The authors investigated whether NS in adulthood at the age of 20 to 29 would be predicted over 14 years by an interaction between the DRD4 gene polymorphism and the mother-reported childhood rearing environment the participant aged 6 to 15 at the time of the mother-report. This question was studied in a sample of children (n = 92), derived from a representative population sample of healthy young Finns (n = 2,149). It was found that when the childhood rearing environment was more hostile (emotionally distant, lowly tolerant towards the child's normal activity, and strict in discipline), participants carrying any 2- or 5- repeat alleles of the DRD4 gene had a significantly greater risk of exhibiting NS scores that were above the 10th percentile on a population distribution of 2,149 adult Finnish women and men, relative to participants who were not carrying the 2- or 5-repeat alleles. The genotype had no effects on NS when the childhood environment was more accepting.
ARTICLE: "Nature and nurture in novelty seeking"
AUTHORS: Liisa Keltikangas-Järvinen, Katri Räikkönen, Jesper Ekelund, Leena Peltonen
Department of Psychology, University of Helsinki, Finland; Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
Citation source: Molecular Psychiatry advance online publication, December 2003 (doi:10.1038/sj.mp.4001433).
For further information on this work, please contact Dr. Liisa Keltikangas-Järvinen, Siltavuorenpenger 20 D, PoBox 9, 00014 University of Helsinki. Phone number: 358-9-1912-9500; Fax: 358-9-1912-9521; Email: Liisa.Keltikangas-Järvinen@helsinki.fi
Molecular Psychiatry is published by the Nature Publishing Group.
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PLEASE CITE MOLECULAR PSYCHIATRY AS THE SOURCE OF THIS MATERIAL.
Molecular Psychiatry