Scientists from Tokyo Medical and Dental University find that antibody fragments encapsulated in nanomicelles can reduce toxic Aβ species in the brain of an Alzheimer's disease model mouse. This breakthrough delivers treatment to where it is needed most, potentially slowing AD progression.
A new study found that New York City rats are susceptible to Alpha, Delta, and Omicron variants of SARS-CoV-2. The researchers also demonstrated a possible link between the virus and rat populations in the city's sewer systems.
A seven-component treatment program, including prompt medical assessment and co-constructing a formulation with the child and family, has been successful in managing FND in children and adolescents. Most healthcare professionals can easily add an FND-informed skill set to their current clinical practice.
Researchers analyzed island mammal species, finding that those with extreme body size shifts are at higher risk of extinction. Conservation efforts should prioritize protecting insular giants and dwarfs, the last evolutionary marvels of island life.
A dramatic rise in unregulated amphetamine use has been observed in Ontario's emergency departments, with a nearly 15-fold increase in ED visits between 2003 and 2020. Individuals accessing EDs for amphetamine-related concerns grew from 233 to 4,146 annually by 2020.
Scientists at the Institute of Nuclear Physics Polish Academy of Sciences have developed new nanocomposites that spontaneously and continuously kill microorganisms. The composites use silver ions or copper ions to destroy cell membranes and oxidative shock, respectively, providing a durable and safe solution for biocidal materials.
Researchers at the University of Virginia have identified a promising approach to delay aging by detoxifying glycerol and glyceraldehyde, harmful by-products of fat. By activating an enzyme called AMAR, they found that microscopic worms lived longer and healthier lives, and similar effects were seen in other lab models.
A research team from the USA used hand-held and tower-based equipment for phenotyping common and tepary beans. They assessed physiological and ground- and tower-based hyperspectral remote sensing measurements to evaluate drought response in 12 common bean and 4 tepary bean genotypes across three field campaigns.
Researchers developed a new AI-driven method to detect and predict defects in 3D printed metals, enabling rapid improvements in additive manufacturing. The method uses X-ray imaging and machine learning to identify pore generation in real-time with near-perfect accuracy.
A Cochrane review found that eliminating hazards around the home, such as clutter and poor lighting, can reduce the risk of falls for older people by around a quarter. Decluttering and reducing hazards had the most benefit for those at high risk of falls.
A team of researchers has created the first-ever insect whole-brain connectome for a Drosophila larva, mapping 3016 neurons and 548,000 synapses. The detailed analysis reveals extensive multisensory integration and cross-hemisphere interaction, with some neural structures resembling those found in machine learning networks.
A randomized trial found that CBD oil did not reduce pain scores after surgical treatment and stent placement for patients with urinary stones. The study involved 90 patients who received either CBD oil or a placebo, with no significant difference in pain reduction or opioid use between the two groups.
A global study involving McMaster University researchers has trialled a potential new treatment for hemophilia A, a life-threatening genetic blood disorder. Once-weekly injections of efanesoctocog alfa can prevent bleeding and promote near-normal activity by the clotting agent factor VIII.
Studies found an association between living close to higher-quality food stores and better weight loss outcomes after bariatric surgery. Living near low-diversity stores was linked to less sustained weight loss, while moderate- or high-diversity stores had no effect.
Scientists discovered the molecular basis of CAMSAP3's role in stabilizing microtubules, which is critical for cell survival and various cellular processes. The findings provide a key concept to understanding how microtubule dynamics control cellular phenomena.
A novel rare mutation in the ABCA12 gene was identified as a cause of Harlequin Ichthyosis through BGI genetic tests. The mutation leads to a severely dysfunctional protein responsible for the disease's serious phenotype.
A new study suggests that a mix of carbon dioxide removal technologies is needed to limit global warming to 1.5 degrees Celsius by the end of this century. The effective path requires multiple methods, including restoring deforested lands and enhanced weathering, to remove necessary amounts of CO2 annually.
A study published in JCI Insight found that COVID-19 infection was associated with higher CMV and EBV antibody responses, while lower CD4+ T-cell counts were linked to ineffective SARS-CoV-2 responses. The research suggests that persistent inflammation may be a contributing factor to these differences.
Researchers have developed a smart contact lens capable of implementing AR-based navigation using a novel electrochromic display technology. The device uses Prussian blue to display directions to the user in real-time, overcame limitations of existing AR devices.
Researchers developed an economic-epidemiological model to assess the impact of no closures. The study found that California's unemployment rate would have been lower, but deaths and hospitalizations from COVID-19 would have increased significantly, exacerbating current inequities.
