Articles tagged with Kinases
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A new tool called KnIT has shown promise in mining all public medical literature and generating hypotheses that can lead to breakthroughs in cancer research. The tool was tested on the protein p53, which is a critical tumor suppressor protein, and accurately predicted the existence of proteins that modify it.
Activation of extracellular signal-regulated kinase 1/2 was shown to protect against hippocampal neuronal injury in a rat model of diabetic cerebral ischemia. However, reduced extracellular signal-regulated kinase 1/2 decreased Ku70 activity and increased Bax expression, leading to increased lost hippocampal neurons.
Researchers have developed a new technique to observe and report on the behavior of kinase signaling proteins in living cells. This allows for the tracking of multiple kinases functioning in living cells, enabling the observation of healthy versus diseased cell comparison and experimental drug effects.
Renal cancer cells grow rapidly when placed in a pro-growth matrix supported by an enzyme typically found in the brain. Inhibiting this kinase halts cancer cell division and spread, suggesting its role in cancer growth.
Researchers found CaM Kinase II plays a significant role in controlling neuropeptide release from neurons, affecting learning, memory, social behaviors, and mood. The study's findings could lead to future therapies targeting altered mood and memory in humans.
A new biochemical technique allows researchers to study how specific proteins called kinases interact to trigger cellular behavior, such as cell movement. The method, developed by Klaus Hahn's team, enables the activation of just one kinase and its interaction with another molecule in real time.
Researchers identified the subunit where binding took place and showed that a known activator fully activates AMPK through biochemical communication with other subunits. This discovery confirms the activation site and enables the modeling of potential drugs.
Scientists have discovered a molecular signalling pathway that helps oral epithelial cells resist Candida infection. The PI3 Kinase pathway is activated within minutes of fungal encounter, protecting against future damage. Boosting this pathway may lead to novel therapies against Candida infections.
A study by Karoline Kollmann and colleagues reveals CDK6's role in regulating tumour growth while also promoting blood vessel formation. The researchers found that a mutant form of CDK6 retains its ability to regulate expression despite losing kinase function.
Maternal alcohol consumption during pregnancy has a detrimental effect on fetal central nervous system development. Prenatal ethanol exposure can lead to changes in cyclin-dependent kinase 5 expression, affecting synaptic plasticity and impairing learning and memory functions in offspring.
Researchers found that chlorinated BPA and modified forms of the chemical produced similar but distinct effects on hormone signaling pathways. The modified BPA worked through membrane estrogen receptors to deactivate key signaling enzymes, potentially leading to cell signaling disruptions.
Researchers at Scripps Research Institute design a dual inhibitor attacking leucine-rich repeat kinase 2 (LRRK2) and c-jun-N-terminal kinase (JNK) enzymes, two proteins closely linked to Parkinson's disease development. The compound may offer a more effective treatment by eliminating complications of individual inhibitors.
Researchers at the Stowers Institute for Medical Research have made a groundbreaking discovery about a protein called Matrimony (Mtrm), which traps and inactivates the powerful Polo kinase. This finding has significant implications for cancer treatment, as Polo kinase is widely considered to be misregulated in many types of cancer.
A study mapping the landscape of kinases in cancerous and non-cancerous tissue identified outlier kinase expression that can be targeted with existing drugs. Researchers found promising combinations, including adding a FGFR4-inhibitor to Herceptin for HER2-positive breast cancer tumors.
Researchers at Ruhr-University Bochum found an overactive CaM kinase II enzyme in failing hearts, which relaxes muscle cells by phosphorylating the giant protein titin. This may lead to a new starting point for treating heart failure.
Scientists at National Jewish Health identified a novel target for treating peanut allergies by inhibiting Pim 1 kinase, which increases in the intestines of allergic mice. Treatment with a small molecule inhibitor reduced allergic symptoms, including diarrhea and histamine levels.
University of Iowa researchers have discovered that CaM kinase II triggers cell death in heart cells following a heart attack. Blocking the enzyme can prevent heart cells from dying and protect against heart failure.
Researchers at Sanford-Burnham Medical Research Institute have developed a new method to generate induced pluripotent stem cells (iPSCs) by adding kinase inhibitors, which significantly increase cellular reprogramming efficiency. This breakthrough has the potential to accelerate disease research and drug development.
A study published in Genetics found that manipulating a hormone-producing cell group in the brain can control blood sugar levels. Fruit flies were used to test the effect of inhibiting AMP-activated kinase, resulting in reduced hyperactivity and lowered sugar release when starved.
A Finnish research team has uncovered the protein structure that regulates cell signalling and blood cell formation, shedding light on haematological disorders. The study provides new opportunities for disease-specific treatment and may lead to targeted therapeutics for common myeloproliferative diseases.
