Researchers found that a tumor protein present in aggressive breast cancers correlates with poor prognosis and growth/spread of disease. GRB-7 protein is related to HER-2/Neu gene, influencing treatment response and potentially informing clinical predictions and new therapies.
Researchers discovered a genetic cause for a rare form of inherited iron deficiency anemia, which may provide insights into iron deficiency in the general population and suggest new treatment approaches. The study identified a gene mutation in the TMPRSS6 protein, leading to excessive hepcidin production and impaired iron absorption.
A £30 million follow-up study will analyze 120,000 DNA samples from people with 25 common diseases, including multiple sclerosis and asthma. The research aims to identify the genes underlying these conditions and develop new treatments.
Researchers at Penn School of Medicine have developed a targeted therapy combination that overcomes treatment resistance in liver cancer by combining sorafenib with the TRAIL pathway. This combination restores sensitivity to cell death and kills cancer cells, offering new hope for patients.
A Mayo-led study found that smoking is associated with an increased risk of developing colorectal tumors lacking DNA repair proteins. Women who smoked were more likely to develop these tumors, which may be due to the loss of function in genes responsible for repairing genetic damage.
A study by researchers at Duke University Medical Center found that exercising mice grew prostate tumors twice as fast as non-exercising mice, potentially leading to improved drug delivery models for cancer treatment. The exercise may increase blood flow to tumors, allowing for better distribution of medicine.
A study at the University of Texas M. D. Anderson Cancer Center found that oral tissue can be used to monitor molecular events in less accessible lung tissue. The research discovered that cells lining the mouth reflect the same antitumor genes silenced in oral and lung tissue, offering a new approach to detecting lung cancer.
Scientists at Georgetown University Medical Center have identified a small molecule that can block the action of the EWS-FLI1 fusion protein responsible for Ewing's sarcoma. This breakthrough could lead to the development of a targeted therapy for this rare and aggressive cancer.
Researchers have identified two potential biomarkers that could help doctors monitor the effectiveness of treatment with sunitinib or bevacizumab for kidney and non-small cell lung cancer. A study found that circulating endothelial progenitor cells (ccEPCs) increase in patients who respond to therapy, while those who do not respond hav...
Researchers found that nicotine increases osteopontin production, promoting cancer cell survival and spread. Elevated osteopontin levels have been detected in pancreatic cancer patients, suggesting a potential role in the cigarette smoking-pancreatic cancer connection.
Researchers at Emory University found that supplementing diet with calcium and vitamin D increased levels of protein Bax, which controls programmed cell death in the colon. This increase may push pre-cancerous cells into programmed cell death, potentially reducing colon cancer risk.
The study reveals that three specific inhibitors of necroptosis, a form of necrotic death, target and inhibit RIP1 kinase, a protein that can direct cells into necrosis. This finding presents a novel avenue for drug development to prevent extensive tissue damage in diseases such as heart attacks and strokes.
Researchers identified a genetic defect affecting energy production in muscles of children with autism spectrum disorders, leading to muscle weakness. The study found that 65% of the children had defects in oxidative phosphorylation, highlighting the importance of understanding how genes impact mitochondrial function.
Researchers at Rockefeller University and the University of Tokyo found that insects use fast-acting ion channels to smell odors, a major break with previous understanding. This new strategy allows for direct detection of odor molecules, bypassing complex biological apparatus previously thought to be necessary.
A study found that moderate drinking in women increases the risk of developing ER+/PR+ breast cancer, with higher risks observed for those who consumed more alcohol. Researchers also identified a link between specific genetic variations and increased breast cancer risk among postmenopausal drinkers.