Articles tagged with Stem Cell Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The journal welcomes Bo Shen, Ph.D., and Luca Peruzzotti-Jametti, M.D., Ph.D. as Early Career Editors, bringing complementary strengths in stem cell niche biology and metabolism to the editorial board. Their perspectives will help ensure rigorous peer review, relevance, and global engagement.
The new NIH policy on research using human fetal tissue could undermine the development of life-saving therapies for various diseases. The ISSCR urges NIH to reconsider its decision and engage constructively with the scientific community to support biomedical research.
The International Society for Stem Cell Research published its most downloaded papers of 2025, reflecting the field's scientific range from pluripotency to regenerative medicine. The journal's mission is to publish rigorous, transparent, and consequential science advancing discovery while informing clinical translation.
Researchers have compiled a comprehensive list of 166 human pluripotent stem cell lines available for clinical applications, guiding researchers and developers in selecting optimal cell lines. The study aims to drive hPSC-derived products towards the clinic, addressing a knowledge gap in off-the-shelf product development.
Dry eye disease affects 5-15% of people, causing symptoms like redness and burning sensation. Researchers generated human tear gland organoids from stem cells to understand the connection between DED and autophagy. They found that disabling autophagy led to cellular disruption, reduced tear protein secretion, and increased cell death.
A novel approach to chronic pain management uses induced pluripotent stem cell-derived peripheral pain-sensing neurons to treat osteoarthritis joint pain. The therapy, SN101, sequesters inflammatory pain factors without transmitting pain signals, preserving joint tissues and relieving chronic pain.
The ISSCR symposium highlights new clinical trial results and emerging technologies advancing PSC-derived cell therapies. Key findings include breakthrough approaches for treating drug-resistant epilepsy and geographic atrophy, as well as durable remission in type 1 diabetes.
Researchers have found that patients with blood cancers can safely receive stem cell transplants from mismatched, unrelated donors using a protective regimen. The study's findings could make transplants accessible to nearly all patients with blood cancers, regardless of ancestry.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
A new retinal organoid platform has identified biomarkers for Leber Congenital Amaurosis (LCA) and allows for genetic testing of patients. The platform uses small 3D structures of retinal cells to classify variants of uncertain significance in LCA genes.
A recent study found that young donors (18-35 years old) with minor HLA differences can provide better survival rates and outcomes compared to older sibling donors. Additionally, gender and CMV status also play a role in donor selection.
Dr. Tara O. Henderson is the recipient of the 2026 Norman J. Siegel New Member Outstanding Science Award, recognizing her groundbreaking research and dedication to improving outcomes for children with cancer. She has established a distinguished record as a mentor and educator, shaping the careers of numerous physicians and scientists i...
Researchers at Kyoto University create a method to produce platelet-producing cells from stem cells, offering an unlimited supply of patient-derived platelets. Monitoring KAT7 levels can help ensure efficient and consistent platelet manufacturing.
The ISSCR, SDB, and the Allen Institute are hosting a three-day scientific symposium featuring early-career scientists, focusing on cross-disciplinary exchange and amplifying emerging leaders in developmental biology and stem cell science. Confirmed topics include data analysis, model systems, spatial awareness, and cell fates.
Researchers used human-induced pluripotent stem cell-derived kidney organoids to model nephronophthisis, revealing the Hippo signaling pathway's role in fibrosis. Inhibiting this pathway with drugs like verteporfin shows promise as a treatment option.
A clinical trial published by The BMJ raised concerns over data irregularities, age criteria violations, and undeclared conflicts of interest. The BMJ has placed an expression of concern on the paper and will investigate fully with institutions and regulatory authorities as necessary.
Scientists at The University of Osaka developed a novel hydrogel that supports the efficient 3D culture of human induced pluripotent stem cells. This new material combines the properties of fibrin and laminin-511, creating a potent, xeno-free scaffold with strong cell adhesion.
Researchers successfully converted human stomach cells into insulin-secreting cells in mice, helping to control blood sugar levels and alleviate diabetes. The approach could potentially be used to treat patients with lost or dysfunctional pancreatic beta cells.
The ISSCR and SCN are partnering to develop a global conversation on workforce development in regenerative medicine, examining current challenges and identifying skills gaps. The joint initiative aims to build the talent required for continued discovery and innovation in the field.
The International Society for Stem Cell Research invites you to celebrate 20 years of induced pluripotent stem cell (iPSC) discovery and chart its future. The symposium features keynote speakers, featured sessions, and presentations on cutting-edge research.
