Articles tagged with Cells
The Targeting Phage Therapy 2026 Congress will bring together experts to address clinical, regulatory, industrial, and hospital infrastructure requirements for phage therapy. The congress aims to move phage therapy from promising science to accessible, validated, and deployable medicine.
Researchers from UNIGE have identified a molecular mechanism regulating cellular balance and found that TORC2's activation is controlled by a molecular 'cork'. This discovery paves the way for targeting this mechanism to treat diseases like cancer and diabetes.
Mechanobiology reveals how physical forces govern cells, tissues, and diseases, leading to breakthroughs in cancer, fibrosis, orthopedic injuries, and vascular diseases. The field is also pioneering mechanical reprogramming and mechanogenetics, enabling personalized mechanical interventions.
A Salk Institute study identifies Fibroblast Growth Factor 1 (FGF1) as the molecular signal that tells the liver when to release fat into the bloodstream, following a precise rhythm timed to the body's internal clock.
A study identified exosomal microRNA-122-3p as a key driver of MASLD pathogenesis. Elevated miR-122-3p levels induced triglyceride accumulation and reactive oxygen species production in liver cells.
A new study from MIT chemists found that changing the composition of the cell membrane can alter the function of a membrane receptor promoting cell growth. Elevated levels of negatively charged lipids can lock the receptor into an overactive state, contributing to cancer cell proliferation.
A recent study reveals that MLKL activation causes direct damage to mitochondria, impairing energy production and leading to functional decline in hematopoietic stem cells. In contrast, deletion or inhibition of MLKL significantly alleviates these defects, suggesting a post-transcriptional mechanism driving HSC aging.
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
Researchers at the University of Groningen discovered that protein clustering in cells leads to reduced movement and improved efficiency in amino acid production. This finding has practical implications for designing efficient cell factories and increasing substance production inside cells.
Researchers generated a comprehensive view of DNA methylation abnormalities in human MDS HSCs, uncovering a novel TET2-GFI1 axis that suppresses malignant transformation. The study identifies key hematopoietic regulators and provides a panoramic view of DNA methylation disruption in MDS.
A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
Researchers have discovered how a disease-causing bacterium uses a single protein to interfere with the body's defenses in multiple ways, offering a clearer picture of how infections take hold at the cellular level. This discovery highlights the importance of targeting specific interactions between bacterial proteins and human cells in...
The Hybrid Oxygenation Bioelectronics system, or HOBIT, shields cells from the immune system while providing access to oxygen and nutrients. The compact device supports higher cell densities in a smaller space, enabling the production of multiple biologic molecules simultaneously.
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
A new platform called ATLAS enables researchers to generate large quantities of cancer cell clusters that accurately model metastasis. Using ATLAS, the Rice team gained insights into the mechanisms that enable cancer clusters to survive in the bloodstream during the metastatic process.
Regulatory B cells produce anti-inflammatory cytokines like IL-10, which dampens inflammatory responses and guides T cells toward regulatory phenotypes. This immune modulation can counteract damaging inflammation and promote neuroprotection.
A research team led by LEE Doyun and KIM Yee-Joon found that the primary visual cortex encodes motion summaries and variability before higher brain regions transform them into category signals. This process, known as ensemble perception, allows the brain to capture the overall structure of a scene at a glance.
Researchers at IISc created a method to precisely steer quantum sensors through living cells, overcame challenges like viscous drag and brownian motion. This breakthrough enables real-time measurement of parameters such as local viscosity and temperature inside cells.
A study led by Oxford University researchers reveals that sperm stored for extended periods deteriorates quickly, regardless of male age. Regular ejaculation has been shown to improve sperm quality in humans and animals alike.
A new study has deciphered the step-by-step assembly of eukaryotic proteasomes, revealing two alternative pathways and a flexible biogenesis process. The findings have far-reaching implications for understanding cellular protein quality control, ageing, and diseases like cancer and neurodegenerative disorders.
Researchers from the University of Tokyo successfully developed a high-pressure freezing method that reduces CPA concentration to 20-30% and improves cell viability and metabolic activity. The method holds promise for cryopreservation in regenerative medicine research, with potential applications in drug testing and cell transplantation.
