Articles tagged with Kinases
Researchers have discovered a complex regulatory circuit involving SRSF1, AURKA, and MYC that promotes aggressive pancreatic cancer progression. The circuit, which involves alternative splicing, can be targeted with an antisense oligonucleotide to reduce tumor cells' viability and trigger apoptosis.
Researchers characterized a hidden intermediate state in Src kinase function, which enables rapid phosphorylation and is essential for T-cell activation and cell migration. This study expands our understanding of kinase function and sets the stage for new therapeutic approaches that selectively target these conformational states.
Researchers discovered that vertebrate lonesome kinase (VLK) triggers direct extracellular interaction for phosphorylation, mediating injury-induced pain. This process attracts N-methyl-D-aspartate (NMDA) receptor proteins, strengthening synaptic connections and enhancing postsynaptic potentials.
A team of researchers at the University of Toronto has identified a protein, Shikimate kinase-like 1 (SKL1), that enables land plants to convert light into energy through photosynthesis. This discovery holds promise for improved herbicides and increased efficiency of photosynthesis in food crops.
Researchers have determined the near-atomic-resolution structure of the human ATR–ATRIP complex, clarifying key features and interactions. The study identified novel binding modes for two clinical ATR inhibitors, VE-822 and RP-3500, providing insights into designing next-generation therapies.
Researchers discovered that herpesvirus protein kinases mimic human cyclin-dependent kinases, regulating viral infection and latency. Phosphorylation of the viral enzyme contributes to its survival and persistence, while phosphorylation downregulates its activity, allowing for balance between host survival and viral persistence.
Researchers at Sanford Burnham Prebys have discovered a way to target the energy supply chain of cancer cells. By understanding how enzymes like ubiquitous mitochondrial creatine kinase (uMtCK) function, scientists can design new treatments that slow or stop tumor growth.
Researchers at University of Arizona Cancer Center found that an immunotherapy previously shown to be ineffective against prostate cancer may have therapeutic potential when combined with a specific protein inhibitor. The study's co-author, Noel Warfel, PhD, identified a way to sensitize prostate tumors to immune checkpoint inhibitors ...
A team led by biologist Thomas Mayer found that a small binding-pocket on cyclin B helps regulate the sequence of cell division events. Without this pocket, malformations occur due to incorrect kinase phosphorylation, leading to potential tumours or infertility.
A team of researchers has identified a calcium-activated bi-kinase module as the central molecular switch driving plant immune response. This discovery sheds light on how plants transmit immune signals from cell to cell without disrupting other signalling chains, using reactive oxygen species and calcium signals.
The study uses generative AI to identify and optimize potent and selective HPK1 inhibitors for immunotherapy. The results show a relatively balanced candidate compound with adequate in vitro ADME, in vivo PK properties, good oral bioavailability, and robust in vivo efficacy in various cancer models.
Researchers at Sanford Burnham Prebys found that pancreatic cancer cells rely on a specific nutrient, glutamine, to fuel their unchecked growth. The study identified two enzymes, aPKC zeta and iota, that play a regulatory role in the process of macropinocytosis, allowing cancer cells to scavenge alternative resources.
Researchers found effective peptidomimetics that can bind to and inhibit Aurora-A's interaction with TACC3 without inhibiting its enzymatic function. This inhibition also showed promise in targeting a different protein-protein interaction between N-Myc and Aurora-A, which is crucial in childhood brain cancers.
A new study from Karolinska Institutet found that people with type 2 diabetes have lower levels of the protein creatine kinase, leading to impaired mitochondrial function and energy production. This impairment may contribute to poorer energy metabolism in individuals with type 2 diabetes.
Researchers at Baylor College of Medicine have discovered DAPK3 as a key regulator of TNBC cell migration. The study found that eliminating DAPK3 protein leads to prevention of migration and invasion in laboratory experiments. Further studies are needed to assess its potential value as a therapeutic target.
KiNet is an interactive web portal that enables researchers to visualize and study kinase-substrate interactions in systemwide contexts. This facilitates the understanding of kinase functions and their implications in diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.
Researchers at the University of Nottingham uncover key regulators of malaria parasites' cell division, revealing NEK1 as a potential drug target. The study aims to find new therapeutic targets for controlling malaria transmission.
Researchers discover PG3 activates p21, PUMA, and DR5 in cancer cells through ATF4 and ISR, independent of p53. The study provides insights into a novel mechanism by which PG3 induces cell death.
A study published in Nature Communications reveals a cellular signaling pathway that promotes heart cell survival. The Mst1-FoxO1-C/EBP-β interaction stimulates protective mechanisms in cardiac myocytes, potentially paving the way for new therapies.
