In people with Rett syndrome, nerve cells have a mechanism called transcriptional buffering to partially compensate for genetic changes. This process helps maintain healthy RNA levels and acts as a defence against genetic variations, suggesting a potential new molecular mechanism in human cells.
A study published by the University of Barcelona found that problem-solving abilities are linked to social exclusion. Dromedaries and goats, which are less integrated into their social groups, demonstrated greater innovation skills.
Researchers found that psilocybin facilitates fear extinction in mice by promoting hippocampal neuroplasticity. The study's results improve our understanding of the restorative effects of psilocybin on the brain and may lead to alternative treatments for PTSD.
Researchers have discovered that nuclear pore IDPs form a dynamic barrier that allows essential cellular factors to pass while blocking viruses and pathogens. The team used synthetic biology, multidimensional fluorescence microscopy, and computer-based simulations to study IDPs in living cells.
Over the past decade, pediatric emergency department visits related to mental health concerns have significantly increased, with a 5-fold rise in suicide-related cases. The study underscores the urgent need for enhanced crisis and emergency mental health services for young people, particularly those experiencing suicidal symptoms.
Researchers analyzed data from over 20,000 US adults, finding that those who lost at least 5% of their body weight showed higher diet quality and more moderate physical activity. However, the study also found that many individuals relied on unsustainable non-evidence-based approaches for weight loss, highlighting the need for a paradig...
The program guide for TVT 2023 showcases over 200 world-renowned faculty experts, with a focus on clinical decision-making and strategies for treating valvular heart disease. The summit highlights the latest advances in transcatheter valve therapy and nonsurgical procedures.
A team of scientists has engineered a new method for building carbon nanocircuits with adaptable bridges, allowing for the fine-tuning of electronic properties and enabling potential applications in advanced electronics and sustainable energy. The breakthrough could also lead to the development of thermoelectric materials with signific...
Researchers identified three novel dual-purpose therapeutic targets using PandaOmics, which could treat both aging and glioblastoma multiforme. The target hypotheses include cyclic nucleotide gated channel subunit alpha 3 (CNGA3), glutamate dehydrogenase 1 (GLUD1) and sirtuin 1 (SIRT1).
Researchers evaluated six AAV vectors in 12 preclinical liver models to identify the most relevant combination for safe and efficient gene therapy. The study proposes using multiple models to provide a more complete picture of vector function, informing clinical decisions.
A researcher at OSU-Cascades is developing an AI-powered smart compost bin that tracks household food waste. The device prompts users to describe deposited items, transcribing notes with automatic speech recognition and collecting 3-D images and sensor measurements.
A new study finds that having daughters has little to no effect on legislators' roll call votes on women's issues. The researchers analyzed a large dataset and replicated previous findings, suggesting that partisanship may have taken precedence over family influences as political polarization increased.
Children's Hospital Los Angeles researchers have identified a disruption in early kidney progenitor cell development linked to the formation of Wilms tumor. The study found that these cells can reproduce the original tumor and are aggressive, drug-resistant, and metastasize like cancer cells.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
A study of 4,791 patients found that taking ACE inhibitors and angiotensin receptor blockers for at least six months prior to ICU admission did not lower the prevalence of delirium. Chronic high blood pressure is a risk factor for ICU-acquired delirium.
Cancer caregivers from lower-income households are more likely to experience debt and work loss compared to non-cancer caregivers. This can lead to increased economic burden, stress, and a reduced ability to retire on time.
A new study identifies four distinct profiles of psychiatric comorbidity in children and adolescents at elevated risk for serious self-harm events. The profiles consider demographic factors, overall psychiatric and medical conditions, and unique patterns of comorbidity that distinguish between age and sex.
A new metric called a correlation ratio has been developed to correlate microscopic-level processes with macroscopic-level behavior in soft materials. This breakthrough allows for the design of new soft materials by tweaking microscale parameters to achieve desired macroscale properties.
A Cornell University-led collaboration has identified transient crystal defects as the cause of rapid degradation in sodium-ion batteries. The researchers used operando X-ray imaging to visualize these defects while the battery was in operation, revealing their formation and self-healing processes.
Researchers at the University of Missouri identified occludin protein as a mediator for cell-to-cell transmission of coronavirus. The study found that damaged occludin protein enables virus replication and spread to neighboring cells, worsening symptoms.