Researchers at the University of Saskatchewan have developed a powerful new tool for analyzing kinases, which are enzymes involved in various cellular processes. The software promises to improve data accuracy and understanding of biology, representing important treatment targets for diseases.
A Purdue University biochemist is creating maps of all the potential routes for cancer cell formation, which could lead to more effective cancer drugs. By identifying kinases and their direct protein targets, researchers can tailor kinase-inhibiting drugs to block multiple pathways and make them more effective.
Researchers have identified an imbalance in the HNF4A gene variant as a potential biomarker for colon cancer. The study suggests that certain genetic variations may make individuals more susceptible to the disease, and drugs targeting Src kinase activity could potentially prevent or treat it.
A new study by University of Iowa researchers pinpoints CaM kinase as the key player in cardiac rupture. Blocking this protein may help prevent cardiac rupture and reduce death risk. The study also found that activated CaM kinase prompts heart muscle cells to produce an enzyme called MMP9, implicated in heart rupture.
A new study creates a comprehensive library of 178 kinase inhibitors targeting 300 enzymes, including those critical for cancer and other diseases. This library will aid researchers in developing cancer drugs that block specific kinases while minimizing side effects.
A new inherited neurometabolic disorder has been discovered, caused by mutations in the ADK gene. The disease, adenosine kinase deficiency, disrupts the methionine cycle, leading to symptoms such as encephalopathy and abnormal liver function.
Researchers at Penn State College of Medicine have discovered a potential new cancer therapy that inhibits two key enzymes in mouse tumor cells, making them more sensitive to chemotherapy. The drug SLM3, which targets GSK-3ß and CDK1, has shown promising results in lab mice.
A new study found that hyperactivation of AMP-activated protein kinase (AMPK) amplifies Huntington's disease by promoting neuronal death and reducing cell survival. The findings suggest that AMPK could be a therapeutic target for the treatment of HD.
Researchers found that Aurora A was up-regulated and activated in epithelial cells lining PKD patient kidneys, binding to and phosphorylating polycystin-2. Inhibition of Aurora A boosted intracellular calcium levels, suggesting it may be a viable therapeutic target for boosting polycystin-2 activity in certain patients.
Researchers discovered that a supposedly inactive protein ROP5 plays a crucial role in Toxoplasma gondii's ability to cause disease, suggesting the possible role of similarly errant proteins in other diseases. The team engineered strains without ROP5 and found the pathogen was unable to cause disease in mice.
Elevated levels of cardiac enzymes after CABG surgery linked to increased mortality risk, particularly among those with high biomarker levels. Higher CK-MB ratios were associated with greater death risk, with a ratio value of 4-5 predicting more than double the expected 30-day mortality.
Childhood cancer researchers have identified checkpoint kinase 1 (CHK1) as a potential new treatment target for neuroblastoma. By blocking CHK1 activity, chemotherapy can be made more effective against the cancer cells.
Researchers at Duke Cancer Institute discover a way to prevent the development of invadopodia structures that enable cancer cells to spread. By blocking Abl and Arg kinases, they also eliminate protein function that burns through tissue, allowing cancer cells to enter new cells.
A new microfluidics-imaging platform can detect cancer growth signaling in tiny biopsy samples, allowing for faster and more efficient screening. This method uses an integrated platform to measure kinase activity from as few as 3,000 cells, enabling direct experimentation on patient samples.
Researchers have discovered two coordinated dance moves performed by skeletons inside neurons during long-term potentiation, a process linked to learning and memory. This finding provides insight into developmental disorders such as Williams syndrome, which affects cognitive strengths and weaknesses.
Researchers have successfully used a drug to reset the body clock of mice, opening up possibilities for treating psychiatric disorders, jet lag, and shift work-related health impacts. The drug works by inhibiting casein kinase 1, a key molecule in the circadian clock mechanism.
Researchers discovered that cancer drugs can inhibit Leishmania's survival and infection ability by targeting its TOR kinase proteins. The study highlights the potential of repurposing existing cancer treatments to combat this debilitating parasite.
Engineered allosteric regulation provides precise control of kinase activity in living cells, enabling scientists to understand cellular processes and dissect the functions of kinases. This new method has exciting applications in basic research and promises to open doors to new scientific insights into cancer and other human diseases.
Researchers at Cold Spring Harbor Laboratory found that blocking PI3 kinase signaling improves memory in aging fruit flies, reducing β-amyloid deposits. The study sheds light on the role of PI3 kinase in Alzheimer's disease and suggests potential therapeutic targets.
A University of Iowa study suggests a way to improve heart treatment by targeting key heart-related mechanisms with drugs that maintain the positive effects of calmodulin kinase II while reducing its negative effects. The findings aim to prevent unwanted calcium activity and related molecular problems that lead to cell overload and death.