A research team led by Magnus Wolf-Watz at Umeå University has discovered the chemistry behind the cell's energy molecule ATP. They found that a small angle change caused by magnesium can significantly speed up the chemical reaction producing ATP, linking structure and catalytic effect.
Researchers develop a method that fuses AlphaFold's strengths with computer simulations based on physics laws to predict protein structures, enabling faster drug development. The approach filters down initial hypotheses to a more manageable set of structures, increasing the effectiveness of pharmaceuticals.
Researchers at Virginia Tech have discovered a possible new pathway to treat colorectal cancer by targeting the NF-kB-inducing kinase (NIK) protein. The study, led by Irving Coy Allen, identifies changes in a significant signaling pathway in human patients and presents potential targets for therapeutics.
Researchers will develop new tools to understand how proteins interact and regulate the nervous system. The project aims to identify new therapeutic targets for brain disorders and generate diagnostic tools.
Legume plants have a unique ability to interact with nitrogen-fixing bacteria, allowing them to thrive without external nitrogen. Researchers identified four essential phosphorylation sites on the SYMRK kinase that mediate this symbiotic relationship.
Groundbreaking research reveals key insights into plant-AM fungi interactions, including the roles of two proteins, CKL1 and CKL2, which control lipid flow essential for fungal survival. This symbiosis could lead to advances in agricultural sustainability and crop resilience.
A new method has been developed to detect potential therapeutic tumor targets in human biopsies, which could lead to more effective personalized medicine. The kinase inhibitor pulldown assay (KiP) enriches and quantifies small amounts of kinases present in biopsy samples, paving the way for future clinical applications.
Researchers at the University of Miami Miller School of Medicine have discovered that glioblastoma cells can mimic healthy neurons, evading drugs and immune systems. They identified key enzymes and protein modifications, including BRAF, which shows promise as a potential therapy target.
A multicenter, retrospective study of Japanese patients treated with JAK inhibitors found impressive remission rates and low disease activity. The study's results contradict previous concerns about the effectiveness of these drugs, suggesting they may be a viable option for patients with other health problems.
Researchers explore kinase inhibitors as targeted therapies for specific CRC subsets, offering hope for improved treatment options. Key findings suggest that uncovering essential kinases for tumor growth can lead to more effective treatment strategies in metastatic or later-stage CRC patients.
Researchers explore CDK9 inhibitors as a promising combination partner in treating hematological malignancies. They discuss the role of cyclin-dependent kinases (CDKs) in these diseases and highlight the potential synergism with other drugs.
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
Scientists at the University of Münster have found a signaling pathway that protects plant stem cells in the root meristem from salt stress. The GSO1 receptor-like kinase helps transport sodium out of cells, preventing damage and promoting survival.
Researchers have cloned the wheat rust resistance genes Lr9 and Sr43, revealing that they encode unusual kinase fusion proteins. This breakthrough enables new options for addressing disease resistance in bread wheat and could lead to heat-resistant versions of the Sr43 gene to adapt to climate change.
Researchers at Baylor College of Medicine have identified a targetable vulnerability in ESR1 fusion-driven breast cancer. Kinase inhibitor pralsetinib suppresses the growth of cancer cells, suggesting potential for treatment.
Researchers found that p21 knockout mice experienced reduced senescent cell presence, alleviated chronic lung inflammation, and improved fitness. Resident epithelial and endothelial cells played a significant role in mediating the p21-dependent inflammatory response.
Researchers at UC San Diego and UC Merced developed a high-throughput method to study the circadian clock in real time, shedding light on its internal functions. The study found that kinases play a crucial role in relaying the circadian rhythm from the core oscillator to gene expression.
Scientists have identified an autoinflammatory disease called Lyn kinase-associated vasculopathy and liver fibrosis (LAVLI) linked to mutations in the LYN gene. The research suggests that Lyn kinase may be a potential therapeutic target for drugs treating non-syndromic small vessel vasculitis and inflammation-induced liver fibrosis.
A new review paper suggests that selective protection of normal cells from chemotherapy could increase the therapeutic window and improve outcomes for cancer patients. The authors propose using antagonistic drug combinations to kill drug-resistant cancer cells, reducing side effects and improving quality of life.
Researchers at University of Bonn discover a backup mechanism in immune cells that ensures efficient antiviral responses despite TBK1 enzyme mutations or complete loss. This mechanism relies on the stability of IKKepsilon protein, which compensates for TBK1 deficiency.
Researchers used AgRenSeq genomic discovery method to identify two genes protecting experimental wheat plants against wheat blast. The study highlights the power of heritage wheat varieties and wild grass relatives in providing disease-fighting diversity.
