A team of researchers has elucidated the mechanics of the endocycle, a novel cell cycle that plays a crucial role in plant and animal growth. By studying genetic transcription factors and enzymes driving endocycling, the team discovered a molecular oscillator that controls cell growth rates.
Researchers used zinc oxide microwires to enhance the efficiency of LEDs by creating a piezoelectric potential that tunes charge transport and carrier injection. The devices showed significant improvement in emission intensity and injection current.
Researchers identified genes responsible for thousands of tiny changes in brain tissue DNA, finding they were active in areas linked to cell renewal. The study provides new insights into how the brain works and may link retrotransposon activity to brain diseases such as Alzheimer's.
A new study creates a comprehensive library of 178 kinase inhibitors targeting 300 enzymes, including those critical for cancer and other diseases. This library will aid researchers in developing cancer drugs that block specific kinases while minimizing side effects.
Patterns formed by a new DNA letter, 5-hydroxymethylcytosine (5-hmC), suggest it has specific functions in stem cells and brain. The study's findings indicate that 5-hmC may poise genes to be turned on after being repressed.
A large-scale community-randomized trial found that community counseling reduced TB prevalence and child infections by half, with costs under $1 per person per year. The ZAMSTAR project, funded by the Bill and Melinda Gates Foundation, improved TB testing and service integration in communities.
Researchers at Gladstone Institutes discovered a protein form linked to Huntington's disease that influences symptom timing and severity. The study offers new avenues for treating not only Huntington's but also similar conditions like Alzheimer's and type 1 diabetes.
Researchers identified the orbitofrontal and anterior cingulate cortex as key players in impaired decision making, leading to addictive and compulsive behavior. The study's findings may pave the way for more targeted treatments for substance abuse and obsessive-compulsive disorders.
New formulas and methods have been developed to analyze across-wind loads and effects on super-tall buildings. These achievements have been adopted in national and local load codes and applied to the structural design of many actual super-tall buildings.
Researchers identify FMRP protein as key player in RNA editing, a process that regulates neural activity. Flies with mutated dFMR1 genes exhibit similar symptoms to humans with Fragile X, including memory and cognitive deficits.
University of Toronto researchers develop high-efficiency OLEDs on plastic, a less costly alternative to traditional glass-based manufacturing, enabling flexible form factors.
A team at Northwestern University has developed a new method to identify thousands of protein molecules quickly, which could lead to the discovery of biomarkers and early disease detection. The approach, known as top-down proteomics, measures proteins intact instead of breaking them down into smaller parts.
A large pad of fat cells in the abdomen provides nutrients that promote the spread and growth of ovarian cancer. Cancer cells reprogram their metabolism to thrive on lipids acquired from fat cells, leading to rapid tumor growth.
Research published in BMC Public Health found that commuting by car or public transport is associated with negative health effects compared to walking or cycling. The study of 21,000 people showed that longer journey times increased the risk of poor health outcomes.