Researchers used deep learning to identify dihydroartemisinin as a potential osteoporosis treatment that maintains mesenchymal stem cell stemness and produces more osteoblasts. The study found that administering DHA extract for six weeks significantly reduced bone loss in mice with induced osteoporosis.
Researchers at Kyushu University have successfully converted brain immune cells into neurons, which restored brain function after a stroke-like injury in mice. The findings suggest that replenishing neurons from immune cells could be a promising avenue for treating stroke in humans.
A nearly intact fossilized bat skull discovered in a 50-million-year-old cave has provided crucial insights into the evolution of bats and their use of echolocation. The find, part of an analysis published in Current Biology, suggests that early bats may have used a form of echolocation similar to that employed by modern species.
Researchers found that DNA damage accumulates in arteries with aging and contributes to impaired vascular function. In mice lacking or heterozygous for the double-strand DNA break repair protein ATM kinase, aging accelerated vascular dysfunction, including increased arterial stiffness and oxidative stress.
A WVU team is providing free technical assistance to local industrial facilities to reduce their impact on environmental and community health. The project aims to support businesses in making changes that benefit their communities while maintaining profitability.
A new study found that residents of neighborhoods with more greenspace tend to have longer telomeres, indicating better cellular health. However, the positive impact of greenspace is not enough to compensate for other environmental challenges like air pollution and racial segregation.
Reduced water flows and rising atmospheric temperatures will warm rivers during droughts, posing challenges for aquatic life and ecosystems. Intense solar radiation and lower water flows accelerate warming, but certain management interventions can help offset high thermal extremes.
Researchers found that mutations at glutamate 152 in Bcl-2 induce apoptosis by liberating cytochrome c from mitochondria, forming a multimeric structure and exposing more BH3 domains. This results in a proapoptotic function.
Researchers from the BMJ Group conducted a UK trial comparing septoplasty to medical management in adults with at least moderate symptoms of a crooked septum. Septoplasty was found to be more effective in improving SNOT-22 scores and quality of life outcomes, suggesting it should be offered to adults with at least moderate symptoms.
A study published in the Journal of Internal Medicine found that SARS-CoV-2 infection may worsen lower urinary tract symptoms in men. The research involved 17,986 men with medication for LUTS, half of whom had COVID-19, and showed a significant increase in urine retention, UTIs, and enlarged prostate issues.
Cedars-Sinai Cancer investigators have identified two promising new treatment options for men with recurrent prostate cancer, improving metastasis-free survival and quality of life. The combination therapy reduced the risk of metastasis or death by 58%, while enzalutamide alone was effective in preventing cancer spread or death.
Researchers have created high-resolution underground images of the Long Valley Caldera, revealing a 'hardened lid' of crystallized rock covering the magma chamber. The findings suggest that the area is not gearing up for another supervolcanic eruption but may experience earthquakes and small eruptions due to cooling and gas release.
Scientists analyzed European power blackouts and found that recovering within 13 hours can reduce up to 52% of power loss from cascading events. The study identifies early warning signs and operational training as key to building resiliency in the system.
Clinical quality registries collect and store health information to optimize healthcare and management in ICUs, providing valuable data for scientific research and epidemiological maps. The review highlights the role of CQRs in benchmarking strategies between hospitals and improving resource management.
A new study validates an MRI biomarker for early onset Alzheimer's disease, identifying a signature pattern of cortical atrophy that replicates across independent samples. The EOAD signature demonstrates clinical validity and accurately differentiates patients with EOAD from healthy controls and those with other cognitive impairments.
Scientists have determined the common octopus' genome structure, consisting of 30 chromosomes with 99.34% sequence consistency. This high-quality reference genome will aid in understanding biological properties and evolutionary history of Octopus vulgaris.
A review in the Journal of Neurochemistry suggests a link between COVID-19 and Alzheimer's disease, with age being the largest contributing factor. Emerging evidence may further support this association, with research assessing influences on AD neuropathology.
The development of a new photonic technique enables the precise control of photonic angular momentum, allowing for the efficient recognition and real-time control of total angular momentum modes. The technique, which involves the symmetrical cascading of two units, has been experimentally demonstrated to recognize up to 42 individual T...
A large Danish study finds that migrants typically receive inferior care for type 2 diabetes, particularly in monitoring and controlling biomarkers. Migrants from Somalia face the worst care, with elevated risks across all indicators.
Researchers found that reversing current warming trend within centuries may prevent ice sheet tipping. However, temporary overshooting can still lead to significant sea-level rise. The study suggests that acting fast and keeping temperatures below 1.5 degrees Celsius is crucial.
