Patients receiving methadone treatment for opioid use disorder show significant decline in fentanyl and heroin use over the course of a year, with average positivity rates dropping from 21.8% to 17.1% for fentanyl and 8.4% to 4.3% for heroin. Methamphetamine and cocaine use remains steady.
A team of researchers from Peking University found that temperature-dependent rock thermal conductivity and specific heat capacity affect the long-term thermal performance of Enhanced Geothermal Systems (EGS). The study showed that increased thermal conductivity improves thermal conduction, while decreased specific heat capacity impair...
A gene-edited calf demonstrates reduced susceptibility to bovine viral diarrhea virus (BVDV) after intentionally altering the CD46 receptor with CRISPR/Cas9. The healthy calf showed no measurable infectious virus in its blood, despite both calves developing antibodies to the virus.
Researchers found that oxytocin levels increase when partner touches arm, then decrease with stranger's touch. Brain activity suggests adaptive responses to recent social context.
Scientists have successfully produced a gene-edited calf with resistance to BVDV, a virus costing the US cattle sector billions annually. The edited calf, named Ginger, displayed significantly reduced susceptibility to the virus without adverse health effects.
Researchers have identified two novel DOF family transcription factors that enhance wheat regeneration and genetic transformation. These findings provide new insights into the transcriptional regulatory network involved in boosting wheat regeneration, offering opportunities for improving crop improvement.
A new study found that social support, sense of community, and depressive symptoms played a role in changes to an online gaming site's social structure over time. Members who reported more social support and a greater sense of community were more likely to form communication ties and connect with others.
Experts urge clinicians to adopt a whole-of-person approach to medical care to address chronic disease and mental health issues related to child abuse and neglect. A trauma-informed biopsychosocial model of health can help reduce the negative impacts of exposure to serious child abuse and neglect.
A new study reveals that cyclic AMP and cGMP bind to ion channels with distinct effects, shedding light on their roles in regulating cell functions. The findings could inspire new treatments for disorders involving ion channel malfunctions.
Scientists have defined a basic toolkit for forming tubular organs in animals, which is thought to be the foundation of organ development in vertebrates. The study uses the sea star as a model organism and reveals that cells can proliferate and migrate simultaneously during tube formation.
Researchers from Aston University and the University of York discovered new insights into how the human brain makes perceptual judgments of the external world. They found that humans can exploit 'defocus blur' to infer perceptual scale, but this process is crude and more heuristic than metrical analysis.
A gene-edited calf, named Ginger, has been born with reduced susceptibility to a major viral pathogen, bovine viral diarrhea virus (BVDV). If confirmed by follow-up research, this approach could offer long-term potential to reduce antimicrobial and antibiotic use in the cattle industry.
A study in Kenya's Nairobi city found that preadolescents' diets are shifting towards unhealthy Western patterns, leading to increased obesity. Researchers suggest interventions using peer counselors and lay health educators to promote healthy lifestyles.
The UC Santa Cruz Genomics Institute will run the Data Coordination Center for the Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes (SSPsyGene) Consortium. The team will coordinate an initial selection of 250 relevant genes from nearly 30,000 protein coding genes in the human genome.
Researchers found that beetles in dead wood diversity is influenced by energy types depending on their position in the food chain, with bottom-dwelling species benefiting from stored energy and top-dwellers responding to solar radiation.
Scientists tracked fertilized Nassau grouper eggs using an underwater microscope, finding that they stayed local in some years but drifted to nearby islands in others. The study reveals the importance of local reproduction and ocean currents in boosting populations and providing spillover benefits for neighboring islands.
A study found that air pollution, especially polycyclic aromatic hydrocarbons, increases neuroinflammation and worsens movement disorders in mice with ischemic strokes. This suggests that air pollution may be a contributing factor to decreased prognosis in stroke patients.
Researchers used AI to study how the hippocampus produces varied replay types efficiently and their purpose. The model showed that sequences are prioritized stochastically according to familiarity and reward positions.
A study published in The Lancet Regional Health - Western Pacific found that carbapenem-resistant Acinetobacter baumannii (CRAB) contaminated the entire ICU, with samples detected on bed units, ventilators, and equipment. The researchers highlight the urgent need for targeted infection prevention and control measures to stem the global...
A 24-year study of freshwater fish exposed to warm water pollution found changes in growth rates, death rates, and size. Despite expectations, the study revealed that warmer waters led to larger fish, contradicting general predictions of global warming's effects on natural ecosystems.
