A research group led by Assistant Professor Megumi Aimoto and Professor Akira Takahara at the Faculty of Pharmaceutical Sciences, Toho University, revealed that pyrazole-3 (Pyr3), a selective inhibitor of the transient receptor potential canonical-3 (TRPC3) channel, a calcium-permeable channel in the heart, prevents the persistence of atrial fibrillation. Atrial fibrillation is a tachyarrhythmia that occurs in the atria and is a major cause of stroke and heart failure. This study demonstrated that the TRPC3 channel is a promising new therapeutic target for atrial fibrillation. Drug therapy targeting TRPC3 channels is expected to provide a new approach for “overcoming” cardiovascular diseases associated with aging and lifestyle habits, including atrial fibrillation. These findings were published in the Biological and Pharmaceutical Bulletin on October 15, 2025.
A research group led by Assistant Professor Megumi Aimoto and Professor Akira Takahara at the Faculty of Pharmaceutical Sciences, Toho University, revealed that pyrazole-3 (Pyr3), a selective inhibitor of the transient receptor potential canonical-3 (TRPC3) channel, a calcium-permeable channel in the heart, prevents the persistence of atrial fibrillation.
Atrial fibrillation is a tachyarrhythmia that occurs in the atria and is a major cause of stroke and heart failure. This study demonstrated that the TRPC3 channel is a promising new therapeutic target for atrial fibrillation. Drug therapy targeting TRPC3 channels is expected to provide a new approach for “overcoming” cardiovascular diseases associated with aging and lifestyle habits, including atrial fibrillation.
These findings were published in the Biological and Pharmaceutical Bulletin on October 15, 2025.
Key Points
Journal:
Biological and Pharmaceutical Bulletin (October 15, 2025) Vol. 48, No. 10, pp. 1547–1554
Article Title:
Anti-atrial Fibrillatory Effects of the TRPC3 Channel Inhibitor Pyrazole-3 in Rats with Atrial Enlargement Induced by Chronic Volume Overload
Authors:
Megumi Aimoto, Yoshinobu Nagasawa, Taichi Kusakabe, Keisuke Kato, Akira Takahara
DOI:
10.1248/bpb.b25-00415
Biological and Pharmaceutical Bulletin
Experimental study
Animals
Anti-atrial Fibrillatory Effects of the TRPC3 Channel Inhibitor Pyrazole-3 in Rats with Atrial Enlargement Induced by Chronic Volume Overload
15-Oct-2025
The authors declare no conflict of interest.