Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
Researchers developed a water-rich, Jell-O-like hydrogel that mimics human tissue's movement, stretching, and relaxation. The hydrogel can be precisely controlled by light, enabling the study of cell behavior and disease modeling.
Researchers at UCSF have discovered a new therapeutic target, SRC, present on up to half of all tumors, which can be targeted with antibody drugs. The enzyme, normally hidden inside cells, is exposed on the surface of tumor cells due to an overactive disposal system, making it an easy target for cancer-killing antibodies.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
Researchers at Washington State University have discovered the microscopic landscape of proteins in plant leaf cells, revealing how they convert sunlight into bioenergy. The study provides a new view of the molecular engine of photosynthesis and its potential for future fine-tuning of crops.
Scientists at UCSF created a new material that enables more predictable organoid growth, allowing for better study of disease and potential tissue replacement. The dynamic gel, invented by Zev Gartner, mimics the body's soft environment and enables precise 3D printing of stem cells.
Researchers identified new neurons that respond to different spatial frequencies, allowing for more precise object recognition, and used digital twins to confirm the findings in mouse brains.
A study published in the journal Immunity has discovered that resident macrophages play a key role in regulating eye pressure, suggesting a promising new target for therapies to prevent glaucoma. The findings highlight the importance of the immune system in maintaining healthy eye pressure.
A new study reveals that astrocytes regulate inhibitory signaling in the cerebellum during development, enabling the emergence of flexible and precise motor coordination. In contrast, younger animals rely on neuron-derived tonic inhibition, which is replaced by astrocyte-derived tonic inhibition in late adolescence.
Researchers at Ohio University discovered that blocking the growth hormone receptor may help make lung cancer treatments more effective. Patients with low GHR tumors survived significantly longer than those with high GHR tumors, highlighting a potential new target for therapy.
Researchers developed a rapid and non-destructive method to monitor iron flux in mesenchymal stromal cells (MSCs) using micromagnetic resonance relaxometry (µMRR). This breakthrough enables real-time insights into MSC's ability to form quality cartilage tissue, paving the way for more consistent manufacturing of MSC-based therapy.
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.
Researchers at the Max Planck Institute for Brain Research discovered that stressed animal cells, including neurons, assemble inactive ribosomes into tightly linked pairs, known as disomes. This novel mechanism relies on a specific piece of ribosomal RNA called an expansion segment to form a precise RNA-RNA interaction.
Research by Amita Sehgal and her team reveals that sleep helps neurons stay healthy by removing oxidative damage through lipid transfer to glia cells. This process is crucial for maintaining neuronal function and may contribute to the development of neurodegenerative diseases like Alzheimer's.
The new center combines large-scale equipment and methods to study individual cells in detail, detecting molecular differences and analyzing reactions to biochemical or genetic changes. This enables new perspectives for medical diagnostics and research, including personalized medicine.
Scientists have discovered a mechanism that explains how exercise improves cognition by shoring up the brain's protective barrier. The study found that an exercise-induced liver protein strengthens the blood-brain barrier, reducing inflammation and cognitive decline associated with Alzheimer's disease.
Research from Salk Institute scientists shows that DNA's dynamic folding process affects gene regulation and expression, with specific regions unfolding at different rates to regulate cell type-specific functions.
A research team led by Universitat Autonoma de Barcelona has discovered the molecular mechanism regulating bacterial cell division. The MraZ protein binds to the dcw gene cluster, enabling coordinated action of proteins necessary for cell division and bacterial wall formation.
A UCalgary study found that adding high doses of vitamin B3 to the treatment plan may help rejuvenate compromised immune cells to kill tumour cells. The clinical trial showed promising results, with 82% of participants free of cancer progression at six-months.
Researchers at the University of Virginia Health System have identified a molecule that blocks the gene responsible for glioblastoma, a fast-growing and deadly brain cancer. The compound shows promise in preventing the invasive cancer from spreading through the brain without causing harm to healthy tissue.
Researchers found molecules such as syringic acid that protect neurons from aging, while others like resveratrol promote neurodegeneration. An AI-powered approach identified potential therapeutic substances to preserve brain function and prevent neurodegenerative diseases.