Studies reveal subtle variations in time and geographical space between Sapiens and Neanderthals. The presence of about 2% of DNA of Neanderthal origin in present-day Eurasians varies slightly between regions.
UBC Okanagan researchers have developed sensors that can detect erosion and breaches in protective coatings, reducing inspection time and error risk. The AI-enabled sensors can also distinguish individual layer erosion within multi-layer coatings, enabling proactive monitoring and addressing of equipment degradation.
Researchers found that children's nasal mucosa has a more active and alert immune system than adults, which helps fight SARS-CoV-2. This innate strong protective mechanism is thought to also defend against other viruses.
Research at Aston University identified four eating behavior patterns in children: 'avid', 'happy', 'typical', and 'fussy'. Children with 'avid' eating behaviors are more likely to be overweight or obese, while caregivers' feeding practices vary significantly across the four categories. The study aims to provide tailored advice for par...
In a phase I trial, an oncolytic virus treatment designed by Brigham researchers extended survival among patients with recurrent glioblastoma, especially those with pre-existing viral antibodies. The therapy reshaped the tumor's surrounding environment to stimulate an anti-tumor immune response.
A new Japanese ecological study found that prefecture-specific SHC participation rates significantly negatively affect treated ESKD incidence and CKD prevalence. Higher SHC participation rates are associated with lower ESKD incidence, suggesting the importance of regular health checkups at a population level.
Researchers from Simon Fraser University and Brigham Young University have developed a new radar technology that significantly improves the detection of polar bear dens in the Arctic. The technology, using Synthetic Aperture Radar (SAR), has been shown to increase den detection by over 66% compared to current industry standards.
A simple MRI scan and a new metric for prostatic urethra length may help identify men at risk of chronic urinary side effects after radiation therapy. The study found that longer prostatic urethras are associated with a higher likelihood of these symptoms, which can impact quality of life.
Researchers at Google Quantum AI and Stanford University have observed the crossover between two regimes: interactions dominating and measurements dominating. They also demonstrated novel quantum teleportation by measuring all but two distant qubits, generating stronger entanglement between them.
Juvenile crown-of-thorns sea stars (COTS) exhibit high tolerance to heatwave conditions that cause coral bleaching and mortality. This finding suggests they may persist as major coral predators in reefs vulnerable to climate change, threatening coral health.
Researchers have identified a new mechanism by which phages evade CRISPR-Cas immune systems in bacteria, revealing a potential approach to make gene editing safer and more efficient. This discovery could lead to the development of bespoke anti-CRISPRs to neutralize CRISPR-Cas systems and provide an alternative to antibiotics.
Researchers mapped mosquito's tree of life, revealing how the insects chose their hosts and evolved disease transmission. The findings suggest mosquitoes started out feeding on amphibians and later moved to other groups as they flourished.
A new method for studying cancer cells' behavior on soft and stiff tissue environments has been developed, revealing crucial survival cues for cell growth. The study challenges the long-held assumption that cells prefer stiffer surfaces, opening up new possibilities for research in cancer biology and tissue engineering.
Researchers create practical way to implement superlensing with minimal losses, breaking through diffraction limit by nearly four times. The method allows scientists to improve super-resolution microscopy, advancing imaging in fields like cancer diagnostics and archaeology.
Regular snoozers who get an extra half hour of sleep show no negative effects on night sleep, mood, or cognitive abilities. In fact, they tend to wake up feeling more alert and quick-thinking.
The study found that New York City's policy effectively reduced tobacco-related disparities, particularly in districts with lower income and greater proportions of non-Hispanic Black residents. By 2022, the city achieved more balanced levels of tobacco retail exposure across its communities.
A new study found that diverse plant species mixtures increase plant productivity, invasion resistance, and soil nitrogen levels. Multispecies mixtures also drive different functions, with legumes benefiting productivity and water availability.
A team of researchers proposes a novel approach to generate three-dimensional holograms directly from regular 2D color images captured using ordinary cameras. This approach utilizes deep learning to transform the image into data that can be used to display a 3D scene or object as a hologram.
A clinical trial published in the New England Journal of Medicine found that adding a second antibiotic, vancomycin, did not protect against infection and may have led to more infections. The study showed no clear benefit from using two antibiotics instead of one.
New research from MIT found that germicidal UV lights can produce potentially harmful compounds in indoor spaces. The study suggests that the lights should be used with appropriate ventilation to minimize health risks. Researchers emphasize that the new UV lights are not a replacement for ventilation but rather a complement to it.