The study provides a breakthrough understanding of the immunoregulatory nature of human tissues, revealing that fibroblasts serve as core regulators of structural immunity in the mouth. The findings lay the groundwork for targeted modulation of fibroblast activity to improve health outcomes in fibrosis, cancer, and autoimmunity.
Huntington's disease is caused by a toxic protein that builds in brain cells and spreads to other cells through tunneling nanotubes. Disrupting this pathway reduces the spread of the disease-causing protein, suggesting a new target for therapy.
A computational method called scSurv links individual cells to patient outcomes using bulk RNA sequencing data, identifying cell populations associated with survival across several cancers. The model estimates the contributions of over 10,000 individual cells to disease risk and prognosis, providing a foundation for precision medicine.
Researchers at the University of Pennsylvania developed lipid nanoparticles that modify immune metabolism to strengthen mRNA vaccines and reduce common side effects. The new lipid boosts the metabolism of immune cells, providing energy for the body's defenses while dialing down inflammatory signals.
Stanford researchers have developed a novel 'scaffold-free' approach for treating damaged muscles, enabling the delivery of more healing cells to the traumatized area. The approach uses a custom molding technology to create dense muscle tissue in customizable geometric shapes and sizes, allowing for more effective muscle regeneration.
Researchers developed a water-rich, Jell-O-like hydrogel that mimics human tissue's movement, stretching, and relaxation. The hydrogel can be precisely controlled by light, enabling the study of cell behavior and disease modeling.
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
Researchers at UCSF have discovered a new therapeutic target, SRC, present on up to half of all tumors, which can be targeted with antibody drugs. The enzyme, normally hidden inside cells, is exposed on the surface of tumor cells due to an overactive disposal system, making it an easy target for cancer-killing antibodies.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
Researchers identified new neurons that respond to different spatial frequencies, allowing for more precise object recognition, and used digital twins to confirm the findings in mouse brains.
Researchers at Washington State University have discovered the microscopic landscape of proteins in plant leaf cells, revealing how they convert sunlight into bioenergy. The study provides a new view of the molecular engine of photosynthesis and its potential for future fine-tuning of crops.
Scientists at UCSF created a new material that enables more predictable organoid growth, allowing for better study of disease and potential tissue replacement. The dynamic gel, invented by Zev Gartner, mimics the body's soft environment and enables precise 3D printing of stem cells.
A new study reveals that astrocytes regulate inhibitory signaling in the cerebellum during development, enabling the emergence of flexible and precise motor coordination. In contrast, younger animals rely on neuron-derived tonic inhibition, which is replaced by astrocyte-derived tonic inhibition in late adolescence.
A study published in the journal Immunity has discovered that resident macrophages play a key role in regulating eye pressure, suggesting a promising new target for therapies to prevent glaucoma. The findings highlight the importance of the immune system in maintaining healthy eye pressure.
Researchers at Ohio University discovered that blocking the growth hormone receptor may help make lung cancer treatments more effective. Patients with low GHR tumors survived significantly longer than those with high GHR tumors, highlighting a potential new target for therapy.
Researchers developed a rapid and non-destructive method to monitor iron flux in mesenchymal stromal cells (MSCs) using micromagnetic resonance relaxometry (µMRR). This breakthrough enables real-time insights into MSC's ability to form quality cartilage tissue, paving the way for more consistent manufacturing of MSC-based therapy.
A new study reveals that astrocytes actively participate in motor-learning circuit rewiring by eliminating synapses in the striatum. The research identifies MEGF10 as a key molecular mediator of this process, which is regulated by dopamine signaling and neural activity.
Researchers from the University of Ottawa have developed a groundbreaking biomaterial that combines strength, adaptability, and biological compatibility for soft tissue repair. The hydrogel is made from synthetic peptides and can be precisely tailored through chemical design, making it an attractive alternative to existing biomaterials.
Researchers at the Max Planck Institute for Brain Research discovered that stressed animal cells, including neurons, assemble inactive ribosomes into tightly linked pairs, known as disomes. This novel mechanism relies on a specific piece of ribosomal RNA called an expansion segment to form a precise RNA-RNA interaction.
Scientists have discovered a mechanism that explains how exercise improves cognition by shoring up the brain's protective barrier. The study found that an exercise-induced liver protein strengthens the blood-brain barrier, reducing inflammation and cognitive decline associated with Alzheimer's disease.