Researchers at KAIST have developed a new sRNA tool that can effectively inhibit target genes in various bacteria, including both Gram-negative and Gram-positive bacteria. The BHR-sRNA system was shown to suppress pathogenicity in antibiotic-resistant pathogens and improve industrial strains for high-value-added chemical production.
A study explores the role of dynamin protein DYN-1 in axonal fusion, revealing its ability to guide injury-induced reparative responses. Researchers found that DYN-1 regulates levels of fusogen, a transmembrane glycoprotein essential for physical repair of damaged axons.
A US study found that 56% of Black and Hispanic Chicagoans witnessed a shooting by age 40, while White residents were exposed to gun violence at less than half the rate. The average age for witnessing a shooting was just 14 years old, with nearly 7% of Black and Hispanic participants being shot before 40.
CARMN is a long noncoding RNA that regulates contractility in both blood vessels and the gastrointestinal tract. Without CARMN, mice cannot survive due to impaired GI tract contraction, leading to conditions like intestinal pseudo-obstruction.
A study published in Physics of Fluids reveals that uneven extraction in coffee brewing can result in weaker espresso and affect its taste. The researchers found that a positive feedback loop between flow and extraction leads to more bitter flavors, making it essential to understand the origin of uneven extraction.
The new Winship Cancer Institute at Emory Midtown offers a unique patient-centered, multidisciplinary cancer care model integrated with innovative research. The $200 million gift from the Robert W. Woodruff Foundation enabled the construction of a state-of-the-art facility featuring five 'care communities' and 80 inpatient beds.
Maynooth University research finds that the obesity treatment drug GLP-1 can restore the body's natural cancer-killing defences by boosting NK cell function. The study shows independent benefits of GLP-1 on cancer risk, beyond its weight loss effects.
Scientists at CNIO identify succinylation as a poorly studied mechanism in cancer research; mutated DLST protein prevents succinylation, leading to pseudohypoxia and tumor growth. Succinylation is crucial for protein function and may be linked to various diseases.
Researchers at NIMS developed MTJ device with world's highest TMR performance through precision interfacial control, increasing sensitivity of magnetic sensors and MRAM capacity.
Researchers at City, University of London have developed the FatNet algorithm, which enables efficient integration of deep learning models into optical accelerators. This breakthrough has significant implications for medical diagnoses, autonomous vehicle technology, and future computing.
The gene LRRC4 regulates synapse formation, stability and excitatory transmission, playing a crucial role in learning, memory formation and storage. It also has key implications in neuronal disorders and aggressive brain and spinal cord cancer.
Researchers at Tohoku University have developed a zinc-air battery with an open circuit voltage of over 2V, overcoming the major bottleneck for metal-air batteries. By arranging acidic/alkaline electrolytes in tandem, they were able to generate a higher voltage and improve output power density.
Researchers develop innovative data compression scheme to facilitate multispeckle diffuse correlation spectroscopy with high pixel resolutions, enabling non-invasive measurement of brain blood flow. The scheme uses field-programmable gate array compression to alleviate computational burdens and expand the use of SPAD cameras in biomedi...
A team of 995 undergraduate and graduate students analyzed 600 real solar flares, casting doubt on the theory that nanoflares heat up the sun's corona. The students' work provided a unique opportunity for early-career scientists to learn about collaborative research.
Researchers in China have created a simple nomogram using easily accessible and automatable detected routine clinical indicators to reduce missed diagnosis and misdiagnosis of Wilson's disease. The study identified six independent predictors of the disease, including serum copper and direct bilirubin.
Researchers found that women with denser breasts who developed cancer had slower declining density over time. The study suggests using past history of density in addition to current estimates to better understand risk levels and potentially identify which breast is at risk.
A new Johns Hopkins Medicine study found that patients with low pain self-efficacy are more likely to use daily prescribed opioids before surgery. Surgeons can use pain self-efficacy scores to identify high-risk patients and provide education and counseling to improve post-surgery outcomes.
Researchers propose that societies flourish by both amassing and distributing resources, with conservatives focusing on accumulation and liberals prioritizing redistribution. The divide between these perspectives has led to growing hostility and disrespect between political opponents.
A new study finds that one-time genomic screening of adults aged 20-60 for hereditary breast and ovarian cancer syndrome, Lynch syndrome, and familial hypercholesterolemia is cost-effective based on quality-adjusted life-year measures. The study suggests that this approach could improve disease management and reduce healthcare costs.
A new study by Brown researchers found that 33.8% of patients with low-dose computed tomography (LDCT) screening had significant incidental findings, many of which were clinically important. The study suggests that standardizing reporting of these findings could improve patient care and reduce unnecessary medical interventions.
