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Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model

10.14.25 | PLOS

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Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model
Representative Wide-Field acquisition of PV interneurons calcium signals before the ischemic lesion, 2 days post-stroke (acute damage) and 42 days post-stroke after 5 weeks of combined rehabilitation with robotic therapy and 40 Hz TACs and 1 week of follow-up. The bright area in the second image locates the ischemic damage. Credit: Vignozzi L, et al., 2025, PLOS Biology, CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/)

Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model


In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology : https://plos.io/4gUkAy5

Article title: Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice

Author countries : Italy, Switzerland

Funding: The study was funded by: Regione Toscana, PERSONA project, bando Salute 2018, https://www.regione.toscana.it/-/bando-ricerca-salute-2018 , SM; H2020 EXCELLENT SCIENCE-European Research Council (ERC) under grant agreement 692943, https://cordis.europa.eu/programme/id/H2020-EU.1.1 ., MC; Regione Toscana, NIMBLE project (20RSVP), bando Salute 2018, https://www.regione.toscana.it/-/bando-ricerca-salute-2018 , (ALAM); THE Tuscany Health Ecosystem ECS_00000017 MUR_ PNRR, https://www.mur.gov.it/it/pnrr/missione-istruzione-e-ricerca , ALAM; Grant Fondazione Baroni 2021, https://fondazionebaroni.it/bandi/ , CS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PLOS Biology

10.1371/journal.pbio.3002806

Experimental study

Animals

Competing interests: The authors have declared that no competing interests exist.

Keywords

Brain Stimulation Motor Control Neuroscience Rehabilitation Robots Robotics

Article Information

Journal
PLOS Biology
DOI
10.1371/journal.pbio.3002806
Method of Research
Experimental study
Subject of Research
Animals
COI Statement
Competing interests: The authors have declared that no competing interests exist.

Contact Information

Claire Turner
PLOS
biologypress@plos.org

How to Cite This Article

APA:
PLOS. (2025, October 14). Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model. Brightsurf News. https://www.brightsurf.com/news/12D5OQO1/combining-non-invasive-brain-stimulation-and-robotic-rehabilitation-improves-motor-recovery-in-mouse-stroke-model.html
MLA:
"Combining non-invasive brain stimulation and robotic rehabilitation improves motor recovery in mouse stroke model." Brightsurf News, Oct. 14 2025, https://www.brightsurf.com/news/12D5OQO1/combining-non-invasive-brain-stimulation-and-robotic-rehabilitation-improves-motor-recovery-in-mouse-stroke-model.html.