A new class of antivirals called Pin1 inhibitors has shown promise in reducing or stopping outbreaks of herpes simplex virus-1 (HSV-1), the common infection behind oral herpes. By stabilizing nuclear membrane structure, Pin1 inhibitors physically trap the virus in the cell nucleus, preventing it from escaping.
The study reveals geographic clusters of high and low screening for breast, cervical, and colorectal cancers in the US Northeast and Southwest. Future studies could examine county-level healthcare access to optimize cancer screening practices.
The Europlanet 2024 Research Infrastructure project has shown that robust evaluation and networking lead to better science and long-lasting collaborations. The project resulted in over 250 publications and conferences, with mentoring programs and expert exchanges supporting early-career researchers.
Researchers at KAIST have developed a core AI semiconductor technology called PIMBA, which combines the Transformer's intelligence with the Mamba's efficiency. This technology results in a four-fold increase in inference speed and a 2.2-fold reduction in power consumption for Large Language Models.
Researchers developed a mangrove leaf-inspired upward-hanging evaporator using 3D photothermal spacer fabric for zero-liquid-discharge desalination, enabling sustainable freshwater production. The system achieves high evaporation rates while simultaneously recovering salt, offering a promising solution for global freshwater demand.
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
A potential new drug called RBM20-ASO has been shown to improve cardiac function in a mouse model of heart failure with preserved ejection fraction (HFpEF). The therapy reduces left ventricular stiffness and abnormal thickening of the heart muscle, even in the presence of comorbidities.
OHSU researchers have developed a unique proof of concept to treat infertility by turning skin cells into eggs capable of producing early human embryos. The technique, known as mitomeiosis, combines the processes of mitosis and meiosis to create gametes.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
A recent study found that cannabis may reduce opioid use among commercially insured patients with cancer diagnoses, indicating potential benefits for pain management. However, further research is needed to confirm the efficacy of cannabis as a treatment for cancer-related pain.
Researchers discovered a 5,500-year-old ceremonial site at Murayghat in Jordan, featuring clusters of dolmen remains and large megalithic structures. The site suggests that early societies coped with disruption by building monuments and redefining social roles.
Scientists at UCL have engineered γδT cells to kill slow-growing bowel cancer cells resistant to chemotherapy. The supercharged cells outperformed regular cells, surviving longer and killing cancer cells even when they couldn't be targeted by chemotherapy.
A team of researchers from Yokohama National University has developed a novel compact superconductive neuron device that operates at high speeds with ultra-low power consumption. The device eliminates variation in elemental circuit characteristics, achieving ideal input-output characteristics and resolving the vanishing gradient problem.
Researchers have developed microscopic nanoparticles that can seek out and attach to damaged liver cells, helping to stop disease progression. The nanoparticles are engineered to recognize and selectively bind to a protein found only on Kupffer cells in the liver, promoting anti-inflammatory behavior and delivering medicine directly to...
A recent study by AWI suggests that the Southern Ocean's ability to absorb CO2 has remained unchanged despite climate change, due to increased density stratification between surface and deep water masses. This 'freshening' of surface water keeps carbon-rich deep water trapped in the lower layer.
A recent study found that most users cannot identify AI bias in training data, unless it affects their own group. Researchers created 12 versions of a prototype AI system to detect facial expressions and tested how users might detect bias in different scenarios.
Researchers at Tohoku University propose a way to detect dark matter using highly sensitive quantum devices connected in network structures. This approach outperforms traditional methods and has potential applications beyond dark matter searches.
Researchers developed a novel dual single-atomic catalyst converting nitrate to nitrogen gas with exceptional efficiency, achieving 92.8% nitrate removal and 95.2% nitrogen selectivity. The FeNC@MgNC-DMCS catalyst demonstrates remarkable stability in long-term flow cell operation.
Researchers used five advanced LLMs to assess their logical reasoning capabilities and found that they consistently complied with requests for false medical information. Targeted training and fine-tuning improved LLMs' abilities to respond to illogical prompts accurately, but challenges remain in aligning models to every type of user.
Researchers used a new high-resolution mapping technique to find small 3D loops connecting regulatory elements and genes that persist during cell division. These loops strengthen when chromosomes become more compact, potentially helping cells 'remember' interactions from one cell cycle to the next.
Duke University researchers have developed a printing technique that can create fully functional and recyclable electronics with features as small as tens of micrometers. This breakthrough has the potential to significantly reduce the environmental impact of the $150 billion electronic display industry.
