Articles tagged with Cells
Researchers at Umea University have identified two autophagy protein complexes as the long-sought sensors of lysosomal damage. These proteins respond to protons or calcium leakage, initiating the repair system that seals the hole, thereby preventing inflammation and cell death.
Researchers from Université de Genève have identified the transporters responsible for each lipid, revealing the complex mechanisms behind their cellular targeting. This study provides valuable insights into lipid biology and its link to various diseases such as Alzheimer's and diabetes.
Researchers at University of British Columbia have successfully grown specialized immune cells called helper T cells from stem cells in a controlled laboratory setting. This breakthrough could lead to more accessible and effective off-the-shelf treatments for various conditions, including cancer, autoimmune disorders, and infectious di...
Researchers develop ddHodge, a geometry-preserving method that accurately reconstructs cell state dynamics. The technique reveals repeating processes like the cell cycle and identifies critical biological moments in embryonic development, tissue regeneration, and cancer progression.
Researchers in Japan discovered that cells eliminate less efficient ribosomes through a 'survival of the fittest' mechanism, ensuring accurate and efficient protein synthesis. This discovery sheds light on how cells maintain quality control and prevents ribosome-related diseases.
Researchers at Virginia Tech have developed a new method for attaching fluorine-18 to trifluoromethyl groups, enabling the tagging of previously inaccessible targets in PET scans. This breakthrough expands the range of molecules that can be imaged, potentially leading to earlier diagnoses and more targeted treatments for diseases.
A team of MIT engineers developed a deep-learning model that predicts how individual cells will fold, divide, and rearrange during a fruit fly's earliest stage of growth. The model achieved 90% accuracy in predicting the movement of 5,000 cells over the first hour of development.
Researchers develop a strategy that delivers record FF of 80.1% and maintains high efficiency even at thin active-layer thickness. The design offers a cost-effective pathway to high-efficiency, thick-film organic solar cells.
Researchers at Ohio State University developed a new approach to immobilize extracellular vesicles in a way that mimics their interactions with tissues. This allows for the study of these particles and their complex interactions with cells, enabling potential applications in disease detection, drug delivery, and biomarker discovery.
Researchers at OIST have discovered that certain cancers can 'lose their sense of time' to avoid cellular stress responses. The study highlights the role of USP28 in stabilizing p53, a known tumor suppressor, and how mutations in this protein can disrupt its function.
Researchers have elucidated the molecular mechanism by which microtubules transmit signals to cells, using the signalling protein GEFH1. The C1 domain of GEFH1 binds specifically to microtubules, activating the RhoA signalling pathway and triggering cellular processes.
Researchers have discovered a key protein structure in the germ cells of male mice that causes deformations in sperm flagellum leading to infertility. The study used ultrastructure expansion microscopy to visualize the centriole, a tiny cylindrical structure critical for sperm movement.
Researchers at UNIGE and HUG have developed CAR-T cells capable of destroying glioblastoma cells by targeting specific proteins present in the tumour environment. The new approach has shown promising results in animal models, paving the way for clinical trials in humans.
Researchers discovered that NDRG3 slows down cellular transport to conserve energy during low-oxygen conditions. The protein acts as a sensor for lactate, which accumulates in cells when oxygen is limited.
Researchers differentiate true 2D passivation from amorphous capping in perovskite solar cells using a single-atom fluorine substitution. The n-type crystalline 2D layer achieves high efficiency and stability, offering a design rule for next-generation modules.
Researchers found that inflammatory stromal cells replace stem-cell-supportive mesenchymal stromal cells in the bone marrow, creating a feed-forward loop of chronic inflammation and suppressing healthy blood formation. This discovery positions inflammation as a central force in early blood disease development.
Scientists have discovered a protein called SCEP3 that ensures even chromosome segregation in plants, preventing infertility and genetic diseases. This finding has implications for plant breeding and understanding human fertility, with the equivalent gene SIX6OS1 potentially playing a role in promoting correct chromosome segregation.
Weill Cornell Medicine researchers have discovered a molecular signal that tumors exploit to exhaust T cells meant to destroy them. By silencing this signal, the body's immunity can be revived and cancer-fighting immune cells restored.
Researchers have identified the cells and connections underlying a fish's ability to dynamically change color to match its surroundings. The study found that specialized skin cells called melanophores control the color change, which helps the zebrafish evade predators by lightening its skin over tens of minutes.
Scientists develop AMOUR method for accurate profiling of surface RNAs and Intact-Surface-FISH for visualization and quantification of representative surface RNAs. The study reveals a rich repertoire of noncoding RNAs on human and murine blood cells, with potential contributions to autoimmunity.
