Researchers have identified a novel approach to enhance anti-tumor immunity in bowel cancer by targeting sugar-coated molecules called sialoglycans on tumor-associated stromal cells. This strategy has shown promise in reversing T-cell mediated immunosuppression and improving treatment outcomes.
The SEMECO cluster aims to accelerate innovation in smart medical devices and implants using AI, modular system architecture, and dedicated microsystems. By closing the gap between technological possibilities and practical application in medicine, SEMECO seeks to develop more effective diagnostics, therapy, and innovative medicines.
A team of scientists has found a way to directly manipulate the spin of electrons in 2D materials like graphene, a long-standing challenge. They used a novel experimental technique to study the properties of how electrons spin in these materials.
Researchers found that fatty liver cells secrete proteins and genetic material that promote the spread of colorectal cancer to the liver. This condition is likely underdiagnosed, affecting over 40% of patients with colorectal cancer, according to a new study published in Cell Metabolism.
Researchers at Brigham and Women's Hospital have characterized the structure of amyloid-beta fibrils in the human brain, revealing their role in Alzheimer's disease progression. The study sheds light on how lecanemab, a US FDA-approved drug, exerts its protective effects by targeting these fibrils.
Researchers at UC Irvine found that exposure to traffic-related air pollution increased the risk of Alzheimer's disease in mouse models. The study showed that particulate matter impaired memory tasks and cognitive function, leading to brain plaque build-up and glial cell activation, key indicators of Alzheimer's disease.
A recent study published in PNAS reveals that succinate plays a critical role in enhancing cancer cell plasticity and identifies PLOD2 as a regulator of succinate during breast cancer progression. Targeting PLOD2 may be a promising strategy to suppress breast cancer metastasis and drug resistance.
The University of Kentucky and its partners in Kentucky and Tennessee have been awarded a $1 million NSF Engines Development Award to advance circular economy technologies. The award aims to create a diverse innovation hub that secures U.S. competitiveness in Next-Generation Manufacturing and supply chain logistics.
Researchers at UMass Chan Medical School identified the Bmal1 gene as a crucial regulator of circatidal behavior in P. hawaiensis, establishing a molecular link between circadian and circatidal clocks. The study provides new insights into the genetics underlying circatidal rhythms.
Interactions between gut bacteria may limit antibiotics' effectiveness in treating C. difficile infections, a study suggests. Researchers found that certain bacterial species make the bacterium tolerant to metronidazole and increase its abundance.
A patient in Cleveland was diagnosed with a corneal ulcer caused by Pseudomonas aeruginosa, a drug-resistant bacterium that's rarely found in eye infections. The contaminated eye drops were identified as the source of infection, and treatment required strong antibiotics to prevent vision loss.
Scientists have identified a specific gene mutation that triggers an inflammatory cascade, driving the development of treatment-resistant cancers. The study reveals a molecular circuitry by which mutations in the STK11 gene cause inflammation to spiral out of control.
A new study in mice reveals that pancreatic cancer's emergence is fueled by the expansion of cell-to-cell communication. Researchers found that plasticity and inflammation reshape cells' identities and local environments, fostering cancer growth. The study provides insights into the earliest cellular events leading to PDAC and potentia...
A study found that defects with deep energy levels deteriorate kesterite thin-film solar cell properties. The research team identified specific types of defects and proposed a method for preventing their formation. This could lead to improved efficiency for these cells.
Researchers at Pohang University of Science & Technology developed a selective catalyst that curbs corrosion in fuel cells, increasing durability three times compared to traditional catalysts. The catalyst's performance is attributed to the robust interaction between titanium dioxide and platinum.
A new charity, Talking Forward, supports families when a loved one is arrested for accessing indecent images of children. Research highlights the trauma caused to these families, who are often overlooked by agencies providing support to direct victims. The charity aims to provide better support and recognition of their experience.
Kavli Institute researchers found that oscillon decay can generate detectable gravitational waves, offering a novel test of early Universe dynamics. This discovery provides a new window into the earliest moments of the Universe and may help address pressing cosmological questions.
A study of over 45,000 individuals found COVID-19-like symptoms without SARS-CoV-2 infection led to higher rates of depression and anxiety eight months post-symptom onset. Researchers also discovered that negative SARS-CoV-2 serologic test results did not mitigate this risk.
Researchers have developed a new instrument to thoroughly characterize the optical properties of specialized eyeglass lenses used to slow myopia progression. The study's findings provide valuable information on how these lenses interact with eye elongation and shed light on their effectiveness in real-world scenarios.
