A new technique, CLivD score, has been developed to improve liver fibrosis treatment. The study found that the CLivD score can identify at-risk individuals, reducing the need for further evaluation and streamlining screening. This approach holds promise for early detection of liver disease and preventing complications.
Researchers developed anti-CTLA-4 nanobodies that promote antitumor immune responses without inducing colitis in mice, advancing the development of next-generation CTLA-4 inhibitors. The study found that these nanobodies can activate a subset of regulatory T cells while preserving antitumor effects.
A new study reveals that people's expectations of being judged negatively by others are often miscalculated when revealing adverse information. In reality, recipients rate the revealers' honesty and trustworthiness more highly than expected. This finding suggests that secrecy may not have the negative impact we think it will.
Researchers found that less than two minutes of electrical stimulation targeting a precise area of the brain could increase participants' hypnotizability for about one hour. Highly hypnotizable individuals have stronger functional connectivity between the left dorsolateral prefrontal cortex and dorsal anterior cingulate cortex.,
Entanglement is crucial for quantum computing, and researchers have proposed a condition to maximize it. The study, published in Physical Review B, uses the Hellmann-Feynman theorem as a reference point to explore finite temperature and quantum critical points.
Researchers discovered novel functions for autophagy genes in controlling different forms of cellular disposal, including misfolded proteins. In nematode C. elegans, inhibition of early-acting autophagy genes extended lifespan and reduced protein aggregates, highlighting a new pathway in aging.
A new study challenges traditional male-focused autism research by revealing striking similarities in synaptic abnormalities and behavioral patterns between male and female mouse models. This finding emphasizes the necessity of considering both sexes to comprehensively grasp the complexities of autism spectrum disorder.
A comparative analysis of three communities surrounding the park found that social relations, local culture, and equity and rights were highly valued. However, fringe communities perceived the most negative impacts in all four dimensions, emphasizing the need for government support and attention to non-economic social impacts
A recent study by Leibniz-IZW and Philipps-Universität Marburg found that forest bats reduce their activity by 77% within a radius of 80-450 meters around operational wind turbines. The researchers suggest noise emission from turbine rotors is the primary cause of this avoidance behavior.
A recent study in Uganda found that asymptomatic individuals with low-level malaria infections had highly variable parasite dynamics and species present. Frequent sampling every other day or daily was sufficient to detect a proportion of infections similar to daily testing, but less frequent tests may miss up to one-third of cases.
A new study from Mass General Brigham researchers found that women who experienced more preconception stress had higher blood sugar levels during pregnancy, a predictor of current and long-term cardiovascular health. The study also discovered that socioeconomic status was associated with preconception stress and blood glucose levels.
A Brazilian study found that incomplete notification of snakebites and underreporting hinder public health actions. Researchers advocate for training health workers to recognize ophidic accidents and complete notification forms correctly.
A Washington State University study found that living near nature can reduce serious psychological distress and improve general health in older adults. Researchers analyzed data from over 42,000 people aged 65 and older, finding a strong association between access to green spaces and better mental and physical health outcomes.
A ground-breaking study published in Nature Communications sheds light on the intricate mechanisms underlying the virulence of Aspergillus fumigatus, specifically focusing on the crucial role of mycotoxin gliotoxin production. The research team identified pivotal roles played by GliT oxidoreductase and GtmA methyltransferase in the sel...
Studies reveal the evolutionary origin of unique traits in carnivorous pitcher plants, where a composite trapping mechanism emerged through 'spontaneous coincidence' of distinct structural, chemical, and mechanical innovations. Marine snails also evolved new biological functions through the recruitment of many alleles, challenging the ...
Researchers harness AI power to predict right ventricle issues from electrocardiograms, promising more innovative tools and improved patient outcomes. The study departs from traditional methods, predicting something not easily quantifiable by other common tests.
Research from Drexel University finds that customers are more likely to remain loyal to a grocery store when using regular checkout service. The perceived ease of checkout, sense of entitlement, and number of items purchased play a role in explaining the effect of loyalty.
Christoph Keller, a world-recognized astronomer, has been appointed as the next Director of the National Solar Observatory (NSO) succeeding Dr. Valentin Pillet. Keller brings extensive experience and expertise in solar physics to lead NSO into its exciting future.
A study published in iScience found that DEET can affect meiosis, leading to abnormal chromosome structure and reduced egg cell quality. This raises concerns about the potential reproductive effects of DEET-containing products in humans. Further research is needed to confirm these findings and inform recommendations for balancing disea...
