Patients with myelofibrosis experience significant symptom improvements when treated with momelotinib, including reduced spleen size and decreased transfusion dependency. The Phase III MOMENTUM trial reports meaningful benefits over standard therapy danazol.
A study published in Nature Astronomy suggests that a volcano-like rupture on the surface of a neutron star could have caused its sudden slowdown. The research used X-ray data from orbiting telescopes to analyze the magnetar's rotation and found evidence supporting this theory.
A study by the American Society of Anesthesiologists found that inaccurately recording anesthesia start times results in lost billing time for anesthesia practices and medical centers. The study analyzed 40,312 procedures and determined a potential loss of $638,671.57 in one year.
A new study suggests that Thai confectioners can gain a competitive advantage by using their country's local heritage and culture. The research found that youngsters in Thailand still enjoy local confectionary as well as Western brands, but local products have strong emotional value to them.
A new study found that online forums provide a sense of community and hope for people with dementia, filling an important gap in their support after diagnosis. The forums allow users to share experiences and receive emotional support from others going through similar experiences, helping to alleviate feelings of isolation.
Researchers found that measles virus mutations in its fusion protein allow it to infect nerve cells, leading to subacute sclerosing panencephalitis. The team's discovery sheds light on the evolutionary mechanisms of viruses like coronaviruses and herpesviruses.
A study suggests that adding extra anesthesiology residency positions can be financially beneficial for hospitals, with cost savings ranging from $440,000 to $1.9 million over three years. This expansion may help address the projected shortage of anesthesia care professionals and reduce staffing costs.
A new study using closed-loop, acoustic stimulation neurotechnology shows significant improvements in sleep quality and autonomic nervous system function in adults with insomnia. The intervention, called CR-SOP, was found to reduce insomnia symptoms and improve heart rate variability and baroreflex sensitivity.
Researchers at the Francis Crick Institute created a comprehensive map of metabolic pathways in mice, then gathered data to put into a model predicting diet effects on liver cancer. The study found specific changes in metabolism associated with unhealthy diets promote cancer cell growth.
A deep learning model distinguishes colon carcinoma from acute diverticulitis in CT images, improving diagnostic performance and reducing false-negative and false-positive findings. The model's sensitivity and specificity were significantly improved, supporting radiologists in patient care.
A joint research team developed a new battery technology using a bilayered anode to enhance reliability and performance. The design allows for high energy density and uniform reaction stability even in thick electrodes, benefiting electric vehicles and electronic devices.
A team from the University of Bath has developed ultra-light aerogel insulation materials with tuneable acoustic properties and other functional properties like thermal and electromagnetic shielding. The technology aims to reduce CO2 emissions by up to 50% in aircraft fleets, contributing to the government's net zero strategy.
Assistant Professor Shuolong Yang and his team aim to develop a scalable process for creating topological quantum materials, which resist decoherence. By using a novel technique inspired by woodblock printing, they hope to create iron selenium tellurium, a potential superconductor for quantum computing.
A team of researchers has found a definitive link between mercury isotopes and the Latest Permian Mass Extinction, the largest extinction event in Earth's history. The study suggests that massive volcanic eruptions in Siberia led to rapid warming and climate change, which contributed to the extinction event.
Five new tree-dwelling snake species were discovered in the jungles of Ecuador, Colombia, and Panama. The research highlights the devastating impact of open-pit mining operations on these unique creatures.
Researchers have developed a novel technique to produce hydrogen peroxide without releasing carbon dioxide, reducing greenhouse gas emissions. The method uses photocatalysis and carbon nitride as a catalyst, making it more cost-effective and environmentally friendly.
A new study led by Columbia researchers discovered a link between serotonin and heart valve disease, specifically degenerative mitral regurgitation. The study found that patients taking selective serotonin reuptake inhibitors (SSRIs) were more likely to develop severe mitral regurgitation and require surgery at a younger age.
A study by UC San Francisco and Stanford Medicine found that removing the oxytocin receptor does not interfere with monogamy or giving birth. Prairie voles bred without receptors for oxytocin showed similar mating, attachment, and parenting behaviors as regular voles.
A new high-throughput MALDI-TOF MS biochemical screen for small molecule inhibitors of ERAP1 has been developed, demonstrating improved stability, reproducibility, and robustness compared to existing assays. The assay's ability to detect other difficult targets makes it a valuable tool in drug discovery.
Researchers found a molecular staple called NIHCOLE that helps liver cancer cells repair broken DNA, making them resistant to radiotherapy. Understanding this mechanism may lead to the development of new strategies to combat liver cancers with poor prognosis.