An international team reconstructed groundwater evolution in the Great Basin, USA, combining calcite deposits and numerical models. The results show the elevation of the water table was three to four times more sensitive to recharge during dry climates.
A new study using NIS data found that patients living in densely populated areas are at a lower risk of mortality from CLI, with females also benefiting from decreased mortality rates. Researchers suggest encouraging active lifestyles and vigorous exercise regimens to prevent progression and decrease mortality risk.
Oregon State University will spearhead a two-year NSF Engines project to advance semiconductor technologies in the Pacific Northwest. The project aims to create a regional innovation ecosystem and provide training programs for a diverse workforce.
Scientists at Duke-NUS Medical School have discovered a protein called ASC2 that inhibits inflammasomes, thereby limiting inflammation in bats. This discovery could lead to the development of new anti-inflammatory drugs for human diseases, including those caused by viral infections and ageing.
A Cochrane review found that individual-level stress management interventions, such as cognitive behavioral training and exercise, can reduce stress in healthcare workers for up to a year. The long-term effects of these interventions remain unknown, highlighting the need for further research.
Researchers developed a biocide-coated polymer that effectively kills MRSA, Covid-19, and resistant bacteria, reducing hospital-acquired infections. The new material can be added to plastic products during manufacture or used as a spray, offering an effective solution to combat antimicrobial resistance.
Researchers reconstruct Holocene fire records using sand dune foot-slope deposits, providing a new perspective on fire regimes and human influence. The study's findings suggest that sand dunes can serve as repositories of fire history, aiding in the expansion of scientific understanding of fire histories around the world.
New research from ESMT Berlin suggests that using machine-based predictions can improve overall accuracy of human decisions, but also increase the likelihood of certain errors and the human's cognitive effort. The study highlights the importance of collaboration between humans and machines to maximize complementary strengths.
A new method developed by Cornell researchers provides tools to interpret discarded X-ray crystallography data, enabling better understanding of proteins' movement, structure, and function. This breakthrough could lead to designing new drugs targeting specific proteins.
Researchers have found sedimentary archives in sand dunes that can reconstruct reliable, multi-millennial fire histories. The discovery aims to expand scientific understanding of fire regimes around the world and uncover the role of humans on fire history.
Review Commons is expanding its scope and scale with added funding, welcoming Biochemical Journal, Genes & Development, Genome Biology, and Immunology & Cell Biology as new affiliate journals. The platform now supports a diverse range of publishers and enables authors to reuse peer reviews for multiple journal submissions.
A team of researchers from the University of Minnesota has successfully measured the expansion rate of the Universe using data from a magnified supernova. Their findings provide new insight into the problem and bring scientists closer to obtaining the most accurate measurement of the Universe's age.
Research finds military veterans exposed to low doses of chemical warfare agents have higher rates of mortality from genitourinary diseases and deaths attributable to alcohol. However, overall cancer incidence is not significantly associated with Porton Down attendance.
The new method enables the synthesis of BCBs with unprecedented ease through a formal [2+2] cycloaddition, achieving regioselectivity and expanding chemists' access to diverse BCB scaffolds. This breakthrough addresses the challenges of BCB synthesis and offers a promising route for pharmaceutical applications.
Scientists have developed a gene-editing technique that allows them to easily engineer specific cancer-linked mutations into mouse models. This new method, based on CRISPR genome-editing technology, enables researchers to explore many unknown mutations and develop new drugs targeting those mutations.
A Phase 3 trial found that mailing HPV self-collection kits and scheduling assistance increased cervical cancer screenings among under-screened, underserved women. The study demonstrated the effectiveness of this approach in breaking down access barriers to screening.
A new AI algorithm named CoDE-ACS can quickly and accurately rule out heart attacks in patients, improving diagnosis and reducing hospital admissions. The tool has the potential to reduce misdiagnosis and inequalities in diagnosis across different populations.
Researchers found that scarring of the collagen framework prevents stem cells from healing damaged tissue in Duchenne muscular dystrophy. The study, published in npj Regenerative Medicine, used mice models to show how fibrosis disrupts cell behavior and hinders muscle regeneration.
Researchers from Hefei Institutes of Physical Science propose a novel approach to treat antibiotics using low-temperature plasma technology, achieving higher efficiency than single antibiotics. The method involves combining CAPJ with PAW, resulting in ecologically safe degradation products.
Researchers identified two clear groups of young horses with distinct reactions to a sudden novel object. The first group exhibited a spike in heart rate and hyper-alert behavior, while the second group calmed quickly after the stimulus. Understanding these genetic components can help match horses with suitable owners and training for ...
