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The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility

08.08.25 | Higher Education Press

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This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive actions of wild-type p53 with the oncogenic properties of mutant p53, highlighting how distinct PIPn-driven signalosomes influence nuclear AKT activation, cytoskeletal dynamics, and metastasis-related behavior. Credit: Xiaoting Hou, Yu Chen, Bo Zhou, Fengting Liu, Lingyun Dai, Chunbo Chen, Noah D. Carrillo, Vincent L. Cryns, Richard A. Anderson, Jichao Sun, Mo Chen

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the nucleus but also integrates two major oncogenic pathways—p53 dysregulation and PI3K-AKT amplification—into a unified mechanism driving cancer cell migration and invasion.

Key points of the review include:

This review highlights the nuclear PIPn-p53 signalosome as a central regulator of cancer cell motility and a promising target for metastasis therapy. The work entitled “The Nuclear Phosphoinositide-p53 Signalosome in the Regulation of Cell Motility” was published in Protein & Cell (Advance access May 26, 2025).

Protein & Cell

10.1093/procel/pwaf043

Systematic review

Not applicable

The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility

26-May-2025

Keywords

Cells

Article Information

Journal
Protein & Cell
DOI
10.1093/procel/pwaf043
Method of Research
Systematic review
Subject of Research
Not applicable
Article Publication Date
2025-05-26
Article Title
The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility

Contact Information

Rong Xie
Higher Education Press
xierong@hep.com.cn

Source

Original Source
https://doi.org/10.1093/procel/pwaf043

How to Cite This Article

APA:
Higher Education Press. (2025, August 8). The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility. Brightsurf News. https://www.brightsurf.com/news/19NK4R01/the-nuclear-phosphoinositide-p53-signalosome-in-the-regulation-of-cell-motility.html
MLA:
"The nuclear phosphoinositide-p53 signalosome in the regulation of cell motility." Brightsurf News, Aug. 8 2025, https://www.brightsurf.com/news/19NK4R01/the-nuclear-phosphoinositide-p53-signalosome-in-the-regulation-of-cell-motility.html.