Bottom Line:
Author: Louis R. Pasquale, M.D., of Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, and colleagues.
Background: XFS is a harmful aging of the eye associated cataracts, elevated intraocular pressure and retinal vein blockage. There is evidence that climate factors contribute to XFS. For example, aboriginal Australians who spend lots of time outdoors have a higher prevalence of the disorder. But the relationship between ultraviolet (UV) radiation (UVR) and XFS needs further study because some reports of a link have not been consistent.
How the Study Was Conducted:
Results: Where people live appears linked to XFS, with each degree of weighted lifetime average residential latitude away from the equator associated with an 11 percent increased odds of XFS. Every hour per week spent outside during the summer, averaged over a lifetime, also was associated with a 4 percent increased odds of XFS. The odds of XFS decreased by 2 percent in the United States, but not in Israel, for every 1 percent of average lifetime summer time during the day that sunglasses are worn. In the United States, a history of working over water or snow also was associated with increased odds of XFS. There appeared to be no association between brimmed hat wear and XFS.
Discussion: "This work provides evidence for a role of reflected UV rays in contributing to XFS. It by no means excludes other genetic and environmental mechanisms in XFS pathogenesis. If confirmed in other studies, there could be reason to consider more widespread use of UV-blocking eyewear in the prevention of XFS."
( JAMA Ophthalmol . Published online September 4, 2014. doi:10.1001/.jamaopthalmol.2014.3326. Available pre-embargo to the media at http://media.jamanetwork.com .)
Editor's Note: Authors made conflict of interest and funding/support disclosures. Please see article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
Media Advisory: To contact author Louis R. Pasquale, M.D., call Mary Leach at (617) 573-4170 or email Mary_Leach@meei.harvard.edu .
JAMA Ophthalmology