Researchers at Cummings School of Veterinary Medicine and Tufts Medical Center have developed a new platform to test cardiac side effects of chemotherapy using canine heart tissue. The platform yields quicker and more comprehensive results than standard rodent models, making it a promising alternative for cancer drug toxicity testing.
A study of 1,300 participants found that increased physical activity 6 months after stroke was associated with better functional outcomes. Interventions targeting individuals with decreasing physical activity in the subacute phase may play a role in improved functional recovery.
A recent study by the University of California, Davis found that coal trains and terminal operations significantly increase fine particulate matter (PM2.5) pollution in urban areas, contributing to serious health problems. The study also highlighted the disproportionate impact on vulnerable populations.
A new study presents a chronic wound murine model that characterizes the role of persistent senescent cell accumulation in delayed wound closure. The molecular profiles of senescent cells demonstrate the adverse influence of SASP factors, highlighting a potential root-cause-driven therapeutic strategy.
A NYU Abu Dhabi study reveals that improvements in visual functions are linked to changes in white matter pathways and specific brain regions. The research confirms the potential of cataract surgery to improve visual function and brain plasticity, especially when performed at a younger age.
Researchers have developed a new approach to constructing thermoelectric modules using silver nanoparticles, enabling efficient energy conversion and operation across various temperatures. The discovery is expected to accelerate the development of advanced modules for power generation and other applications.
A historic study reveals the West Antarctic Ice Sheet was smaller and more dynamic in recent geologic past than previously thought, with implications for global sea level rise. The researchers analyzed sediment and water samples from subglacial lake Mercer Lake to infer the region's geologic history.
New research published in the journal SURGERY found that obesity is associated with increased risk of complications following surgery, including infection, blood clots, and kidney complications. Patients with overweight or obesity had higher risk-adjusted odds of developing these post-operative outcomes compared to those of normal weight.
A team led by the Chinese Academy of Sciences has found a well-preserved 'Marine Dwarf World' from 462 million years ago at Castle Bank, Wales. The site features over 150 species, including arthropods, worms, sponges, and starfish, with many preserved in minute detail.
Researchers at the University of Pennsylvania School of Engineering and Applied Science have created a photonic device that provides programmable on-chip information processing without lithography. This breakthrough enables superior accuracy and flexibility for AI applications, overcoming limitations of traditional electronic systems.
Researchers at the University of Illinois Chicago have identified a key protein involved in viral reinfections that could be targeted by antiviral drugs. Inhibiting heparanase activity can protect against herpes simplex virus type 1 reinfection, potentially leading to breakthroughs in preventing recurrent infections.
A team of researchers predicts a strong El Niño event in late 2023, driven by the buildup of warm water in the western Pacific. The study suggests that an even stronger event could occur if westerly wind bursts occur during the spring and early summer.
A multi-institutional study found that dengue virus sequences have evolved dramatically in India, with different serotypes deviating from their ancestral sequences. Dengue 2 has become more dominant across the country, while Dengue 4 is making a niche for itself in South India.
A study supported by the National Institutes of Health found that younger women are nearly twice as likely to be rehospitalized after a heart attack as men. The disparity is largely due to higher rates of risk factors such as obesity and depression among women, which contribute to more adverse outcomes.
A new study suggests that increased exposure to air pollution may be associated with first hospital admissions for acute kidney injury. The research found a link between PM2.5, NO2, and O3 exposure and an increased risk of AKI, even at low annual exposures.
Researchers at UMass Amherst characterized two types of surface water in hyperarid salars, which are crucial habitats for animals like flamingoes and vicuñas. The study helps manage these ecosystems by treating terminal and transitional pools differently.
Researchers discovered that a certain short-wave or blue sensitive cone circuit is absent in marmosets and differs from the macaque monkey's circuit. This finding suggests that humans have unique neural wiring for color vision that may be linked to recent evolutionary adaptations.
Researchers at the University of Texas at Austin developed a semantic decoder that translates brain activity into text, allowing individuals with speech disabilities to communicate. The system has been trained on extensive hours of podcasts and can decode continuous language, capturing the gist of what is being said or thought.
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
A recent study found that the police murder of George Floyd led to a three-week spike in firearm assaults on U.S. police officers, but this trend quickly subsided. The researchers caution against using the term 'war on cops' and instead suggest focusing on evidence-based solutions to reduce violence.
