Cells
Articles tagged with Cells
Blocking TGF-β signaling may strengthen efficacy of osteoporosis therapy
Inspired by the brain, researchers build smarter, more efficient computer hardware
Tomato-derived lycopene shields gut cells from fungal toxins
Reading genetic activity from living cells without destroying them
Researchers at TUM develop NTVE, a process that uses virus-like particles to shuttle messenger RNA out of living cells, allowing for repeated sampling and analysis. This enables precise monitoring of stem cell development and potential applications in cell therapies and tumor research.
MIT researchers show how chromatin movement helps control gene expression
Researchers at MIT have found that chromatin can exist in two different categories: constrained and free, which affects its interaction with genes and DNA regulatory sequences. This study provides insight into gene regulation and DNA repair processes.
Study identifies a key mechanism in the degeneration of motor neurons in ALS
A team of researchers has identified a key mechanism in the degeneration of motor neurons in ALS, revealing that chaperone-mediated autophagy is significantly reduced in patients. This finding suggests that this cellular system may be a potential therapeutic target to slow disease progression.
FAU study reveals how camels ‘beat the heat’ at the cellular level
Researchers found that camels have a more flexible and coordinated response to heat stress, allowing them to maintain stability even at higher temperatures. In contrast, human cells tend to respond in a more rigid way, making them less adaptable under heat stress.
Stage-specific gene expression changes reveal early triggers of cellular aging
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
Tiny flexible lasers enable force sensing inside living cells
Researchers developed tiny flexible lasers that can measure forces inside living cells, enabling insights into biological processes such as early development and tumor progression. The micro-lasers exhibit mechanical stiffness similar to living cells and can measure forces up to 50 nanonewtons.
Wild flatworms heal wounds
Researchers from Lund University successfully harnessed the regenerative capacity of Scandinavian flatworms to accelerate wound healing in human skin models. The study found that signalling molecules from flatworm exosomes increased skin thickness and improved wound healing rates, including accelerated blood vessel regeneration.
Researchers identify the ‘organizer’ cells that build bone marrow
A new study reveals the developmental mechanism of bone marrow formation, identifying septoclasts as early organizers followed by LepR-expressing bone marrow stromal cells. These specialized cell populations work together to build the bone marrow environment through a hardwired process supported by RANKL.
New experimental drug may restore movement after stroke
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
Phage therapy at a turning point: Valencia 2026 to define the next era of antibacterial medicine
The Targeting Phage Therapy 2026 Congress will bring together experts to address clinical, regulatory, industrial, and hospital infrastructure requirements for phage therapy. The congress aims to move phage therapy from promising science to accessible, validated, and deployable medicine.
A molecular “cork” controls cellular activity
Researchers from UNIGE have identified a molecular mechanism regulating cellular balance and found that TORC2's activation is controlled by a molecular 'cork'. This discovery paves the way for targeting this mechanism to treat diseases like cancer and diabetes.
How tiny mechanical forces control stem cell fate — insights from mechanobiology
Mechanobiology reveals how physical forces govern cells, tissues, and diseases, leading to breakthroughs in cancer, fibrosis, orthopedic injuries, and vascular diseases. The field is also pioneering mechanical reprogramming and mechanogenetics, enabling personalized mechanical interventions.
How the internal liver clock orchestrates daily fat secretion
A Salk Institute study identifies Fibroblast Growth Factor 1 (FGF1) as the molecular signal that tells the liver when to release fat into the bloodstream, following a precise rhythm timed to the body's internal clock.
Exosomal miR-122-3p identified as key driver of metabolic dysfunction-associated steatotic liver disease
A study identified exosomal microRNA-122-3p as a key driver of MASLD pathogenesis. Elevated miR-122-3p levels induced triglyceride accumulation and reactive oxygen species production in liver cells.
MIT study reveals a new role for cell membranes
A new study from MIT chemists found that changing the composition of the cell membrane can alter the function of a membrane receptor promoting cell growth. Elevated levels of negatively charged lipids can lock the receptor into an overactive state, contributing to cancer cell proliferation.
Beyond cell death: The hidden drivers of stem cell aging
A recent study reveals that MLKL activation causes direct damage to mitochondria, impairing energy production and leading to functional decline in hematopoietic stem cells. In contrast, deletion or inhibition of MLKL significantly alleviates these defects, suggesting a post-transcriptional mechanism driving HSC aging.
Scientists engineer a tool to “edit” brain circuits and enhance memory
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Proteins cluster in cells for faster performance
Researchers at the University of Groningen discovered that protein clustering in cells leads to reduced movement and improved efficiency in amino acid production. This finding has practical implications for designing efficient cell factories and increasing substance production inside cells.
