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Thirty years of Ca2+ spark research: Digital principle of cell signaling unveiled

12.25.24 | Higher Education Press

Exemplary Ca2+ signaling microdomains. Cartoon illustration of various microdomains featured in different types of cells, all being artificially integrated in a hypothetical single cell. (1) Cardiac dyad. Single LTCC openings generate Ca2+ sparklets to activate a RYR2 Ca2+ nanospark in the cleft and a Ca2+ spark of 2 μm diameter in the surrounding space, as well as a Ca2+ blink in the connected ER/SR cistern. (2) Skeletal muscle triad (half structure illustrated). Arrayed RYR1 is mechanically ga Credit: Fujian Lu, Pengcheng Yang, Donghui Zhang, Xianhua Wang, Heping Cheng

The Advantages of the Digital System :

Future Research Directions:

This review offers a transformative view of calcium signaling, paving the way for further exploration of its intricate mechanisms and applications in understanding and treating diseases.

The work entitled “ Thirty years of Ca2+ spark research: digital principle of cell signaling unveiled ” was published on Biophysics Reports (published on Oct., 2024).

Biophysics Reports

10.52601/bpr.2024.240031

Experimental study

Cells

Thirty years of Ca2+ spark research: digital principle of cell signaling unveiled

1-Oct-2024

Keywords

Life Sciences

Article Information

Journal

Biophysics Reports

DOI

10.52601/bpr.2024.240031

Method of Research

Experimental study

Subject of Research

Cells

Article Publication Date

2024-10-01

Article Title

Thirty years of Ca2+ spark research: digital principle of cell signaling unveiled

Contact Information

Rong Xie

Higher Education Press

xierong@hep.com.cn

Source

Original Source

https://journal.hep.com.cn/br/EN/10.52601/bpr.2024.240031

How to Cite This Article

APA:

Higher Education Press. (2024, December 25). Thirty years of Ca2+ spark research: Digital principle of cell signaling unveiled. Brightsurf News. https://www.brightsurf.com/news/12D7O3O1/thirty-years-of-ca2-spark-research-digital-principle-of-cell-signaling-unveiled.html

MLA:

"Thirty years of Ca2+ spark research: Digital principle of cell signaling unveiled." Brightsurf News, Dec. 25 2024, https://www.brightsurf.com/news/12D7O3O1/thirty-years-of-ca2-spark-research-digital-principle-of-cell-signaling-unveiled.html.