Researchers from Kyoto University have found that immature oligodendrocyte progenitor cells can switch fate to restore blood flow after stroke. These low-oxygen-conditioned OPCs migrate to the stroke region and survive, promoting new blood vessel formation and partially restoring brain function.
Researchers at Gladstone Institutes discover a gene called HMGN1 that disrupts DNA packaging and regulation, leading to heart malformations in people with Down syndrome. Removing the extra copy of HMGN1 from mice with Down syndrome prevents heart defects, paving the way for potential treatments.
The acquisition unifies genetics and stem cell research expertise to accelerate discovery and translate science into therapies. Researchers will gain access to advanced platforms, including the NYSCF Global Stem Cell Array, to study disease mechanisms and test treatments.
Researchers at UIC discovered that platelet factor 4 helps regulate hematopoietic stem cell division and proliferation. Adding the protein to old blood cells reversed signs of aging in mice and human stem cells, suggesting a promising therapeutic target for preventing or improving age-related disorders.
The ISSCR 2026 Annual Meeting will bring together academic and industry leaders to explore advances in stem cell science and regenerative medicine. Scientists can submit abstracts by February 25, 2026, for oral presentations and Travel and Merit Awards.
The International Society for Stem Cell Research (ISSCR) has released a comprehensive guide to accelerate the translation of human pluripotent stem cell-derived therapies into clinical trials and commercial use. The guidance outlines key principles and decision points for developing safe, effective, and regulatory-compliant products.
The ASAP study found that transplantation as soon as possible does not provide a survival advantage over remission induction, but reduces hospital stays and chemotherapy exposure. Age and AML genetics are the most important risk factors influencing survival.
The journal has appointed 13 distinguished researchers from around the world to expand its representation across stem cell science disciplines. The new Editorial Board members include experts in basic biology, translational research, clinical application, and ethical considerations.
Scientists successfully derive and maintain self-renewing and pluripotent ESCs from chickens and seven other bird species using a growing medium of egg yolk. The study holds promise for applications in studying embryonic development, producing lab-grown poultry, and reviving endangered birds.
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
Research with human fetal tissue has been instrumental in advancing biomedicine and saving millions of lives. The ISSCR asserts that this work is essential for understanding human development, infertility, and diseases like diabetes and neurodegenerative disorders.
The ISSCR and NCOB will conduct an international horizon scan on stem cell research, gathering insights into the field's future and its ethical implications. The analysis will inform the ISSCR Guidelines and support researchers, clinicians, and regulators worldwide.
The ISSCR will host its 2028 Annual Meeting in Copenhagen, Denmark, bringing together researchers, clinicians, industry leaders, and policymakers from over 80 countries. The event will support new frontiers in stem cell science and regenerative medicine, fostering global collaboration and discovery of cutting-edge scientific advances.
Early-life changes in fAD brain cells have been identified using stem cell-derived brain organoids, revealing key features of Alzheimer's disease. Treatment with Thymosin beta 4 has shown promise in reversing AD-specific changes.
The DKMS John Hansen Research Grant is supporting innovative research projects in blood cancer therapy, aiming to improve treatment outcomes. The grant, worth almost €1 million, will support young scientists with a focus on transplant immunology and novel diagnostic and therapeutic strategies.
The International Society for Stem Cell Research (ISSCR) and STEMCELL Technologies have partnered to develop a free, on-demand course on the ISSCR Standards for Human Stem Cell Use in Research. The course will provide practical guidance on applying the standards to enhance rigor and reproducibility in human stem cell research worldwide.
The ISSCR has released an updated set of guidelines for stem cell research and clinical translation, incorporating advances in human stem cell-based embryo models. The new guidelines aim to provide clear guidance on the development and application of these innovative models.
A new study has found that TAF1 operates as a key molecular switch in adult hematopoietic stem cell maintenance and lineage commitment. This discovery challenges prevailing models of gene regulation and has the potential to lead to new therapeutic strategies targeting the molecule, which could improve blood production and transplantation.
A new route of delivering gene therapy is being explored, potentially reducing invasiveness and increasing accessibility. Researchers will test a novel approach on non-human primates, aiming to expand access to office-based treatments.
Researchers at The Hebrew University of Jerusalem have found that mesenchymal stem cell secretions can help protect mammary cells from stress while increasing milk fat production. This breakthrough could lead to healthier cows and richer, creamier milk without the need for additives or heavy processing.
Researchers have developed novel three-dimensional liver organoids using bile acids, which retain hepatocyte-like features and can be sustained in long-term cultures. These organoids demonstrate a unique gene expression profile similar to fetal hepatocytes and support replication of hepatitis viruses.
