Researchers identified abnormal keratin expression patterns in senescent ocular surface cells, which may contribute to severe ocular surface diseases. Gene expression profiles showed substantial differences between senescent and non-senescent cells, highlighting their potential role in pathology.
A recent study used a dense measurement network to track the transport of crop residue burning pollutants from Punjab to Delhi NCR, revealing high levels of PM2.5. The measurements showed that the Indian national air quality standard for PM2.5 were frequently exceeded in the region.
Scientists from Osaka University found a shorter Rubicon isoform that boosts autophagy in B cells, leading to increased memory B cell generation and enhanced recall responses. This discovery sheds light on manipulating B cell memory and resolving conflicting findings about Rubicon's functions.
A new study finds that drier ecosystems in savannas and grasslands have a greater potential for carbon storage when fires are less frequent. Over the past two decades, soil carbon rose by an estimated 23% in dryland savanna-grasslands, while it declined by 25% in more humid regions.
A study of 33 physicians across 17 specialties found that chatbots provided largely accurate information to diverse medical queries. However, the chatbots had important limitations that require further research and model development.
Researchers at the University of Birmingham found that individuals with fatty liver disease are three times more likely to have a personality disorder than those without. Lifestyle modifications, such as changes in diet and exercise, can prevent disease progression but often fail to be implemented due to mental health factors.
Researchers developed a new technology to test new drugs against liver diseases by recreating the real human liver environment. The model consists of live liver cells in an artificial blood vessel system, allowing for controlled testing and monitoring.
Researchers discovered that users' prior beliefs about an AI chatbot's motives significantly impact their interactions with the agent. Priming users to believe certain things about the AI's empathy, neutrality, or manipulation influences their perception of its trustworthiness and effectiveness.
Researchers used a unique X-ray technique to capture soundwaves' propagation in a diamond crystal, revealing ultrafast structural phenomena that were previously beyond scientific reach. The breakthrough enables real-time imaging of solid materials with unprecedented resolution and speed.
Researchers discovered that intrinsically disordered regions (IDRs) in proteins play a critical role in chromatin regulation and gene expression. IDRs form droplets called condensates that separate from surrounding fluid, allowing proteins to congregate and carry out cellular activities.
A recent study published in Nature found that massive low-earth orbit communications satellites like BlueWalker 3 can outshine bright stars, disrupting astronomical observations. The satellite's large antenna system causes an abrupt increase in brightness, affecting not only visual observations but also radio astronomy.
Researchers found that electrical signals in the hippocampus differ immediately before recalling true and false memories. The study used epilepsy patients to measure neural activity leading up to correct or false recall, revealing a reduction in low-frequency activity associated with contextual similarity.
Researchers used custom-designed headsets to evaluate headpulse biometrics among Australian Rules Football players and found brain abnormalities in 81% of those inflicted with concussion. These alterations lasted 14 days beyond expected recovery times.
Researchers at Nagoya University developed a niobium waveguide that enhances high-precision communications for Beyond 5G/6G networks. The waveguide's conductivity improves with cooling, reducing losses and increasing data transmission accuracy.
A study of hospitalized adults with new-onset atrial fibrillation found that 1 in 3 patients experienced a recurrent episode of AF within a year. This rate is approximately 7 times higher than in matched control participants, suggesting that oral anticoagulation therapy may be warranted for these patients.
Researchers have sequenced the genomes of transmissible shellfish cancers, revealing high levels of genomic instability not seen in other cancers. The study focused on the common cockle, a species that belongs to one of the oldest groups of animals on Earth.
A recent study on Roosmalens' dwarf porcupine has revealed new information about its distribution in the Madeira biogeographical province of the Amazon Forest. The research found that the species is likely endemic to this region and has a wider distribution in southern Amazonia than previously thought.
Researchers found that fly brain uses a three-step computation to distinguish motion patterns, dividing the workload across multiple levels. This approach helps flies detect even slight changes in motion and stay on course.
Researchers found that MDMA increased feelings of connection and oxytocin levels in volunteers, while methamphetamine also showed similar effects. These findings suggest potential therapeutic benefits for traditional talk therapy.
Researchers discovered a synthetic plant biology approach to prevent protein aggregation in human cells and nematodes, using the plant enzyme stromal processing peptidase (SPP) derived from chloroplasts. This finding opens the door to testing SPP as a potential therapy for Huntington's disease.
Researchers at MedUni Vienna discovered that dormant tumor cells surviving chemotherapy can be targeted through the inhibition of P-glycoprotein, opening new possibilities for delaying relapse. This breakthrough could represent a step forward in treating aggressive triple-negative breast cancer, which has limited treatment options and ...