Purdue University researchers have discovered a new mathematical framework that measures stress and stretching field topologies for complex fluids. This breakthrough applies to polymeric fluids used in groundwater remediation and other industries, enabling more accurate predictions of fluid transport.
Early plasticity in coastal plants like sea campion enables rapid adaptation to new environments, including toxic substances. The research found that beneficial plasticity in ancestral plants increases the likelihood of gene reuse during parallel adaptation.
Research reveals that prairie voles can form enduring pair-bonds and provide parental care without oxytocin receptor signaling, contradicting previous studies. While mutant voles lack milk release, they still nurse and rear pups to weaning age, suggesting species-specific roles of oxytocin receptor signaling.
The study analyzed all-cause and cause-specific mortality rates among pregnant and recently pregnant women in the US. It found significant racial and ethnic disparities in mortality rates, highlighting the need for targeted interventions to address health inequities.
A UAB researcher discovered a new definition of Petri nets that reconciles two longstanding mathematical approaches, allowing for the reconciliation of geometric and algebraic semantics. This breakthrough has been used in epidemiological modeling, including COVID-19 research.
A new study from Brigham Young University researchers found no variability in endurance thresholds or performance among women across their menstrual cycles. Women's performance was consistent with men's, challenging the long-held assumption that hormonal changes during menstruation affect exercise capability.
A study by the University of Freiburg has found that auxin influences the fertility of spreading earthmoss, with PINC protein playing a crucial role. The research reveals that sperm swim better without PINC and that its absence leads to increased abortions in Physcomitrella moss.
Researchers found that female lymphoma patients who received afternoon chemotherapy had a 12.5 times reduced mortality rate and a 2.8 times decreased cancer recurrence rate compared to morning treatment. This is due to the body's natural circadian rhythm, which affects white blood cell counts and bone marrow proliferation.
A new therapy, called spinal cord associative plasticity (SCAP), is showing promise in animal studies by enabling rats with spinal cord injuries to regain function of their arms. The treatment targets the nervous system connections spared by injury and causes lasting change in synapses or neurons.
Researchers have developed a chemical variation that significantly improves the stability of perovskite thin films in solar cells, achieving efficiencies of up to 24.6%. The new coating, b-pV2F, wraps around individual microcrystals like a soft shell, reducing thermal stress and increasing efficiency.
The University of Missouri has received a $2 million grant from the Department of Justice to help detect potential threats to school safety in rural Missouri schools. The project will partner with up to 26 rural school districts and utilize technology software to monitor online activity for threatening language or images.
Researchers at Imperial College London found that around half of Earth's zinc inventory came from asteroids in the outer Solar System, contributing to the emergence of life on Earth. The study suggests that this material supplied other important volatiles like water, crucial for sustaining life.
Research suggests that a new combination of drugs is needed to find an effective treatment for TB meningitis due to multidrug-resistant strains. The FDA-approved BPaL regimen is not effective in treating TB meningitis because bedaquiline and linezolid cannot penetrate the blood-brain barrier.
Researchers at Northumbria University are developing artificial intelligence to forecast space weather and predict serious space storms. The technology aims to protect the Earth's power grid and communication systems from disruptions caused by solar eruptions.
A new, portable mosquito repellent device has been tested successfully in a four-week semi-field study, showing effectiveness in preventing multiple species of mosquitos from entering the testing site. The device uses transfluthrin as a spatial repellent and eliminates the need for applying topical repellents or insecticides.
A new analysis of seismic data recorded after the Tonga eruption has revealed two distinct sequences of events, including quasi-periodic explosions and a massive final event. The study used back-projection techniques to tease out details from teleseismic P waves, shedding light on the volcano's internal dynamics.
A new hybrid catalyst converts CO2 into ethylene in one pot, using abundant earth materials. The catalyst achieves high efficiency in CO2 reduction to CO, with up to 60% conversion rate to ethylene.
A study published in JACC: Clinical Electrophysiology found a significant correlation between periodontitis and fibrosis in the left atrium, which can lead to atrial fibrillation. Researchers suggest that periodontal care could aid in comprehensive management of atrial fibrillation.
Researchers at IRB Barcelona have discovered the ch-TOG protein's key role in microtubule initiation, crucial for cell functions and division. The protein facilitates the binding of tubulin molecules, enabling microtubule formation and growth.
A Lund University study evaluates 'Operation: Save the Bees' campaign, finding that creating meadows with diverse flowering species and planting older flowers improves pollinator numbers. The researchers also highlight the importance of investing in effective measures to support urban biodiversity.
Researchers found that continuous glucose monitors and wearable devices pose challenges for patients and caregivers, including issues with hardware, software, and device use. Nearly three-quarters of participants experienced low blood sugar levels, highlighting the need for improved technology to manage diabetes effectively.