A study found that students with lower grades, public high school attendees, and those from low-income families were less likely to believe they could attain a bachelor's degree. Meanwhile, advanced placement courses, college tours, and positive peer pressure boosted confidence in success.
University of Pittsburgh researchers created a universal receptor system allowing T cells to recognize any cell surface target. This enables highly customizable CAR T cell and other immunotherapies for treating cancer and diseases, with potential applications in solid tumors.
Researchers developed a virtual framework to investigate the effectiveness of optoacoustic tomography for breast cancer screening in people with darker skin. The results confirmed that tumors can be harder to locate in individuals with darker skin, highlighting the need to optimize imaging systems to mitigate racial bias.
A systematic review of 14 clinical trials found solriamfetol to be the most effective treatment for excessive daytime sleepiness (EDS) in people with obstructive sleep apnea (OSA). Anti-fatigue medications like solriamfetol, armodafinil–modafinil, and pitolisant also showed promise in combating fatigue.
NUTRITION 2023 will cover the latest developments in nutrition science, with over 1,800 original research studies submitted for presentation. The event brings together nutritional professionals from around the globe to discuss key topics such as sustainable diets and their impact on health.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Researchers have streamlined a widely used chemical reaction to create new manufacturing opportunities. The innovative method uses two distinct metal catalysts and produces water as a waste product, allowing for the efficient creation of complex molecules from easily accessible substrates. This breakthrough has significant implications...
Researchers from Zhejiang University have developed a compact spectrometer that integrates multiple taper tips for hyperspectral imaging. The spectrometer utilizes complex leaky modes speckles projected from a curved microfiber taper tip to uniquely determine the wavelength of the input signal.
The article highlights the risks of AI misuse, including its impact on democracy, job loss, and social division. Experts warn that self-improving AGI poses an existential threat to humanity, and call for regulation to minimize harm and maximize benefits.
A new E-MOTIVE solution dramatically improves outcomes for women experiencing postpartum haemorrhage (PPH), a leading cause of maternal mortality worldwide. The study found a 60% reduction in severe bleeding and fewer blood transfusions, potentially saving thousands of lives globally.
A new study found a strong link between bone biomarkers and survival rates in men with hormone-sensitive prostate cancer treated with hormone therapy. The research, published in European Urology, analyzed results from a large clinical trial and found that elevated bone biomarkers were associated with an increased risk of death.
A study by UOC researchers found that Spanish courts impose milder punishments and lower compensation amounts when a victim's partner or ex-partner is accused of rape. In cases involving intimate partners, only 22% of rulings mentioned this as an aggravating factor, leading to milder sentences.
A lack of women in sports medicine roles hinders progress and perpetuates inequity, with women making up less than 25% of senior authors and 20% of team doctors. The specialty can break the cycle by promoting inclusivity, diversity, and equal opportunities.
Researchers at McMaster University have found that solriamfetol is the most effective treatment for excessive daytime sleepiness (EDS) in individuals with obstructive sleep apnea (OSA). A systematic review of 14 clinical trials and analysis of data from various databases revealed solriamfetol to be the best option.
Researchers engineered bacteria to visually record environment using swarm patterns and deep learning. The system can detect pollutants and toxic compounds in the environment, enabling a low-cost detection and recording system.
A Cochrane review found that most antidepressants used to manage chronic pain lack sufficient evidence of their effectiveness, with only duloxetine showing reliable pain relief. The review also revealed that harms from many commonly recommended drugs have not been well studied, posing a global public health concern.
A new immunotherapy treatment developed by UCF researchers uses targeted IL-2 to fight respiratory viral infections with improved outcomes in animal studies. The treatment promotes an antiviral inflammatory response and reduces bronchial inflammation.
Researchers used computational tools and medical record analysis to investigate the effects of statin drugs on COVID-19 patients. They found that only certain statins, including simvastatin and atorvastatin, reduced mortality risk in COVID-19 patients, while others had no effect.
Scientists have successfully tracked fin whales using fibre-optic cables in the Norwegian Arctic archipelago of Svalbard. The system, called Distributed Acoustic Sensing (DAS), allows for simultaneous location and tracking of whales over an 1800 km² area with relatively low infrastructure investment.
A team of researchers from the University of Oklahoma and Yale University has developed a super-resolution imaging platform technology to visualize nanoparticles within cells. The technique, called expansion microscopy, enables 3-D imaging with resolutions as low as 10 nanometers, allowing for safer and more efficient nanomedicines.