Researchers at Korea Advanced Institute of Science and Technology used optical traps to throw chilled rubidium atoms over a distance of 4.2 micrometers, achieving 94% success rate. The technology could enable dynamic quantum computing and study single-atom collisions.
Researchers say parents' well-intentioned efforts to protect children from harm have inadvertently deprived them of independence and opportunities for self-directed play. This decline in 'child's play' is linked to rising anxiety, depression, and suicide rates among school-aged children.
British and American English speakers use the word “right” in distinct ways. In everyday conversations, Brits use “right” to signal that what they hear is informative and relevant. This linguistic difference might contribute to the stereotype that British people are smarter due to their sophisticated accent.
The prevalence of metabolically healthy obesity (MHO) has been found to increase significantly among U.S. adults over the past two decades, according to a new study published in JAMA Network Open. The research highlights the need for effective strategies to improve metabolic health status and prevent obesity-related complications.
Research shows that social learning significantly enhances a honey bee's ability to perform the complex waggle dance, which communicates food source location. Inexperienced bees who observed older bees learn from them and improve their dance accuracy over time.
A team of researchers, including Holger Schünemann, are creating evidence-based guidelines to identify, prevent, assess, and manage post-COVID-19 condition. The guidelines aim to improve the lives of Canadians affected by long COVID.
A study by University of Maryland researchers found that lenient standardized test evaluators led to grade inflation, drawing wealthier residents to neighborhoods and driving up housing prices. As a result, amenities like shops and services followed, leading to gentrification and improved school quality.
Researchers have developed a new imaging approach to diagnose advanced non-alcoholic fatty liver disease (NASH). The enzyme-sensitive nanoprobe emits signals that can be detected by MRI techniques, providing more accurate and sensitive data for diagnosis. This breakthrough aims to improve the treatment outcomes of NASH patients.
Researchers have discovered how germ cells form ring canals, small bridges that connect sibling cells across species. The study provides new insights into developmental biology and may offer clues to diseases such as colorectal cancer and immunodeficiency syndromes.
Guinea grass, an invasive species in Texas, uses a combination of crowding and chemical toxins to suppress native plants. The researchers found that the toxicity of guinea grass increases dramatically when its shading effect is combined with its chemical warfare, making it harder for native plants to survive.
Research by University of Florida researchers found that disinformation ads on Facebook use a clear recipe with short ad buys, familiar language, and big budgets to reach more people. The most engaging ads were full of positive feelings encouraging good emotions about one's own groups rather than bad emotions towards others.
Researchers have developed a new sea ice model that can analyze the size and thickness of individual ice floes and their motion in greater detail. This allows for more precise predictions about their behavior, especially in areas where climate change has led to an increase in loose sea ice.
Engineers at Caltech develop new material made from interconnected microscale knots, which absorb more energy and deform more while maintaining their original shape. These knotted materials exhibit a tensile toughness that far surpasses unknotted materials, with 92% more energy absorption and twice the strain required to snap.
A new study reveals that intergalactic gas can activate and feed supermassive black holes at the heart of galaxies. The researchers found a direct connection between gas outside galaxies and active supermassive black holes, with misaligned gas playing a significant role in their growth.
A study of female endurance athletes found that disturbances in eating behaviors predict a shorter sports career, as well as increased injuries. Menstrual dysfunction was also linked to both shorter careers and more frequent injuries.
A study led by the University of Calgary found a 22% increase in children and adolescents seeking emergency department care for suicide attempts and an 8% increase for suicidal ideation during the pandemic. This trend contradicts the overall decrease in pediatric ER visits, highlighting the need for mental health resources and services.
A comprehensive European allergy atlas has been compiled, revealing regional and climate-related differences in sensitisation to allergens. The study found varying sensitisation patterns across Europe, with certain regions having lower sensitivity to house dust mites and higher sensitivity to peanut and fruit allergens.
Researchers found that those perceiving an oral exam as a challenge tend to perform better and have lower cortisol levels. Experts advise examiners to create a supportive atmosphere to reduce stress. This study highlights the importance of self-efficacy in presentation performance.
A new study by Monterey Bay Aquarium reveals the key components contributing to successful releases of orphaned southern sea otters back into the wild. The research emphasizes the strong maternal drive of surrogate female sea otters in nurturing and caring for pups, resulting in a three-quarters success rate.
Researchers at the University of Birmingham have devised a way to fabricate a complex structure, previously found only in nature, to control light in the visible range. This new approach uses self-assembled colloidal particles to create chiral photonic crystals with tailored optical properties.