Base-resolution DNA methylation map of MDS stem cells reveals new disease mechanism
Researchers generated a comprehensive view of DNA methylation abnormalities in human MDS HSCs, uncovering a novel TET2-GFI1 axis that suppresses malignant transformation. The study identifies key hematopoietic regulators and provides a panoramic view of DNA methylation disruption in MDS.
Characteristics of CD4+T-cell reduction and pulmonary infections in critically ill immunocompromised patients
A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
How bacteria outsmart the immune system: Two-pronged strategy revealed
Researchers have discovered how a disease-causing bacterium uses a single protein to interfere with the body's defenses in multiple ways, offering a clearer picture of how infections take hold at the cellular level. This discovery highlights the importance of targeting specific interactions between bacterial proteins and human cells in...
Solving the oxygen problem in cell-based drug delivery
The Hybrid Oxygenation Bioelectronics system, or HOBIT, shields cells from the immune system while providing access to oxygen and nutrients. The compact device supports higher cell densities in a smaller space, enabling the production of multiple biologic molecules simultaneously.
Role of uric acid in steatotic liver disease pathogenesis
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
Scalable platform sheds light on how cancer spreads
A new platform called ATLAS enables researchers to generate large quantities of cancer cell clusters that accurately model metastasis. Using ATLAS, the Rice team gained insights into the mechanisms that enable cancer clusters to survive in the bloodstream during the metastatic process.
The brain’s ability to grasp the “gist” of a visual scene begins earlier than expected
A research team led by LEE Doyun and KIM Yee-Joon found that the primary visual cortex encodes motion summaries and variability before higher brain regions transform them into category signals. This process, known as ensemble perception, allows the brain to capture the overall structure of a scene at a glance.
Regulatory B cells: Neuroprotective potential in neurological disorders
Regulatory B cells produce anti-inflammatory cytokines like IL-10, which dampens inflammatory responses and guides T cells toward regulatory phenotypes. This immune modulation can counteract damaging inflammation and promote neuroprotection.
The hidden cost of sperm storage: Ejaculates found to deteriorate across the animal kingdom
A study led by Oxford University researchers reveals that sperm stored for extended periods deteriorates quickly, regardless of male age. Regular ejaculation has been shown to improve sperm quality in humans and animals alike.
Flexible assembly: alternative pathways in proteasome biogenesis deciphered
A new study has deciphered the step-by-step assembly of eukaryotic proteasomes, revealing two alternative pathways and a flexible biogenesis process. The findings have far-reaching implications for understanding cellular protein quality control, ageing, and diseases like cancer and neurodegenerative disorders.
Quantum sensors on the move
Researchers at IISc created a method to precisely steer quantum sensors through living cells, overcame challenges like viscous drag and brownian motion. This breakthrough enables real-time measurement of parameters such as local viscosity and temperature inside cells.
Successful use of high-pressure freezing for cell cryopreservation
Researchers from the University of Tokyo successfully developed a high-pressure freezing method that reduces CPA concentration to 20-30% and improves cell viability and metabolic activity. The method holds promise for cryopreservation in regenerative medicine research, with potential applications in drug testing and cell transplantation.
Massey researchers lead international collaboration of first-ever, multi-platform digital atlas of oral tissues
The study provides a breakthrough understanding of the immunoregulatory nature of human tissues, revealing that fibroblasts serve as core regulators of structural immunity in the mouth. The findings lay the groundwork for targeted modulation of fibroblast activity to improve health outcomes in fibrosis, cancer, and autoimmunity.
FAU discovery of tiny cell ‘tunnels’ finds new path to slow Huntington’s disease
Huntington's disease is caused by a toxic protein that builds in brain cells and spreads to other cells through tunneling nanotubes. Disrupting this pathway reduces the spread of the disease-causing protein, suggesting a new target for therapy.
Deep learning model predicts how individual cells influence disease outcomes
A computational method called scSurv links individual cells to patient outcomes using bulk RNA sequencing data, identifying cell populations associated with survival across several cancers. The model estimates the contributions of over 10,000 individual cells to disease risk and prognosis, providing a foundation for precision medicine.
Engineered lipid nanoparticles reprogram immune metabolism for better mRNA vaccines
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Stanford researchers develop novel "scaffold-free" approach for treating damaged muscles
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
New hydrogel platform mimics human tissue, can be controlled by light
Researchers developed a water-rich, Jell-O-like hydrogel that mimics human tissue's movement, stretching, and relaxation. The hydrogel can be precisely controlled by light, enabling the study of cell behavior and disease modeling.