A new study by Northumbria University found that consuming Quorn protein for two weeks reduced 'bad' LDL cholesterol levels by 12% and waist circumference by almost 1cm. This could lead to a 9% lower risk of dying from a stroke or coronary heart disease, according to the research.
Computer simulations reveal that water molecules play a key role in the formation of biomolecular condensates, which act as specific microreactors for biochemical reactions. The confinement of water molecules inside these condensates is an unfavorable driving force, while their freedom outside is favorable.
Researchers at Dana-Farber Cancer Institute uncover the role of disordered protein regions in controlling chromatin remodeling complexes, shedding light on their contribution to cancer development. The study highlights the importance of sequence-specific interactions within these proteins for proper gene regulation.
Researchers found that soil viruses exhibit dynamic and changing behavior after dry soils are watered, with a diverse range of virus types and minimal turnover. This suggests that viruses may play a more nuanced role in shaping bacterial communities and ecosystems than previously thought.
Researchers found that Rh sensitization, a condition where the body mounts an immune response to fetal red blood cells, rarely occurs during the first trimester. The study's results could change pregnancy care guidelines and reduce unnecessary treatments, conserving valuable human blood products.
New plant cell walls exhibit significantly different mechanical properties compared to surrounding parental walls, enabling cells to alter their local shape and influence the growth of plant organs. Researchers have discovered that new cell walls in some plants are 1.5 times stiffer than the parental cell walls.
A pilot study in Catalonia found that self-sampling is a feasible and acceptable method for diagnosing asymptomatic mpox. The study identified 7 positive cases, including 3 asymptomatic individuals, and estimated the prevalence of infection at 6.19%.
A worldwide audit of testosterone deficiency in men with type 2 diabetes found that testosterone replacement therapy improves glycaemic control for up to 2 years. The study suggests that the ongoing effect of testosterone on insulin resistance and fat reduction contributes to the improvement in blood sugar levels.
A study published in The Lancet Oncology reveals a genetic explanation for increased second-cancer risk and mortality among childhood cancer survivors. The research identified specific genes associated with this increased risk, enabling personalized cancer screening and prevention strategies.
Researchers from USTC achieve chemically controlled reversible magnetic phase transition in 2D organometallic lattices using the lactim-lactam tautomerization process. This method offers novel pathways for controlling electrical and magnetic characteristics of materials.
A global decade-long study found that people impacted by floods are at significantly increased risk of dying between three and six weeks after the event. The risk of death increases by up to 4.9% for respiratory deaths and persists for up to 60 days, with peak mortality rates reached around 25 days.
A real-world study of over 23,000 adults with type 2 diabetes found that semaglutide significantly improved blood sugar control and weight loss for up to 3 years. The study showed that patients who had never taken a GLP-1 RA or those with higher adherence achieved more pronounced reductions in blood sugar levels and weight loss.
Men with metastatic prostate cancer in Sweden experienced an average survival rate increase of six months after dual treatment was introduced from 2016 onwards. This improvement coincides with the gradual rollout of 'dual treatment', combining standard hormone therapy and chemotherapy or androgen receptor blockers.
Armida Labs, a UCR-founded pharmaceutical company, has received a $400,000 NIH Small Business Innovation Research grant to develop its breakthrough pancreatic cancer therapy Targefrin. The grant will enable the company to gather industry-standard data for human clinical trials.
The study aims to identify genetic and molecular factors associated with susceptibility and progression of liver disease in Hispanics/Latinos. Researchers will collect data from 300 participants, including those with metabolic-associated fatty liver disease and healthy controls.
Chaowei Yang and his team are creating an automatic training dataset labeling tool to produce high-quality training datasets. The project aims to partner with a startup or small business to create a concrete proposal for innovation programs.
Researchers highlight the importance of identifying childhood verbal abuse as a standalone subtype of child maltreatment to ensure targeted prevention. The review found that verbal abuse can have lasting impacts on children's wellbeing, including emotional and psychological repercussions.
Researchers developed a method to form tailored nanoscale windows in porous materials called MOFs using an architectural arch-forming template. This approach enables precise control over structure formation, leading to the creation of new materials with potential gas separation, medical applications and energy security benefits.
Researchers at Oregon State University discovered a novel strain of Paenibacillus bacteria with probiotic qualities that could help alleviate canine inflammatory bowel disease. The bacteria can digest complex carbohydrates and has antimicrobial properties, promoting anti-inflammatory immune responses in the gut.
The study found that Paxlovid treatment was associated with reduced risk of COVID-19 hospitalization or death in clinically extremely vulnerable individuals. Severely immunocompromised patients showed the greatest benefit from this treatment.
