Astronomers have discovered a sulfurous atmosphere on the smallest and coldest exoplanet known, providing clues to its formation process. The planet's unique orbit and composition offer insights into how planets are created.
Pristimerin selectively targets thioredoxin reductase, inducing apoptosis and inhibiting tumor growth. ROS accumulation triggers oxidative stress, leading to targeted destruction of cancer cells.
A study found that pay-for-performance incentives increased home dialysis use and kidney transplant rates. The End-Stage Renal Disease Treatment Choices model did not associate these outcomes with changes in racial or socioeconomic disparities.
A new study suggests that baby-led weaning, a method of introducing solid foods to infants through self-feeding, can meet nutritional needs and promote healthy growth. The study found that baby-led weaning was associated with higher weight-for-age and weight-for-length scores compared to conventionally weaned infants.
FM0807 reduces blood glucose levels, improves liver function, and decreases kidney damage in diabetic mice. The compound also inhibits inflammatory markers and alters SMAD2/3 expression, suggesting a protective role in regulating JAK2/STAT3 and TGF-β1/SMAD2/3 signaling pathways.
Fine roots' lifespan varies across tree species, with evolutionary history playing a key role in shaping global patterns. Phylogeny, root traits, and environmental factors regulate fine root lifespan, with gymnosperms having longer lifespans than angiosperms.
A six-year study found that consuming diets more closely aligned with the Mediterranean and DASH diets can lower levels of harmful blood markers and reduce cardiovascular disease risk. These dietary patterns emphasize plant-based foods, healthy fats, lean proteins, and low intake of processed foods and sugars.
A recent study published in the American Society for Nutrition reveals that focusing on minimally processed foods does not guarantee a nutritious diet. The research found that even with lower processing levels, diets can be high in unhealthy components and low in nutritional value.
Researchers propose using ultrashort laser pulses to generate terahertz radiation by accelerating electrons and stopping them in a dielectric layer. The proposal aims to increase the efficiency of photo emissive coatings to scale up such sources.
During the COVID-19 pandemic, low-income adults experienced improved health care affordability, resulting in reduced income-based disparities. Prescription medication affordability also increased across all income groups, suggesting a potential widening of existing inequities if safety-net policies are unwound.
Between 2013 and 2023, private equity firms acquired 41 outpatient cardiology practices, corresponding to 342 clinic sites. The study highlights the critical need to monitor the effects of private equity acquisitions on quality of care and outcomes for patients with cardiovascular disease.
A new study found that eating baby carrots just three times a week significantly increased skin carotenoid levels in young adults. The combination of baby carrots and a multivitamin containing beta carotene also showed an interactive effect on skin carotenoid accumulation.
A large study found that older adults consuming higher amounts of ultra-processed foods were about 10% more likely to die over a median follow-up of 23 years. Higher intake was associated with modest increases in death from any cause and heart disease, but not cancer-related deaths.
A new imaging technique developed at Memorial Sloan Kettering Cancer Center shows promise for detecting deadly forms of lung and prostate cancer. The technology targets DLL3, a ligand found on cancer cells, making them more visible on PET scans.
A new study reveals that a type of desert moss called Syntrichia caninervis has the potential to grow on Mars due to its ability to tolerate extreme temperatures, radiation, and dehydration. The researchers tested the moss's resilience in various conditions and found it to be one of the most radiation-tolerant organisms known.
A new study found that claustrum neurons regulate engagement with sensory information during tasks and sleep. Increased activity in these neurons reduces impulsivity and improves performance.
A new study finds that single-payer financing based on the current federal income tax schedule can increase progressivity of household payments. Rate setting led to slight increases in payments for higher-income households, while spending growth targets reduced payments slightly across all income groups.
Researchers have discovered compounds that convert the Bcl-2 protein, which protects cancer cells, into a tumor killer. The findings open the door to promising therapies for breast cancer and other malignancies that rely on Bcl-2 to evade treatment and develop drug resistance.
Ephemeral streams are a substantial pathway for water transfer with significant implications for water quality, transporting pollutants and sediments to rivers and lakes. A recent study found that these streams account for over half of annual discharge from U.S. drainage networks, highlighting the need for enhanced regulation.
A new mouse study suggests that elenolic acid can lower blood sugar levels and promote weight loss in obese mice with diabetes. The compound was found to induce the release of metabolic hormones GLP-1 and PYY, leading to improved glucose regulation and insulin sensitivity.
A recent study published by American Society for Nutrition found that paternal fish oil supplementation can lead to lower body weight and improved metabolic health in offspring. Researchers gave male mice a high-fat diet with or without added fish oil, then mated them with female mice on a healthy low-fat diet.