Researchers have generated a first large-scale stem cell bank from over 100 individuals with extreme Alzheimer's disease risk. This new resource, called iPSC Platform to Model Alzheimer’s disease Risk (IPMAR), will facilitate studies on the impact of genetic variants in cellular models of AD.
The International Society for Stem Cell Research has selected five distinguished early career scientists to serve as Early Career Editors for Stem Cell Reports. The new editors bring expertise in cell differentiation, tissue engineering, and precision therapies to the journal.
Hideyuki Okano has been elected President of the International Society for Stem Cell Research (ISSCR), an organization dedicated to promoting excellence in stem cell science. He will champion inclusive excellence, advance discovery, and ensure that the transformative promise of stem cell science benefits the world.
Professor Eran Meshorer's groundbreaking research in epigenetics and stem cell biology has uncovered critical insights into chromatin structure and gene expression. His work has broad implications for regenerative medicine, developmental biology, and understanding neurological disorders.
A recent study published in Stem Cell Reports found that microgravity accelerates skeletal muscle degeneration, leading to a decline in muscle strength and protein content. The researchers used an ISS lab-on-chip model to simulate ageing-related muscle loss and discovered that electrical stimulation can mitigate these changes.
Researchers have created 'spinal cord-like' microtissues from stem cells to study ALS-linked neuroinflammation. These microtissues, derived from ALS patients and healthy donors, exhibit distinct inflammatory responses, enabling the testing of FDA-approved drugs for personalized treatment approaches.
Dr. Britta Will has been appointed as the permanent director of the Ruth L. and David S. Gottesman Institute, succeeding Ulrich Steidl. Her research focuses on restoring blood regeneration in older adults and those with cancer. She aims to advance fundamental research into stem cell function and tissue regeneration to combat chronic de...
A study found that exercise improves the maturation of transplanted stem cells and their integration with host neurons in a rodent model of Parkinson's disease. This enhancement is attributed to increased secretion of beneficial proteins in exercising rats, promoting transplant survival and function.
Researchers developed a human alpha cell model from immature stem cells, closely resembling pancreas-derived cells. The stem cell-derived alpha cells responded to diabetic conditions with elevated glucagon secretion and dysregulation.
Researchers have discovered that mature liver cells transform into immature states and divide rapidly in response to damaged tissue, a process similar to what occurs in human patients with drug-induced liver injury. This understanding could lead to more effective treatments for liver failure by targeting the regenerative program.
The ISSCR 2026 Annual Meeting will bring together global stem cell experts to discuss key scientific themes and applications. The meeting will take place at the Palais des congrès de Montréal from July 8-11, 2026.
A new gene therapy has successfully restored immune function in nine children with severe leukocyte adhesion deficiency-I (LAD-I), a rare genetic disorder. The treatment has eliminated symptoms and reduced severe infections, offering a life-changing benefit to these patients.
A highly sensitive bone marrow test has shown to double survival rates for patients with AML mutations in NPM1 and FLT3 genes, allowing for early detection of potential relapse. This trial indicates that regular molecular testing can improve long-term survival rates by restarting treatment earlier.
Dr. Ulrich Steidl, a leading expert in blood diseases, has been elected to the Association of American Physicians for his groundbreaking research on myelodysplastic syndromes and acute myeloid leukemia. His work seeks to understand the characteristics of pre-leukemic stem cells and develop drugs to interrupt their progression.
Researchers at City of Hope discovered a novel target for preventing age-related abdominal fat by identifying the cellular culprit behind midsection widening in middle age. The study found that aging triggers the arrival of new adult stem cells and enhances the body's massive production of new fat cells, especially around the belly.
Scientists successfully grow chimpanzee naive-type pluripotent stem cells, revealing key mechanisms for self-renewal and differentiation. The study's findings shed light on the evolutionary conservation of these properties, offering a powerful tool for investigating early developmental processes.
Scientists at the University of Copenhagen have created 'super stem cells' that outperform regular stem cells by developing into multiple cell types. These 'super stem cells' show promise in improving fertility treatment, particularly IVF success rates, by producing essential tissue for early embryonic development.
Participants who took the supplement showed improvements in grip strength, lower body mobility, and reductions in body weight. The supplement appeared to reduce stem cell turnover, regulate immune function, and influence gene activity related to stress response.
Researchers at MIT have discovered that a genetic variant can lead to defects in transfer RNA molecules, causing embryonic face cells to fail to fuse properly. This study sheds light on the molecular mechanisms underlying cleft lip and cleft palate formation.