Scientists have identified a new mechanism that helps the body burn more energy, leading to increased fat burning and lean muscle mass. The study suggests that targeting the Fyn kinase enzyme may offer a promising approach for developing new weight loss treatments.
Researchers from EMBL have discovered the molecular structure of a key protein involved in cellular communication systems that are affected in neurodegeneration, cancer and cardiovascular disease. The study provides insights into how this protein functions and how it can be targeted with drugs to develop new treatments.
A TGen-led team has identified three kinases that cause hyperphosphorylation of tau protein, leading to the dismantling of microtubule bridges within brain cells. This process disrupts synaptic connections and can lead to memory loss and thinking problems associated with Alzheimer's disease.
The kinase IKK phosphorylates mutated Huntingtin protein to promote its removal, but also increases neurotoxicity in later stages of the disease. This dual role highlights the complexity of IKK's function in Huntington's disease.
Scientists at the University of Pennsylvania School of Medicine have developed a new model of skin cancer that sheds light on the role of Src kinase and its anti-oncogene counterpart, Srcasm. The study found that Fyn, a member of the Src family of proteins, is a potent oncogene in skin cancer, while Srcasm levels are decreased and acti...
Researchers have developed a mathematical model of heart cells to understand the effects of oxidized CaM kinase on cardiac electrical activity. Oxidation activates the enzyme, leading to a vicious cycle that advances heart disease.
Researchers at Fox Chase Cancer Center have identified a unique method to inhibit signaling enzymes called kinases using the small molecular inhibitor IPA-3. By targeting PAK1's regulatory domain, IPA-3 is highly selective and takes a more-or-less backdoor approach to shutting down cancer cells.
Researchers found that Aurora B kinase helps regulate XIST's chromatin binding by phosphorylating chromatin proteins during mitosis. This study provides insight into X chromosome silencing and may lead to a better understanding of noncoding RNAs and their role in regulating heterochromatin.
Researchers at Vanderbilt University Medical Center used NMR methods to determine the structure of diacylglycerol kinase (DAGK), a large bacterial protein that resides within the cell membrane. The study suggests that similar methods can be applied to other membrane proteins, including G protein-coupled receptors, which are targets for...
Researchers at University of Iowa discovered that calcium/calmodulin-dependent protein kinase II (CaM kinase II) activation can increase heart rates, contrary to traditional beta-adrenergic receptor stimulation understanding. This finding suggests inhibiting CaM kinase II function could help control heart rate problems in people with a...
Researchers found a link between CaM kinase II inhibition and reduced inflammatory gene expression in heart muscle cells. Inhibition of CaM kinase II protected mice from heart damage, highlighting a potential new treatment target.
Researchers from the University of Iowa have discovered that calmodulin kinase II contributes to arrhythmia in Timothy syndrome, a rare disease affecting only 20 people worldwide. Inhibiting this enzyme can prevent irregular heartbeats.
Researchers at the University of Texas Medical Branch have discovered a key biochemical link in the process by which Ebola Zaire virus infects cells. By activating the PI3 kinase pathway, Ebola tricks the cell into drawing it into an endosome, where it can reproduce itself.
A study by University of Iowa researchers reveals a new dimension for a key heart enzyme and sheds light on an important biological pathway involved in cell death in heart disease. The team found that oxidation can sustain the enzyme's activity, which is implicated in arrhythmias, hypertrophy, and heart cell death.
The study reveals that three specific inhibitors of necroptosis, a form of necrotic death, target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. This finding presents a novel avenue for drug development to prevent extensive tissue damage in diseases such as heart attacks and strokes.
Researchers discover that the Warburg effect, a unique metabolic process in cancer cells, is essential for tumor growth. The M2 form of pyruvate kinase (PKM2) plays a critical role in this process, enabling cancer cells to rapidly proliferate and produce energy through anaerobic glycolysis.
The Hawley Lab has identified two molecular mechanisms that restart the meiotic cycle in oocytes, including the controlled expression of Polo kinase and the inactivation of inhibitory protein Matrimony. This discovery has significant implications for understanding egg maturation and releasing, as well as treating infertility and cancer.
Researchers have identified two proteins controlling the pause in meiotic division, with Matrimony preventing Polo kinase from working until sufficient levels are reached. This work may lead to new treatments for infertility and cancer, as Polo kinase is strongly expressed in tumor cells.
Researchers at OHSU have identified the WNK kinase protein complex as a master switch that regulates blood pressure. The study reveals how this complex modulates salt and potassium balance in the kidney, raising or lowering blood pressure depending on its functioning.
A study published in JCI Journals reveals that disturbances in sphingolipid metabolism may be a key factor in early pregnancy loss. Sphingosine kinase 1 (Sphk1) and Sphk2 proteins play a crucial role in metabolizing these fats, which are essential for placental development.