Cells move in groups during biological processes, but researchers have made a surprising discovery that upends understanding of how cells move. Negative viscosity, which propels cells forward, has been found to increase metabolic activity in affected regions.
Researchers introduce a new single-cell sorting strategy operating directly in air to overcome constraints of fixed microfluidic channels. The system achieves exceptionally high accuracy and survival rates, enabling flexible sorting of multiple cell subpopulations from complex samples.
Researchers at Science Tokyo discover that a single amino acid deletion in the antibody's lower hinge transforms it into a stable half-IgG1 molecule with altered immune activity. This finding provides a blueprint for engineering next-generation antibody therapies.
Researchers have developed a new AI tool called VASCilia that provides unprecedented 3D views of cochlear hair cells. The tool accelerates the imaging process by 50-fold, allowing scientists to analyze cells with greater precision and accuracy. This advancement offers new insights into hearing loss caused by damaged inner ear hair cells.
A new study identified deoxyhypusine synthase as a critical regulator of macrophage maturation and long-term survival. Without this enzyme, monocytes fail to differentiate into functional tissue-resident macrophages, leading to impaired tissue maintenance and inflammation.
Researchers at John Innes Centre and Earlham Institute developed a powerful single-cell visualisation technique to understand wheat spike development. The study reveals distinct expression patterns across spikes, shedding light on why basal spikelets fail to achieve full size.
Research highlights glial cells as dynamic regulators of brain health, playing both protective and harmful roles in neural function. Promising therapeutic targets include oligodendrocyte dysfunction, mitochondrial transfer, and extracellular vesicle engineering.
Researchers at NTU Singapore have found that a common bacterium produces reactive oxygen species that impairs wound healing. Neutralizing this process with an antioxidant enzyme restores skin cells' ability to migrate and heal, offering a potential solution to tackle antibiotic-resistant strains.
A research team at Goethe University Frankfurt has compiled a catalog of human E3 ligases and mapped their relationships, revealing family-specific functions. The study identifies 40 additional E3 ligases suitable for PROTAC development, expanding the range of tissues and diseases targeted by degradation therapies.
Researchers have developed a new method to print custom microstructures directly into living cells, enabling the study of biological functions and instilling enhanced properties. The breakthrough uses light-sensitive materials and laser polymerization to create structures within cells.
Researchers have discovered that feline infectious peritonitis virus infects a broader range of immune cells, including B lymphocytes and T lymphocytes. The findings suggest that the virus can persist in these cells even after treatment, potentially leading to long-term immune problems.
Researchers discovered genes that regulate fibroblast growth, which builds the scaffolding between cells. Adjusting these factors reversed age-related changes and improved health outcomes in mice. The study offers new opportunities to understand and reverse aging-related diseases.
Researchers at Umea University have identified two autophagy protein complexes as the long-sought sensors of lysosomal damage. These proteins respond to protons or calcium leakage, initiating the repair system that seals the hole, thereby preventing inflammation and cell death.
Researchers at University of British Columbia have successfully grown specialized immune cells called helper T cells from stem cells in a controlled laboratory setting. This breakthrough could lead to more accessible and effective off-the-shelf treatments for various conditions, including cancer, autoimmune disorders, and infectious di...
Researchers from Université de Genève have identified the transporters responsible for each lipid, revealing the complex mechanisms behind their cellular targeting. This study provides valuable insights into lipid biology and its link to various diseases such as Alzheimer's and diabetes.
Researchers develop ddHodge, a geometry-preserving method that accurately reconstructs cell state dynamics. The technique reveals repeating processes like the cell cycle and identifies critical biological moments in embryonic development, tissue regeneration, and cancer progression.
Researchers in Japan discovered that cells eliminate less efficient ribosomes through a 'survival of the fittest' mechanism, ensuring accurate and efficient protein synthesis. This discovery sheds light on how cells maintain quality control and prevents ribosome-related diseases.
Researchers at Virginia Tech have developed a new method for attaching fluorine-18 to trifluoromethyl groups, enabling the tagging of previously inaccessible targets in PET scans. This breakthrough expands the range of molecules that can be imaged, potentially leading to earlier diagnoses and more targeted treatments for diseases.
A team of MIT engineers developed a deep-learning model that predicts how individual cells will fold, divide, and rearrange during a fruit fly's earliest stage of growth. The model achieved 90% accuracy in predicting the movement of 5,000 cells over the first hour of development.