A large Chinese study found that acute air pollution exposure is associated with an increased risk of arrhythmia, with the strongest link seen in atrial flutter and supraventricular tachycardia. Exposure to pollutants like nitrogen dioxide was found to persist for up to 24 hours after initial exposure.
A UNIGE team analyzed the socio-economic impacts of 248 electricity transition scenarios on 296 European regions, finding that southern and south-eastern regions may be more vulnerable to negative effects. The benefits of a low-carbon electricity sector tend to concentrate in richer northern Europe.
The American Thoracic Society International Conference Abstracts publication features selected abstracts on COPD treatment, including a study on improving depression through home-based pulmonary rehabilitation. The issue also highlights recent findings on sleep apnea severity, as well as research on health equity and access to care.
A new sensing system, SAWSense, repurposes technology from bone-conduction microphones to detect surface-acoustic waves on various surfaces. The system recognizes different inputs with 97% accuracy, enabling intuitive input mechanisms for smart objects and medical sensing applications.
A Mass General Brigham expert calls for additional measures to expand access to lifesaving buprenorphine treatment and harm-reduction services. The federal government's elimination of the X waiver is necessary but not sufficient to achieve overdose-prevention goals, according to the authors.
Researchers at Columbia University found that increased access to mental health care is associated with lower suicide rates in the US. The study used a new method to measure access to care and found that areas with shorter travel times to providers had significantly lower suicide rates.
A recent research project led by Myeong Lee at George Mason University seeks to address the difficulties people with disabilities face when accessing vital services. The study's findings will provide suggestions for enhancing the state's information systems, making them more accessible and improving overall well-being and health outcomes.
A study analyzing three years of power outages across the US found that Americans bearing the brunt of climate change and health inequities are most at risk in four regions. Heavy precipitation, tropical cyclones, and storms with high winds make power outages more likely, especially in the South, Northeast, and Appalachia. The research...
A team of researchers found that prosumers, who produce their own electricity, can lower transmission charges when generating less energy. However, when producing a large amount of renewable energy, transmission charges increase. The study suggests levying a per-MWh tax on prosumer consumption to reduce the likelihood of death spirals.
A new study found that people exposed to moderate aircraft noise were less likely to get the minimum recommended sleep each night. The risk increased among those living near airports or large water bodies, as well as those with no hearing loss. Exposure levels as low as 45 dB were associated with short sleep duration.
Researchers found that older children can learn visual tasks and exhibit increased white matter plasticity after surgery to remove congenital cataracts. This suggests that the window of brain plasticity extends beyond childhood and that all children may benefit from treatment.
Scientists create high-performance bulk magnesium diboride superconducting magnets with low-cost technique, exhibiting good critical current density and trapped magnetic field. The work paves the way for commercialization of MgB2 superconducting magnets.
Researchers at University of Michigan created a realistic driving simulation based on a 'crash-prone' intersection in Ann Arbor. The NeuralNDE uses real-time data to test the safety of autonomous vehicles, reducing the need for actual crashes.
Physicists have developed a controlled system of interdependent superconducting networks, a physical analogy to the interdependent networks involved in the Italy blackout. The study shows that coupled systems exhibit an abrupt transition, while separate networks show a smooth transition, as predicted by the theory.
A 50-year global meta-analysis of bird reproductive output found that a warming climate negatively affects larger and migratory bird species. The study, published in the Proceedings of the National Academy of Sciences, reveals that smaller, sedentary species are less affected by climate change.
Researchers found that only four products increased lutein liberation in spinach smoothies, with cow's milk and coconut milk showing the most improvement. Plant-based drinks like soymilk had a negative effect on lutein content.
A team of scientists at SLAC and Argonne National Laboratory has developed an algorithm that pairs machine-learning techniques with classical beam physics equations to precisely predict a particle beam's distribution of positions and velocities. This detailed information will help improve experimental reliability, especially at higher ...
A new Michigan statewide study found that inducing labor at 39 weeks of pregnancy does not necessarily reduce the risk of cesarean births. In fact, for some birthing individuals, it may even have the opposite effect if hospitals don't take a thoughtful approach to induction policies.
A new study published in PNAS reports surge of gamma activation in dying brains of humans and animals post-cardiac arrest, hinting at conscious-like activity.
Researchers investigate the γ-TuRC complex, a key player in microtubule formation and stabilization. The study reveals that γ-TuRC can cap microtubules independently of nucleation, contributing to their formation outside of centrosomes during mitosis.