Researchers at USC Keck School of Medicine have identified two new avenues for treating diverse forms of ALS by suppressing genes and inhibiting proteins. The findings suggest that targeting SYF2 gene suppression and PIKFYVE kinase inhibition may lead to broadly effective treatments for the disease.
Researchers have developed a sophisticated AI algorithm, SPHINKS, that can refine omics datasets and pinpoint protein kinases responsible for tumor growth in glioblastoma. The algorithm has the potential to provide personalized treatments for patients with aggressive brain cancer.
Scientists have mapped out over 300 protein kinases and their targets, which could yield new leads for cancer drugs. The comprehensive atlas helps researchers identify signaling pathways that differ between normal and cancerous cells, or between treated and untreated cancer cells.
Researchers developed a new way to study the sensory system used by pathogenic bacteria to infect humans. They screened thousands of peptides against a bacterial sensor and discovered 13 new human antimicrobial peptides (AMPs) that activate the sensor. The findings suggest an arms race between humans and bacteria, with each evolving ne...
A new review paper discusses the role of CDK4 in regulating the cell cycle and its involvement in cancer. The study highlights the importance of CDK4/6 inhibitors as treatments for ER+ breast cancer and their potential utility in multiple tumor types.
Researchers identified USP7 as a novel cyclin F-interacting protein that stabilizes cyclin F protein. The study also found that USP7 regulates cyclin F mRNA, with pharmacological inhibition resulting in downregulation of cyclin F mRNA.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
The study found that protein kinase CK2 plays a key role in regulating CD8+ T cell activation, metabolic reprogramming and differentiation during infection by the intracellular pathogen Listeria monocytogenes. In mouse models, deletion of the CK2α catalytic subunit impaired CD8+ T cell function.
Researchers used live fluorescence imaging experiments to uncover the mechanism behind cell volume regulation, revealing that WNK kinases activate the 'switch' through phase separation. This discovery has implications for human health, particularly in relation to kidney function and salt-sensitive hypertension.
A new experimental drug has shown promising results in treating liver cancer, with two patients experiencing a partial response to the treatment. The drug, NMS-01940153E, targets an enzyme that plays a critical role in cell division and growth, and its side effects are manageable.
Researchers found that sapanisertib can kill the malaria parasite at several stages during its life cycle, including in the liver and red blood cells. The study's findings offer new hope against a disease that kills over half a million people annually.
Researchers aim to understand the role of FAK in promoting key changes in vascular smooth muscle cells that contribute to atherosclerosis. Preliminary evidence suggests that inhibiting FAK may block VSMC transdifferentiation and promote plaque stability.
A new study reveals that higher body temperature can alter key proteins in individuals with mevalonate kinase deficiency, a devastating genetic disorder. The research provides insights into the underlying physiology of the condition and suggests potential new treatment approaches.
A new study reveals how a rare genetic mutation affects an enzyme involved in learning and memory, leading to enhanced activation and potential treatment options. Researchers have developed a method of protein analysis that enabled them to identify a potential treatment using existing medicine.
A study by CNIC scientists has identified a key role for the MKK3/6–p38γ/δ signaling pathway in cardiac hypertrophy. Inhibition of p38α promotes an unexpected activation of the other branch of the pathway, consisting of the proteins MKK3, p38γ, and p38δ. This activation induces another key pathway in cardiac hypertrophy, the mTOR pathway.
A recent study published in Cancer Research identified a unique vulnerability in certain high-risk cancers that can be exploited for targeted therapy. Researchers found that cancer cells with alternative lengthening of telomeres (ALT) have a common weakness, leading to resistance to DNA-damaging agents and chemotherapy.
Scientists discovered a 'Goldilocks zone' for enzyme docking interactions, where the binding strength is 'just right', maximizing catalytic efficiency. By simulating system interactions, researchers developed an equation predicting optimal docking strength for various enzymes.
Researchers from the US and Japan have discovered the mechanism of GTP recognition by a tumor-promoting kinase, leading to the evolution of a GTP sensor kinase. This finding could lead to the development of a new cancer-treating drug that targets PI5P4Kβ using GTP instead of ATP.
Researchers at TTUHSC will investigate common mechanisms of resistance and sensitivity in alternate telomere lengthening (ALT) cancers, with a focus on targeting ATM kinase inhibitors for therapy. The team aims to develop clinical trials for patients with ALT+ cancers.
The newly developed KANPHOS database provides comprehensive information on kinase-associated protein phosphorylation, facilitating research into neural signaling pathways. The database contains information on phosphoproteins, phosphorylation sites, and participant kinases, allowing for searches based on various parameters.