Researchers at University Medical Center Utrecht have discovered new genetic abnormalities associated with ALS, improving understanding and providing leads for targeted treatments.
The project brings together eight perspectives to develop tools for documentation, legal clarity and traceability, supporting lawful activity and enforcement.
Researchers at UW–Madison identified a way to program longer-lasting T cells, which can recognize more stable parts of viruses and offer a path to broader protection. The new strategy has the potential to provide longer-lasting immunity against respiratory infections like the flu and COVID-19.
Researchers developed a new way to generate stable signals of light using microscopic ring-shaped devices, enabling the production of optical frequency combs. This technology has the potential to simplify system design and improve efficiency in high-speed optical communications for data centres.
A simple ECG test can identify racehorses at risk of cardiac arrhythmias during high-intensity exercise. The test uses short ECG recordings taken at rest or light exercise to distinguish horses likely to develop premature beats.
A new twin study reveals that innate IQ is a key predictor of future socio-economic status, with genetics playing a significant role. The study found that IQ is approximately 75% genetically predicted and that socio-economic status is mostly explained by genetics.
A study published in eLife found that adolescents focus more on their own interests compared to adults when navigating social dilemmas. The researchers recruited 261 participants, aged 14-17 and 18-30 years, to play a repeated cooperation game called the Prisoner's Dilemma Game.
The American Thoracic Society has received a $50,000 donation from William Martin, MD, and his wife Joyce, to support the Public Advisory Roundtable (PAR), which aims to prioritize patients' experiences in ATS activities. This gift will help PAR elevate patient care and inform research endeavors to improve lung health worldwide.
A team of researchers at Kyoto University found that cooperative breeding in Lake Tanganyika's lamprologine cichlids first emerged around 4 million years ago. The study reveals a link between cooperative breeding and smaller body sizes, as well as reduced clutch size.
Researchers have discovered a remarkably well-preserved iron-smelting workshop in eastern Senegal that dates back to the 4th century BCE. The site, which was used for nearly eight centuries, provides new insights into late prehistoric metallurgical practices in Africa.
Researchers at Aalborg University aim to identify biological changes driving disease development with a comprehensive pre-diagnostic study of early Crohn's disease. They will analyze thousands of blood samples from patients prior to diagnosis to develop a predictive model.
The PerQdisc procedure, a less-invasive treatment option, preserves the outer part of the disc, maintaining mobility and restoring functionality. Dr. Luis Tumialan's first patient experienced significant pain relief and was able to resume normal activities shortly after the procedure.
Dr. Cameron J. Gettel receives the Jeffrey H. Silverstein Memorial Award for his work advancing emergency care for older adults, improving care transitions, and reducing financial burden of acute care. He is recognized as an emerging national leader in geriatric emergency care.
A review of international studies found that regular physical activity, a Mediterranean-style diet, and stress management can help reduce endometriosis-related pain and improve quality of life. The study also introduces the fasting-mimicking diet as a potential approach for managing gynecological conditions.
Researchers tracked movement, acceleration, depth, and water temperature for nine hammerheads in Florida and the Bahamas waters. They found great hammerheads can effectively hunt fast-moving prey like blacktip sharks in winter and tarpon in summer, suggesting they may tolerate changing climates better than other species.
Researchers from KIT and Chile are testing direct extraction methods to access critical raw materials like lithium in brine deposits, reducing energy consumption and environmental impact. The BRIDGE initiative aims to develop more benign and efficient processes, with potential applications in Europe.
A study from NTNU found that pupils who believe they can improve through effort also enjoy their subjects more and perform better at school. This attitude is linked to well-being, perceived mastery, and grades in Norwegian and physical education.
Researchers developed an AI model that can detect several neurodegenerative diseases, including Alzheimer's and Parkinson's, from a single blood sample. The model uses protein measurements from over 17,000 patients and outperforms previous models.
A new study by University of East London researchers reveals that women are being shut out of workplaces due to a hidden time gap caused by unpaid care and rigid social expectations. This 'time squeeze' leaves women with less time for networking, training, and progression, hindering their career advancement.
Researchers developed an interpretable machine learning algorithm, scOMM, to classify cell types consistently across different single-cell methods. The integration strategies and scOMM establish a robust approach for cell atlas generation in complex tissues, leading to the discovery of previously undetected rare cell types.
The study measures the temporal duration of individual pulses of bright squeezed vacuum (BSV), a unique quantum state of light. Each BSV pulse lasts just around 27 femtoseconds, placing it firmly in the ultrafast regime.