A recent study found that nearly half of those who lost Medicaid coverage during the Medicaid unwinding process were left uninsured by late 2023. The researchers also discovered that individuals who had been disenrolled reported significantly worse access to healthcare, including more cost-related delays in care and less affordability.
Research findings suggest that higher intakes of calcium and zinc before conception can lower the risk of hypertensive disorders during pregnancy. Participants with higher pre-conception intakes of these essential minerals were 24% less likely to experience hypertensive disorders compared to those with lower intakes.
A survey study found that 6 months into Medicaid unwinding, 1 in 8 beneficiaries reported exiting the program, with wide state variation. Many who lost coverage experienced gaps in care, and adults exiting Medicaid faced more difficulties accessing healthcare services than those remaining enrolled.
Researchers at USC Keck School of Medicine discovered that a low-salt diet can stimulate kidney regeneration and repair in mice by targeting the macula densa region. This finding holds promise for developing a new therapeutic approach to treat chronic kidney disease, which affects millions worldwide.
Researchers found major differences between postmortem and living prefrontal cortex brain tissues, with higher levels of RNA editing in postmortem tissues. These discoveries will shape the development of diagnostics and therapies for brain diseases, highlighting the need to study both living and postmortem samples.
A new study found that engaging in meaningful social interactions with peers is associated with lower loneliness and greater affective well-being. The research also highlights the importance of context in these interactions, suggesting that online or offline settings have a positive impact on well-being during lockdowns.
Researchers have designed prototype devices for layer filters, valves, and reversers using layer-polarized chiral topological domain wall modes in MnBi2Te4. These devices offer a theoretical basis for establishing layertronics with dissipationless manipulation of layer degree of freedom.
A study predicts that tropical rains will shift northward in the coming decades, impacting regions such as central Africa, northern South America, and Pacific island states. The shift is caused by changes in the atmosphere spurred by carbon emissions, which would have significant effects on agriculture and economies.
Researchers developed electrochemical molecular imprinting technology to enhance Li-S battery performance by creating tailored defects in metal sulfides. The approach promotes selective binding to target products, increasing energy density and cycle stability.
A recent study published in JAMA found that transgender women on hormone therapy have drastically lower PSA levels, which may lead to delayed diagnosis and treatment of prostate cancer. The researchers analyzed Veterans Health Administration records and recommended caution when interpreting PSA values in transgender women.
Research highlights occupational nerve injuries as a predictable mechanism, often caused by compression, stretch, vibration, and repetitive muscle movements. The study aims to equip clinicians with understanding of biomechanical factors that interact with anatomy to damage nerves.
A new study creates a framework to reduce confusion around fish consumption during pregnancy and provide clearer guidance on risks and benefits. The research found that consuming low-mercury fish was beneficial, while high-mercury fish was detrimental to neurodevelopment.
A national survey found that 61% of Americans are unaware that primary care physicians can prescribe medications for opioid use disorder. Despite recent policy changes, barriers to accessing these medications remain. Increasing public awareness and education is crucial to improve access to treatment.
Researchers used drones to map loko iʻa at the community level, providing insights into flooding and future sea level rise impacts. Drones accurately estimated observed flooding during extreme high tide events, while LiDAR models overestimated flooding by two to five times.
A new compact scheme for coherent beam combining is developed to deliver high average power femtosecond lasers at 2.0 μm, overcoming the limitations of previous systems. The scheme achieves an efficiency of ~81% and generates pulses with peak powers up to 4 MW.
Researchers found that a live biotherapeutic product CBM588, when taken orally, can improve health outcomes in people with metastatic kidney cancer. The study, published in Nature Medicine, suggests that the agent may enhance effectiveness of FDA-approved cancer immunotherapies by adjusting the gut microbiome.
Researchers explore the feasibility of deep learning models in segmenting lesions on PET/CT images to improve salvage radiation therapy planning for prostate cancer. The study demonstrates promising potential to reduce inter- and intra-observer variations, leading to more accurate treatment outcomes.
A new Europe-wide clinical framework aims to collect high-quality biological samples from patients, enabling researchers and clinicians to understand the genetic, biological, and other factors involved in childhood bone cancer. This will guide the development of tailored treatments for each patient's cancer type.
Researchers estimate that between 280 to 360 meteorites strike Mars each year, forming impact craters greater than 8 meters across. The study uses seismic data from the NASA InSight Mission to make this estimate, which is five times higher than previously thought.
Researchers successfully increase inner ear synapses in young mice to produce supranormal hearing, supporting a hypothesis on the cause of hidden hearing loss in humans. The study suggests that preserving or increasing synapses may improve auditory processing and offer new treatment options for certain hearing disorders.
