Articles tagged with Cells
A new trial aims to restore the function of worn-out T cells, a type of white blood cell that helps coordinate the body's immune response. The Phase 1 trial will focus on exhausted or senescent T cells, which accumulate with age and in chronic disease, and may help improve immune resilience and support healthier ageing.
A University of Guelph researcher has discovered a common skincare ingredient that may target acute myeloid leukemia by blocking the fat-to-fuel process in cancer cells. The compound inhibits ABCD1 protein production, causing leukemia cells to die while healthy cells adapt and survive.
Researchers at UCLA may have discovered a new way to heal damaged kidneys by blocking the protein ENPP1. Blocking this protein speeds up repair after kidney injury in mice, according to a recent study published in Cell Stem Cell.
Researchers discovered a single amino acid change that allows coronaviruses to interact with human and bat immune systems differently, shifting the body's response to infection. This alteration enables benign animal viruses to adapt to humans and cause severe disease.
By identifying three distinct developmental stages of photoreceptor cells, researchers aim to determine which cell population is most capable of forming neuronal connections in the eye. This may lead to improved treatment outcomes for late-stage blinding conditions through cell-based therapies.
Researchers have made major steps toward solving the mystery of how brain aneurysms form by identifying key cell types and genetic pathways involved. The study's findings provide new insights into a clinical paradox: smaller aneurysms can still rupture, and offer opportunities for early intervention to prevent ruptures.
A groundbreaking study identifies a direct energy route between mitochondria and the nucleus, supporting gene regulation, chromatin remodeling, and cell differentiation. The finding challenges traditional assumptions about energy transfer in cells and has significant implications for understanding health and disease.
A University of Ottawa-led study has discovered a hidden network driving glioblastoma's aggressive growth, highlighting a promising target for next-generation therapies. The research reveals that a protein called OSMR plays a critical role in tumor progression and supports the survival of brain tumour stem cells.
Researchers from Florida Atlantic University have identified a key immune pathway that appears to drive damaging inflammation in Huntington disease. Blocking this pathway reduced brain inflammation, protected neurons, and improved movement in a humanized mouse model of the disease.
Researchers found a unique protein called YAF9B that helps plants protect their stem cells from DNA damage. This discovery sheds light on how plants coordinate DNA repair processes, which could improve future crops by guiding more precise genome editing.
Cellular senescence has emerged as a key biological process linked to aging and age-related disease. Researchers have identified major features of senescence, including stable proliferative arrest and the senescence-associated secretory phenotype (SASP), which can influence inflammation and tissue dysfunction.
TIGIT is a second-generation immune checkpoint that exerts immunosuppressive effects through multiple pathways, promoting a hypoxic tumor microenvironment. Combination with PD-1 inhibitors has shown remarkable promise, improving objective remission rates and progression-free survival.
Researchers from six Asian countries have launched a coordinated effort to create an artificial single-celled biological system. The 10-year roadmap aims to develop stable phospholipid vesicles with minimal genomes, endogenous synthesis of key metabolites, and true self-replication.
The new method allows for scalable production of cell-containing capsules, maintaining cell viability and enabling studies on dynamic interactions. Researchers can customize capsule size and properties, making the technique useful for drug screening, regenerative medicine, and basic cell biology research.
A recent study identified a new type of β-1,2-glucan-binding protein in bacteria, which binds cyclic β-1,2-glucans and has implications for understanding bacterial interactions with these complex molecules. The discovery opens up new avenues for developing biological pesticides to protect crops from pathogens.
Researchers found that repeated vaping can create harmful byproducts in high-puff electronic cigarettes, including methylglyoxal and glyoxal, which are associated with significant cell damage. The study suggests that users of heavily used devices may inhale higher levels of these compounds than those using fresh devices.
New research reveals that cells slow down heat dissipation due to unique biomolecules, changing our understanding of heat conduction. This phenomenon could affect treatments for conditions linked to body temperature changes.
Researchers found that a vitamin D analog reduced fibroblast activation and increased T cell infiltration in pancreatic tumors, improving chemotherapy responses and progression-free survival. Patients with high vitamin D receptor expression also had longer overall survival.
A team of researchers at Kyoto University has discovered that the protein ZO-1 plays a crucial role in collective cell migration by riding ERK activation waves to podosomes on the basal cell surface. This movement enhances force generation, extracellular matrix degradation, and invasive cell migration.