Researchers develop a strategy that delivers record FF of 80.1% and maintains high efficiency even at thin active-layer thickness. The design offers a cost-effective pathway to high-efficiency, thick-film organic solar cells.
Researchers at Ohio State University developed a new approach to immobilize extracellular vesicles in a way that mimics their interactions with tissues. This allows for the study of these particles and their complex interactions with cells, enabling potential applications in disease detection, drug delivery, and biomarker discovery.
Researchers at OIST have discovered that certain cancers can 'lose their sense of time' to avoid cellular stress responses. The study highlights the role of USP28 in stabilizing p53, a known tumor suppressor, and how mutations in this protein can disrupt its function.
Researchers have elucidated the molecular mechanism by which microtubules transmit signals to cells, using the signalling protein GEFH1. The C1 domain of GEFH1 binds specifically to microtubules, activating the RhoA signalling pathway and triggering cellular processes.
Researchers have discovered a key protein structure in the germ cells of male mice that causes deformations in sperm flagellum leading to infertility. The study used ultrastructure expansion microscopy to visualize the centriole, a tiny cylindrical structure critical for sperm movement.
Researchers at UNIGE and HUG have developed CAR-T cells capable of destroying glioblastoma cells by targeting specific proteins present in the tumour environment. The new approach has shown promising results in animal models, paving the way for clinical trials in humans.
Researchers discovered that NDRG3 slows down cellular transport to conserve energy during low-oxygen conditions. The protein acts as a sensor for lactate, which accumulates in cells when oxygen is limited.
Researchers differentiate true 2D passivation from amorphous capping in perovskite solar cells using a single-atom fluorine substitution. The n-type crystalline 2D layer achieves high efficiency and stability, offering a design rule for next-generation modules.
Researchers found that inflammatory stromal cells replace stem-cell-supportive mesenchymal stromal cells in the bone marrow, creating a feed-forward loop of chronic inflammation and suppressing healthy blood formation. This discovery positions inflammation as a central force in early blood disease development.
Scientists have discovered a protein called SCEP3 that ensures even chromosome segregation in plants, preventing infertility and genetic diseases. This finding has implications for plant breeding and understanding human fertility, with the equivalent gene SIX6OS1 potentially playing a role in promoting correct chromosome segregation.
Weill Cornell Medicine researchers have discovered a molecular signal that tumors exploit to exhaust T cells meant to destroy them. By silencing this signal, the body's immunity can be revived and cancer-fighting immune cells restored.
Researchers have identified the cells and connections underlying a fish's ability to dynamically change color to match its surroundings. The study found that specialized skin cells called melanophores control the color change, which helps the zebrafish evade predators by lightening its skin over tens of minutes.
Scientists develop AMOUR method for accurate profiling of surface RNAs and Intact-Surface-FISH for visualization and quantification of representative surface RNAs. The study reveals a rich repertoire of noncoding RNAs on human and murine blood cells, with potential contributions to autoimmunity.
Alec Whited's published study reveals a previously unknown cellular pathway that enhances waste removal, potentially treating autoimmune diseases and improving wound healing. The research, coauthored with a UTA doctoral student, was recently published in Genetics, a prestigious journal.
A new study reveals that increasing NAD⁺ levels corrects RNA splicing mistakes, improving brain function and restoring memory in animal models of Alzheimer's disease. The researchers discovered a previously unidentified pathway involving the protein EVA1C, which plays a crucial role in correcting tau-related neuronal damage.
Researchers at MIT developed microscopic, wireless bioelectronics that can identify and travel to specific brain regions without human guidance. These implants provide focused treatment for brain diseases like Alzheimer's and multiple sclerosis by wirelessly powering electrical stimulation in precise areas.
Scientists have discovered that immune cells shed their glycocalyx layer to move into tissues, changing the understanding of inflammatory skin diseases like psoriasis. This finding may lead to new approaches in developing drugs targeting immune cell movement and treating infections and inflammatory diseases.
Researchers at Wayne State University are investigating how eosinophils influence corneal response to infection, focusing on microbial keratitis and potential therapeutic strategies to preserve vision. The goal is to identify new treatments that fight infection while minimizing tissue damage.