Articles tagged with Cells
Secreted proteins offer promising therapeutic avenues for metabolic dysfunction-associated steatotic liver disease (MASLD). Recent research highlights their potential as therapeutic targets, but translating preclinical findings into effective clinical treatments remains challenging.
Scientists established intrahepatic cholangiocyte organoids from Syrian hamsters, which withstand cooling-rewarming stress better than mouse-derived counterparts. shICOs maintain lower ROS levels and lipid peroxidation under cold exposure through enhanced anti-ferroptosis ability.
The study identifies two distinct neuronal populations affected by Alzheimer's disease: EC-stellate neurons lost and GFAP⁺ neurons expanding with glia-like features. These findings highlight energy metabolism dysfunction and neuronal identity changes in AD progression.
Researchers have surpassed the Shockley-Queisser efficiency limit in photovoltaic cells by delivering 50-60% power-conversion efficiency at low temperatures. This breakthrough opens up new possibilities for extreme-environment energy harvesting, with potential applications in cryogenic and deep-space power.
Researchers developed a parallel microdevice that combines high-throughput intracellular delivery with automated single-cell image cytometry using AI. The device can deliver gene-silencing RNA and plasmid DNA across multiple cell types, enabling broad utility for cell engineering and personalized therapies.
The study found that a specific spinal circuit is involved in both ejaculation and arousal, and integrates sensory inputs to adjust its output based on the animal's internal state. The researchers also discovered that Gal⁺ neurons receive sensory input from the penis and can trigger ejaculation, but their effects are suppressed by brai...
Macrophage lysosomes regulate reactive oxygen and nitrogen species production, with pH influencing the balance between killing microbes and avoiding self-harm. The study provides insights into immune regulation using nanoelectrochemical sensors.
Researchers develop one-molecule, self-regulated 'bilateral anchoring' for high-performance rigid and flexible PSCs, achieving record efficiencies while extending device lifetime under real-world stress. The innovative design enables commercial viability of squaric acid as a single-component modifier for stable PSCs on any substrate.
A joint team from The University of Osaka revealed that soft particles exhibit unique focusing patterns compared to rigid particles, influencing their focusing behavior. The study provides fundamental insights into the underlying physics, offering a new theoretical model explaining particle behavior under various flow regimes.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
Researchers found that nerves with a response to stimulation had a greater likelihood of recovering on their own, while those without a response had a low chance of functional recovery. The study uses intraoperative electrical nerve stimulation as a tool to distinguish between recoverable and non-recoverable nerve injuries.
Researchers reexamined the genetic conflict in the maternal-fetal interface, finding a delicate balance of cooperation and competition that ensures successful pregnancy. The study sheds light on pregnancy complications like placenta accreta and preeclampsia, and may have broader implications for cancer metastasis.
A new computational tool called scODIN simplifies single-cell analysis by automating cell type identification in scRNA-seq data. It allows users to define specific cell subsets at different levels of detail and recognizes cells with intermediate phenotypes or transitional states, capturing complexity missed by traditional methods.
A research team from Nara Institute of Science and Technology developed a dynamic microfluidic channel that adjusts to particle size, increasing impedance flow cytometry's sensitivity and accuracy. The platform also leverages clogging as a strategy to optimize performance.
Researchers found that an astrocytic 'brake' mechanism, fueled by the neurotransmitter GABA, blocks spinal cord repair after injury. Inhibiting this pathway with the MAOB inhibitor KDS2010 enables recovery of spinal cord function in animal models.
Researchers found that mutations in the CFAP410 gene change its interaction with another protein, making motor neuron cells more vulnerable to DNA damage and cell death. This discovery provides new insights into the mechanisms underlying Motor Neurone Disease and highlights potential targets for new therapies.
A team of researchers from the University of Ottawa has developed a new workflow to study autophagy, a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out components. The study reveals novel signaling mechanisms regulating autophagy in response to numerous disease-related stress conditions.
Researchers introduce a dicyandiamide-based molecular bridge strategy to passivate defects and regulate phase distribution in quasi-2D perovskite solar cells, achieving record efficiencies and improved stability. This approach enables scalable development of efficient and durable next-generation perovskite photovoltaics.
Researchers at SMART Alliance for Research and Technology developed a powerful tool to scan thousands of biological samples and detect transfer ribonucleic acid (tRNA) modifications, which help control cell growth and response to diseases. The tool opens up new possibilities for disease research, diagnostics, and treatment development.