Scientists at the Garvan Institute of Medical Research captured 'housekeeping' immune cells actively attacking and engulfing live melanoma cells. These macrophages patrol the edges of melanoma tumours, steadily engulfing cancer cells and slowing tumour growth. The discovery has big implications for immunotherapy.
Researchers at ISTA uncovered why keratin plays an essential part in embryonic cell movement and organization. Without keratin, the process slows dramatically, leading to tissue collapse and loss of cellular alignment. Keratin helps maintain the structural integrity and cohesion of cells during early development.
Scientists at Kaunas University of Technology discovered that low-frequency ultrasound can dissociate erythrocyte aggregates into single cells, decreasing blood viscosity. This effect may improve oxygen exchange and support treatment of cardiovascular diseases, Alzheimer's disease, and diabetes.
Researchers found that self-propelled particles can spontaneously form clusters when navigating a dense colony of dividing cells. The growing medium creates an environment that transforms the particles' behavior, making them behave like active Brownian particles and attracting them to each other without explicit interaction.
Researchers identify TGF-β signaling pathway as key regulator of osteoblast quiescence, suggesting its inhibition can aid in reactivation of dormant osteoblasts. Combining TGF-β-blocking antibodies with anti-sclerostin treatment shows promising therapeutic potential for osteoporosis treatment.
University of Missouri researchers develop organic transistors that process information like biological neural networks, boosting brain-like computing and potentially leading to more energy-efficient artificial intelligence. The approach could lead to significant improvements in tasks such as pattern recognition and decision-making.
A recent study found that lycopene protects porcine intestinal epithelial cells from DON-induced damage by inhibiting PGAM5-mediated mitophagy-dependent ferroptosis. Lycopene increases tight junction proteins, reduces ROS levels, and stabilizes mitochondrial function, restoring barrier integrity.
Researchers at TUM develop NTVE, a process that uses virus-like particles to shuttle messenger RNA out of living cells, allowing for repeated sampling and analysis. This enables precise monitoring of stem cell development and potential applications in cell therapies and tumor research.
Researchers at MIT have found that chromatin can exist in two different categories: constrained and free, which affects its interaction with genes and DNA regulatory sequences. This study provides insight into gene regulation and DNA repair processes.
A team of researchers has identified a key mechanism in the degeneration of motor neurons in ALS, revealing that chaperone-mediated autophagy is significantly reduced in patients. This finding suggests that this cellular system may be a potential therapeutic target to slow disease progression.
Researchers found that camels have a more flexible and coordinated response to heat stress, allowing them to maintain stability even at higher temperatures. In contrast, human cells tend to respond in a more rigid way, making them less adaptable under heat stress.
Researchers developed tiny flexible lasers that can measure forces inside living cells, enabling insights into biological processes such as early development and tumor progression. The micro-lasers exhibit mechanical stiffness similar to living cells and can measure forces up to 50 nanonewtons.
Researchers identified stage-specific gene expression changes that occur during cellular senescence, revealing an early immune-activating response and a shift in cellular priorities. This study offers new insight into the molecular mechanisms of aging and highlights potential therapeutic strategies for delaying age-related decline.
A new study reveals the developmental mechanism of bone marrow formation, identifying septoclasts as early organizers followed by LepR-expressing bone marrow stromal cells. These specialized cell populations work together to build the bone marrow environment through a hardwired process supported by RANKL.
Researchers from Lund University successfully harnessed the regenerative capacity of Scandinavian flatworms to accelerate wound healing in human skin models. The study found that signalling molecules from flatworm exosomes increased skin thickness and improved wound healing rates, including accelerated blood vessel regeneration.
The Targeting Phage Therapy 2026 Congress will bring together experts to address clinical, regulatory, industrial, and hospital infrastructure requirements for phage therapy. The congress aims to move phage therapy from promising science to accessible, validated, and deployable medicine.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
Researchers from UNIGE have identified a molecular mechanism regulating cellular balance and found that TORC2's activation is controlled by a molecular 'cork'. This discovery paves the way for targeting this mechanism to treat diseases like cancer and diabetes.