A Johns Hopkins study reveals that cysteine metabolism shapes CD8+ T-cell function, with implications for boosting cancer-killing immune responses. Limiting cysteine in laboratory models enhanced anti-tumor immunity but impaired T-cell expansion and weakened anti-tumor activity.
Researchers have developed a compact chemiresistive biosensor that directly transduces biochemical reactions into electrical signals, detecting creatinine concentrations from 1 to 300 mg/dL with high sensitivity and selectivity. The sensor's two-electrode design eliminates the need for reference electrodes and operates in just 35 seconds.
A new genetic 'roadmap' provides a navigational framework for more precise diagnosis and treatment of intrahepatic cholangiocarcinoma. The framework identifies five molecular subtypes, each associated with distinct therapeutic vulnerabilities, enabling targeted treatment strategies.
A new study warns of a 20-year window to act on climate and land use policies to prevent further biodiversity loss in Britain. Sustainable practices like strong emissions action and reduced meat consumption could save up to 69 fewer species from extinction.
T-DNA-free genome editing technologies enable precise, transgene-free crop modification, reducing biosafety concerns and increasing public acceptance. These innovative strategies leverage visual screening systems, genetic self-elimination, transient expression, and delivery mechanisms to accelerate crop breeding.
A nationwide Japanese trial found that catheter ablation did not reduce the risk of recurrent stroke or major cardiovascular events in patients with atrial fibrillation who had recently experienced a stroke. The study, which enrolled 251 patients and followed them for over three years, suggests that routine addition of catheter ablatio...
Researchers find that investing in climate adaptation can coexist with fiscal stability, but institutional quality and interest costs play crucial roles. The study analyzed data from 172 countries between 1995 and 2020 and found no structural conflict between the two goals.
The study achieves stable welding between sapphire and Invar under non-optical-contact conditions, with a maximum shear strength of 11.73 MPa. High-speed imaging techniques reveal the coupling of linear absorption and nonlinear absorption at the interface, sustaining plasma and energy deposition.
Researchers developed a scalable strategy for fabricating large-area electrochromic smart windows using tungsten oxide films, enabling practical industrial production. The technology reduces building energy consumption by up to 140.0 MJ m−2 compared to conventional windows, showcasing significant energy-saving potential.
Researchers developed a wearable scent display that can blend up to eight fragrances in real time, enhancing immersive virtual experiences. The device uses advanced components to precisely control odor intensity and delivery.
Recent breakthroughs improve transformation efficiency and broaden transformable crops, supporting global food security. Emerging strategies enhance plant regeneration and gene delivery via biologically mediated and non-biological methods.
Advanced AI models outperform clinicians in certain pediatric diagnostic tasks, especially for rare conditions. The study's findings suggest that AI can be a valuable tool when used alongside human expertise to improve diagnostic accuracy and reduce the risk of missed diagnoses.
A new analysis estimates that exposure to di-2-ethylhexylphthalate (DEHP) contributed to 1.97 million preterm births in 2018, equivalent to 8% of global total. The study also linked DEHP to 74,000 newborn deaths and found a significant health burden across regions with rapidly growing plastics industries.
Research reveals that viruses can eavesdrop on each other using chemical signals, which may not always benefit the listener. This 'cross-talk' between species can lead to incorrect decision-making by the eavesdropper.
Researchers developed a lab-grown organoid system that faithfully mimics human adrenal gland development and forms complex tissue structures. The system enables the study of adrenal biology, cortisol production in response to stress, and disease development, with potential applications for regenerative therapies.
A study of viral abundance in the Sargasso Sea reveals that viruses with cyclical changes in abundance are most active at night, infecting heterotrophic host microbes. This finding opens new questions about the ecological services provided by oceans and highlights the importance of including viruses in ocean models.
The new joint department combines expertise in medical devices, neuroengineering, imaging science, and more to advance biomedical research and translate discoveries into meaningful health advances. The partnership aims to accelerate the translation of discoveries into improvements in human health.
Researchers discovered that antibiotic resistance genes were present in all groups, including patients with COPD, asthma, pulmonary fibrosis, and sarcoidosis, as well as healthy individuals. The study also found that recent antibiotic use was linked to higher prevalence of resistance genes.
A higher testosterone level does not always indicate well-being in men, according to a study at the University of Gothenburg. Muscle health and inflammation are linked to testosterone levels, but symptoms like fatigue and depression have weaker connections.