Scientists have developed a novel label-free approach to measure biomolecular condensate composition, resolving concentrations of five molecules in complex mixtures. This new method, ATRI, uses refractive index and tie-line measurements to determine condensate composition with unprecedented detail.
Researchers at Lund University identify genetic toolkit to program dendritic cell subtypes for targeted cancer treatment. The discovery could lead to more precise and powerful immunotherapies by supplying patients with tailored dendritic cells.
Researchers at Salk Institute discover a new microprotein, SLC35A4-MP, that regulates mitochondrial structure and function in brown fat tissue. The study reveals the microprotein's role in maintaining healthy cellular metabolism and regulating body temperature.
Researchers from UNSW identify a crucial protein, CHP1, that acts as a central director in fat metabolism, promoting lipid droplet growth and regulating key enzymes. This discovery advances basic knowledge of cellular fat storage and opens new avenues for future research into metabolic disorders.
Cells use a stopwatch-like mechanism to measure the length of messenger RNA (mRNA) tails, achieving molecular accuracy in vital processes like gene expression. The discovery reveals that two proteins, CPAC and Nab2, set the tail's length by timing their interaction, with the final length determined by a race between their speeds.
Researchers discovered that single bacterial cells carry a 'memory' of their past environments, passing it down through generations. This finding could explain why antibiotics and vaccines sometimes fail and may point to more precise treatments.
Scientists have developed a new approach to analyze proteins in individual cells during blood cell formation, bypassing mRNA intermediates. This study reveals the correlation between mRNA levels and protein expression, shedding light on the role of essential proteins in maintaining stem cell populations.
Researchers visualize extracellular matrix in living organism and discover principles of self-organization, indicating large fluctuations in protein production between individual cells. The structure forms rounded or polygonal boundaries that dynamically evolve as the organism grows, making it resemble a foam.
A University of Missouri-led study has uncovered how poplar trees can naturally adjust a key part of their wood chemistry based on changes in their environment, supporting improved bioenergy production. The discovery sheds light on the role of lignin and its potential to create better biofuels and sustainable products.
Neurons in the gut produce adrenomedullin 2, which expands group 2 innate lymphoid cells and provides therapeutic benefit in inflammatory bowel disease preclinical models. Elevated expression of ADM2 was found in patients with inflammatory bowel disease, suggesting a promising therapeutic target.
A new study demonstrates the potential to produce cellular spheroids from clinically relevant embryonic stem cells to generate scaffold-free chondrogenic or osteochondrogenic graft tissues. The researchers successfully cultured ES-MSC cellular spheroids, which matured into neocartilage tissues expressing cartilage-associated genes.
The conference will explore the latest breakthroughs in skin ageing research, targeting molecular mechanisms and real-world applications. Key findings include the importance of understanding skin ageing's intrinsic and extrinsic factors to develop comprehensive solutions.
Researchers have discovered a new approach for treating proteinopathies by targeting dysregulated nuclear speckles, which can lead to neuron degeneration. Pyrvinium pamoate has been shown to improve proteostasis in various disease models, including Alzheimer's, Parkinson's, and tauopathies.
Researchers investigate regional-specific gut microbial distribution, revealing its critical role in metabolic and immune regulation. Key findings include duodenal mucosal resection reducing small intestinal bacterial overgrowth and machine learning integrating multi-omics data to predict microbial dynamics.
The nuclear phosphoinositide-p53 signalosome modulates AKT activation in the nucleus, integrating two oncogenic pathways into a unified mechanism driving cancer cell motility. This complex is highlighted as a central regulator of cancer cell migration and a promising target for metastasis therapy.
Researchers aim to widen ADCs' therapeutic window and application scope by integrating AI, single-cell sequencing, and combination therapies. Precise antigen selection is crucial to minimize toxicity and improve efficacy in targeted cancer therapy.
The study resolved cryo-EM structures of the Nipah virus polymerase complex, unveiling binding modes between RdRp/PRNTase domains and the P tetramer. Two conserved zinc-binding sites were identified essential for polymerase activity.
Dynamin 1 regulates EMT progression, cell polarity and migration through N-cadherin endocytosis and recycling, promoting ovarian cancer metastasis. The study identifies DNM1 as a critical regulator of EMT-associated metastasis.
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
The "HippoBox" project aims to investigate neuroplastic changes in the hippocampus using brain organoids in real weightlessness. The research could provide new insights into cognitive health of space travelers and potential treatments for depression and dementia.
A major new textbook on autophagy is now available, encapsulating over 30 years of research in this growing field. The book, titled Autophagy – From Molecular Mechanisms to Flux Control in Health and Disease, aims to make the learning process easier for students and scientists alike.