Researchers have discovered that certain bacteria can use radioactive elements americium and curium to replace lanthanides in their metabolism. This finding has significant implications for bioremediation and the separation of lanthanides and actinides.
Researchers developed a new integral imaging-based tabletop light field 3D display with a large viewing angle of 68.7°, enabling users to view correct 3D images from large oblique positions. The display's compound lens array balances depth of field and 3D spatial resolution, resulting in superior imaging quality.
Scientists from Forsyth Institute develop CRISPR-based diagnostic tool that can detect specific oral pathogens with high sensitivity and specificity. The test can be performed in a dental office without technical expertise, providing comprehensive information on oral health and systemic diseases like diabetes, heart disease, and cancer.
A team of researchers is exploring the potential of HDAC inhibitors to treat sickle cell disease by reactivating the fetal hemoglobin gene. Early evidence suggests that panobinostat, a specific inhibitor, can increase fetal hemoglobin levels in red blood cells and mouse models.
Adults with sleep apnea are at greater risk for long COVID, according to a new study. The research team found that patients with sleep apnea had a 12% increase in risk for long-term symptoms after their initial infection, and a 75% increase in risk compared to those without sleep apnea.
This book provides a comprehensive guide to navigating the challenges of entrepreneurship, offering insights from a multi-year research project. It shares lessons and strategies for identifying business opportunities, executing ideas, and adapting to environmental changes.
Researchers used AI to analyze speech patterns of patients with Parkinson's disease, finding they spoke in shorter sentences with more verbs and fewer common nouns. The study suggests potential early detection methods for the condition through conversational analysis.
Researchers have found that supermassive black holes are more likely to grow and release energy when inside galaxies expected to collide. The study used a new technique to determine galaxy distances, providing insight into the growth of these black holes during cosmic noon.
A new study suggests that allowing bedside nurses to independently order C. difficile testing can significantly reduce the time to receive test results, potentially decreasing clinical and economic burdens of CDI infections. The policy change also showed a decrease in patient infections and hospital economic costs.
A mobile app called SCI Step Together encourages people with partial spinal cord injuries to get active by setting goals, tracking activities, and connecting with others. The study found that participants who used the app had greater fulfillment of basic psychological needs, including independence, competence, and belonging.
Researchers found improved cookstoves produce twice as many harmful ultrafine air pollution particles (PM0.1) as conventional stoves. Despite reducing fine particles by up to 65%, they increase ultrafine particle emission.
The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to identify and catalog genetic variants in different individuals, enabling research into development, aging and disorders. A $15 million grant from the NIH Common Fund supports this project, led by Dr. Ting Wang and co-led by Dr. Hui Shen.
Researchers have identified extreme field reversals around FRB 20190520B, a persistently active repeating Fast Radio Burst. This finding provides insights into the turbulent magnetized environment surrounding the cosmic explosion, which may be caused by signal passage through a companion's halo.
A new study from Keck Medicine of USC reveals that heavy alcohol use may be more damaging to the liver for people with metabolic syndrome, more than doubling the risk of advanced liver disease. This condition, characterized by symptoms such as abdominal fat, high blood pressure, and high cholesterol, affects over one in three Americans.
Researchers found that imagining an index finger as five times smaller improves tactile discrimination threshold, while imagining it larger worsens it. This suggests top-down influence of beliefs on perception, supporting the idea that cognitive content can shape sensory experience.
Researchers at Stevens Institute of Technology created a digital platform to enable organizations to share satellite data, accelerating earth science research. The New Observing Strategies Testbed (NOS-T) facilitates complex missions like wildfire spotting and landslides prediction without revealing private information.
A new paper reveals that Henry Hilton, Central Park's Treasurer and VP, was behind the order to destroy life-size models of dinosaurs and prehistoric creatures in 1871. The destruction was part of a struggle for control of New York city following the American Civil War.
Clinical studies with children as participants often require more time, people, and resources than initially budgeted. The study found that pediatric clinical studies cost 59% more on average than the initial proposal, highlighting a need for accurate budgeting.
Researchers develop a new composite strategy to produce clean Landsat images with reduced cloud and shadow errors. The approach uses an algorithm to select pixels from multiple dates to create a virtual median-value point, detecting and replacing clouds and shadows in the process.
A new, free online language course is available to learn the Ojibwe language, spoken in Indigenous communities around the Great Lakes. The course uses spaced repetition software to help learners memorize vocabulary and grammar.
Researchers at the University of Illinois have identified strong correlations between SARS-CoV-2 cases and deaths, temperature, and latitude. The studies suggest that the virus is genetically encoded to exhibit seasonal behavior, which could be influenced by vaccine design.