A recent study found that liraglutide, a GLP-1R agonist, rapidly improves insulin sensitivity in individuals with obesity and pre-diabetes. Insulin sensitivity is crucial for controlling blood glucose levels, and improved sensitivity reduces the risk of developing Type 2 diabetes or improving its treatment.
MIT researchers successfully produced a miniaturized quadrupole filter using additive manufacturing, achieving precision comparable to commercial-grade filters at a fraction of the cost and weight. This breakthrough enables the development of portable mass spectrometers for rapid chemical analysis in remote settings.
A recent study published in Nature Communications found that Long-COVID patients experience fatigue due to reduced energy production by mitochondria in muscle cells. The research suggests a biological cause for the persistent exhaustion, opening up potential treatment avenues.
A recent study reveals that two-thirds of babies born with sickle cell disease are born in areas scoring high or very high on the scale of social vulnerability. This highlights the need for targeted efforts to support families affected by this genetic blood disease.
An international study classifies groundwater as a keystone ecosystem, emphasizing its critical role in sustaining both humanity and biodiversity. The researchers propose eight key themes for improved groundwater conservation to reduce biodiversity loss and counterbalance climate change.
Scientists studied the evolution of live-birth in marine snails and found that it happened gradually through small incremental steps. The team identified 50 genes associated with reproductive mode and estimated their origin time, showing that innovation can evolve progressively over time.
A new study from Chiba University introduces a novel system for evaluating muscle coordination and fatigue using bull's-eye electrodes. The system provides images of muscle activity at nine different points, enabling the assessment of muscle disorder due to fatigue.
This integrated study applies a new plate tectonics model to interpret major geological phenomena on Archean cratons, eliminating the illusion that continental crust did not originate from plate tectonics. The results provide insights into the evolution of early Earth and the origin of continental crust.
The Science journals have partnered with Proofig AI to detect image-related issues before publication. The adoption of Proofig AI positions authors to resolve image-related issues before a paper is published, ensuring the highest standards of accuracy in work published.
Researchers at UH are expanding research knowledge and building a new curriculum for students to address climate change impacts on food crops. They aim to improve plant growth and build resistance against extreme weather events, such as droughts and heat waves.
Researchers have developed a method to coherently tile multiple titanium:sapphire crystals together, breaking through the current 10-petawatt limit. This technology enables ultra-intense ultrashort lasers with high conversion efficiencies, stable energies, and broadband spectra.
A KAIST research team developed a new conductive polymer material that achieved both high electrical performance and elasticity, introducing the world’s highest-performing stretchable organic solar cell. The team built a device that can be stretched up to 40% during operation, demonstrating its applicability for wearable devices.
A team of researchers created five unique all-α protein structures with non-uniformly arranged α-helices, holding immense potential for designing functional proteins. The novel approach enables the generation of a diverse set of all-α protein structures by combining typical motifs and canonical α-helices.
Researchers have discovered a brain circuit that mediates panic disorder, consisting of specialized neurons that send and receive the neuropeptide PACAP. Inhibiting PACAP signaling reduces panic symptoms, offering promising findings for future treatments.
A study of 2,709 patients with limited English proficiency found higher sepsis mortality rates among certain racial and ethnic groups. The findings suggest a need for equitable care models to address language-based inequities in healthcare.
Researchers at EPFL have developed a novel CAR-T cell therapy that surpasses traditional methods by producing its own medicine to survive in tumor environments. The treatment has achieved a 100% success rate in clinical trials and shows potential for lowering production costs, making it more accessible for cancer patients.
The study introduces a novel dataset and evaluation system for aerial visible-to-infrared image translation, offering advantages in lower costs, higher efficiency, and enhanced downstream task performance. This technology has significant potential applications in surveillance, environmental monitoring, and disaster response.
Researchers from Fordham University partnered with Bronx schools to collect real-time air quality data through a citizen science project. The study highlighted the disproportionate impact of pollution on low-income communities and inspired students to develop an interest in science.
A pair of proteins YAP and TAZ have been identified as conductors of bone development in the womb. They help direct blood vessel integration into cartilage, a vital aspect of bone development, and may provide insight into genetic diseases such as osteogenesis imperfecta.
The American Physical Society's March Meeting will feature nearly 900 sessions and 11,000 individual presentations on various topics. The conference will be held in person in Minneapolis and online from March 3-8.
A team of researchers, led by Associate Professor Hiroyuki Fujioka from Tokyo Institute of Technology, investigated the feasibility of bound tetraneutron emission in thermal neutron-induced fission of Uranium-235. They found that the instrumental neutron activation method can be applied to address open questions in nuclear physics.
