Skokie, IL - The ISSCR is updating its Guidelines for Stem Cell Research and Clinical Translation to respond to recent scientific advances that include the use of pluripotent stem cell (PSC) to create models of early human embryo development (see Stem Cell Reports 14:1-6). As the science continues to advance, it raises important scientific, clinical, ethical, and societal issues for researchers, regulators, and funding agencies. The ISSCR believes the scientific community must address these challenges to establish parameters for research in this area.
Stem cell-based models of early embryo development are important to enable researchers to study early human development without destroying human embryos. The ability to model early embryo development through the culture of stem cells may also make it possible to ethically study periods of human development that are poorly understood or difficult to model using animal embryos. This area of research could improve fertility treatment and prevent the development of certain congenital diseases.
The ISSCR will develop detailed guidance on this area of research in the updated ISSCR Guidelines that will be released in early 2021. Until the Guidelines are released, the ISSCR encourages researchers and institutions to observe the following principles and current recommendations when considering research in this area:
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The revision of the ISSCR Guidelines is an international effort being led by Robin Lovell-Badge, PhD, FRS, Francis Crick Institute, UK. Amander Clark, PhD, University of California, Los Angeles, USA and Janet Rossant, PhD, FRS, FRSC, Gairdner Foundation, Canada are co-chairing the group working on embryo models, which includes Ali Brivanlou, PhD, The Rockefeller University, USA, Jianping Fu, PhD, University of Michigan, USA, Kazuto Kato, PhD, Osaka University, Japan, Debra Mathews, PhD, MA, Johns Hopkins University, USA, Kathy Niakan, PhD, Francis Crick Institute, UK, Nicolas Rivron, PhD, Maastricht University, Netherlands, Mitinori Saitou, MD, PhD, Kyoto University, Japan, Azim Surani, PhD, FMedSci, FRS, University of Cambridge, UK, and Fuchou Tang, PhD, Peking University, China.
About the International Society for Stem Cell Research
With nearly 4,000 members from more than 60 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health. Additional information about stem cell science is available at A Closer Look at Stem Cells, an initiative of the Society to inform the public about stem cell research and its potential to improve human health.
Stem Cell Reports