Babies born to women who do not consume enough folic acid (sometimes referred to as folate or vitamin B9) are at high risk of developing neural tube defects (i.e., defects in the development of the spinal cord or brain). This is the reason underlying the recommendation that women who are pregnant take a folic acid supplement. A team of researchers, led by Bermans Iskandar, at the University of Wisconsin, Madison, has now generated data in rodents suggesting that folic acid might also help promote healing in injured brain and spinal cord. Specifically, the team was able to uncover a molecular pathway by which folate can promote nerve cell regeneration following injury in rodents.
In an accompanying commentary, Matthias Endres and Golo Kronenberg, at Charité – Universitätsmedizin Berlin, Germany, discuss how these data, together with the safety and simplicity of folate supplementation, provide a rationale for testing whether folate supplementation is beneficial for patients with spinal cord and brain trauma.
TITLE: Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation
AUTHOR CONTACT:
Bermans J. Iskandar
University of Wisconsin, Madison, Wisconsin, USA.
Phone: 608.263.9651; Fax: 608.263.1728; E-mail: iskandar@neurosurg.wisc.edu .
View this article at: http://www.jci.org/articles/view/40000?key=7699cee3397c28e321ac
ACCOMPANYING COMMENTARY
TITLE: Neuronal injury: folate to the rescue?
AUTHOR CONTACT:
Matthias Endres
Charité – Universitätsmedizin Berlin, Berlin, Germany.
Phone: 49.30.450.560.102; Fax: 49.30.450.560.932; E-mail: matthias.endres@charite.de .
View this article at: http://www.jci.org/articles/view/40764?key=TpndN64MezO2HHZ2NCmW
Journal of Clinical Investigation