Researchers have created a three-dimensional computer simulation of the light emitted following a neutron star merger, producing results similar to an observed kilonova. The simulation takes into account various processes and material interactions, enabling predictions for any viewing direction.
A study by researchers at Keck School of Medicine of USC found that Black cancer survivors experience slowdowns in diagnosis and delivery of care due to exposure to racial discrimination. Positive interactions, such as ready access to providers and displays of empathy, were identified as key factors in improving care.
A new AI algorithm developed by Cedars-Sinai can detect atrial fibrillation in people without symptoms, improving stroke prevention. The algorithm was trained on over a million electrocardiogram readings and accurately predicted cases of atrial fibrillation within 31 days.
Researchers from Aarhus University found that current inventory methods rely solely on nitrogen content, neglecting degradability and leading to misleading inventories. The study suggests a distinction between mature and immature crop residues could improve accuracy and target mitigation strategies.
The study found that satellite cells possess an inherent capacity to sense and respond to regenerative cues independent of external signals from non-myogenic cells. Macrophages played a crucial role in regulating MuSC proliferation and differentiation, but their reduction led to impaired cell division and increased fibrosis.
EMBL researchers have systematically profiled over 10,000 drug combinations for their effectiveness against common multidrug-resistant bacteria. The team identified over a thousand interactions, including both synergies and antagonisms, with distinct effects on Gram-positive and Gram-negative bacteria.
The study found that precision oncology therapies require genomic biomarker screening for patient selection and have expanded over the years. The analysis showed a slow expansion in approvals from 1998 to 2017 and a rapid increase from 2017 to 2022, with 86 out of 198 approved drugs classified as precision oncology drugs.
Researchers have developed enzydynamic therapy at nanoscale using nanozymes to regulate reactive oxygen species (ROS), which can cause oxidative damage in living organisms. This approach has the potential to treat various diseases, including malignancies, neurodegeneration, and inflammation.
Scientists have discovered two 'switch' regions in the structure of the K-Ras protein that are affected by dangerous mutations. These regions, located near a protein loop, can amplify cell division and lead to cancer. Researchers say their findings provide new insights into the mechanisms of these mutations and potential drug targets.
A recent analysis found that assisted reproductive technology cycles using a gestational carrier resulted in higher live birth rates and an increased risk of twins. Despite national recommendations, more than one-quarter of embryo transfers involved two or more embryos, highlighting the need for improved guidelines.
Scientists propose new temperature guidelines for data centers that may help reduce energy consumption and save money. Researchers found that raising the temperature to around 41°C could lead to significant savings, with some areas able to rely entirely on free-cooling, reducing energy costs by up to 56%.
A new study finds that fertilized lawns are hotspots of nitrogen export into our water and atmosphere, posing a growing environmental health problem. Changing just 5-10% of suburban lawns to alternative landscaping might have a major effect on watershed-wide nitrogen export.
Engineers developed a nanoparticle vaccine targeting S100A9, a protein that attracts cancer cells to the lungs. The vaccine significantly reduced lung tumor growth and improved survival rates in mice with metastatic breast cancer after surgery.
Scientists at Buck Institute reveal how NAD+ decline affects female reproductive function and longevity. Adding CD38 to the puzzle, they found that this enzyme degrades NAD+, accelerating aging processes. Targeting CD38 may offer new approaches to enhance fertility and overall healthspan.
A study at Washington State University found that implicit bias training improved police behavior toward homeless individuals, particularly in terms of offering polite greetings and de-escalating volatile situations. The trained officers also reported 50% fewer discrimination complaints overall.
Researchers identified key regulatory mechanisms and cell types in follicle development, finding a critical role for FOXO1 in mediating differences between obese mice. Alterations were also seen in extrafollicular cells, including tumor-like cells, which warrant attention given obesity's link to ovarian cancer.
A new national study finds that lesbian, gay, and bisexual adolescents in the US are more than twice as likely to report binge eating than their heterosexual peers. Stressors like discrimination and stigma can lead to poor self-esteem and disordered eating.
Researchers developed robotic prosthetic ankles controlled by nerve impulses, allowing amputees to move more naturally and improving stability. The study found that users were significantly more stable when using the robotic prototype, changing their postural control strategy and mimicking the body's behavior.
Researchers found amoeboid cells in pancreatic cancer produce CD73, which drives spread and weakens immune system. Blocking CD73 reduced cancer spread to liver and decreased immune cell support.
A new asynchronous distributed PEV charging protocol has been developed to manage the charging patterns of scattered electric vehicles, ensuring network reliability and seamless user experience. The protocol preserves user privacy by not disclosing individual user-state information, addressing concerns in previous studies.