A nationwide study found no significant association between telemedicine adoption and changes in US ambulatory visits or total medical spending. The expansion of telemedicine has eased concerns about increased utilization and spending, as the growth did not lead to large increases in these areas.
Researchers at Johannes Gutenberg University Mainz have made new constraints on dark matter particles using precision measurements of barium monofluoride molecules. The study found bounds on hypothetical Z' bosons that mediate electron-nucleus interactions, potentially shedding light on dark matter.
A new thermal barrier coating system features a dense eutectic core-shell structure that enhances CMAS resistance via dynamic sealing and self-removal. The coating combines a mechanically robust, deformable Zr-Ta-O top layer with a traditional YSZ underlayer.
Researchers developed a novel ultra-high-temperature, highly insulating, and corrosion-resistant TBC material using first-principles calculations. The material exhibits excellent mechanical and thermophysical properties, including low thermal conductivity, high coefficient of thermal expansion, and excellent toughness.
The Centre of Excellence in Modelling and Simulation for Next Generation Ports (C4NGP) at NUS College of Design and Engineering aims to design the port of the future. The C4NGP focuses on creating sustainable ports with reduced environmental impact.
A new model for predicting outcomes in hypertrophic cardiomyopathy has been developed by incorporating prospective data, including clinical history, imaging, and blood biomarker tests. This study found that integrating these methods into risk assessment can improve the prediction of fatal and nonfatal cardiac events.
A new study by Yale University finds that garlic's diallyl disulfide compound blocks mating in mosquitoes and flies, including species that spread diseases. The finding could lead to environmentally friendly and inexpensive pest control methods.
Research suggests that exposure to environmental pollutants in early life can negatively affect bone development. A study of 88 healthy infants found associations between certain endocrine-disrupting chemicals and lower bone mineral density, emphasizing the importance of protecting vulnerable windows during pregnancy and after birth.
Researchers have developed a new computational workflow combining generative AI with atomistic simulations to identify promising platinum alloy catalyst structures for hydrogen fuel cells. The method produces high-performing candidates from several material combinations, addressing a longstanding challenge in catalyst design.
Researchers at Columbia University's Zuckerman Institute have developed a brain-controlled hearing system that can help people focus on one conversation among many. The system, which leverages the brain's natural ability to filter through background noise, dynamically isolates specific conversations in real-time.
A cohort study found a potential association between GLP-1 RA use and improved survival rates among obese breast cancer patients with related metabolic conditions. Further evaluation of GLP-1 RA therapy in randomized clinical trials is warranted based on these findings.
Researchers found ancient Chinese water buffalo feather decorations contained multiple bird species, including hoopoe, black-headed grosbeak, and yellow-bellied whistler. They also identified the adhesive as water buffalo glue, providing insights into cultural connections and species origins.
The Bioinspired123D system uses a 3-billion-parameter language model to generate reliable 3D design behavior from small models. The system achieves near fourfold performance improvement over larger state-of-the-art language models and demonstrates direct compatibility with standard additive manufacturing workflows.
Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.
The 2026 Carbon Future Young Investigator Award honors 10 recipients for their exceptional research potential and innovative capabilities in carbon-related science and technology fields. The award also acknowledges 30 Honorable Mention Award recipients, who have demonstrated significant contributions to their respective research areas.
The CRISPR/Cas13d system effectively targets and degrades hepatitis E virus RNA, reducing viral replication and infectious virus production. A limited combination of short guide RNAs can cover most viral variants, providing a promising approach to combatting the rapid adaptability of viruses.
A new editorial provides guidance on writing constructive peer reviews, emphasizing key takeaways such as 'picking battles' and maintaining professional courtesy. The guidance aims to elevate scientific data quality while mitigating impacts on authors' reputation and mental wellbeing.
The study found substantial state-level variation in HPV vaccine uptake, with Northeastern states exhibiting higher rates and Southern states showing lower rates. Several sociodemographic factors were not significant predictors of vaccination rates, highlighting the need for targeted interventions to improve vaccine uptake.
Researchers at KAIST demonstrated a chip-scale photonic approach for generating ultralow-noise and highly stable microwave and millimeter-wave signals based on optical frequency combs. The study enabled direct transfer of optical-reference stability to the microcomb, achieving record-breaking performance in low-offset frequencies.