Researchers at King Abdullah University of Science and Technology have achieved a new benchmark in integration density and efficiency by stacking six semiconductor transistors. This feat enables larger area electronics while maintaining performance, opening possibilities for flexible electronics and the Internet of Things.
A new study finds that visceral and hepatic fat are strongly linked to carotid artery thickening and clogging, increasing cardiovascular risk. Hidden fat can silently increase heart disease risk even in people who appear healthy.
Researchers developed sulfated yeast to adsorb targeted elements from solutions, absorbing 2.3 times more copper than previous phosphate-modified baker's yeast. The new method effectively desorbs and re-adsorbs metals using hydrochloric acid, providing a sustainable solution for rare earth recovery.
Researchers at Newcastle University found that Tofacitinib, a Janus kinase inhibitor, increased leg muscle volume in patients with rheumatoid arthritis. Muscle volume increased by an average of 242 cm3 after 6 months, reversing sarcopenia in some participants.
A Simon Fraser University study confirms that women's running shoes are not designed for female runners, prioritizing comfort, fit, and injury prevention. Researchers found that shoe designs shift over time with age and pregnancy, and competitive runners seek performance-enhancing features without sacrificing comfort.
A new AI-based risk assessment tool, GRACE 3.0, has shown better predictability of future risk for heart attack patients compared to traditional methods.
The research team created a directional radiative cooling thermal protective window by integrating a visible transparent broadband directional emitter and Low-E film with commercial PC windows. The window features high visible transparency and low emissivity, making it effective at reflecting thermal radiation and preventing heat absor...
A team of researchers from the University of Otago has developed algorithms that enable centimetre-level positioning in smartwatches. This breakthrough uses the Google GnssLogger app and combines precise signals from global navigation satellite systems.
Researchers have introduced a new theoretical framework that enables the confinement of light to extreme scales in lossless dielectric materials. Narwhal-shaped wavefunctions, discovered through singular dispersion equation, trap light at sub-diffraction volumes.
Researchers at Edith Cowan University have developed a new way to measure biological age using AI, combining IgG N-glycome and transcriptome data. The method, called gtAge, predicts age with high accuracy and links to health markers, offering potential for early detection of age-related diseases.
Scientists found that CtBP2 levels decrease with age, but are higher in long-lived individuals. This biomarker may estimate the degree of aging and overall health status.
A new AI-based method optimizes the operation of solar power generation and battery storage systems, reducing imbalance penalties by approximately 47% compared to conventional control methods. The method maintains stable profits throughout the four seasons and can handle real-world uncertainties such as sudden weather changes and compl...
A study at Kyoto University found that nearly half of Japanese medical students and residents held misconceptions about diabetes, such as a genetic cause or shorter life expectancy. The research suggests that clinical lectures may not be enough to address the stigma, highlighting the need for improved medical education curricula in Japan.
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
Researchers have discovered that deep sleep plays a crucial role in controlling cerebrospinal fluid dynamics, which is essential for clearing waste from the brain. During slow-wave sleep, changes in cerebrospinal fluid signals are time-locked to slow brain waves and other neural events.
An international research team has proposed a more open and transparent platform for comparative climate research, allowing researchers from diverse regions to participate. This may lead to more balanced scientific basis for global climate policy, with increased consideration of developing countries' perspectives.
A new meta-analysis of 125 studies reveals that adding biochar to composting systems boosts compost quality and slashes harmful greenhouse gas emissions by up to 51%. Biochar improves aeration, holds nutrients, and creates a favorable habitat for beneficial microbes, accelerating the composting process.
A recent study suggests that combining rewetting with biochar and iron sulphate additions can significantly slow down carbon loss from drained agricultural peat soils. This combination enhances carbon storage by suppressing soil enzymes and promoting the formation of iron-bound carbon compounds.
Cancer cells hijack embryonic gene editors to drive rapid growth and adaptation. Researchers discovered that cancer cells activate early developmental splicing factors to create embryo-like potential. This finding may lead to new treatments by detecting splicing factor changes or targeting specific editing tools.
A landmark study analyzed health data from over 600,000 patients across 10 countries to assess patient risk for non-ST-elevation acute coronary syndrome (NSTE-ACS). The AI-powered model GRACE 3.0 predicts risk more accurately and guides personalized treatment decisions.
