Brg1-mutant mice die at mid-gestation due to defective erythropoiesis. Commenting on the relevance to human disease, the authors pointed out that "although much is known about the biochemistry of SWI/SNF chromatin-remodeling complexes, not as much is known about their role in development and physiology.
This Brg1 mutation is significant because it reveals a role for these complexes in beta-globin regulation and erythropoiesis and may provide insight into common ailments such as beta thalassemia and anemia."
Genes & Development