Researchers analyzed a large dataset of Japanese Instagram ads to identify linguistic patterns linked to click-through rates. The study found that word choices for supplement and cosmetic ads differed significantly, with risk-related words boosting CTR in supplement ads, while motion-related language increased CTR in cosmetic ads.
The study utilizes high-sensitivity LC-MS to quantify TCA cycle intermediates in mouse ocular tissues, revealing dual differences in metabolic characteristics based on spatial distribution and biological sex. Key findings include tissue-specific metabolic phenotypes and sexual dimorphism of metabolic profiles.
A new study by Technische Universität Berlin reveals that teaching Large Language Models to mimic human intuition and reasoning improves their ability to provide accurate medical care-seeking advice. The 'human reasoning blueprint' approach increased overall accuracy across all models, with significant gains in self-care advice.
Photoacoustic imaging uses lasers to reveal hidden blood vessels and nerve bundles, guiding surgeons for fewer complications. The technique enables real-time augmented reality video feeds during laparoscopic surgeries.
A postdoctoral program will be conducted by NYU researchers on quantum algorithms and applications, sponsored by IBM, with a focus on chemistry, computer science, materials science, physics, and optimization. The collaboration aims to advance quantum computing for large-scale, fault-tolerant quantum computers.
Researchers propose that ibasho, community-led spaces of belonging and social purpose, support long-term recovery and resilience. By restoring routines, roles, and neighborhood connections, ibasho helps individuals regain stability, dignity, and a sense of purpose after disasters.
Researchers from Columbia University have developed a theory explaining how carbon dioxide cools the stratosphere, even as it warms Earth's surface and lower atmosphere. The study reveals that CO2 molecules interact with infrared light in a specific 'Goldilocks zone' that expands with increasing atmospheric CO2 levels.
A recent study by Rockefeller University researchers provides the most comprehensive view to date of how HIV-1 escapes broadly neutralizing antibodies. The study identified over 100 mutations that enable viral strains to resist these antibodies, with some requiring only a single amino acid change.
Researchers have identified a hidden mechanism explaining why breast cancer can return years after successful treatment. Slow-growing breast cancer cells can form microscopic tumours that silently tick away in distant organs, evading detection for decades.
Protein language models have immense potential but lack explainability, leading to concerns over reliability and safety. Researchers propose four key places to understand a model's decision-making process and outline the need for more transparent and trustworthy AI in biotechnology.
A new study found that a fluid surrounding many ovarian tumors, known as ascites, helps cancer cells survive and spread. Researchers discovered that a decades-old cholesterol drug, bezafibrate, can disrupt this protection by altering fat storage and iron control, making cancer cells more vulnerable to existing treatments.
Researchers caution that weakening core safeguards in carbon markets risk worsening climate impacts and increasing net carbon emissions. Indigenous land stewardship is vital for maintaining intact ecosystems and vital carbon sinks, but alternative support mechanisms are needed to preserve the integrity of climate action.
A feasibility study assesses the integration of PeroCycle's patented carbon recycling technology into Jindal Steel's operations, aiming to reduce CO2 emissions and lower reliance on fossil-based agents. The partnership could set a new global benchmark for low-emission steel production in the Middle East.
The publisher achieved a 35% reduction in supply chain emissions through sustainable digital publishing, plastic-free packaging, and optimized book supply chains. Taylor & Francis trained over 70,000 researchers in low-income regions to publish their work, enhancing access to research and knowledge.
The new certification framework covers the full IEC therapy process, including patient selection, clinical care, and post-infusion monitoring. It emphasizes critical aspects unique to IEC therapies, such as chain-of-identity and recognition of therapy-specific toxicities.
Preprints.org announces a new award to recognize widely read and shared preprints from the past decade. The platform, which hosts over 126,000 preprints, aims to increase early research dissemination across the scholarly community and the wider public.
A study found that cefiderocol and levofloxacin improved survival rates and reduced bacterial burdens in mice with severe hemorrhagic pneumonia. However, instances of hemorrhage differed between the two treatments. The results suggest that levofloxacin may be more effective against this infection.
Researchers developed a method to separate and quantify proton transport at individual interfaces in ultrathin ionomer films, enabling the evaluation of interfacial transport properties. The study revealed that proton transport at different interfaces is of a similar order of magnitude.