A study in Brazil found that agricultural certification can encourage compliance with environmental laws, but doesn't necessarily reduce deforestation or increase natural regeneration. Certified coffee farms showed a general tendency for increased compliance, particularly in protected areas like the Atlantic Rainforest.
Researchers at IISc found that grazing by livestock leads to lower carbon storage in soil compared to wild herbivores due to antibiotic use. Re-wilding soils and quarantining animals could help offset the damage.
A newly funded research project is exploring the link between HIV-induced aging and Alzheimer's disease. The team aims to develop a drug delivery system to increase HIV suppression in the brain and decrease associated neurocognitive disorders.
The MIDAS platform enables systematic discovery of elusive protein-metabolite interactions, revealing 830 new PMIs in human carbohydrate metabolism. The study identifies previously unknown regulatory mechanisms, including lactate dehydrogenase regulation by ATP, with potential therapeutic applications.
A new biosensor developed by Penn State researchers offers dynamic insights into manganese's role in biological systems, opening doors to new research applications. The sensor's capabilities may lead to breakthroughs in understanding photosynthesis, host-pathogen interactions, and neurobiology.
A study found that only 8.91% of websites that obtain user consent comply correctly with GDPR regulations. Researchers used automated methods to analyze web-tracking techniques and detected nearly 7 tracking cookies per website on average.
New research reveals that Gen Z values authenticity in online personal branding strategies, using platforms like LinkedIn to project strong impressions. Study findings suggest that imperfection is beneficial for job seekers, with employers seeking unique points and cultural fit.
Research finds that both conservative and liberal Americans share fake news due to a fear of exclusion from their social groups. The study suggests that pre-bunking methods and highlighting the importance of accurate news can help reduce the spread of fake news.
Dr. Natasha Kekre, a University of Ottawa associate professor and hematologist, has secured millions in funding and published numerous peer-reviewed papers on CAR-T cellular therapies for cancer treatment. Her work has advanced the immunotherapy field in Canada and made her an expert in cancer immunotherapies.
Researchers propose adjusting spring and autumn time changes to optimize daylight usage, rather than abolishing them. They argue that modern societies can benefit from seasonal time regulation, despite temporary disruptions.
The giant faba bean genome has been successfully sequenced, offering insights into its traits such as drought tolerance and protein content. This breakthrough has the potential to improve crop yields and reduce reliance on artificial fertilizers, making faba bean a more attractive crop for sustainable agriculture.
Researchers discovered a new species of bacteria, Sulfurimonas pluma, living in cold, oxygen-saturated hydrothermal plumes globally. The microorganism uses hydrogen as an energy source, contrary to previous assumptions and expanding our understanding of its ecological role.
The study introduces a novel SC-ASC strategy for fabricating high-quality perovskite single crystal arrays with precise control over shape, resolution, and position accuracy. The method enables the growth of high-Q-factor lasers and stable photodetectors.
Experts call for a legally-binding treaty to govern Earth's orbit, citing the growing threat of satellite debris. With an expected 60,000 satellites in orbit by 2030, scientists warn that large parts of space could become unusable if action is not taken immediately.
A trial using PSMA-PET/CT scans has shown that clinicians changed their treatment plans for patients with clinically significant prostate cancer in 19% of cases, helping to detect more cancers. The technique was found to be beneficial in high-risk patients but also led to false positives requiring further investigations.
Chemists have developed a high-performance catalyst specifically designed for solid-state mechanochemical synthesis, achieving efficient reactivity at near room temperature. The approach uses a metal catalyst attached to a long polymer molecule, which traps the catalyst in a fluid-phase, enabling fast and energy-efficient reactions.
A new study found that toxic online rows about trophy hunting are becoming increasingly abusive on Twitter, with 7% of tweets containing abusive content. This hostile atmosphere is silencing conservation viewpoints and policymakers are less aware of them.
The new homogeneous catalyst enables the direct synthesis of hydrogen peroxide with improved efficiency and safety. The process requires only one step and no separation of gases from the reaction flask.
A study by University of Cologne researchers found that virtual reality gamers completed tasks faster with higher levels of general intelligence and processing capacity. The results suggest VR games can be used as a tool for predicting job performance, bridging the gap between research and practice.
Researchers at University of Galway discovered that individuals experiencing depression symptoms are more likely to suffer acute strokes and experience poor recovery outcomes. The INTERSTROKE study, involving 26,877 adults across 32 countries, revealed a significant link between depressive symptoms and stroke risk.