New expansion microscopy methods, dubbed Magnify, allow researchers to observe nanoscale biological structures with standard microscopes. The protocol retains biomolecules intact, enabling simultaneous imaging of proteins, lipids, and carbohydrates.
Researchers have developed a technique to record cellular events in a long protein chain, allowing them to reconstruct the timing of gene activation, response to drugs, and other processes. This method has potential applications in understanding memory formation, aging, and disease progression.
The CNIC study reveals two distinct mechanisms by which cells detect and respond to forces of varying strength, one mediated by caveolae and the other by newly discovered dolines. This finding has significant implications for understanding pathological processes such as atherosclerosis and neurodegenerative diseases.
The São Paulo School of Advanced Science on Stem Cell Biology will highlight the latest scientific advances in stem cell therapy and tissue bioengineering. Internationally renowned scientists will present state-of-the-art science and results of new research.
MIT scientists use single-cell profiling to analyze the cellular function of brain cells affected by Alzheimer's disease, identifying five main areas of disruption. The study reveals specific molecular programs and gene regulation changes that could lead to valuable biomarkers and therapeutic interventions.
The American College of Physicians recommends bisphosphonates as initial pharmacologic treatment to reduce fracture risk in osteoporosis patients. Long-term use may increase risks, so treatment duration should be limited to 5 years or less.
A recent study found a significant decrease in influenza activity in China during the 2020-2022 COVID-19 pandemic, particularly in winter and spring. The observed reduction in influenza seasonality may be attributed to everyday COVID-19 public health interventions.
A study in California prisons found that recent vaccination and boosters significantly reduced infectiousness of COVID-19, with a 11% decrease per additional dose. Prior infection also provided protection, with a 23% risk of transmission compared to 33% for those who had never been infected.
Researchers found that early prenatal alcohol exposure changes gene function and epigenome in placenta and human embryonic stem cells. These changes are associated with altered DNA methylation patterns, particularly in genes linked to nervous system development, such as DPPA4 and FOXP2.
Adults with higher serum sodium levels were more likely to develop chronic conditions, show signs of advanced biological aging, and die at a younger age. Optimal hydration may be associated with slower aging and reduced risk of chronic diseases.
Researchers at UCSF have developed a novel approach to prevent antibodies from triggering immune rejection of engineered therapeutic and transplant cells. By using a decoy receptor, they can capture the antibodies and take them out of circulation before they can kill the therapeutic cells.
A new computer program, DeepMosaic, uses artificial intelligence to detect mosaic mutations in genetic sequences. This method enables accurate detection of mosaic mutations, which cause hundreds of unsolved and untreatable disorders, including epilepsy.
ETH Zurich researchers have created a range of affordable fluorescent inks with machine learning algorithms to determine the right molecular subunits. The new dyes can be used for security features and applications like solar power plants and organic light-emitting diodes.
A new method, SPOTS, maps gene activity patterns and protein presence in cells across tissue samples with unprecedented resolution. This enables the creation of complex maps of organs, including diseased ones, which could be widely useful in basic and clinical research.
A mouse study found that proteins made by stem cells in mice with dry eye disease may be new targets for treating injuries to the cornea. The researchers identified a key gene, SPARC, that is activated in response to injury in dry eye disease and found higher levels of its protein are associated with better healing.