The review discusses how metabolic cell death, distinct from traditional forms of regulated cell death like apoptosis, arises from imbalances in cellular metabolism due to nutrient and metal overload or depletion. It emphasizes the therapeutic potential of targeting these unique metabolic vulnerabilities in cancer cells, which frequently undergo metabolic reprogramming.
The highlights from the study include:
The review underscores the significance of metabolic cell death pathways, highlighting their potential as novel therapeutic targets in cancer treatment. By understanding the specific metabolic vulnerabilities of cancer cells, therapies can be designed to induce ferroptosis, cuproptosis, disulfidptosis, lysozincrosis, or alkaliptosis selectively, offering new avenues to overcome resistance to conventional therapies. The comprehensive exploration of these pathways not only expands the understanding of cancer biology but also paves the way for innovative treatment strategies that exploit the unique metabolic characteristics of cancer cells. The work entitled “ Metabolic Cell Death in Cancer: Ferroptosis, Cuproptosis, Disulfidptosis, and Beyond ” was published on Protein & Cell (published on Mar. 1, 2024).
Protein & Cell
Systematic review
Cells
Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond
1-Mar-2024