A new study from Sylvester Comprehensive Cancer Center suggests that prophylactic treatment can significantly reduce the rate of cytokine release syndrome (CRS) in multiple myeloma patients. This approach could eliminate hospital stays and broaden access to immunotherapy treatments for more cancer patients.
A team of scientists identified VAP as a molecular anchor that stabilizes mitochondria near synapses in dendrites, supporting memory formation and plasticity. The discovery links VAP to ALS-linked protein and suggests that mitochondrial stabilization is critical for neuronal function and health.
Researchers have identified brief seizures accompanied by muscle convulsions as a potential cause of sudden, unexpected deaths in young children. A study analyzed data from over 300 SUDC cases and found that five out of seven recordings showed direct evidence of seizures before the child's death.
Research reveals bacteria in human gut use diverse enzymes to generate energy from organic compounds, producing metabolites with implications for human health. The study identifies 22 alternative metabolites used by three families of gut bacteria, showcasing their remarkable adaptability.
A recent US study challenges the notion of a replication crisis in psychology, arguing that flawed intuition and low power in replication studies are to blame. The researchers propose using formal models to estimate expected replication rates, rather than relying on intuitive assumptions.
Researchers analyzed five decades of US data, finding climate conditions and soil productivity key factors affecting honey production. Herbicide application and land use also contributed to declines in honey yields.
Researchers discovered 50 genetic changes underlying the switch from egg-laying to live-bearing in marine snails, which evolved within the past 100,000 years. The findings provide insights into the evolutionary process and potential benefits of live-bearing, including increased reproductive success in new habitats.
Researchers discovered a link between PPFIA3 dysfunction and a rare neurodevelopmental disorder. The study identified 17 unique variants in the PPFIA3 gene, which cause delayed development, intellectual disability, and other symptoms.
Researchers found that mutations in IDO2 can affect dopamine release and lead to ASD-like behaviors. IDO2 KO mice exhibited changes in microglia populations, which may contribute to synaptic abnormalities.
Scientists have mapped neuroblastoma tumors at the cell level and discovered a brake on the immune system that can be blocked with existing immunotherapy. A new combination treatment targeting TIGIT and PD-L1 is being developed, showing promising results in lab experiments.
Researchers developed mathematical models based on real events data from the Swedish Trauma Registry, showing that AI models outperformed clinical outcomes. The study highlights the potential of AI-powered decision support to improve ambulance staff's ability to assess injury severity and potentially save more lives.
Researchers used data from Hubble Space Telescope to determine the true colors of Neptune and Uranus, revealing they are a similar shade of greenish blue. The main difference is that Neptune has a slight hint of additional blue due to a thinner haze layer on that planet.
A large-scale German-wide randomized controlled trial found that high-dose therapy with glucocorticoids is not more effective than standard treatment for sudden hearing loss. However, it was associated with a higher risk of side effects. Several hundred thousand people worldwide suffer from sudden hearing loss each year.
Researchers established a molecular link between specific B12-producing gut bacteria and acetylcholine production in C. elegans, a neurotransmitter important to memory and cognitive function. A diet rich in these bacteria reduced seizure-like behavior in mutant worms by restoring excitatory/inhibitory balance.
Researchers have developed a new approach to creating liquid-crystal phase modulators that are polarization-independent and can achieve large phase depths. The devices use a light-controlled azimuth angle (LCAA) process to create multi-microdomain, orthogonally twisted structures with precise alignment.
A new study from the University of Illinois finds that high-striving minority youth in early adolescence may experience accelerated puberty development, a potential indicator of 'skin-deep resilience,' which can lead to physiological changes such as inflammation and metabolic disorders.
Scientists have made significant progress in understanding ultrafast electron dynamics by tracking the motion of electrons released from zinc oxide crystals using laser pulses. The research team combined photoemission electron microscopy and attosecond physics technology to achieve temporal accuracy, enabling them to study the interact...
Researchers from UC San Francisco have found that Paxlovid treatment does not reduce the risk of developing long COVID. They also discovered a higher proportion of individuals with acute symptoms rebounding after treatment, and those who took Paxlovid were just as likely to develop severe Long COVID symptoms as those who did not.
The UC San Diego Center for Learning Health Systems Science will provide training for clinicians and researchers in the emerging field of learning health systems science. The center aims to improve patient outcomes, enhance healthcare efficiency, and increase diversity in the workforce.
A recent study investigates how deceased individuals' consent affects societal acceptance of digital resurrection. The research found that explicit consent increases acceptability by two points, while 59% of respondents disagree with their own digital resurrection, highlighting the need for clear legal regulations on the subject.