Researchers from Aarhus University have discovered that combining a cancer-fighting viral agent with the drug 4-Octyl-Itaconate (4-OI) enhances its effectiveness in treating resistant cancers. This groundbreaking finding may lead to new treatment options for previously incurable diseases.
A pilot study found that remote cognitive rehabilitation using TELE-Self-GEN improved memory performance and daily life functionality in individuals with MS. The virtual intervention demonstrated high levels of participant satisfaction and effectiveness.
Researchers explored Cognizin Citicoline's effects on neurons, astrocytes, and microglia, revealing its potential as a supplement for cognitive decline. The study's findings suggest that Cognizin Citicoline may support brain health and cognitive function.
Researchers develop an artificial fusion protein combining UndB with catalase, creating a whole cell biocatalyst that converts fatty acids to alkenes with high efficiency. The biocatalyst produces pure 1-alkene as a valuable biofuel and can be used to generate a large number of hydrocarbons.
Researchers developed a new model to assess the risks and benefits of fish consumption during pregnancy. The model considers average mercury content in consumed fish, indicating that low-mercury fish intake is beneficial for neurodevelopment, while high-mercury fish consumption is detrimental.
Scientists have discovered tiny, bright objects in the early universe that are packed with hundreds of millions of years old stars, defying conventional thinking about galaxy evolution. The objects also harbor surprisingly large supermassive black holes, estimated to be 100 to 1,000 times more massive than our Milky Way's black hole.
Researchers at Moffitt Cancer Center have developed a groundbreaking synthesis method for producing withanolides, a class of compounds that inhibit cancer cell growth and induce cell death. The scalable production of these compounds will advance cancer research and treatment development, offering new hope for patients.
Researchers uncover the plant's sophisticated genetic adaptations, including a whole-genome duplication event that bolstered its cold tolerance and other alpine-specific survival traits. The discovery provides valuable insights into the genetic basis of alpine adaptation and could inform agricultural practices in challenging environments.
A new system using on-pack pH indicators provides a direct visual cue of meat quality, overcoming traditional best-before labels. The study presents an innovative trio of pH indicators, designed to offer a visual assessment of raw beef freshness in modified atmospheric packaging (MAP) conditions.
South Korean researchers have successfully developed technology to mass-produce quantum dot lasers, widely used in data centers and quantum communications. The ETRI Optical Communication Components Research Section has developed indium arsenide/gallium arsenide (InAs/GaAs) quantum dot laser diodes on gallium-arsenic (GaAs) substrates.
A newly developed deep learning algorithm has outperformed existing methods in predicting osteoporosis risk, potentially leading to earlier diagnoses and better outcomes. The model identified key factors such as weight, age, and grip strength as significant contributors to osteoporosis risk.
Researchers found that AI models that analyze medical images can predict patient demographics with high accuracy but struggle to diagnose patients from diverse backgrounds. The models use demographic shortcuts, leading to incorrect results for women, Black people, and other groups.
Researchers develop mechanobiomaterials inspired by biomechanics to modulate biological responses with material-tissue mechanical interactions. This approach aims to create biomaterials that can adapt to changing mechanical environments in vivo, enhancing the body's regenerative potential and repairing various tissues.
A recent study proposes a multi-dimensional approach to map disease relationships using genomic, chemical, and clinical data. The research reveals significant distinctions from the classical International Classification of Diseases system and highlights potential links between previously separate conditions.
Researchers at Weill Cornell Medicine have identified cellular and molecular markers that can predict when pancreatic cancer will spread to the liver or other organs. The study found that patients with early-stage pancreatic cancer who showed signs of immune exhaustion were more likely to develop liver metastases.
Researchers at Helmholtz-Zentrum Berlin have successfully generated coherent, high-power light using ultrafast electrons in storage rings. By reducing the electron bunch length below the wavelength, they created a source with outputs of several kilowatts.
A team of researchers has completed the diploid genome assembly of the Malbec grapevine, revealing the genetic factors that contribute to its exceptional wine quality. The study identifies polymorphic regions and gene expression differences among clones, shedding light on the molecular mechanisms driving clonal variation.
Carbon nanotube fibers exhibit excellent mechanical properties, surpassing traditional ballistic fibers in terms of dynamic strength and energy absorption. The innovative multiscale structural optimization strategy achieved a breakthrough in both quasi-static and dynamic strength.
Researchers suggest eyed needles were used for adornment, signifying the transition from utilitarian to social purposes in clothing. The innovation allowed for more complex, layered clothing and decorative items, marking a significant shift in human attire.