A new study reveals that EU consumers are 'exporting' negative environmental impacts to their Eastern European neighbours while keeping economic benefits within the EU. The bulk of environmental pressures and impacts associated with EU consumption are felt in countries outside the bloc, with uneven distribution of costs and benefits wi...
A recent study found that most US children use makeup and body products containing carcinogens and toxic chemicals like lead, asbestos, and PFAS. The survey of over 200 parents revealed that 79% of children under 12 use these products, with many reporting unintentional ingestion or prolonged exposure.
A new study published in the Journal of Dental Research has found that heavy smokers with severe periodontitis do not receive any benefits from treatment. The study suggests that smoking cessation is crucial for effective treatment and may even worsen the disease during active treatment. The findings highlight the need to rethink pract...
Silicate weathering helps regulate Earth's climate by removing CO2 from the atmosphere at lower temperatures. The process is influenced by various landscape-scale conditions and physical processes, with temperature sensitivity varying depending on these factors.
Researchers from Waseda University measured the energy spectrum of boron and the B/C flux ratio in high-energy cosmic rays using the CALorimetric Electron Telescope. The results indicate a different spectral index for boron compared to carbon, with implications for our understanding of cosmic ray propagation mechanisms.
Researchers developed a novel technology to engineer proteins targeting specific DNA sequences, offering a new approach to gene therapies. The system generates engineered zinc fingers that bind to any given sequence of DNA, potentially treating diseases caused by genetic mutations.
Researchers at the University of Chicago have designed a temperature-sensing building material that changes its infrared color to absorb or emit heat based on outside temperatures. This innovation aims to reduce building energy consumption and greenhouse gas emissions, making it an essential step towards a more sustainable future.
Expanding seaweed farming could reduce demand for terrestrial crops and greenhouse gas emissions by up to 2.6 billion tonnes per year. The study identified millions of available hectares of ocean suitable for farming, with the Indonesian EEZ showing great potential.
Researchers at Ben-Gurion University of the Negev discovered a new compound derived from marine red microalga that exhibits effective antimicrobial activity against bacteria and fungus. The compound's unique structure, featuring long and dense spikes, allows it to poke holes in bacterial membranes and kill off infections.
A recent study published in Zoo Biology found that flamingo flocks should be between 50-100 individuals to encourage successful reproduction and sustain populations. Adding new individuals can increase reproductive success, while climatic variables play a limited role.
A new study reveals that alien plant species are expanding their range to higher elevations at an accelerated rate, affecting mountain ecosystems globally. The number of invasive species has increased by 16% worldwide over the past decade, with neophytes colonizing niches that match their climatic preferences.
Researchers developed a translational step forward in treating brain tumors using intraventricular immunovirotherapy, which has shown safety and efficacy in recent clinical trials. This approach uses oncolytic herpes simplex virus type-1 to target high-grade glioma with promising results.
A team of researchers led by Boston College Assistant Professor Brian Zhou developed a new quantum sensor technique to image and understand the origin of photocurrent flow in Weyl semimetals. They found that the electrical current flows in a four-fold vortex pattern around where light is shined on the material.
Researchers will investigate how ducks' immune systems act as a reservoir for the highly infectious H5N1 virus and engineer antibodies to prevent transmission to other animals and humans. They aim to develop ways to purify antibody-producing cells from ducks and assemble a pool of antibodies to understand their molecular features.
Plant-based protein products are generally reported positively in UK newspapers, but issues such as high processing levels and environmental footprints of protein crops dominate the narrative. The study suggests that big business involvement is also a significant concern.
Researchers at the Istituto di Ricerca in Biomedicina discovered coldspots within the coronavirus spike protein, which are remarkably conserved across variants. Antibodies targeting these coldspots showed promise in blocking virus infection and protecting against disease in preclinical models.
Researchers at the University of Toronto have developed a two-layer coating made of polydimethylsiloxane (PDMS) brushes that significantly reduces microfibre shedding from synthetic fabrics. The coating, which can reduce pollution by more than 90%, is environmentally friendly and has been shown to work on various surfaces including gla...
A science advisory highlights critical gaps in research on developmental care interventions for infants with complex congenital heart disease. The advisory calls for prioritizing research and implementation of developmental care to improve neurodevelopmental outcomes.
A study analyzed 105 cat interactions to categorize them into playful, aggressive, or intermediate groups. The majority (56.2%) were classified as playful, while 28.6% were agonistic. Intermediate behavior was observed in 15.2% of cats, exhibiting characteristics of both play and aggression.