Research by Amita Sehgal and her team reveals that sleep helps neurons stay healthy by removing oxidative damage through lipid transfer to glia cells. This process is crucial for maintaining neuronal function and may contribute to the development of neurodegenerative diseases like Alzheimer's.
The new center combines large-scale equipment and methods to study individual cells in detail, detecting molecular differences and analyzing reactions to biochemical or genetic changes. This enables new perspectives for medical diagnostics and research, including personalized medicine.
A research team led by Universitat Autonoma de Barcelona has discovered the molecular mechanism regulating bacterial cell division. The MraZ protein binds to the dcw gene cluster, enabling coordinated action of proteins necessary for cell division and bacterial wall formation.
Research from Salk Institute scientists shows that DNA's dynamic folding process affects gene regulation and expression, with specific regions unfolding at different rates to regulate cell type-specific functions.
A UCalgary study found that adding high doses of vitamin B3 to the treatment plan may help rejuvenate compromised immune cells to kill tumour cells. The clinical trial showed promising results, with 82% of participants free of cancer progression at six-months.
Researchers at the University of Virginia Health System have identified a molecule that blocks the gene responsible for glioblastoma, a fast-growing and deadly brain cancer. The compound shows promise in preventing the invasive cancer from spreading through the brain without causing harm to healthy tissue.
Researchers found molecules such as syringic acid that protect neurons from aging, while others like resveratrol promote neurodegeneration. An AI-powered approach identified potential therapeutic substances to preserve brain function and prevent neurodegenerative diseases.
Cells move in groups during biological processes, but researchers have made a surprising discovery that upends understanding of how cells move. Negative viscosity, which propels cells forward, has been found to increase metabolic activity in affected regions.
Researchers introduce a new single-cell sorting strategy operating directly in air to overcome constraints of fixed microfluidic channels. The system achieves exceptionally high accuracy and survival rates, enabling flexible sorting of multiple cell subpopulations from complex samples.
Researchers at Science Tokyo discover that a single amino acid deletion in the antibody's lower hinge transforms it into a stable half-IgG1 molecule with altered immune activity. This finding provides a blueprint for engineering next-generation antibody therapies.
Researchers have developed a new AI tool called VASCilia that provides unprecedented 3D views of cochlear hair cells. The tool accelerates the imaging process by 50-fold, allowing scientists to analyze cells with greater precision and accuracy. This advancement offers new insights into hearing loss caused by damaged inner ear hair cells.
A new study identified deoxyhypusine synthase as a critical regulator of macrophage maturation and long-term survival. Without this enzyme, monocytes fail to differentiate into functional tissue-resident macrophages, leading to impaired tissue maintenance and inflammation.
Research highlights glial cells as dynamic regulators of brain health, playing both protective and harmful roles in neural function. Promising therapeutic targets include oligodendrocyte dysfunction, mitochondrial transfer, and extracellular vesicle engineering.
Researchers at John Innes Centre and Earlham Institute developed a powerful single-cell visualisation technique to understand wheat spike development. The study reveals distinct expression patterns across spikes, shedding light on why basal spikelets fail to achieve full size.
Researchers at NTU Singapore have found that a common bacterium produces reactive oxygen species that impairs wound healing. Neutralizing this process with an antioxidant enzyme restores skin cells' ability to migrate and heal, offering a potential solution to tackle antibiotic-resistant strains.
A research team at Goethe University Frankfurt has compiled a catalog of human E3 ligases and mapped their relationships, revealing family-specific functions. The study identifies 40 additional E3 ligases suitable for PROTAC development, expanding the range of tissues and diseases targeted by degradation therapies.
Researchers have developed a new method to print custom microstructures directly into living cells, enabling the study of biological functions and instilling enhanced properties. The breakthrough uses light-sensitive materials and laser polymerization to create structures within cells.
Researchers discovered genes that regulate fibroblast growth, which builds the scaffolding between cells. Adjusting these factors reversed age-related changes and improved health outcomes in mice. The study offers new opportunities to understand and reverse aging-related diseases.
Researchers have discovered that feline infectious peritonitis virus infects a broader range of immune cells, including B lymphocytes and T lymphocytes. The findings suggest that the virus can persist in these cells even after treatment, potentially leading to long-term immune problems.