A study from The University of Tokyo predicts HSC quality based on real-time cellular behavior using advanced imaging technology and machine learning. The researchers discovered previously hidden diversity within HSC populations and found that kinetic features could predict the expression levels of a key gene related to 'stemness'.
Researchers have discovered a key role of centrosomes in signaling cells to proliferate despite DNA damage, enabling cancer resistance. The study suggests targeting Polo-like kinase 1 could prevent adaptation to therapy-induced DNA damage and drug resistance.
A new approach by MIT researchers allows scientists to efficiently estimate how combinations of treatments will affect a group, enabling fewer costly experiments while gathering more accurate data. The framework considers the scenario where all treatments are assigned in parallel and controls the outcome by adjusting treatment rates.
Researchers found that telomerase inactivation in immune cells or connective tissue cells slows tumor growth, but creates conditions for aggressiveness. In contrast, endothelial cell preservation suppresses metastasis.
A new cell type has been identified in Burmese pythons that produces large particles made from calcium, phosphorus, and iron to digest bones. This specialized cell type helps limit excessive calcium absorption and is found in multiple python and boa species as well as the Gila monster.
Researchers found that inhibitory neurons born later in brain development mature faster than those produced earlier, ensuring a balanced neural network. This regulation is controlled by genetic mechanisms and may contribute to developmental disorders.
Researchers at Lund University are advancing knowledge about lipid nanoparticles, which could guide them to the right destination within cells. The technique has potential for treating cancer, genetic disorders, and neurological conditions.
Researchers at the University of Konstanz and Queen Mary University of London have made a significant breakthrough in artificial blood production by identifying the molecular signal CXCL12 that triggers the expulsion of the nucleus in red blood cells. This finding could lead to more efficient artificial blood production and has far-rea...
A novel fluorescent probe, SLY, has been developed to precisely identify hepatocellular carcinoma tissue using sialylated glycans on the cell surface. The probe outperforms conventional methods by clearly distinguishing tumor margins within liver tissues.
Scientists have developed a new tool named scICE to tackle the stability problem in single-cell RNA sequencing data. The tool provides a way to validate clustering outcomes mathematically, ensuring higher confidence in conclusions drawn from single-cell data.
Researchers have identified a gene signature indicative of hepatic ferroptosis using an iron overload-induced mouse model and validated it in human liver injury systems. The study highlights the role of ferroptosis in liver injuries and offers potential therapeutic targets.
The Arc Institute has launched its inaugural Virtual Cell Challenge, a public competition using AI to solve one of biology's biggest challenges. Competitors will train models on gene expression data from over half a billion cells and predict changes in gene activity when individual genes are silenced.
Researchers have identified a previously unknown organelle called the hemifusome that plays a crucial role in cellular sorting and recycling. This discovery could lead to targeted treatments for complex genetic disorders like Hermansky-Pudlak syndrome, which affects multiple systems in the body.
Researchers at Johns Hopkins Medicine have made a breakthrough in developing a gene therapy that can permanently put HIV into a dormant state. The therapy uses human immune system cells and amplifies a molecule within HIV that induces long-term dormancy.
A six-year study reveals betaine's role in orchestrating body-wide geroprotective signals, countering aging through inflammation regulation and immune system rejuvenation. Betaine supplementation replicates exercise benefits, including alleviating cellular aging and slashing inflammation systemically.
Researchers have made a breakthrough in the fight against aging by reprogramming human stem cells to resist aging and stress. In a 44-week experiment on elderly macaques, they found that the engineered cells reversed multiple signs of aging, including cognitive function, tissue damage, and age-related degenerative conditions.
Researchers at City of Hope have made significant progress in understanding the role of paxillin in cellular signaling networks, providing new insights into potential cancer treatments. The study reveals that disrupting the interaction between paxillin and focal adhesion proteins could be a viable target for therapy.
The histone modification H3K4me3 is crucial for chromosome and spindle stabilization, normal oocyte development, and embryonic competence. Removing H3K4me3 leads to destabilized spindles, impaired embryonic development, and decreased fertility.
Researchers found that eukaryotes could survive in shallow pools of water atop ice sheets, similar to modern-day meltwater ponds in Antarctica. These environments supported diverse communities of early complex life, influenced by salinity levels.
Researchers discovered a new tumor-suppressive response targeting RNA Polymerase 1, inhibiting cancer cell growth and enhancing responsiveness to immunotherapies. The Pol 1 inhibitor BOB-42 reduced tumor growth by up to 77% in melanoma and colorectal cancers.