Researchers found that mature mangroves can tolerate high rates of subsidence and sea level rise, but sediment availability is crucial for their effectiveness. In areas with insufficient sediment, mangroves' ability to stabilize coastlines will deteriorate, leading to inland migration of communities.
A new study published in Neuron reveals that pericytes, a type of vascular cell, play a vital role in teaming up with neurons to form and store long-term memories. The research found that insulin-like growth factor 2 (IGF2) produced by pericytes enhances memory formation and storage.
A team of scientists at Osaka Metropolitan University has made significant strides in precision printing using an optical vortex laser-based technique. This innovation enables the precise placement of minuscule droplets with micrometer-scale accuracy, opening up new possibilities for microprinting technologies.
A large study of 491,000 participants found that loneliness was associated with an increased risk of developing Parkinson's disease. The findings suggest that loneliness is a significant psychosocial determinant of health and may contribute to the development of the neurodegenerative disorder.
Researchers have developed a new approach to treating invasive bladder cancer, combining chemotherapy and immunotherapy, which may preserve quality of life. In a phase 2 clinical trial, approximately 43% of patients achieved complete response without surgical removal of the bladder.
A 10-year study found that even low doses of radiation may contribute to an increased risk of diabetes among emergency workers at the Fukushima nuclear power plant. Researchers analyzed data from over 6,000 workers and found a significant association between low-dose radiation exposure and a higher risk of developing diabetes.
The University of Texas at Austin and its researchers are among the institutions receiving $45.6 million in grants to develop new semiconductor technologies and manufacturing processes. The funding, part of the NSF Future of Semiconductors program, aims to enhance performance and energy efficiency of semiconductor devices.
Researchers developed a precise historical reconstruction of the Red Sea circulation using fine-grained regional data. The new analysis reveals new characteristics of current circulation, temperature, salinity, and oceanic behavior, improving decision-making for megadevelopments like those in Saudi Arabia.
Researchers developed a scalable framework to quantify field-level agricultural carbon outcomes, integrating sensing techniques and advanced ecosystem models. The study provides a reliable method for measuring individual farm field-level greenhouse gas emissions and offers insights into the impact of farming practices on climate change.
A new compartment in mammalian cells, the exclusome, has been discovered to house DNA rings that can be ejected from the nucleus. This process helps protect chromosomes from foreign DNA that could disrupt cellular function. The discovery sheds light on a potential link between the exclusome and autoimmune diseases.
A recent study conducted at the University of São Paulo's Medical School found that isolating patients with carbapenem-resistant Enterobacteriaceae (CRE) in emergency departments (ER) for over two days can significantly reduce CRE transmission. The researchers also discovered that the ER structure, including bed layout and hand hygiene...
A groundbreaking study published in JAMA Pediatrics found that 37% of children diagnosed with autism as toddlers no longer meet the criteria for ASD around the age of six. Children with lower adaptive skills are more likely to have ASD persist later in life. The findings underscore the need for ongoing assessments throughout a child's ...
Researchers discovered that in obesity, low-density lipoprotein (LDL) does not function normally, increasing the risk of cardiovascular disease. However, after bariatric surgery, LDL quality improves and correlates with weight loss, suggesting a lower risk of CVD.
A study from Oregon State University found that commercial whaling in the 20th century led to a loss of maternal DNA lineages among blue and humpback whales, potentially resulting in cultural memory loss. Whale populations near South Georgia Island have begun to recover, but the genetic diversity remains low.
Researchers have pinpointed the crucial changes in a membrane protein that allow Antarctic octopuses to function normally in freezing temperatures. By swapping specific amino acids, scientists discovered three key modifications that together enable the pump to work efficiently, allowing the octopus's nervous system to adapt and thrive.
Research from Rutgers University reveals that 1.77% of 16-year-olds in northeastern New Jersey have autism spectrum disorder (ASD), with significant disparities among males, females, and socioeconomic groups.
A study published in Diabetologia found that daily dark tea drinkers had a 53% lower risk of prediabetes and a 47% reduced risk of type 2 diabetes compared to non-drinkers. Drinking dark tea may help improve blood sugar control by increasing glucose excretion in urine and reducing insulin resistance.
Researchers identified PUCH, a novel enzyme that produces small molecules called piRNAs to detect and prevent parasitic DNA from replicating in our genomes. This discovery sheds light on how our immune system works and may have implications for understanding innate immunity.
Researchers have discovered a new species of calcifying phytoplankton, Calciopappus curvus, found in the Sargasso Sea near Bermuda. The species is distinct from others in its genus and boasts intricate skeletons that may aid movement or protection.