A real-world study compared LLMs to human physicians in challenging lung cancer cases, finding that LLMs excel in rare cases with high comprehensiveness and specificity scores. However, they struggle with refractory cases, where physicians' reasoning stability is crucial.
Researchers found that circadian regulation shapes tumor microenvironment and determines patient responses to immune checkpoint blockade therapies. Disrupting these rhythms can suppress immune responses and diminish treatment efficacy.
Research investigates vortex-induced motion in semi-submersible FOWTs under varying incidence angles, revealing the influence of structural components on wake dynamics. The study's findings suggest optimizing platform design to reduce fatigue and enhance operational stability.
This study analyzed RA-related mortality trends in US postmenopausal women from 1999 to 2023, revealing a significant decline in age-adjusted mortality rates from 5.75 to 2.51 per 100,000. Despite the overall decrease, disparities persist by race/ethnicity and region.
SPH simulations provide physically consistent insights into flow dynamics, impact forces, and affected areas in catastrophic hazard scenarios. High-quality visualization enables intuitive representations that support emergency planning and decision-making.
Researchers identified three molecularly distinct subtypes of endometrial cancer with different clinical outcomes and therapeutic vulnerabilities. The study suggests that stratifying patients based on network-level molecular disruptions may offer more clinically actionable insights for treatment selection.
Researchers identified a cell-penetrating peptide from scorpion venom that targets heat shock protein HSP90β and promotes fat-burning transcription factor PPARα activity. This approach enhances fatty acid oxidation and reduces liver fat, inflammation, and fibrosis in diet-induced mouse models of metabolic liver disease.
Researchers created pea-sized mini-stomachs with three main regions, replicating human stomach function and acid secretion. The study models a rare genetic disease, paving the way for personalized treatment and accelerated clinical approval.
The review highlights the dynamic balance between pro-inflammatory and tolerogenic macrophage states at the maternal-fetal interface. Imbalance or impairment of these cells is linked to adverse pregnancy outcomes such as miscarriage, placenta-related disorders, and preterm birth.
A new approach combining Principal Component Analysis (PCA) and Discrete Wavelet Transform (DWT) enables accurate damage localization even with a limited number of sensors. The method reduces costs while improving detection accuracy, supporting broader implementation in real-world bridge health monitoring.
This review analyzes molecular mechanisms of DDR pathways in mediating chemotherapy resistance, elucidating correlations with BRCA1/2 deficiency and ATM/ATR signaling pathway dysregulation. The study presents a novel molecular synergy model between DDR regulation and Immune Checkpoint Blockade to enhance immunotherapy responses.
The conversion of waste lignocellulosic biomass into high-value soil amendments can enhance soil structure, increase water retention, and lock away carbon. Several technological pathways are explored, including slow pyrolysis, mild torrefaction, and solid-state fermentation.
The inaugural issue of SES features an editorial, review articles, and research papers on frontier topics such as fire risk assessment and AI-enabled emergency technology upgrading. These studies provide valuable insights for academia, industry, and policymakers.
This study found differences in fecal microbiome and bile acid content between preterm infants with parenteral nutrition-associated cholestasis (PNAC) and those without PNAC. PNAC development was associated with higher abundance of Proteobacteria, Fusobacteriota, and lower Bacteroidota in cholestatic infants.
The Institute of Science and Technology Austria (ISTA) has received a significant donation to advance trustworthy AI technology. The €5 million gift from Garrett Camp will support fundamental research in artificial intelligence, focusing on interdisciplinary collaboration and long-term impact.