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
A meta-analysis of GLP-1 receptor agonist studies found potential safety signals for gastrointestinal side effects, while some evidence suggested a link to reduced respiratory disease risk. Further research is needed to confirm the latter association.
Researchers simulated 27 evacuation scenarios to determine the safest cabin layout, finding that a specific distribution of elderly passengers can significantly impact evacuation time. The study suggests airlines implement strategic seating arrangements to optimize safety without compromising efficiency.
A Northwestern University study found that imagination is not just a copy of sensation, but emerges at later stages of processing when the brain represents information holistically. The researchers mapped brain activity during imagination and perception, finding overlap in higher-level association areas.
Researchers from ISTA identify two white dwarfs, Gandalf and Moon-Sized, which share five properties, including X-ray emission, despite being isolated objects. These discoveries suggest the existence of a new class of star remnants with unique magnetic and rotational properties.
A framework has been developed to identify candidate pathogenic variants hidden among uncertain significance variants detected in comprehensive genomic profiling. The framework was tested using BRCA1 and BRCA2 genes, leading to the classification of a previously unknown variant as pathogenic.
Among highly boosted patients with cancer, overall postacute sequelae risk was not elevated compared to noninfected patients; hospitalized COVID-19 patients remained at increased risk despite therapeutics. Vaccination and boosting remain important in mitigating long COVID among immunocompromised patients
A new model study suggests that the EU's emissions trading system can be used to capture CO2 on a large scale, with potential removals ranging from 68-86 million tonnes annually by 2050. The system could provide industry with planning security for residual emissions if dedicated support programmes are implemented.
New research demonstrates that restoring the physical stiffness of the gingival tissue can fundamentally change how cells respond to infection, potentially paving the way for new treatments. The study uses a hydrogel system to investigate how gum tissue stiffness impacts periodontal disease inflammation.
Researchers have developed a new CAR T therapy that targets tumor-supporting cells in pancreatic cancer, paving the way for a potentially safer and more effective treatment. The therapy uses lipid nanoparticles to deliver CAR instructions directly to patient T cells, resulting in higher expression rates and improved efficacy compared t...
A study led by Brown University researchers analyzed lung screening data to identify abnormalities outside the lungs that warrant follow-up care. Cancer-related findings appeared in about 3% of screening rounds and were linked to a higher risk of extrapulmonary cancers, particularly urinary system cancers.
A clinical trial by University of Auckland researchers found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery. Despite the extra therapy, neither group did better than a cohort who received standard care alone.
A new study introduces a simple intervention of introducing forest soil on an entryway doormat, which shifted the indoor microbiome of Finnish homes closer to bacterial profiles found outdoors. This could lead to health promotion, especially in urban settings, by reducing encounters with environmental microbes linked to inflammatory di...
Hyperbolic localized plasmon resonances were achieved in an anisotropic two-dimensional crystal, enabling tunable optical chirality and potential applications in miniaturized photonic components, spectroscopic sensors, and molecular fingerprinting.
A new study demonstrates that deprescribing glucose-lowering medications in type 2 diabetes patients can lead to clinically meaningful reductions in body mass index and blood glucose levels. Lifestyle changes, such as dietary modifications and increased physical activity, were commonly observed in these patients.
A Southwest Research Institute-led study finds protons and heavy ions react differently to solar magnetic reconnection events, revealing a more complex magnetic engine. This new data contradicts current models, showing protons generate waves that scatter them more efficiently.
Researchers have discovered two new species of half leaf-fingered geckos, one named after Prof. Dr. Thomas Ziegler, from Son La Province in northwestern Vietnam. The new species highlight the importance of conservation efforts for Southeast Asia's imperiled ecosystems.
A new study finds that ending birthright citizenship would have the largest relative growth of unauthorized births among Asians, while Latinos would comprise 93% of the U.S.-born population without legal status in 2050. The policy change could disenfranchise highly educated immigrants who contribute to the economy.
Researchers found that trematode parasites are more abundant in cooler temperate waters, defying the typical pattern of higher biodiversity near the equator. Temperature and host mobility play a major role in shaping parasite distributions, with certain species thriving in areas where hosts can tolerate infections better.
A study found that Tamil civilians experienced nearly four times more PTSD after intragroup violence compared to intergroup violence, with intragroup violence inflicting three to five times more trauma. Intergroup violence was positively associated with post-traumatic growth, while intragroup violence showed no such effect.