Mechanobiology reveals how physical forces govern cells, tissues, and diseases, leading to breakthroughs in cancer, fibrosis, orthopedic injuries, and vascular diseases. The field is also pioneering mechanical reprogramming and mechanogenetics, enabling personalized mechanical interventions.
A Salk Institute study identifies Fibroblast Growth Factor 1 (FGF1) as the molecular signal that tells the liver when to release fat into the bloodstream, following a precise rhythm timed to the body's internal clock.
A study identified exosomal microRNA-122-3p as a key driver of MASLD pathogenesis. Elevated miR-122-3p levels induced triglyceride accumulation and reactive oxygen species production in liver cells.
A recent study reveals that MLKL activation causes direct damage to mitochondria, impairing energy production and leading to functional decline in hematopoietic stem cells. In contrast, deletion or inhibition of MLKL significantly alleviates these defects, suggesting a post-transcriptional mechanism driving HSC aging.
A new study from MIT chemists found that changing the composition of the cell membrane can alter the function of a membrane receptor promoting cell growth. Elevated levels of negatively charged lipids can lock the receptor into an overactive state, contributing to cancer cell proliferation.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers at the University of Groningen discovered that protein clustering in cells leads to reduced movement and improved efficiency in amino acid production. This finding has practical implications for designing efficient cell factories and increasing substance production inside cells.
Researchers generated a comprehensive view of DNA methylation abnormalities in human MDS HSCs, uncovering a novel TET2-GFI1 axis that suppresses malignant transformation. The study identifies key hematopoietic regulators and provides a panoramic view of DNA methylation disruption in MDS.
A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
Researchers have discovered how a disease-causing bacterium uses a single protein to interfere with the body's defenses in multiple ways, offering a clearer picture of how infections take hold at the cellular level. This discovery highlights the importance of targeting specific interactions between bacterial proteins and human cells in...
The Hybrid Oxygenation Bioelectronics system, or HOBIT, shields cells from the immune system while providing access to oxygen and nutrients. The compact device supports higher cell densities in a smaller space, enabling the production of multiple biologic molecules simultaneously.
A new platform called ATLAS enables researchers to generate large quantities of cancer cell clusters that accurately model metastasis. Using ATLAS, the Rice team gained insights into the mechanisms that enable cancer clusters to survive in the bloodstream during the metastatic process.
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
A research team led by LEE Doyun and KIM Yee-Joon found that the primary visual cortex encodes motion summaries and variability before higher brain regions transform them into category signals. This process, known as ensemble perception, allows the brain to capture the overall structure of a scene at a glance.
Regulatory B cells produce anti-inflammatory cytokines like IL-10, which dampens inflammatory responses and guides T cells toward regulatory phenotypes. This immune modulation can counteract damaging inflammation and promote neuroprotection.
A new study has deciphered the step-by-step assembly of eukaryotic proteasomes, revealing two alternative pathways and a flexible biogenesis process. The findings have far-reaching implications for understanding cellular protein quality control, ageing, and diseases like cancer and neurodegenerative disorders.
Researchers at IISc created a method to precisely steer quantum sensors through living cells, overcame challenges like viscous drag and brownian motion. This breakthrough enables real-time measurement of parameters such as local viscosity and temperature inside cells.
A study led by Oxford University researchers reveals that sperm stored for extended periods deteriorates quickly, regardless of male age. Regular ejaculation has been shown to improve sperm quality in humans and animals alike.
The study provides a breakthrough understanding of the immunoregulatory nature of human tissues, revealing that fibroblasts serve as core regulators of structural immunity in the mouth. The findings lay the groundwork for targeted modulation of fibroblast activity to improve health outcomes in fibrosis, cancer, and autoimmunity.
Researchers from the University of Tokyo successfully developed a high-pressure freezing method that reduces CPA concentration to 20-30% and improves cell viability and metabolic activity. The method holds promise for cryopreservation in regenerative medicine research, with potential applications in drug testing and cell transplantation.
Huntington's disease is caused by a toxic protein that builds in brain cells and spreads to other cells through tunneling nanotubes. Disrupting this pathway reduces the spread of the disease-causing protein, suggesting a new target for therapy.
A computational method called scSurv links individual cells to patient outcomes using bulk RNA sequencing data, identifying cell populations associated with survival across several cancers. The model estimates the contributions of over 10,000 individual cells to disease risk and prognosis, providing a foundation for precision medicine.
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.