new study reveals that Dupuytren's disease, a hand disorder affecting Northern Europeans, has a significant genetic component tied to Neandertal ancestry. Researchers identified three variants of Neandertal origin as major risk factors for the condition.
Scientists have found that tiger mosquitoes can transmit the chikungunya virus as effectively at 20°C as at 28°C, raising concerns about its spread in temperate regions. The study reveals different gene expression profiles and microbiome changes in infected mosquitoes, which could lead to increased transmission of the pathogen.
Researchers at UCL have developed base-edited T-cells that can fight leukemia, showing promise in a NHS clinical trial. Three patients with relapsed T-cell leukaemia were treated with the cells, with one patient experiencing complete remission after just four weeks.
Researchers have identified a phenomenon that could help coral reef managers plan and act for the future. Ocean processes during El Niño strengthened the North Equatorial Counter Current, driving cooler plankton-rich waters to Palmyra's coral reefs and enabling them to better manage heat stress.
Researchers have developed a new way to identify proteins based on their amino acid content, which can predict protein function and facilitate the development of new biological drugs. The method shows promise in cancer research, where it can help design more targeted treatments by linking survivin and PRC2 proteins.
A recent study found that cognitive enhancers, such as Ritalin and modafinil, may actually inhibit performance and productivity in neurotypical workers and students. Participants who performed well on a complex decision-making task showed decreased accuracy and efficiency when taking the drugs.
Research by the University of Illinois reveals that soybean pods play a vital role in photosynthesis, contributing to seed yield. The study found that pod and seed photosynthesis account for 13% of final seed weight and 9% of overall canopy photosynthesis.
The latest DESI data release provides a precise 3D map of the universe with high certainty. The data also sheds new light on cosmic acceleration and the nature of gravity at large scales.
Researchers found that an older adult's performance on the phone menu test was associated with Alzheimer's disease pathology, including amyloid and tau depositions. The test detected clinically meaningful changes in daily functioning before pronounced symptoms of cognitive decline began.
Researchers at Oregon State University found that newly planted coastal switchgrass on sand dunes can accelerate erosion from extreme waves. The study suggests that vegetation initially creates a physical barrier but also increases water penetration into the sediment bed, leading to destabilization and accelerated scarp formation.
Researchers discovered the abundance of rock-forming elements in WASP-76 b's atmosphere, which matches its host star and our own Sun closely. The team found that certain elements are depleted due to temperature conditions, providing insight into the sensitivity of giant planet atmospheres.
Researchers at PNNL have created a comprehensive database of understudied quantum materials, enabling the use of machine learning to understand their properties. The database, published in Nature Publishing Group's journal 'Scientific Data,' contains 672 unique structures and 50,337 individual atomic configurations.
Researchers developed an innovative imaging approach using two-photon microscopy to analyze retinal microcirculation, revealing significant changes in blood flow that may indicate brain diseases. The study suggests that microcirculation in the retina could serve as a promising predictor of cerebrovascular diseases.
A new AI-based technique measures brain fluid flow with unprecedented accuracy, revealing pressures and three-dimensional flow rates. This breakthrough could lead to the development of new treatments for Alzheimer's, small vessel disease, strokes, and traumatic brain injuries.
Researchers at the University of Toronto have made a breakthrough in understanding dark matter and its impact on the universe's large-scale structure. By analyzing cosmic microwave background data and galaxy clustering patterns, they suggest that ultra-light axion particles could account for the observed lack of clumpiness.
A novel technique allows for the observation of colloidal particle degradation in real-time, providing valuable insight into the mechanisms of micro- and nanoplastics origin and change over time. The study demonstrates the potential to assess temperature variations, ultraviolet light, and stress on nanoscale particles.
A new pilot study published in JAMA Psychiatry demonstrates the potential role of probiotic supplementation in supporting mood and mental health in adults with Major Depressive Disorder. The study found significant improvements in depression and anxiety scores over an eight-week period, with notable benefits seen from week four onwards.
Researchers developed a noninvasive diagnostic test to identify intact sperm in infertile men with nonobstructive azoospermia. The test uses protein biomarkers AKAP4 and ASPX to visualize well-developed sperm, potentially increasing success rates for surgical sperm extraction. This breakthrough may lead to new male birth control drugs ...
Researchers found that countries relying on a broader range of energy sources experience longer recovery times. However, the extent of reliance on renewable energy consistently accounted for a major proportion of the variability in economic recovery time.
Researchers created a detailed 3D image of the synapse, a key juncture in neuronal communication. The model reveals the precise geometry of interactions between individual cells, which may hold the key to understanding neurodegenerative diseases.
Researchers discovered the scale effect of ordered media on circularly polarized luminescence (CPL) signals, with measurement entropy being a dominant factor. Different luminescent materials were used to discuss macroscopic anisotropy's impact on CPL signals.
Researchers found that bumblebees use both vision and smell to navigate, with scent marks playing a crucial role in pinpointing the nest entrance in visually ambiguous situations. In experiments, bumblebees overwhelmingly focused on locations suggested by scent marks when visual landmarks were conflicting.
Researchers at Rutgers University found that vaginal seeding restored beneficial bacteria to the skin surface and stools of C-section babies, similar to those born vaginally. The study suggests that this technique may help prevent metabolic and immune-related diseases in C-section babies.
A patient with kidney cancer overcame several metastases with temsirolimus, leading researchers to identify key mutations that make this treatment effective. The study found that patients with USP9X mutations have altered autophagy and respond better to temsirolimus.
Researchers from McGill University and Ontario Tech University examine the drivers of specialty drug diffusion. They propose a framework that suggests clinical studies affect the diffusion through a multi-stage scientific evidence production process. The study finds that marketing activities have no significant effect on prescriptions.
A study found that harm reduction treatment reduced substance use, including cannabis and polysubstance use, among people experiencing homelessness. Participants in the treatment group used cannabis 41% fewer days than the control group. The approach led to improved quality of life and basic needs, making it a sustainable option.
The TCT 2023 Program Guide features four days of innovation and cutting-edge science in interventional cardiovascular medicine. The event marks 35 years of leading the field and will gather top researchers and clinicians to present evidence-based research.
A study of 142 nations found a strong link between access to formal financial services and lower COVID-19 mortality rates. Access to bank accounts, credit cards, or loans from a financial institution is a key predictor of lower mortality risk, even stronger than comorbidities.
Scientists at UCSF and NIBSC have developed two new oral polio vaccines with genetically engineered weakened poliovirus to reduce reversion to dangerous forms. These vaccines aim to boost the World Health Organization's efforts to eradicate polio, which has persisted despite successful international vaccination campaigns.
A plant-based, oral delivery of proinsulin regulated blood sugar within 15 minutes similar to naturally secreted insulin in diabetic mice. This method eliminates the need for expensive laboratory equipment and results in a shelf-stable product, making it more affordable and accessible.
University of Queensland researchers used a video game algorithm to study the behavior of molecules within live brain cells. The algorithm, originally designed for tracking bullets in combat games, was adapted to analyze the movement and clustering of tiny molecules within brain cells.
Researchers found rock-forming elements in the atmosphere of WASP-76 b, which suggests it might have accreted a smaller Mercury-like planet. The discovery provides unprecedented insight into the presence and abundance of rock-forming elements in giant planets.
Many physicians and scientists reported being harassed on social media due to their advocacy, often based on gender, race, or disability. The study highlights the need for greater protection and support for individuals facing online abuse.