Uncovering a key signaling pathway linking liver cancer and fibrosis
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
Molecular garbage on tumors makes easy target for antibody drugs
Researchers at UCSF have discovered a new therapeutic target, SRC, present on up to half of all tumors, which can be targeted with antibody drugs. The enzyme, normally hidden inside cells, is exposed on the surface of tumor cells due to an overactive disposal system, making it an easy target for cancer-killing antibodies.
Boron agents termed GluBs reach previously untreatable tumors
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
How mice see: Newly discovered nerve cells perceive more than just edges
Researchers identified new neurons that respond to different spatial frequencies, allowing for more precise object recognition, and used digital twins to confirm the findings in mouse brains.
New study sheds light on protein landscape crucial for plant life
Researchers at Washington State University have discovered the microscopic landscape of proteins in plant leaf cells, revealing how they convert sunlight into bioenergy. The study provides a new view of the molecular engine of photosynthesis and its potential for future fine-tuning of crops.
Dynamic gel helps scientists grow organs more reliably in the lab
Scientists at UCSF created a new material that enables more predictable organoid growth, allowing for better study of disease and potential tissue replacement. The dynamic gel, invented by Zev Gartner, mimics the body's soft environment and enables precise 3D printing of stem cells.
Astrocytes shape motor coordination development in late adolescence
A new study reveals that astrocytes regulate inhibitory signaling in the cerebellum during development, enabling the emergence of flexible and precise motor coordination. In contrast, younger animals rely on neuron-derived tonic inhibition, which is replaced by astrocyte-derived tonic inhibition in late adolescence.
Immune cells play key role in regulating eye pressure linked to glaucoma
A study published in the journal Immunity has discovered that resident macrophages play a key role in regulating eye pressure, suggesting a promising new target for therapies to prevent glaucoma. The findings highlight the importance of the immune system in maintaining healthy eye pressure.
New study identifies growth hormone receptor as possible target to improve lung cancer treatment
Researchers at Ohio University discovered that blocking the growth hormone receptor may help make lung cancer treatments more effective. Patients with low GHR tumors survived significantly longer than those with high GHR tumors, highlighting a potential new target for therapy.
SMART develops rapid iron measurement to improve cartilage repair through cell therapy
Researchers developed a rapid and non-destructive method to monitor iron flux in mesenchymal stromal cells (MSCs) using micromagnetic resonance relaxometry (µMRR). This breakthrough enables real-time insights into MSC's ability to form quality cartilage tissue, paving the way for more consistent manufacturing of MSC-based therapy.
Dopamine selects, astrocytes refine: a new mechanism for motor-learning circuit rewiring
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Smarter tissue and organ repair thanks to made in Ottawa next-gen hydrogel
Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.
Ribosomes in pairs
Researchers at the Max Planck Institute for Brain Research discovered that stressed animal cells, including neurons, assemble inactive ribosomes into tightly linked pairs, known as disomes. This novel mechanism relies on a specific piece of ribosomal RNA called an expansion segment to form a precise RNA-RNA interaction.
Scientists find a mechanism for how exercise protects the brain
Scientists have discovered a mechanism that explains how exercise improves cognition by shoring up the brain's protective barrier. The study found that an exercise-induced liver protein strengthens the blood-brain barrier, reducing inflammation and cognitive decline associated with Alzheimer's disease.
The cells that never sleep: How slumber lets neurons clean up and stay healthy
Research by Amita Sehgal and her team reveals that sleep helps neurons stay healthy by removing oxidative damage through lipid transfer to glia cells. This process is crucial for maintaining neuronal function and may contribute to the development of neurodegenerative diseases like Alzheimer's.
New center for cell research
The new center combines large-scale equipment and methods to study individual cells in detail, detecting molecular differences and analyzing reactions to biochemical or genetic changes. This enables new perspectives for medical diagnostics and research, including personalized medicine.
Molecular mechanism regulating bacterial cell division discovered
A research team led by Universitat Autonoma de Barcelona has discovered the molecular mechanism regulating bacterial cell division. The MraZ protein binds to the dcw gene cluster, enabling coordinated action of proteins necessary for cell division and bacterial wall formation.
Does the motion of our DNA influence its activity?
UCalgary study investigates the use of a common vitamin to treat the aggressive brain cancer glioblastoma
A UCalgary study found that adding high doses of vitamin B3 to the treatment plan may help rejuvenate compromised immune cells to kill tumour cells. The clinical trial showed promising results, with 82% of participants free of cancer progression at six-months.
Scientists ID potential treatment for deadliest brain cancer
Researchers at the University of Virginia Health System have identified a molecule that blocks the gene responsible for glioblastoma, a fast-growing and deadly brain cancer. The compound shows promise in preventing the invasive cancer from spreading through the brain without causing harm to healthy tissue.