Alec Whited's published study reveals a previously unknown cellular pathway that enhances waste removal, potentially treating autoimmune diseases and improving wound healing. The research, coauthored with a UTA doctoral student, was recently published in Genetics, a prestigious journal.
A new study reveals that increasing NAD⁺ levels corrects RNA splicing mistakes, improving brain function and restoring memory in animal models of Alzheimer's disease. The researchers discovered a previously unidentified pathway involving the protein EVA1C, which plays a crucial role in correcting tau-related neuronal damage.
Researchers at MIT developed microscopic, wireless bioelectronics that can identify and travel to specific brain regions without human guidance. These implants provide focused treatment for brain diseases like Alzheimer's and multiple sclerosis by wirelessly powering electrical stimulation in precise areas.
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
Researchers at Wayne State University are investigating how eosinophils influence corneal response to infection, focusing on microbial keratitis and potential therapeutic strategies to preserve vision. The goal is to identify new treatments that fight infection while minimizing tissue damage.
Researchers discover molecules that can rewire G protein-coupled receptor signaling, turning busy receptors into precision tools. The findings hold promise for new treatments with fewer side effects.
Researchers discovered that docosahexaenoic acid (DHA) plays a crucial role in heart regeneration by triggering specific genes involved in the process. Injection of DHA improves cardiac function in adult mice after myocardial infarction, while also facilitating cardiomyocyte proliferation and inhibiting fibrosis and inflammation.
Researchers engineered midnolin for targeted protein degradation using cryo-EM structures and developed chimeras for non-native high-profile targets. This study provides a paradigm-shifting solution to challenges in targeted protein degradation approaches.
Scientists have identified a previously unknown genetic disease, MINA syndrome, which damages motor neurons and affects movement and muscle control. The disease is caused by a rare genetic mutation in the NAMPT protein, leading to symptoms such as muscle weakness, loss of coordination, and foot deformities.
Researchers developed a computational tool to identify genetic vulnerabilities in memory-making brain cells linked to Alzheimer's. The 'seismic' algorithm integrates genetic data with single-cell RNA sequencing, revealing a detailed picture of affected cell types and their genetic programs.
The study found that 1-year DMEK success rates were high regardless of donor diabetes status. No restrictions on using tissue from donors with diabetes for DMEK are recommended based on the results.
UCSF researchers found a key cellular switch driving pulmonary fibrosis and developed a new therapy to block it in mice. The treatment works by preventing healthy lung cells from converting to harmful cell types, reducing scarring and improving lung function.
Graz University of Technology and the University of Regensburg are conducting research on the interaction of cell types at the blood-brain barrier, with a particular focus on sex-specific differences in depression. The study aims to identify mechanisms contributing to depression and develop targeted therapies.
Researchers at UTA discovered that mitochondria can protect a cell from dying by taking in calcium, regulating complex cell death. The findings offer insights into brain development and disease, potentially leading to targeted treatments.
The research team developed a unique alginate-collagen interpenetrating network (IPN) hydrogel system that mimics the mechanical properties of tissues. Fibroblasts cultured on the hydrogels exhibited unprecedented behavioral patterns, including cell aggregation and reprogramming-related gene expression upregulation. The positive feedba...
Researchers have developed a novel strategy using Ti3C2Tx MXene nanosheets to enhance thermal conductivity and optoelectronic performance in perovskite solar cells. This study offers a promising route toward high-efficiency, thermally stable photovoltaics.
A new study reveals that astrocytes, a type of glial cell, are responsible for stabilizing memories through repeated engagement. The researchers found that Fos activity in astrocytes only occurs during recall, and that these cells can be activated to produce stable memories.
Researchers at Shinshu University found that cardamom seed extract enhances the production of antiviral proteins called type I interferons, which play a crucial role in defending against viral infections. The study suggests that cardamom could be a potential source of antiviral treatment.
Research reveals that ovarian aging is not just about egg quality, but also the surrounding cells and tissues. The study found that eggs cluster in pockets surrounded by egg-free zones, which decline in density with age, influencing egg lifespan and maturation.
Researchers at MIT have developed a new way to engineer CAR-NK cells that are less likely to be rejected by the patient's immune system, making them a promising treatment for cancer. The cells can destroy most cancer cells while evading the host immune system, and may offer a better safety profile than traditional CAR-T cells.
A £1.55m study examines the effect of long-term vaping on respiratory health in 200 healthy smokers and non-smokers. The research aims to provide insight into vaping's biological effects on lung cells, immune cells, and airway microbiome.
