Kinases are an important class of enzymes that catalyze the phosphorylation of proteins, lipids, sugars, nucleosides, and other cellular components. They play key regulatory roles in all aspects of eukaryotic cell physiology and their deregulation is associated with a number of pathological conditions, which make kinases key targets in drug discovery efforts, primarily in oncology.
This collection is unique because clones in the collection represent protein kinases as well as non-protein kinases, are fully sequenced verified, full-length, and can be sub-cloned by recombination based methodologies. This gene collection will be a useful resource for the scientific community and will facilitate high-throughput cellular and biochemical assays and structural studies of this important gene family.
Proceedings of the National Academy of Sciences