Research suggests that jellyfish bycatch can provide high-quality collagen without compromising quality. This circular bioeconomy solution offers new economic opportunities for small-scale fisheries while reducing waste. The collaboration with fishers revealed a willingness to participate in recycling jellyfish bycatch, but also highli...
Research in Canadian Medical Association Journal found that babies born to mothers with endometriosis are at a higher risk of congenital anomalies. The study included over 1.4 million births and found an increased risk of cardiovascular, gastrointestinal, genital, and musculoskeletal anomalies as well as neoplasms and tumours.
Researchers found that glutamic acid induces two transcriptional repressors, StbZIP53-like2 and StERF091, which suppress polyphenol oxidase genes linked to browning. This cooperative regulatory module alleviates browning in fresh-cut potatoes.
This innovative material combines the mechanical flexibility of an organic hydrogel with exceptional microwave absorption properties. The synergy between MXene and carbon dots provides a powerful tool for managing electromagnetic pollution in wearable electronics.
Researchers have developed an electrochemical route to produce hydrogen peroxide directly from oxygen and water under ambient conditions. Single-atom electrocatalysts play a crucial role in steering oxygen reduction chemistry towards the desired two-electron pathway.
Researchers develop hemoglobin-based nanoparticles to deliver tigecycline directly to Klebsiella pneumoniae infection sites, improving survival rates and reducing bacterial burden. The novel strategy overcomes dose-limiting toxicity and enhances pharmacokinetics of the antibiotic.
The HF-REVERT trial found that CDR132L improved secondary endpoints, including LVEF and NT-proBNP, but not the primary endpoint of LVESVI. Target engagement was confirmed by decreased plasma levels of microRNA-132. The therapy was well-tolerated with no significant safety concerns.
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
Researchers found that low-dose digoxin and digitoxin reduced worsening heart failure events in patients with mild-to-moderate heart failure and reduced ejection fraction. The treatment was generally well-tolerated and safe, offering a cheap and effective option for managing the condition.
The APOE2 gene variant is linked to exceptional longevity and reduced Alzheimer's risk, thanks to its ability to help human neurons keep their DNA intact and resist cellular senescence. This study reveals a previously underappreciated function of the gene, shifting attention away from its role in cholesterol transport.
A new international study found that genetic variations in the PAM gene can reduce the effectiveness of GLP-1 receptor medications, such as Ozempic. Researchers discovered that 44% of people with these genetic variants experienced reduced glucose lowering properties, and only 11% achieved recommended glucose levels.
The study introduces a triboelectric-driven framework that unifies visual, tactile, auditory, olfactory, and gustatory inputs within a self-powered architecture. The system demonstrates high-accuracy cross-modal recognition and adaptive sensory reconfiguration, offering a new pathway toward energy-autonomous robotic cognition.
Researchers develop a light-driven antenna-reactor photocatalyst that achieves highly efficient alkyne semihydrogenation under ambient conditions. The system promotes efficient hydrogen dissociation while steering the reaction toward selective semihydrogenation, enabling near-complete conversion with excellent selectivity.
The 'Ozempic Era' suggests a paradigm shift in understanding obesity, blaming commercial food systems rather than individual failings. Emerging medical data on GLP-1 agonists may drive policy responses to regulate ultra-processed foods.
A new study found that reducing annual working hours by 1% is linked to a small decline in obesity rates across 33 OECD countries, with the impact being stronger for men than women. Higher income levels and urbanization also showed significant correlations with lower obesity prevalence.
A pooled analysis of trials reveals semaglutide's safety and efficacy in individuals aged 65 years and older with obesity. The study found significant reductions in body weight and improvements in cardiometabolic risk factors, with a lower proportion of adverse events compared to placebo.
A new post-hoc analysis examined daily oral orforglipron treatment for obesity, with or without diabetes, in users aged 65 years and over. The study found that orforglipron significantly reduced body weight and improved blood sugar markers compared to placebo, with a similar safety profile to the overall ATTAIN clinical trial population.
A study of 65 countries found that consuming food away from home is consistently associated with obesity. Eating out is driven by sociodemographic factors such as sex, age, income, and education, and is linked to higher energy intake and body mass index.