A new method has been developed to generate induced natural killer cells and CAR-engineered NK cells from cord blood-derived hematopoietic stem and progenitor cells. This approach increases the induction efficiency of NK cells and lowers the cost of CAR engineering, offering a promising avenue for cancer immunotherapy.
Double negative T cells (DNT cells) play an indispensable role in suppressing intestinal inflammation, acting as antigen-presenting cells. Their impaired function may contribute to the pathogenesis of Crohn’s disease, suggesting they could be a potential therapeutic target.
A diet rich in cysteine has been shown to activate immune cells that help regenerate intestinal tissue, potentially offering a new way to heal tissue damage from radiation or chemotherapy treatment. The researchers found that cysteine initiates a chain of events leading to the activation of CD8 T cells, which produce cytokines like IL-...
A protective mechanism involving actin filaments forms in the cell nucleus to prevent DNA loss and stabilize the nucleus. This mechanism allows cancer cells to survive high mechanical stress during migration, which is crucial for metastasis.
Researchers have identified chemical fossils in ancient rocks that suggest the ancestors of modern-day demosponges were among the first animals to evolve. The discovery, made by a team of MIT geochemists, builds on previous findings and provides strong evidence for the early origins of life on Earth.
Researchers are developing monolithic perovskite/perovskite/silicon triple-junction solar cells to overcome the theoretical efficiency limit of crystalline silicon. The cells feature tunable bandgaps, low-cost fabrication, and excellent optoelectronic properties.
Secreted proteins offer promising therapeutic avenues for metabolic dysfunction-associated steatotic liver disease (MASLD). Recent research highlights their potential as therapeutic targets, but translating preclinical findings into effective clinical treatments remains challenging.
Scientists established intrahepatic cholangiocyte organoids from Syrian hamsters, which withstand cooling-rewarming stress better than mouse-derived counterparts. shICOs maintain lower ROS levels and lipid peroxidation under cold exposure through enhanced anti-ferroptosis ability.
The study identifies two distinct neuronal populations affected by Alzheimer's disease: EC-stellate neurons lost and GFAP⁺ neurons expanding with glia-like features. These findings highlight energy metabolism dysfunction and neuronal identity changes in AD progression.
Researchers have surpassed the Shockley-Queisser efficiency limit in photovoltaic cells by delivering 50-60% power-conversion efficiency at low temperatures. This breakthrough opens up new possibilities for extreme-environment energy harvesting, with potential applications in cryogenic and deep-space power.
Researchers developed a parallel microdevice that combines high-throughput intracellular delivery with automated single-cell image cytometry using AI. The device can deliver gene-silencing RNA and plasmid DNA across multiple cell types, enabling broad utility for cell engineering and personalized therapies.
The study found that a specific spinal circuit is involved in both ejaculation and arousal, and integrates sensory inputs to adjust its output based on the animal's internal state. The researchers also discovered that Gal⁺ neurons receive sensory input from the penis and can trigger ejaculation, but their effects are suppressed by brai...
Macrophage lysosomes regulate reactive oxygen and nitrogen species production, with pH influencing the balance between killing microbes and avoiding self-harm. The study provides insights into immune regulation using nanoelectrochemical sensors.
Researchers develop one-molecule, self-regulated 'bilateral anchoring' for high-performance rigid and flexible PSCs, achieving record efficiencies while extending device lifetime under real-world stress. The innovative design enables commercial viability of squaric acid as a single-component modifier for stable PSCs on any substrate.
A joint team from The University of Osaka revealed that soft particles exhibit unique focusing patterns compared to rigid particles, influencing their focusing behavior. The study provides fundamental insights into the underlying physics, offering a new theoretical model explaining particle behavior under various flow regimes.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
Researchers found that nerves with a response to stimulation had a greater likelihood of recovering on their own, while those without a response had a low chance of functional recovery. The study uses intraoperative electrical nerve stimulation as a tool to distinguish between recoverable and non-recoverable nerve injuries.
Researchers reexamined the genetic conflict in the maternal-fetal interface, finding a delicate balance of cooperation and competition that ensures successful pregnancy. The study sheds light on pregnancy complications like placenta accreta and preeclampsia, and may have broader implications for cancer metastasis.
Researchers found that an astrocytic 'brake' mechanism, fueled by the neurotransmitter GABA, blocks spinal cord repair after injury. Inhibiting this pathway with the MAOB inhibitor KDS2010 enables recovery of spinal cord function in animal models.