Researchers have created a new model that shows how planet formation timing influences planetary composition and density. The study suggests that older, rocky planets are less dense than younger ones due to the varying lifetimes of stars.
This study introduces a novel kinetic control strategy to modulate supramolecular dissociation kinetics, enabling the regulation of dissociation rates over a wide range. The researchers found that steric hindrance controls supramolecular dissociation kinetics and material properties, resulting in stable networks with improved mechanica...
Researchers have discovered a new twist on a classic material that can advance quantum computing and make modern data centers more energy efficient. By reshaping barium titanate into ultrathin strained thin films, the team improved the conversion of signal-carrying electrons into signal-carrying photons by over ten times.
A study published in Water Resources Research reveals that human groundwater pumping has depleted Tucson-area aquifers more than natural climate variation over the past few decades. The research team reconstructed groundwater ages, recharge rates, and water table depths using chemical and isotopic markers.
Researchers discovered that bats in full sun bat boxes can warm to temperatures exceeding 50°C while sleeping, leading to dehydration and death. Providing bats with a choice of roosts in the same location, some constructed for stable temperature and others for quick cooling or warming, could help prevent this risk.
Researchers found that caregivers often change safe sleep practices for infants when they are ill, which can increase the risk of sudden unexpected infant death. The study's findings emphasize the need for targeted interventions to reinforce safe sleep practices during illness.
A team of researchers from NASA Goddard and Penn State found that fragments of molecules from E. coli bacteria can survive for over 50 million years in pure water ice, but degrade faster in mixed soil samples. This suggests that future Mars missions should target locations with pure ice or ice-dominated permafrost to search for life.
A new study from Yale University proposes a new model for the Earth's magnetic field that finds structure in its variability, rather than dismissing it as chaotic. By analyzing Ediacaran rocks, researchers have found an ordered geometry with shifts in the planet's magnetic poles that appear to have tumbled all the way around the planet.
161 Otago scientists named among the world's best, with Professor Christine Winterbourn at number 1578 and others in various fields. The recognition highlights the strength of science research at the University, with notable achievements in biology, microbiology, food science, and more.
A Brazilian city was effectively protected against dengue by introducing a bacteria called Wolbachia into the local mosquito population, significantly lowering dengue incidence. The program, led by Monash University and the World Mosquito Program, resulted in a nearly 90% reduction in dengue cases.
Mikkael Sekeres has been elected to the Executive Committee of the American Society of Hematology (ASH), a four-year term starting after the 2025 ASH Annual Meeting. He will help strengthen the organization's mission in shaping the future of hematology.
Researchers at University of Hawaiʻi at Mānoa identified Caulobacter inopinatus, a previously unknown species found in seawater collected near Oʻahu's south shore. The discovery highlights the connection between land and sea ecosystems through microbial exchanges.
University of Oklahoma researchers suggest creating a trust fund to increase and sustain funding for the Indian Health Service, addressing chronic underfunding that has led to health disparities among Indigenous populations. The proposed trust fund model is similar to the Vaccine Injury Compensation Trust Fund and aims to generate ongo...
Researchers at Penn State developed a tool to analyze seismic activities linked to Arctic sea ice movements, providing insights into ice characteristics and interactions. The new approach can help coastal communities assess threats from drifting sea ice, such as erosion and wave creation.
Dr. Benjamin P. Brown proposes a targeted approach to improve the accuracy and speed of machine learning in drug discovery. His work focuses on creating a more generalizable deep learning framework for structure-based protein-ligand affinity ranking.
A new AI model developed by researchers at Penn State has shown promise in accurately counting a child's bite rate, a potential indicator of obesity risk. The system is currently about 70% as successful as human bite counters, but holds potential for identifying children who need to slow their eating rate and adjust their diet.
A new study found that the growing age imbalance in the duty solicitor scheme risks eroding trust in the criminal justice system. The study warns of a looming generational crisis due to the financial burden of self-funding Solicitors Qualifying Examination fees, which is deterring younger solicitors from entering the profession.
The American Heart Association has launched a new grant program to equip 40 high school and college Heart Clubs with CPR training and resources. This initiative aims to double survival rates from cardiac arrest by 2030 and empower students and educators to learn lifesaving skills.
The American Heart Association and NFL team up to boost CPR readiness, with 30 NFL player ambassadors promoting the lifesaving skill. Millions of people now understand the critical importance of being prepared for sudden cardiac arrest.